{"id":69013,"date":"2026-03-13T11:58:53","date_gmt":"2026-03-13T11:58:53","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&p=69013"},"modified":"2026-05-21T07:14:11","modified_gmt":"2026-05-21T07:14:11","slug":"kpv-lysine-proline-valine","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/kpv-lysine-proline-valine\/","title":{"rendered":"KPV (Lysine-Proline-Valine)"},"content":{"rendered":"

<\/p>\n

\n

Quick Answer \u2014 What is KPV?<\/h3>\n

KPV<\/strong> is the Lys-Pro-Val tripeptide \u2014 the C-terminal anti-inflammatory fragment of alpha-melanocyte stimulating hormone (\u03b1-MSH). Unlike broader melanocortin analogs, KPV has no pigmentation activity<\/strong>; its research signal is purely anti-inflammatory via NFkB inhibition and mast-cell stabilization. Studied for IBD, allergic inflammation, and skin-inflammation research. Supplied in 5\u00a0mg and 10\u00a0mg lyophilized vials for laboratory research use only.<\/p>\n<\/div>\n

Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdzkumn\u00e9 lyofilizovan\u00e9 peptidy \u00b7 HPLC \u010distota \u226599% (COA na vy\u017e\u00e1d\u00e1n\u00ed) \u00b7 Diskr\u00e9tn\u00ed teplotn\u011b stabiln\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 p\u0159eprava peptid\u016f \u00b7 1,400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Specifikace<\/th>\nDetail<\/th>\n<\/tr>\n<\/thead>\n
CAS \u010d\u00edslo<\/strong><\/td>\n67727-97-3<\/td>\n<\/tr>\n
item2<\/strong><\/td>\nC16<\/sub>H30<\/sub>N4<\/sub>O4<\/sub><\/td>\n<\/tr>\n
item7<\/strong><\/td>\n342.43 Da<\/td>\n<\/tr>\n
item9<\/strong><\/td>\nLys-Pro-Val (\u03b1-MSH 11\u201313)<\/td>\n<\/tr>\n
item11<\/strong><\/td>\nitem12<\/td>\n<\/tr>\n
item13<\/strong><\/td>\n\u226599% (HPLC ov\u011b\u0159eno, COA na vy\u017e\u00e1d\u00e1n\u00ed)<\/td>\n<\/tr>\n
Skladov\u00e1n\u00ed<\/strong><\/td>\nLyofilizovan\u00e9: 2\u20138 \u00b0C (lednice) pro pracovn\u00ed z\u00e1sobu; \u221220 \u00b0C pro dlouhodob\u00e9 skladov\u00e1n\u00ed neotev\u0159en\u00fdch vialek. Rekonstituovan\u00e9: 2\u20138 \u00b0C, pou\u017eijte do ~30 dn\u016f. Chra\u0148te p\u0159ed sv\u011btlem. Nefreeze\u2013thaw rekonstituovan\u00fd roztok.<\/td>\n<\/tr>\n
Rozpustnost<\/strong><\/td>\nBakteriostatick\u00e1 voda (doporu\u010deno) nebo steriln\u00ed voda pro krat\u0161\u00ed dobu pou\u017eit\u00ed<\/td>\n<\/tr>\n
Pouze pro v\u00fdzkum<\/strong><\/td>\nPouze pro laboratorn\u00ed v\u00fdzkum. Nen\u00ed ur\u010deno pro diagnostick\u00e9 nebo terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/p>\n

What Is KPV?<\/h2>\n

KPV<\/strong> is the three-letter one-letter-code shorthand for the Lys-Pro-Val tripeptide<\/strong> \u2014 the C-terminal three amino acids (positions 11\u201313) of alpha-melanocyte stimulating hormone (\u03b1-MSH). In the 1980s\u20131990s, multiple research groups noticed that the full \u03b1-MSH molecule produced two functionally separable effects: the well-known N-terminal MC-receptor pigmentation\/arousal activity, and a C-terminal anti-inflammatory<\/strong> activity. When the C-terminal KPV tripeptide was synthesised and tested in isolation, it reproduced the anti-inflammatory effects without the pigmentation side-effects.<\/p>\n

Molecular weight approximately 342.4\u00a0Da. KPV is one of the smallest peptides in the melanocortin family and one of the most-studied anti-inflammatory research tripeptides. It is supplied as a high-purity lyophilized powder. KPV is ur\u010den pouze pro laboratorn\u00ed v\u00fdzkum<\/strong> and is not intended for human or veterinary diagnosis or therapy. For mechanism, IBD research history, and stacking context, see our KPV research guide<\/a>.<\/p>\n

Mechanism of Action \u2014 Three Anti-Inflammatory Pathways<\/h2>\n

KPV’s anti-inflammatory activity operates through at least three complementary pathways, all of which converge on reducing inflammatory signaling without affecting other melanocortin functions:<\/p>\n