{"id":69013,"date":"2026-03-13T11:58:53","date_gmt":"2026-03-13T11:58:53","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&#038;p=69013"},"modified":"2026-05-21T07:14:11","modified_gmt":"2026-05-21T07:14:11","slug":"kpv-lysine-proline-valine","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/kpv-lysine-proline-valine\/","title":{"rendered":"KPV (Lysine-Proline-Valine)"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background: #fff8e1; border-left: 4px solid #f5a623; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<h3 style=\"margin: 0 0 8px 0; font-size: 16px; color: #1a4a6b;\">Rychl\u00e1 odpov\u011b\u010f \u2014 Co je KPV?<\/h3>\n<p style=\"margin: 0;\"><strong>KPV<\/strong> je tripeptid Lys-Pro-Val \u2014 C-termin\u00e1ln\u00ed protiz\u00e1n\u011btliv\u00fd fragment alfa-melanocyt stimuluj\u00edc\u00edho hormonu (\u03b1-MSH). Na rozd\u00edl od \u0161ir\u0161\u00edch melanokortinov\u00fdch analog\u016f m\u00e1 KPV <strong>\u017e\u00e1dnou pigmenta\u010dn\u00ed aktivitu<\/strong>; jeho v\u00fdzkumn\u00fd \u00fa\u010dinek je \u010dist\u011b protiz\u00e1n\u011btliv\u00fd prost\u0159ednictv\u00edm inhibice NFkB a stabilizace \u017e\u00edrn\u00fdch bun\u011bk. Studov\u00e1n pro IBD, alergick\u00fd z\u00e1n\u011bt a v\u00fdzkum ko\u017en\u00edho z\u00e1n\u011btu. Dod\u00e1v\u00e1 se v lyofilizovan\u00fdch vialk\u00e1ch po 5 mg a 10 mg pouze pro laboratorn\u00ed v\u00fdzkum.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background: #f4f8fb; border: 1px solid #d8e3eb; padding: 12px 16px; margin: 16px 0; border-radius: 4px; font-size: 14px;\"><strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdzkumn\u00e9 lyofilizovan\u00e9 peptidy \u00b7 HPLC \u010distota \u226599% (COA na vy\u017e\u00e1d\u00e1n\u00ed) \u00b7 Diskr\u00e9tn\u00ed teplotn\u011b stabiln\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 p\u0159eprava peptid\u016f \u00b7 1,400+ ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size: 14px; color: #444; margin: 8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<table class=\"medsbase-spec-table\" style=\"width: 100%; border-collapse: collapse; margin: 18px 0; font-size: 14px;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 8px 12px; text-align: left; width: 30%;\">Specifikace<\/th>\n<th style=\"padding: 8px 12px; text-align: left;\">Detail<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>CAS \u010d\u00edslo<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">67727-97-3<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>item2<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">C<sub>16<\/sub>H<sub>30<\/sub>N<sub>4<\/sub>O<sub>4<\/sub><\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>item7<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">342,43 Da<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>item9<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Lys-Pro-Val (\u03b1-MSH 11\u201313)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>item11<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Lyofilizovan\u00fd pr\u00e1\u0161ek (nebo v dodan\u00e9 form\u011b)<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>item13<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u226599% (HPLC ov\u011b\u0159eno, COA na vy\u017e\u00e1d\u00e1n\u00ed)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Skladov\u00e1n\u00ed<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Lyofilizovan\u00e9: 2\u20138 \u00b0C (lednice) pro pracovn\u00ed z\u00e1sobu; \u221220 \u00b0C pro dlouhodob\u00e9 skladov\u00e1n\u00ed neotev\u0159en\u00fdch vialek. Rekonstituovan\u00e9: 2\u20138 \u00b0C, pou\u017eijte do ~30 dn\u016f. Chra\u0148te p\u0159ed sv\u011btlem. Nefreeze\u2013thaw rekonstituovan\u00fd roztok.<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Rozpustnost<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Bakteriostatick\u00e1 voda (doporu\u010deno) nebo steriln\u00ed voda pro krat\u0161\u00ed dobu pou\u017eit\u00ed<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Pouze pro v\u00fdzkum<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Pouze pro laboratorn\u00ed v\u00fdzkum. Nen\u00ed ur\u010deno pro diagnostick\u00e9 nebo terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><!-- \/medsbase-tldr-answer --><\/p>\n<h2>Co je KPV?<\/h2>\n<p><strong>KPV<\/strong> je t\u0159\u00edp\u00edsmenn\u00e1 jednop\u00edsmenn\u00e1 zkratka pro <strong>tripeptid Lys-Pro-Val<\/strong> \u2014 C-termin\u00e1ln\u00ed t\u0159i aminokyseliny (pozice 11\u201313) alfa-melanocyt stimuluj\u00edc\u00edho hormonu (\u03b1-MSH). V 80. a 90. letech 20. stolet\u00ed n\u011bkolik v\u00fdzkumn\u00fdch t\u00fdm\u016f zjistilo, \u017ee cel\u00e1 molekula \u03b1-MSH vyvol\u00e1v\u00e1 dva funk\u010dn\u011b odd\u011blen\u00e9 \u00fa\u010dinky: dob\u0159e zn\u00e1mou N-termin\u00e1ln\u00ed MC-receptorovou aktivitu spojenou s pigmentac\u00ed\/vzru\u0161en\u00edm a C-termin\u00e1ln\u00ed <strong>protiz\u00e1n\u011btliv\u00fd<\/strong> aktivitu. Kdy\u017e byl C-termin\u00e1ln\u00ed tripeptid KPV syntetizov\u00e1n a testov\u00e1n izolovan\u011b, reprodukoval protiz\u00e1n\u011btliv\u00e9 \u00fa\u010dinky bez vedlej\u0161\u00edch \u00fa\u010dink\u016f na pigmentaci.<\/p>\n<p>Molekulov\u00e1 hmotnost p\u0159ibli\u017en\u011b 342,4 Da. KPV je jeden z nejmen\u0161\u00edch peptid\u016f v rodin\u011b melanokortin\u016f a jeden z nejv\u00edce studovan\u00fdch protiz\u00e1n\u011btliv\u00fdch v\u00fdzkumn\u00fdch tripeptid\u016f. Je dod\u00e1v\u00e1n jako lyofilizovan\u00fd pr\u00e1\u0161ek vysok\u00e9 \u010distoty. KPV je <strong>ur\u010den pouze pro laboratorn\u00ed v\u00fdzkum<\/strong> a nen\u00ed ur\u010den pro lidskou nebo veterin\u00e1rn\u00ed diagnostiku nebo terapii. Pro mechanismus, historii v\u00fdzkumu IBD a kontext kombinov\u00e1n\u00ed viz n\u00e1\u0161 <a href=\"https:\/\/medsbase.com\/cs\/kpv-peptide-anti-inflammatory-guide\/\">v\u00fdzkumn\u00fd pr\u016fvodce KPV<\/a>.<\/p>\n<h2>Mechanismus \u00fa\u010dinku \u2014 T\u0159i protiz\u00e1n\u011btliv\u00e9 dr\u00e1hy<\/h2>\n<p>Protiz\u00e1n\u011btliv\u00e1 aktivita KPV funguje prost\u0159ednictv\u00edm nejm\u00e9n\u011b t\u0159\u00ed dopl\u0148uj\u00edc\u00edch se drah, kter\u00e9 v\u0161echny sm\u011b\u0159uj\u00ed ke sn\u00ed\u017een\u00ed z\u00e1n\u011btliv\u00e9ho signalizov\u00e1n\u00ed bez ovlivn\u011bn\u00ed dal\u0161\u00edch funkc\u00ed melanokortin\u016f:<\/p>\n<ul>\n<li><strong>inhibice NFkB<\/strong> \u2014 KPV blokuje translokaci NFkB do j\u00e1dra, \u010d\u00edm\u017e zabra\u0148uje transkripci proz\u00e1n\u011btliv\u00fdch cytokin\u016f v\u010detn\u011b TNF-alfa, IL-6, IL-1\u03b2 a IL-8. NFkB je hlavn\u00edm regul\u00e1torem z\u00e1n\u011btliv\u00e9 genov\u00e9 exprese, tak\u017ee blokov\u00e1n\u00ed jeho aktivace m\u00e1 \u0161irok\u00fd, upstream protiz\u00e1n\u011btliv\u00fd \u00fa\u010dinek.<\/li>\n<li><strong>Stabilizace \u017e\u00edrn\u00fdch bun\u011bk<\/strong> \u2014 KPV sni\u017euje degranulaci \u017e\u00edrn\u00fdch bun\u011bk a uvol\u0148ov\u00e1n\u00ed histaminu ve v\u00fdzkumn\u00fdch modelech. Toto je odli\u0161n\u00fd mechanismus od inhibice NFkB a je zvl\u00e1\u0161t\u011b relevantn\u00ed pro v\u00fdzkum alergick\u00e9ho z\u00e1n\u011btu a topick\u00fdch model\u016f ko\u017en\u00edho z\u00e1n\u011btu.<\/li>\n<li><strong>Odd\u011blen\u00ed peptidu od \u03b1-MSH<\/strong> \u2014 proto\u017ee KPV je pouze C-termin\u00e1ln\u00ed fragment, <strong>neaktivuje MC1R<\/strong> (pigmenta\u010dn\u00ed receptor) ani MC4R (receptor spojen\u00fd s bd\u011blost\u00ed\/ p\u0159\u00edjmem potravy). T\u00edm se mechanisticky odd\u011bluje protiz\u00e1n\u011btliv\u00e1 aktivita od dal\u0161\u00edch \u00fa\u010dink\u016f \u03b1-MSH \u2014 na rozd\u00edl od \u0161ir\u0161\u00edch analog\u016f MC, jako je <a href=\"https:\/\/medsbase.com\/cs\/melanotan-ii\/\">Melanotan II<\/a> nebo <a href=\"https:\/\/medsbase.com\/cs\/pt-141\/\">PT-141<\/a>.<\/li>\n<\/ul>\n<p>Praktick\u00fd v\u00fdzkumn\u00fd d\u016fsledek: KPV je \u201c\u010dist\u00fd\u201d protiz\u00e1n\u011btliv\u00fd v\u00fdzkumn\u00fd n\u00e1stroj, kter\u00fd vytv\u00e1\u0159\u00ed protiz\u00e1n\u011btliv\u00fd sign\u00e1l \u03b1-MSH bez \u00fa\u010dink\u016f na op\u00e1len\u00ed, bd\u011blost nebo modulaci chuti k j\u00eddlu, co\u017e komplikuje interpretaci v\u00fdzkumu s pou\u017eit\u00edm pln\u011b dlouh\u00fdch agonist\u016f MC.<\/p>\n<h2>Publikovan\u00e9 v\u00fdzkumn\u00e9 aplikace<\/h2>\n<p>KPV se pou\u017e\u00edv\u00e1 v laboratorn\u00edch v\u00fdzkumn\u00fdch kontextech, kter\u00e9 zkoumaj\u00ed:<\/p>\n<ul>\n<li><strong>V\u00fdzkum IBD a kolitidy<\/strong> \u2014 modely z\u00e1n\u011btliv\u00e9ho st\u0159evn\u00edho onemocn\u011bn\u00ed u hlodavc\u016f; KPV je aktivn\u00ed jak subkut\u00e1nn\u00ed, tak peror\u00e1ln\u00ed cestou, co\u017e jej \u010din\u00ed neobvykle flexibiln\u00edm pro v\u00fdzkum GI z\u00e1n\u011bt\u016f (Brzoska et al., Endocr Rev 2008)<\/li>\n<li><strong>Alergick\u00fd z\u00e1n\u011bt<\/strong> \u2014 v\u00fdzkum stabilizace \u017e\u00edrn\u00fdch bun\u011bk a uvol\u0148ov\u00e1n\u00ed histaminu v modelech alergie a atopie<\/li>\n<li><strong>Ko\u017en\u00ed z\u00e1n\u011bt<\/strong> \u2014 v\u00fdzkumn\u00e9 modely ekz\u00e9mu, psori\u00e1zy a kontaktn\u00ed dermatitidy; v n\u011bkter\u00fdch v\u00fdzkumn\u00fdch protokolech se objevuj\u00ed topick\u00e9 formulace<\/li>\n<li><strong>Hojen\u00ed ran<\/strong> \u2014 protiz\u00e1n\u011btliv\u00e1 f\u00e1ze v\u00fdzkumu hojen\u00ed ran, \u010dasto kombinovan\u00e1 s <a href=\"https:\/\/medsbase.com\/cs\/bpc-157\/\">BPC-157<\/a> pro kombinovan\u00fd protiz\u00e1n\u011btliv\u00fd \u00fa\u010dinek a pokryt\u00ed r\u016fstov\u00fdmi faktory<\/li>\n<li><strong>Z\u00e1n\u011bt kloub\u016f<\/strong> \u2014 v\u00fdzkumn\u00e9 modely artritidy a z\u00e1n\u011btu kloub\u016f u hlodavc\u016f<\/li>\n<li><strong>V\u00fdzkum kombinov\u00e1n\u00ed<\/strong> \u2014 \u010dasto spojov\u00e1n s <a href=\"https:\/\/medsbase.com\/cs\/bpc-157\/\">BPC-157<\/a> v\u00fdzkum GI a pojivov\u00e9 tk\u00e1n\u011b, kde je pot\u0159eba protiz\u00e1n\u011btliv\u00fd \u00fa\u010dinek + oprava tk\u00e1n\u011b<\/li>\n<li><strong>Srovn\u00e1vac\u00ed v\u00fdzkum melanokortin\u016f<\/strong> \u2014 vedle sebe <a href=\"https:\/\/medsbase.com\/cs\/melanotan-ii\/\">Melanotan II<\/a> a <a href=\"https:\/\/medsbase.com\/cs\/pt-141\/\">PT-141<\/a> k izolaci \u010dist\u00e9ho protiz\u00e1n\u011btliv\u00e9ho \u00fa\u010dinku vs. \u00fa\u010dink\u016f na MC-receptory<\/li>\n<\/ul>\n<p>Pro \u0161ir\u0161\u00ed kontext protiz\u00e1n\u011btliv\u00fdch a hojiv\u00fdch peptid\u016f viz <a href=\"https:\/\/medsbase.com\/cs\/peptides\/\">katalog v\u00fdzkumn\u00fdch peptid\u016f<\/a>.<\/p>\n<h2>Dostupn\u00e9 s\u00edly a koncentrace<\/h2>\n<p>MedsBase nab\u00edz\u00ed KPV v n\u00e1sleduj\u00edc\u00edch lyofilizovan\u00fdch velikostech vial:<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">S\u00edla vialky<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Typick\u00e9 pou\u017eit\u00ed<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Velikosti balen\u00ed<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>5 mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Kr\u00e1tk\u00e9 v\u00fdzkumn\u00e9 protokoly, pilotn\u00ed d\u00e1vkov\u00e1n\u00ed \u2014 podporuje ~10 aplikac\u00ed po 500 mcg<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10, 20 nebo 30 vialek<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>10 mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Standardn\u00ed v\u00fdzkumn\u00e1 s\u00edla \u2014 podporuje ~20 aplikac\u00ed po 500 mcg<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10, 20 nebo 30 vialek<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>V\u00fdzkumn\u00e9 protokoly KPV se li\u0161\u00ed v z\u00e1vislosti na modelov\u00e9m syst\u00e9mu \u2014 200\u2013500 mcg SC denn\u011b pro syst\u00e9mov\u00fd protiz\u00e1n\u011btliv\u00fd v\u00fdzkum, nebo top\u00e1ln\u00ed\/or\u00e1ln\u00ed cesty pro v\u00fdzkum GI a k\u016f\u017ee. V\u0161echny s\u00edly jsou dod\u00e1v\u00e1ny jako lyofilizovan\u00fd pr\u00e1\u0161ek s \u010distotou 99%+ HPLC.<\/p>\n<h2>Jak se porovn\u00e1v\u00e1 \u2014 KPV vs. dal\u0161\u00ed protiz\u00e1n\u011btliv\u00e9\/melanokortinov\u00e9 peptidy<\/h2>\n<p>KPV je jeden z nej\u010dist\u0161\u00edch protiz\u00e1n\u011btliv\u00fdch peptid\u016f ve v\u00fdzkumu, proto\u017ee jeho \u00fa\u010dinek je velmi \u00fazce zam\u011b\u0159en\u00fd. Ve srovn\u00e1n\u00ed s p\u0159\u00edbuzn\u00fdmi slou\u010deninami:<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Krit\u00e9rium<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">KPV<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">BPC-157<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Melanotan II<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>D\u00e9lka<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">3 aminokyseliny<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">15 aminokyselin<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">7 aminokyselin (cyklick\u00e9)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Prim\u00e1rn\u00ed aktivita<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Pouze protiz\u00e1n\u011btliv\u00e9<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Protiz\u00e1n\u011btliv\u00e9 + oprava tk\u00e1n\u00ed + receptor GH<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u0160irok\u00fd agonista MC (MC1-5)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Aktivita MC-receptoru<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u017d\u00e1dn\u00e1 (pouze C-konec)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u017d\u00e1dn\u00e9<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">MC1, MC3, MC4, MC5<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Efekt na pigmentaci<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u017d\u00e1dn\u00e9<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u017d\u00e1dn\u00e9<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Siln\u00e1 (prim\u00e1rn\u00ed sign\u00e1l)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>V\u00fdzkumn\u00e9 aplikace<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">IBD, alergie, z\u00e1n\u011bt k\u016f\u017ee<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u0160lachy, st\u0159eva, regenerace sval\u016f<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Melanogeneze, fotoprotekce<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Pro v\u00fdzkum z\u00e1n\u011bt\u016f tr\u00e1vic\u00edho traktu je kombinace KPV + BPC-157 obzvl\u00e1\u0161t\u011b \u010dast\u00e1, proto\u017ee KPV poskytuje protiz\u00e1n\u011btlivou signalizaci v po\u010d\u00e1te\u010dn\u00ed f\u00e1zi, zat\u00edmco BPC-157 m\u00e1 r\u016fstov\u011b-faktorovou aktivitu pro opravu tk\u00e1n\u00ed. Toto je pops\u00e1no v na\u0161em <a href=\"https:\/\/medsbase.com\/cs\/bpc-157-peptide-healing-recovery-guide\/\">v\u00fdzkumn\u00e1 p\u0159\u00edru\u010dka BPC-157<\/a>.<\/p>\n<h2>Skladov\u00e1n\u00ed a rekonstituce<\/h2>\n<p><strong>P\u0159ed rekonstituci:<\/strong> lyofilizovan\u00e9 lahvi\u010dky skladujte v chladni\u010dce p\u0159i 2\u20138 \u00b0C v p\u016fvodn\u00edm obalu, stabiln\u00ed a\u017e 36 m\u011bs\u00edc\u016f. Vyvarujte se cykl\u016fm zmrazov\u00e1n\u00ed a rozmrazov\u00e1n\u00ed pr\u00e1\u0161ku.<\/p>\n<p><strong>Postup rekonstituce:<\/strong> injektujte bakteriostatickou vodu po bo\u010dn\u00ed st\u011bn\u011b lahvi\u010dky s peptidem podle v\u00fd\u0161e uveden\u00e9ho sch\u00e9matu. Jemn\u011b zakru\u017ete \u2013 ned\u011blejte <strong>ne<\/strong> prot\u0159ep\u00e1vejte \u2014 a nechte 5\u201310 minut pro \u00fapln\u00e9 rozpu\u0161t\u011bn\u00ed. Roztok by m\u011bl b\u00fdt \u010dir\u00fd a bezbarv\u00fd.<\/p>\n<p><strong>Po rekonstituci:<\/strong> skladujte v chladni\u010dce p\u0159i 2\u20138 \u00b0C a pou\u017eijte do 30 dn\u016f. Nefreezujte rekonstituovan\u00fd roztok.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3>K \u010demu se KPV pou\u017e\u00edv\u00e1 ve v\u00fdzkumu?<\/h3>\n<p>KPV se pou\u017e\u00edv\u00e1 v laboratorn\u00edm v\u00fdzkumu zam\u011b\u0159en\u00e9m na protiz\u00e1n\u011btlivou biologii, z\u00e1n\u011btliv\u00e1 st\u0159evn\u00ed onemocn\u011bn\u00ed (IBD) a kolitidu, alergick\u00e9 z\u00e1n\u011bty, z\u00e1n\u011bty k\u016f\u017ee (modely ekz\u00e9mu\/psori\u00e1zy), z\u00e1n\u011btlivou f\u00e1zi hojen\u00ed ran, z\u00e1n\u011bty kloub\u016f a srovn\u00e1vac\u00ed farmakologii melanokortin\u016f. Je <strong>ne<\/strong> schv\u00e1leno FDA a je zde prod\u00e1v\u00e1no v\u00fdhradn\u011b pro laboratorn\u00ed v\u00fdzkum.<\/p>\n<h3>Jak se KPV li\u0161\u00ed od Melanotanu II nebo PT-141?<\/h3>\n<p>KPV je pouze t\u0159\u00edaminokyselinov\u00fd C-termin\u00e1ln\u00ed fragment alfa-MSH, zat\u00edmco Melanotan II a PT-141 jsou pln\u011b nebo t\u00e9m\u011b\u0159 pln\u011b cyklick\u00e9 analogy MSH. To znamen\u00e1, \u017ee KPV m\u00e1 <strong>\u017e\u00e1dnou aktivitu na melanokortinov\u00e9 receptory<\/strong> a tedy \u017e\u00e1dn\u00e9 \u00fa\u010dinky na pigmentaci (MC1R), vzru\u0161en\u00ed (MC4R) nebo chu\u0165 k j\u00eddlu (MC4R) \u2013 pouze protiz\u00e1n\u011btlivou aktivitu prost\u0159ednictv\u00edm NFkB a mastocytov\u00fdch drah.<\/p>\n<h3>Jak\u00e1 je typick\u00e1 v\u00fdzkumn\u00e1 d\u00e1vka KPV?<\/h3>\n<p>Publikovan\u00e9 preklinick\u00e9 protokoly obvykle pou\u017e\u00edvaj\u00ed 200\u2013500 mcg subkut\u00e1nn\u011b denn\u011b pro syst\u00e9mov\u00fd protiz\u00e1n\u011btliv\u00fd v\u00fdzkum. N\u011bkter\u00e9 v\u00fdzkumy IBD a z\u00e1n\u011bt\u016f k\u016f\u017ee vyu\u017e\u00edvaj\u00ed or\u00e1ln\u00ed nebo topickou aplikaci. 10 mg lahvi\u010dka rekonstituovan\u00e1 s 2,0 mL bakteriostatick\u00e9 vody poskytne koncentraci 5 mg\/mL \u2013 10 d\u00edlek na U-100 st\u0159\u00edka\u010dce dod\u00e1 500 mcg.<\/p>\n<h3>Je KPV schv\u00e1leno FDA?<\/h3>\n<p>Ne. KPV neobdr\u017eelo schv\u00e1len\u00ed FDA, EMA ani \u017e\u00e1dn\u00e9ho jin\u00e9ho regul\u00e1tora. V\u00fdzkum pln\u00e9ho peptidu alfa-MSH a KPV p\u0159isp\u011bl k v\u00fdvoji melanokortinov\u00fdch l\u00e9k\u016f obecn\u011b, ale samotn\u00e9 KPV z\u016fst\u00e1v\u00e1 ur\u010deno pouze pro v\u00fdzkumn\u00e9 \u00fa\u010dely. Ve\u0161ker\u00e9 KPV prod\u00e1van\u00e9 dodavateli pro peptidov\u00fd v\u00fdzkum je ur\u010deno pouze pro laboratorn\u00ed v\u00fdzkum.<\/p>\n<h3>M\u016f\u017ee b\u00fdt KPV u\u017e\u00edv\u00e1no or\u00e1ln\u011b pro v\u00fdzkum IBD?<\/h3>\n<p>Ano. Na rozd\u00edl od v\u011bt\u0161iny peptid\u016f, kter\u00e9 jsou degraduov\u00e1ny \u017ealude\u010dn\u00edmi enzymy, si KPV zachov\u00e1v\u00e1 ur\u010ditou protiz\u00e1n\u011btlivou aktivitu i p\u0159i peror\u00e1ln\u00edm pod\u00e1n\u00ed, jak ukazuje publikovan\u00fd v\u00fdzkum u IBD a kolitidy. To jej \u010din\u00ed neobvykle flexibiln\u00edm pro v\u00fdzkum gastrointestin\u00e1ln\u00edho z\u00e1n\u011btu, kde peror\u00e1ln\u00ed pod\u00e1n\u00ed c\u00edl\u00ed p\u0159\u00edmo na tr\u00e1vic\u00ed trakt. V\u00fdzkumn\u00e9 protokoly se li\u0161\u00ed podle modelu \u2014 subkut\u00e1nn\u00ed pod\u00e1n\u00ed z\u016fst\u00e1v\u00e1 dominantn\u00ed syst\u00e9movou cestou.<\/p>\n<h3>Jak by m\u011blo b\u00fdt KPV skladov\u00e1no?<\/h3>\n<p>Lyofilizovan\u00e9 lahvi\u010dky: v chladni\u010dce p\u0159i 2\u20138 \u00b0C v p\u016fvodn\u00edm obalu, stabiln\u00ed a\u017e 36 m\u011bs\u00edc\u016f. Rekonstituovan\u00fd roztok: v chladni\u010dce p\u0159i 2\u20138 \u00b0C, pou\u017e\u00edt do 30 dn\u016f. Rekonstituovan\u00fd roztok nezmrazovat.<\/p>\n<h3>Jak p\u0159iprav\u00edm KPV k pou\u017eit\u00ed?<\/h3>\n<p>Postupujte podle v\u00fd\u0161e uveden\u00e9ho rekonstitu\u010dn\u00edho sch\u00e9matu. P\u0159idejte bakteriostatickou vodu po st\u011bn\u011b lahvi\u010dky, jemn\u011b zakru\u017ete a nechte 5\u201310 minut pro \u00fapln\u00e9 rozpu\u0161t\u011bn\u00ed. Ne <strong>ne<\/strong> t\u0159epat.<\/p>\n<h3>Lze KPV a BPC-157 kombinovat ve v\u00fdzkumu?<\/h3>\n<p>Ano \u2014 tato kombinace je jedn\u00edm z nej\u010dast\u011bj\u0161\u00edch v\u00fdzkumn\u00fdch p\u0159\u00edstup\u016f u z\u00e1n\u011bt\u016f tr\u00e1vic\u00edho traktu a pojivov\u00e9 tk\u00e1n\u011b. KPV poskytuje protiz\u00e1n\u011btlivou signalizaci p\u0159es NFkB dr\u00e1hu; <a href=\"https:\/\/medsbase.com\/cs\/bpc-157\/\">BPC-157<\/a> zat\u00edmco BPC-157 zaji\u0161\u0165uje opravu tk\u00e1n\u00ed a r\u016fstovou aktivitu p\u0159es VEGF dr\u00e1hu. Mechanizmy se sp\u00ed\u0161e dopl\u0148uj\u00ed ne\u017e p\u0159ekr\u00fdvaj\u00ed.<\/p>\n<h3>Jak\u00e9 s\u00edly nab\u00edz\u00ed MedsBase?<\/h3>\n<p>MedsBase nab\u00edz\u00ed KPV v lyofilizovan\u00fdch vial\u00e1ch o s\u00edle 5 mg a 10 mg. Ka\u017ed\u00e1 s\u00edla je dostupn\u00e1 v balen\u00edch po 10, 20 nebo 30 vial\u00e1ch. V\u0161echny vials maj\u00ed HPLC \u010distotu 99%+ a na vy\u017e\u00e1d\u00e1n\u00ed je k dispozici certifik\u00e1t o anal\u00fdze.<\/p>\n<h3>Zp\u016fsobuje KPV ve v\u00fdzkumu vedlej\u0161\u00ed \u00fa\u010dinky?<\/h3>\n<p>Publikovan\u00e9 preklinick\u00e9 studie uv\u00e1d\u011bj\u00ed v\u00fdrazn\u011b \u010dist\u00fd bezpe\u010dnostn\u00ed profil. Proto\u017ee KPV nem\u00e1 aktivitu na melanokortinov\u00e9 receptory, nedoch\u00e1z\u00ed u n\u011bj k pigmentaci, vzru\u0161en\u00ed ani \u00fa\u010dink\u016fm na krevn\u00ed tlak, kter\u00e9 jsou n\u011bkdy pozorov\u00e1ny u pln\u00fdch agonist\u016f MC receptor\u016f. U typick\u00fdch v\u00fdzkumn\u00fdch d\u00e1vek nebyly identifikov\u00e1ny \u017e\u00e1dn\u00e9 v\u00fdznamn\u00e9 ne\u017e\u00e1douc\u00ed sign\u00e1ly. Dlouhodob\u00e1 data o bezpe\u010dnosti u lid\u00ed nejsou k dispozici.<\/p>\n<h3>Jak\u00fd je polo\u010das KPV?<\/h3>\n<p>KPV (Lys-Pro-Val) je tripeptid s kr\u00e1tk\u00fdm plazmatick\u00fdm polo\u010dasem, kter\u00fd je typick\u00fd pro mal\u00e9 nemodifikovan\u00e9 peptidy \u2014 odhaduje se na m\u00e9n\u011b ne\u017e 30 minut. Jeho hlavn\u00ed v\u00fdzkumn\u00e1 aplikace je gastrointestin\u00e1ln\u00ed, kde studie lok\u00e1ln\u00edho pod\u00e1n\u00ed ukazuj\u00ed \u00fa\u010dinky na st\u0159evn\u00ed epiteli\u00e1ln\u00ed bu\u0148ky a populace imunitn\u00edch bun\u011bk, kter\u00e9 p\u0159etrv\u00e1vaj\u00ed i po vymizen\u00ed peptidu z plazmy, co\u017e je p\u0159ipisov\u00e1no p\u0159\u00edm\u00e9 interakci s receptory na st\u0159evn\u00ed sliznici.<\/p>\n<h3>Jak KPV sni\u017euje z\u00e1n\u011bt ve v\u00fdzkumn\u00fdch modelech?<\/h3>\n<p>KPV je C-termin\u00e1ln\u00ed tripeptid \u03b1-MSH (alfa-melanocyty stimuluj\u00edc\u00edho hormonu) a zachov\u00e1v\u00e1 v\u011bt\u0161inu protiz\u00e1n\u011btliv\u00e9 aktivity mate\u0159sk\u00e9ho peptidu prost\u0159ednictv\u00edm aktivace MC1R receptoru. V modelech kolitidy a po\u0161kozen\u00ed st\u0159ev KPV sni\u017euje signalizaci NF-\u03baB, sni\u017euje produkci proz\u00e1n\u011btliv\u00fdch cytokin\u016f (IL-1\u03b2, IL-6, TNF-\u03b1) a podporuje integritu st\u0159evn\u00ed epiteli\u00e1ln\u00ed bari\u00e9ry. Jeho mal\u00e1 velikost usnad\u0148uje p\u0159\u00edm\u00fd vstup do epiteli\u00e1ln\u00edch bun\u011bk bez pot\u0159eby nosn\u00fdch protein\u016f.<\/p>\n<h3>Mohu si objednat KPV pro mezin\u00e1rodn\u00ed p\u0159epravu?<\/h3>\n<p>Ano. MedsBase expeduje KPV do cel\u00e9ho sv\u011bta prost\u0159ednictv\u00edm na\u0161\u00ed specializovan\u00e9 s\u00edt\u011b pro p\u0159epravu peptid\u016f. Objedn\u00e1vky obsahuj\u00edc\u00ed pouze peptidy maj\u00ed n\u00e1rok na na\u0161i samostatnou slu\u017ebu peptidov\u00e9 p\u0159epravy. Z\u00e1silky jsou expedov\u00e1ny v teplotn\u011b kontrolovan\u00e9m balen\u00ed s pln\u00fdm sledov\u00e1n\u00edm.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Dal\u0161\u00ed peptidy pro v\u00fdzkum regenerace a v\u00fdkonnosti<\/h2>\n<ul>\n<li><a href=\"\/cs\/bpc-157\/\"><strong>BPC-157<\/strong><\/a> \u2014 Body Protection Compound \u2014 v\u00fdzkum regenerace \u0161lach, vaz\u016f a st\u0159ev<\/li>\n<li><a href=\"\/cs\/tb-500\/\"><strong>TB-500<\/strong><\/a> \u2014 Fragment Thymosin Beta-4 \u2014 v\u00fdzkum regenerace m\u011bkk\u00fdch tk\u00e1n\u00ed a c\u00e9v<\/li>\n<li><a href=\"\/cs\/ipamorelin\/\"><strong>Ipamorelin<\/strong><\/a> \u2014 Selektivn\u00ed agonista ghrelinu \u2014 \u010dist\u00fd pulz r\u016fstov\u00e9ho hormonu bez kortizolu\/prolaktinu<\/li>\n<li><a href=\"\/cs\/cjc-1295-with-dac\/\"><strong>CJC-1295 with DAC<\/strong><\/a> \u2014 Analog GHRH s prodlou\u017een\u00fdm polo\u010dasem<\/li>\n<li><a href=\"\/cs\/ghk-cu\/\"><strong>GHK-Cu<\/strong><\/a> \u2014 M\u011b\u010fn\u00fd peptid \u2014 v\u00fdzkum regenerace k\u016f\u017ee a pojivov\u00e9 tk\u00e1n\u011b<\/li>\n<\/ul>\n<p><!-- medsbase-peptide-guide-cta --><\/p>\n<h2>Dal\u0161\u00ed \u010dten\u00ed<\/h2>\n<div style=\"background: #f4f8fb; border-left: 4px solid #2c7cb0; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<p style=\"margin: 0 0 8px 0;\"><strong>\ud83d\udcd6 Seznamte se s v\u00fdzkumem tohoto peptidu<\/strong><\/p>\n<p style=\"margin: 0;\">P\u0159e\u010dt\u011bte si n\u00e1\u0161 kompletn\u00ed pr\u016fvodce zalo\u017een\u00fd na d\u016fkazech: <a href=\"https:\/\/medsbase.com\/cs\/kpv-peptide-anti-inflammatory-guide\/\"><strong>KPV \u2014 C-termin\u00e1ln\u00ed fragment alfa-MSH pro protiz\u00e1n\u011btliv\u00fd v\u00fdzkum<\/strong><\/a>. Pokr\u00fdv\u00e1 farmakologii NFkB, stabilizaci \u017e\u00edrn\u00fdch bun\u011bk, historii v\u00fdzkumu IBD, protokoly pro peror\u00e1ln\u00ed a subkut\u00e1nn\u00ed pod\u00e1n\u00ed a kombinaci s BPC-157.<\/p>\n<\/div>\n<p><!-- pep-seo-v1 --><\/p>","protected":false},"excerpt":{"rendered":"<p>\u2705 Podporuje opravu tk\u00e1n\u00ed<br \/>\n\u2705 Sni\u017euje oxida\u010dn\u00ed stres<br \/>\n\u2705 Moduluje imunitn\u00ed odpov\u011b\u010f<br \/>\n\u2705 Zvy\u0161uje bun\u011b\u010dnou odolnost<br \/>\n\u2705 Zlep\u0161uje integritu epitelu<\/p>\n<p><strong>KPV<\/strong> obsahuje syntetickou peptidovou slou\u010deninu.<\/p>","protected":false},"featured_media":70964,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[5426],"product_tag":[5472,5473],"class_list":{"0":"post-69013","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptides","7":"product_tag-kpv","8":"product_tag-lysine-proline-valine","10":"first","11":"instock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/69013","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=69013"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/70964"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=69013"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=69013"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=69013"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=69013"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}