{"id":68952,"date":"2026-03-03T07:29:50","date_gmt":"2026-03-03T07:29:50","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&p=68952"},"modified":"2026-05-21T07:14:11","modified_gmt":"2026-05-21T07:14:11","slug":"semax","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/semax\/","title":{"rendered":"Semax"},"content":{"rendered":"

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Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Semax?<\/h3>\n

Semax<\/strong> je syntetick\u00fd heptapeptid zalo\u017een\u00fd na fragmentu 4\u201310 adrenokortikotropn\u00edho hormonu (ACTH). Vyvinut\u00fd v \u00dastavu molekul\u00e1rn\u00ed genetiky v Rusku, je to nootropn\u00ed a neuroprotektivn\u00ed v\u00fdzkumn\u00fd peptid nejzn\u00e1m\u011bj\u0161\u00ed pro siln\u00e9 zv\u00fd\u0161en\u00ed BDNF<\/strong> a intranaz\u00e1ln\u00ed pod\u00e1n\u00ed do CNS<\/strong>. Schv\u00e1len v Rusku jako l\u00e9k na zotaven\u00ed po mrtvici \u2014 neschv\u00e1len FDA. Dod\u00e1v\u00e1 se v lyofilizovan\u00fdch vialk\u00e1ch o obsahu 5 mg a\u017e 10 mg pouze pro laboratorn\u00ed v\u00fdzkum.<\/p>\n<\/div>\n

Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdzkumn\u00e9 lyofilizovan\u00e9 peptidy \u00b7 HPLC \u010distota \u226599% (COA na vy\u017e\u00e1d\u00e1n\u00ed) \u00b7 Diskr\u00e9tn\u00ed teplotn\u011b stabiln\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 p\u0159eprava peptid\u016f \u00b7 1,400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Specifikace<\/th>\nDetail<\/th>\n<\/tr>\n<\/thead>\n
CAS \u010d\u00edslo<\/strong><\/td>\n80714-61-0<\/td>\n<\/tr>\n
item2<\/strong><\/td>\nC37<\/sub>H51<\/sub>N9<\/sub>O10<\/sub>S<\/td>\n<\/tr>\n
item7<\/strong><\/td>\n813,93 Da<\/td>\n<\/tr>\n
item9<\/strong><\/td>\nMet-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)<\/td>\n<\/tr>\n
item11<\/strong><\/td>\nLyofilizovan\u00fd pr\u00e1\u0161ek (nebo v dodan\u00e9 form\u011b)<\/td>\n<\/tr>\n
item13<\/strong><\/td>\n\u226599% (HPLC ov\u011b\u0159eno, COA na vy\u017e\u00e1d\u00e1n\u00ed)<\/td>\n<\/tr>\n
Skladov\u00e1n\u00ed<\/strong><\/td>\nLyofilizovan\u00e9: 2\u20138 \u00b0C (lednice) pro pracovn\u00ed z\u00e1sobu; \u221220 \u00b0C pro dlouhodob\u00e9 skladov\u00e1n\u00ed neotev\u0159en\u00fdch vialek. Rekonstituovan\u00e9: 2\u20138 \u00b0C, pou\u017eijte do ~30 dn\u016f. Chra\u0148te p\u0159ed sv\u011btlem. Nefreeze\u2013thaw rekonstituovan\u00fd roztok.<\/td>\n<\/tr>\n
Rozpustnost<\/strong><\/td>\nBakteriostatick\u00e1 voda (doporu\u010deno) nebo steriln\u00ed voda pro krat\u0161\u00ed dobu pou\u017eit\u00ed<\/td>\n<\/tr>\n
Pouze pro v\u00fdzkum<\/strong><\/td>\nPouze pro laboratorn\u00ed v\u00fdzkum. Nen\u00ed ur\u010deno pro diagnostick\u00e9 nebo terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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Co je Semax?<\/h2>\n

Semax<\/strong> (Met-Glu-His-Phe-Pro-Gly-Pro, sekvence MEHFPGP) je syntetick\u00fd peptid o sedmi aminokyselin\u00e1ch vyvinut\u00fd v 80. letech 20. stolet\u00ed v Rusk\u00e9m \u00fastavu molekul\u00e1rn\u00ed genetiky t\u00fdmem Mekhedova, Maly\u0161eva a spolupracovn\u00edk\u016f. Jde o strukturn\u00ed analog fragmentu ACTH 4\u201310 \u2014 centr\u00e1ln\u00ed biologicky aktivn\u00ed oblasti adrenokortikotropn\u00edho hormonu \u2014 modifikovan\u00fd C-termin\u00e1ln\u00ed sekvenc\u00ed Pro-Gly-Pro, kter\u00e1 prodlu\u017euje polo\u010das a zlep\u0161uje penetraci do CNS.<\/p>\n

Semax je schv\u00e1len v Rusk\u00e9 federaci<\/strong> jako l\u00e9\u010div\u00fd p\u0159\u00edpravek na p\u0159edpis pro akutn\u00ed ischemickou c\u00e9vn\u00ed mozkovou p\u0159\u00edhodu a indikace kognitivn\u00edch poruch, prod\u00e1van\u00fd pod obchodn\u00edmi n\u00e1zvy Semax a Semaks. Nen\u00ed schv\u00e1len FDA, EMA ani dal\u0161\u00edmi z\u00e1padn\u00edmi regul\u00e1tory, tak\u017ee z\u00e1padn\u00ed v\u00fdzkumn\u00edci k n\u011bmu maj\u00ed p\u0159\u00edstup pouze pro v\u00fdzkumn\u00e9 \u00fa\u010dely. Molekulov\u00e1 hmotnost p\u0159ibli\u017en\u011b 813,9 Da. Dod\u00e1v\u00e1 se jako lyofilizovan\u00fd pr\u00e1\u0161ek vysok\u00e9 \u010distoty pro rekonstituci s bakteriostatickou vodou. Semax je ur\u010den pouze pro laboratorn\u00ed v\u00fdzkum<\/strong> mimo sv\u00e9 schv\u00e1len\u00e9 \u00fazemn\u00ed p\u016fsobnosti. Pro mechanismus, klinickou historii a v\u00fdzkumn\u00fd kontext viz n\u00e1\u0161 v\u00fdzkumn\u00fd pr\u016fvodce Semaxem<\/a>.<\/p>\n

Mechanismus \u00fa\u010dinku \u2014 BDNF, melanokortin a penetrace do CNS<\/h2>\n

Farmakologie Semaxu kombinuje t\u0159i vlastnosti, kter\u00e9 z n\u011bj \u010din\u00ed neobvykle dob\u0159e prostudovan\u00fd nootropick\u00fd v\u00fdzkumn\u00fd peptid:<\/p>\n