{"id":68942,"date":"2026-03-03T07:07:09","date_gmt":"2026-03-03T07:07:09","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&p=68942"},"modified":"2026-05-21T07:14:11","modified_gmt":"2026-05-21T07:14:11","slug":"epitalon","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/epitalon\/","title":{"rendered":"Epitalon"},"content":{"rendered":"

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Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Epitalon?<\/h3>\n

Epitalon<\/strong> (Ala-Glu-Asp-Gly, AEDG) je syntetick\u00fd tetrapeptidov\u00fd analog p\u0159\u00edrodn\u00edho peptidu epif\u00fdzy. \u00dast\u0159edn\u00ed prvek v\u00fdzkumn\u00e9ho programu Vladimira Khavinsona o dlouhov\u011bkosti v Rusku, studuje se pro \u00fa\u010dinky na d\u00e9lku telomer, cirkadi\u00e1nn\u00ed rytmus a genovou expresi ve v\u00fdzkumu st\u00e1rnut\u00ed. Dod\u00e1v\u00e1 se v lyofilizovan\u00fdch vialk\u00e1ch po 10 mg a 50 mg v\u00fdhradn\u011b pro laboratorn\u00ed v\u00fdzkum.<\/p>\n<\/div>\n

Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdzkumn\u00e9 lyofilizovan\u00e9 peptidy \u00b7 HPLC \u010distota \u226599% (COA na vy\u017e\u00e1d\u00e1n\u00ed) \u00b7 Diskr\u00e9tn\u00ed teplotn\u011b stabiln\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 p\u0159eprava peptid\u016f \u00b7 1,400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Specifikace<\/th>\nDetail<\/th>\n<\/tr>\n<\/thead>\n
CAS \u010d\u00edslo<\/strong><\/td>\n307297-39-8<\/td>\n<\/tr>\n
item2<\/strong><\/td>\nC14<\/sub>H22<\/sub>N4<\/sub>O9<\/sub><\/td>\n<\/tr>\n
item7<\/strong><\/td>\n390.35 Da<\/td>\n<\/tr>\n
item9<\/strong><\/td>\nAla-Glu-Asp-Gly (AEDG)<\/td>\n<\/tr>\n
item11<\/strong><\/td>\nLyofilizovan\u00fd pr\u00e1\u0161ek (nebo v dodan\u00e9 form\u011b)<\/td>\n<\/tr>\n
item13<\/strong><\/td>\n\u226599% (HPLC ov\u011b\u0159eno, COA na vy\u017e\u00e1d\u00e1n\u00ed)<\/td>\n<\/tr>\n
Skladov\u00e1n\u00ed<\/strong><\/td>\nLyofilizovan\u00e9: 2\u20138 \u00b0C (lednice) pro pracovn\u00ed z\u00e1sobu; \u221220 \u00b0C pro dlouhodob\u00e9 skladov\u00e1n\u00ed neotev\u0159en\u00fdch vialek. Rekonstituovan\u00e9: 2\u20138 \u00b0C, pou\u017eijte do ~30 dn\u016f. Chra\u0148te p\u0159ed sv\u011btlem. Nefreeze\u2013thaw rekonstituovan\u00fd roztok.<\/td>\n<\/tr>\n
Rozpustnost<\/strong><\/td>\nBakteriostatick\u00e1 voda (doporu\u010deno) nebo steriln\u00ed voda pro krat\u0161\u00ed dobu pou\u017eit\u00ed<\/td>\n<\/tr>\n
Pouze pro v\u00fdzkum<\/strong><\/td>\nPouze pro laboratorn\u00ed v\u00fdzkum. Nen\u00ed ur\u010deno pro diagnostick\u00e9 nebo terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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Co je Epitalon?<\/h2>\n

Epitalon<\/strong> (tak\u00e9 naz\u00fdvan\u00fd Epithalon<\/strong> nebo Peptid AEDG<\/strong>) je syntetick\u00fd peptid slo\u017een\u00fd ze \u010dty\u0159 aminokyselin: L-Ala-L-Glu-L-Asp-Gly. Jde o syntetick\u00fd analog p\u0159\u00edrodn\u00edho peptidu epif\u00fdzy zvan\u00e9ho epithalamin<\/em>, izolovan\u00e9ho z bovinn\u00edho extraktu epif\u00fdzy a charakterizovan\u00e9ho Vladimirem Khavinsonem a kolegy v Petrohradsk\u00e9m institutu biorregulace a gerontologie po\u010d\u00ednaje 80. lety 20. stolet\u00ed.<\/p>\n

Epitalon pat\u0159\u00ed mezi nejstudovan\u011bj\u0161\u00ed peptidy v rusk\u00e9m v\u00fdzkumn\u00e9m programu dlouhov\u011bkosti, s publikovan\u00fdmi preklinick\u00fdmi a mal\u00fdmi klinick\u00fdmi studiemi sahaj\u00edc\u00edmi \u010dty\u0159i desetilet\u00ed. Deklarovan\u00e9 \u00fa\u010dinky \u2014 aktivace telomer\u00e1zy, remodelace chromatinu, prodlou\u017een\u00ed \u017eivota u modelov\u00fdch organism\u016f, normalizace melatoninov\u00fdch rytm\u016f u star\u0161\u00edch v\u00fdzkumn\u00fdch subjekt\u016f \u2014 jsou v\u00fdznamn\u00e9, ale poch\u00e1zej\u00ed z \u00fazk\u00e9 v\u00fdzkumn\u00e9 skupiny; nez\u00e1visl\u00e9 replikace na Z\u00e1pad\u011b jsou omezen\u00e9. Molekulov\u00e1 hmotnost p\u0159ibli\u017en\u011b 390,4 Da. Dod\u00e1v\u00e1 se jako vysoce \u010dist\u00fd lyofilizovan\u00fd pr\u00e1\u0161ek pro rekonstituci s bakteriostatickou vodou. Epitalon je ur\u010den pouze pro laboratorn\u00ed v\u00fdzkum<\/strong>. Pro hlub\u0161\u00ed mechanismus, kontext v\u00fdzkumu Khavinsona a shrnut\u00ed zalo\u017een\u00e9 na v\u011bdeck\u00fdch faktech viz n\u00e1\u0161 Pr\u016fvodce v\u00fdzkumem Epitalonu<\/a>.<\/p>\n

Mechanismus \u00fa\u010dinku \u2014 telomer\u00e1za, signalizace epif\u00fdzy, exprese gen\u016f<\/h2>\n

Navrhovan\u00e9 mechanismy Epitalonu zasahuj\u00ed do v\u00edce biologick\u00fdch syst\u00e9m\u016f. V\u00fdzkum sp\u00ed\u0161e nazna\u010duje ne\u017e jednozna\u010dn\u011b prokazuje p\u0159\u00edm\u00fd mechanismus, ale v publikovan\u00e9 literatu\u0159e se konzistentn\u011b objevuj\u00ed t\u0159i cesty:<\/p>\n