{"id":68897,"date":"2026-03-02T18:06:52","date_gmt":"2026-03-02T18:06:52","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&p=68897"},"modified":"2026-05-21T07:14:11","modified_gmt":"2026-05-21T07:14:11","slug":"ipamorelin","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/ipamorelin\/","title":{"rendered":"Ipamorelin"},"content":{"rendered":"

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Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Ipamorelin?<\/h3>\n

Ipamorelin<\/strong> je syntetick\u00fd pentapeptidov\u00fd sekretagog r\u016fstov\u00e9ho hormonu, kter\u00fd se v\u00e1\u017ee na receptor ghrelinu (GHS-R1a) a spou\u0161t\u00ed pulzn\u00ed uvol\u0148ov\u00e1n\u00ed GH bez<\/strong> bez zv\u00fd\u0161en\u00ed kortizolu nebo prolaktinu \u2014 tato selektivita jej odli\u0161uje od star\u0161\u00edch GHRP. Ve v\u00fdzkumu se \u010dasto kombinuje s CJC-1295 pro zes\u00edlen\u00ed amplitudy pulz\u016f GH. Dod\u00e1v\u00e1 se v lyofilizovan\u00fdch vial\u00e1ch o obsahu 2 mg a\u017e 10 mg v\u00fdhradn\u011b pro laboratorn\u00ed v\u00fdzkum.<\/p>\n<\/div>\n

Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdzkumn\u00e9 lyofilizovan\u00e9 peptidy \u00b7 HPLC \u010distota \u226599% (COA na vy\u017e\u00e1d\u00e1n\u00ed) \u00b7 Diskr\u00e9tn\u00ed teplotn\u011b stabiln\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 p\u0159eprava peptid\u016f \u00b7 1,400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Specifikace<\/th>\nDetail<\/th>\n<\/tr>\n<\/thead>\n
CAS \u010d\u00edslo<\/strong><\/td>\n170851-70-4<\/td>\n<\/tr>\n
item2<\/strong><\/td>\nC38<\/sub>H49<\/sub>N9<\/sub>O5<\/sub><\/td>\n<\/tr>\n
item7<\/strong><\/td>\n711,86 Da<\/td>\n<\/tr>\n
item9<\/strong><\/td>\nAib-His-D-2-Nal-D-Phe-Lys-NH2<\/sub><\/td>\n<\/tr>\n
item11<\/strong><\/td>\nLyofilizovan\u00fd pr\u00e1\u0161ek (nebo v dodan\u00e9 form\u011b)<\/td>\n<\/tr>\n
item13<\/strong><\/td>\n\u226599% (HPLC ov\u011b\u0159eno, COA na vy\u017e\u00e1d\u00e1n\u00ed)<\/td>\n<\/tr>\n
Skladov\u00e1n\u00ed<\/strong><\/td>\nLyofilizovan\u00e9: 2\u20138 \u00b0C (lednice) pro pracovn\u00ed z\u00e1sobu; \u221220 \u00b0C pro dlouhodob\u00e9 skladov\u00e1n\u00ed neotev\u0159en\u00fdch vialek. Rekonstituovan\u00e9: 2\u20138 \u00b0C, pou\u017eijte do ~30 dn\u016f. Chra\u0148te p\u0159ed sv\u011btlem. Nefreeze\u2013thaw rekonstituovan\u00fd roztok.<\/td>\n<\/tr>\n
Rozpustnost<\/strong><\/td>\nBakteriostatick\u00e1 voda (doporu\u010deno) nebo steriln\u00ed voda pro krat\u0161\u00ed dobu pou\u017eit\u00ed<\/td>\n<\/tr>\n
Pouze pro v\u00fdzkum<\/strong><\/td>\nPouze pro laboratorn\u00ed v\u00fdzkum. Nen\u00ed ur\u010deno pro diagnostick\u00e9 nebo terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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Co je Ipamorelin?<\/h2>\n

Ipamorelin<\/strong> je syntetick\u00fd pentapeptid pat\u0159\u00edc\u00ed do rodiny peptid\u016f uvol\u0148uj\u00edc\u00edch r\u016fstov\u00fd hormon (GHRP). Vyvinut\u00fd spole\u010dnost\u00ed Novo Nordisk v 90. letech a poprv\u00e9 charakterizovan\u00fd Raunem et al. (Eur J Endocrinol, 1998) je klasifikov\u00e1n jako sekretagog r\u016fstov\u00e9ho hormonu<\/strong> \u2014 slou\u010denina, kter\u00e1 spou\u0161t\u00ed endogenn\u00ed uvol\u0148ov\u00e1n\u00ed GH aktivac\u00ed receptoru ghrelinu (GHS-R1a) na somatotropech hypof\u00fdzy.<\/p>\n

Sekvence: Aib-His-D-2-Nal-D-Phe-Lys-NH2<\/sub>. Molekulov\u00e1 hmotnost p\u0159ibli\u017en\u011b 711,9 Da. Na rozd\u00edl od star\u0161\u00edch GHRP (GHRP-2, GHRP-6, hexarelin) je ipamorelin pozoruhodn\u00fd svou \u010distou hormon\u00e1ln\u00ed selektivitou<\/strong> \u2014 uvol\u0148uje GH bez v\u00fdznamn\u00e9ho zv\u00fd\u0161en\u00ed kortizolu, prolaktinu nebo ACTH. Tato selektivita je d\u016fvodem, pro\u010d se ipamorelin stal nejstudovan\u011bj\u0161\u00edm GHRP 21. stolet\u00ed. Dod\u00e1v\u00e1 se jako vysoce \u010dist\u00fd lyofilizovan\u00fd pr\u00e1\u0161ek pro rekonstituci s bakteriostatickou vodou. Ipamorelin je ur\u010den pouze pro laboratorn\u00ed v\u00fdzkum<\/strong> a nen\u00ed ur\u010den pro lidskou nebo veterin\u00e1rn\u00ed diagnostiku \u010di terapii. Pro mechanismus, publikovan\u00fd v\u00fdzkum a protokoly kombinace viz n\u00e1\u0161 V\u00fdzkumn\u00fd pr\u016fvodce Ipamorelin & CJC-1295<\/a>.<\/p>\n

Mechanismus \u00fa\u010dinku \u2014 Selektivn\u00ed agonismus ghrelinov\u00e9ho receptoru<\/h2>\n

Ipamorelin se v\u00e1\u017ee na receptor pro sekretagog r\u016fstov\u00e9ho hormonu typ 1a (GHS-R1a)<\/strong>, endogenn\u00ed receptor pro ghrelin. Receptor je exprimov\u00e1n na somatotropech hypof\u00fdzy a v j\u00e1d\u0159e hypothalamick\u00e9ho oblouku a jeho aktivace spou\u0161t\u00ed pulzn\u00ed uvol\u0148ov\u00e1n\u00ed r\u016fstov\u00e9ho hormonu z hypofyz\u00e1rn\u00edch z\u00e1sobn\u00edch granul\u00ed.<\/p>\n