{"id":69005,"date":"2026-03-13T11:51:26","date_gmt":"2026-03-13T11:51:26","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&p=69005"},"modified":"2026-05-21T07:14:11","modified_gmt":"2026-05-21T07:14:11","slug":"cjc-1295-without-dac","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/cjc-1295-without-dac\/","title":{"rendered":"CJC-1295 bez DAC"},"content":{"rendered":"

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Rychl\u00e1 odpov\u011b\u010f \u2014 Co je CJC-1295 bez DAC?<\/h3>\n

CJC-1295 bez DAC<\/strong> (tak\u00e9 naz\u00fdvan\u00fd Mod GRF 1-29<\/strong>) je syntetick\u00fd modifikovan\u00fd analog GHRH (1-29) s kr\u00e1tk\u00fdm polo\u010dasem v plazm\u011b p\u0159ibli\u017en\u011b 30 minut. Na rozd\u00edl od verze s DAC postr\u00e1d\u00e1 albumin-v\u00e1zaj\u00edc\u00ed \u010d\u00e1st, co\u017e vytv\u00e1\u0159\u00ed pulzn\u00ed<\/strong> nam\u00edsto trval\u00e9ho GH sign\u00e1lu. Tento kinetick\u00fd profil z n\u011bj \u010din\u00ed preferovan\u00fd v\u00fdzkumn\u00fd n\u00e1stroj, kdy\u017e z\u00e1le\u017e\u00ed na \u010dasov\u00e1n\u00ed pulz\u016f. Dod\u00e1v\u00e1 se v lyofilizovan\u00fdch vialech o obsahu 2 mg a\u017e 10 mg pouze pro laboratorn\u00ed v\u00fdzkum.<\/p>\n<\/div>\n

Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdzkumn\u00e9 lyofilizovan\u00e9 peptidy \u00b7 HPLC \u010distota \u226599% (COA na vy\u017e\u00e1d\u00e1n\u00ed) \u00b7 Diskr\u00e9tn\u00ed teplotn\u011b stabiln\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 p\u0159eprava peptid\u016f \u00b7 1,400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Specifikace<\/th>\nDetail<\/th>\n<\/tr>\n<\/thead>\n
CAS \u010d\u00edslo<\/strong><\/td>\n863288-34-0 (rodi\u010dovsk\u00e1 slou\u010denina) \u00b7 446262-90-4 (forma Mod-GRF 1\u201329 \u0161iroce citovan\u00e1)<\/td>\n<\/tr>\n
item2<\/strong><\/td>\nC152<\/sub>H252<\/sub>N44<\/sub>O42<\/sub><\/td>\n<\/tr>\n
item7<\/strong><\/td>\n3367.92 Da<\/td>\n<\/tr>\n
item9<\/strong><\/td>\nD-Ala-Tyr-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2<\/sub> (Mod-GRF 1\u201329, bez DAC linkeru)<\/td>\n<\/tr>\n
item11<\/strong><\/td>\nLyofilizovan\u00fd pr\u00e1\u0161ek (nebo v dodan\u00e9 form\u011b)<\/td>\n<\/tr>\n
item13<\/strong><\/td>\n\u226599% (HPLC ov\u011b\u0159eno, COA na vy\u017e\u00e1d\u00e1n\u00ed)<\/td>\n<\/tr>\n
Skladov\u00e1n\u00ed<\/strong><\/td>\nLyofilizovan\u00e9: 2\u20138 \u00b0C (lednice) pro pracovn\u00ed z\u00e1sobu; \u221220 \u00b0C pro dlouhodob\u00e9 skladov\u00e1n\u00ed neotev\u0159en\u00fdch vialek. Rekonstituovan\u00e9: 2\u20138 \u00b0C, pou\u017eijte do ~30 dn\u016f. Chra\u0148te p\u0159ed sv\u011btlem. Nefreeze\u2013thaw rekonstituovan\u00fd roztok.<\/td>\n<\/tr>\n
Rozpustnost<\/strong><\/td>\nBakteriostatick\u00e1 voda (doporu\u010deno) nebo steriln\u00ed voda pro krat\u0161\u00ed dobu pou\u017eit\u00ed<\/td>\n<\/tr>\n
Pouze pro v\u00fdzkum<\/strong><\/td>\nPouze pro laboratorn\u00ed v\u00fdzkum. Nen\u00ed ur\u010deno pro diagnostick\u00e9 nebo terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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Co je CJC-1295 bez DAC?<\/h2>\n

CJC-1295 bez DAC<\/strong> (b\u011b\u017en\u011b naz\u00fdvan\u00fd Mod GRF 1-29<\/strong> nebo jednodu\u0161e tetrasubstituovan\u00fd GRF 1-29<\/strong>) je syntetick\u00fd 30-aminokyselinov\u00fd analog hormonu uvol\u0148uj\u00edc\u00edho r\u016fstov\u00fd hormon. Sd\u00edl\u00ed stejnou z\u00e1kladn\u00ed peptidovou sekvenci jako CJC-1295 with DAC<\/a> \u2014 \u010dty\u0159i aminokyselinov\u00e9 substituce na p\u016fvodn\u00ed sekvenci GHRH (1-29) poskytuj\u00ed odolnost v\u016f\u010di \u0161t\u011bpen\u00ed DPP-IV \u2014 ale postr\u00e1d\u00e1 albumin-v\u00e1zaj\u00edc\u00ed modifikaci DAC<\/strong> kter\u00e1 prodlu\u017euje polo\u010das v \u201cs DAC\u201d verzi.<\/p>\n

Praktick\u00fd d\u016fsledek absence DAC: polo\u010das v plazm\u011b z\u016fst\u00e1v\u00e1 v rozmez\u00ed minut a\u017e hodin (~30 minut) nam\u00edsto dn\u016f. V\u00fdzkumn\u00e9 protokoly proto vyu\u017e\u00edvaj\u00ed v\u00edce\u010detn\u00e9 denn\u00ed injekce (obvykle 2\u20133x) k udr\u017een\u00ed sign\u00e1lu GHRH, nikoli t\u00fddenn\u00ed d\u00e1vkov\u00e1n\u00ed jako u verze s DAC. Toto napodobuje kr\u00e1tk\u00fd, pulzn\u00ed profil endogenn\u00edho GHRH a je preferovan\u00fdm v\u00fdzkumn\u00fdm n\u00e1strojem, kdy\u017e z\u00e1le\u017e\u00ed na na\u010dasov\u00e1n\u00ed pulz\u016f \u2013 zejm\u00e9na v protokolech studuj\u00edc\u00edch fyziologickou pulzaci GH spolu s agonisty ghrelinov\u00e9ho receptoru, jako je ipamorelin<\/a>.<\/p>\n

Molekulov\u00e1 hmotnost p\u0159ibli\u017en\u011b 3 367 Da. Dod\u00e1v\u00e1 se jako vysoce \u010dist\u00fd lyofilizovan\u00fd pr\u00e1\u0161ek pro rekonstituci s bakteriostatickou vodou. CJC-1295 bez DAC je ur\u010den pouze pro laboratorn\u00ed v\u00fdzkum<\/strong> a nen\u00ed ur\u010den pro lidskou nebo veterin\u00e1rn\u00ed diagnostiku \u010di terapii. Pro mechanismus, v\u00fdzkumn\u00fd kontext a protokoly kombinov\u00e1n\u00ed viz na\u0161e V\u00fdzkumn\u00fd pr\u016fvodce Ipamorelin & CJC-1295<\/a>.<\/p>\n

Mechanismus \u00fa\u010dinku \u2013 Pulzn\u00ed signalizace GHRH<\/h2>\n

Mod GRF 1-29 p\u016fsob\u00ed stejnou cestou p\u0159es receptor GHRH v hypof\u00fdze jako p\u0159irozen\u00fd GHRH, ale s kinetick\u00fdm profilem, kter\u00fd jej odli\u0161uje jak od p\u0159irozen\u00e9ho GHRH, tak od verze s DAC:<\/p>\n