{"id":69029,"date":"2026-03-13T12:12:34","date_gmt":"2026-03-13T12:12:34","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&p=69029"},"modified":"2026-05-21T07:14:11","modified_gmt":"2026-05-21T07:14:11","slug":"ss-31-elamipretide","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/ss-31-elamipretide\/","title":{"rendered":"SS-31 (Elamipretide)"},"content":{"rendered":"

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Rychl\u00e1 odpov\u011b\u010f \u2014 Co je SS-31 (Elamipretide)?<\/h3>\n

SS-31<\/strong> (tak\u00e9 naz\u00fdvan\u00fd Elamipretide<\/strong> nebo Bendavia<\/strong>) je syntetick\u00fd tetrapeptid, kter\u00fd selektivn\u011b v\u00e1\u017ee kardiolipin<\/strong> na vnit\u0159n\u00ed mitochondri\u00e1ln\u00ed membr\u00e1n\u011b, stabilizuje funkci mitochondri\u00ed p\u0159i stresu. Vyvinuto laborato\u0159\u00ed Szeto-Schiller a nyn\u00ed v pozdn\u00ed f\u00e1zi klinick\u00e9ho v\u00fdvoje spole\u010dnost\u00ed Stealth BioTherapeutics s ozna\u010den\u00edm FDA jako l\u00e9k na vz\u00e1cn\u00e9 mitochondri\u00e1ln\u00ed onemocn\u011bn\u00ed. Dod\u00e1v\u00e1 se v lyofilizovan\u00fdch vial\u00e1ch o obsahu 5 mg a\u017e 50 mg pouze pro laboratorn\u00ed v\u00fdzkum.<\/p>\n<\/div>\n

Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdzkumn\u00e9 lyofilizovan\u00e9 peptidy \u00b7 HPLC \u010distota \u226599% (COA na vy\u017e\u00e1d\u00e1n\u00ed) \u00b7 Diskr\u00e9tn\u00ed teplotn\u011b stabiln\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 p\u0159eprava peptid\u016f \u00b7 1,400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Specifikace<\/th>\nDetail<\/th>\n<\/tr>\n<\/thead>\n
CAS \u010d\u00edslo<\/strong><\/td>\n736992-21-5<\/td>\n<\/tr>\n
item2<\/strong><\/td>\nC32<\/sub>H49<\/sub>N9<\/sub>O5<\/sub><\/td>\n<\/tr>\n
item7<\/strong><\/td>\n639.80 Da<\/td>\n<\/tr>\n
item9<\/strong><\/td>\nD-Arg-2\u2032,6\u2032-Dmt-Lys-Phe-NH2<\/sub> (Bendavia, MTP-131)<\/td>\n<\/tr>\n
item11<\/strong><\/td>\nLyofilizovan\u00fd pr\u00e1\u0161ek (nebo v dodan\u00e9 form\u011b)<\/td>\n<\/tr>\n
item13<\/strong><\/td>\n\u226599% (HPLC ov\u011b\u0159eno, COA na vy\u017e\u00e1d\u00e1n\u00ed)<\/td>\n<\/tr>\n
Skladov\u00e1n\u00ed<\/strong><\/td>\nLyofilizovan\u00e9: 2\u20138 \u00b0C (lednice) pro pracovn\u00ed z\u00e1sobu; \u221220 \u00b0C pro dlouhodob\u00e9 skladov\u00e1n\u00ed neotev\u0159en\u00fdch vialek. Rekonstituovan\u00e9: 2\u20138 \u00b0C, pou\u017eijte do ~30 dn\u016f. Chra\u0148te p\u0159ed sv\u011btlem. Nefreeze\u2013thaw rekonstituovan\u00fd roztok.<\/td>\n<\/tr>\n
Rozpustnost<\/strong><\/td>\nBakteriostatick\u00e1 voda (doporu\u010deno) nebo steriln\u00ed voda pro krat\u0161\u00ed dobu pou\u017eit\u00ed<\/td>\n<\/tr>\n
Pouze pro v\u00fdzkum<\/strong><\/td>\nPouze pro laboratorn\u00ed v\u00fdzkum. Nen\u00ed ur\u010deno pro diagnostick\u00e9 nebo terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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Co je SS-31 (Elamipretide)?<\/h2>\n

SS-31<\/strong> je syntetick\u00fd bun\u011b\u010dn\u011b prostupn\u00fd tetrapeptid (D-Arg-2\u20196\u2032-dimethyl-L-Tyr-L-Lys-L-Phe, tak\u00e9 zkr\u00e1cen\u011b Szeto-Schiller 31<\/strong>) vyvinut\u00fd Hazel Szeto a Peterem Schillerem na Weill Medical College Cornellovy univerzity po\u010d\u00e1tkem 90. let. Je tak\u00e9 zn\u00e1m pod farmaceutick\u00fdmi v\u00fdvojov\u00fdmi n\u00e1zvy Elamipretide<\/strong> a Bendavia<\/strong>, a klinicky jej vyv\u00edj\u00ed spole\u010dnost Stealth BioTherapeutics<\/strong>.<\/p>\n

Na rozd\u00edl od v\u011bt\u0161iny v\u00fdzkumn\u00fdch peptid\u016f, kter\u00e9 se v\u00e1\u017eou na bun\u011b\u010dn\u00e9 povrchov\u00e9 receptory, SS-31 je mitochondri\u00e1ln\u011b c\u00edlen\u00e1 l\u00e1tka<\/strong> kter\u00e1 prostupuje bun\u011b\u010dn\u00fdmi a organelov\u00fdmi membr\u00e1nami, aby dos\u00e1hla vnit\u0159n\u00ed mitochondri\u00e1ln\u00ed membr\u00e1ny, kde se v\u00e1\u017ee kardiolipin<\/strong> \u2014 fosfolipid, kter\u00fd je pro toto m\u00edsto unik\u00e1tn\u00ed. Tato selektivn\u00ed vazba lipid\u016f je z\u00e1kladem jeho mechanismu \u00fa\u010dinku a odli\u0161uje SS-31 od t\u00e9m\u011b\u0159 v\u0161ech ostatn\u00edch v\u00fdzkumn\u00fdch peptid\u016f.<\/p>\n

Molekulov\u00e1 hmotnost p\u0159ibli\u017en\u011b 640 Da. SS-31 m\u00e1 ozna\u010den\u00ed FDA jako l\u00e9\u010divo pro vz\u00e1cn\u00e1 onemocn\u011bn\u00ed<\/strong> pro prim\u00e1rn\u00ed mitochondri\u00e1ln\u00ed myopatii a byl p\u0159edm\u011btem n\u011bkolika klinick\u00fdch studi\u00ed na lidech \u2014 co\u017e jej \u0159ad\u00ed d\u00e1le v klinick\u00e9m v\u00fdvoji ne\u017e v\u011bt\u0161inu v\u00fdzkumn\u00fdch peptid\u016f. Je dod\u00e1v\u00e1n jako lyofilizovan\u00fd pr\u00e1\u0161ek vysok\u00e9 \u010distoty ur\u010den pouze pro laboratorn\u00ed v\u00fdzkum<\/strong> (klinick\u00fd produkt Stealth je samostatn\u00fd regulovan\u00fd terapeutick\u00fd p\u0159\u00edpravek). Pro hlub\u0161\u00ed pochopen\u00ed mechanismu, historii v\u00fdzkumu v laborato\u0159i Szeto a kontext klinick\u00fdch studi\u00ed viz n\u00e1\u0161 v\u00fdzkumn\u00fd pr\u016fvodce SS-31<\/a>.<\/p>\n

Mechanismus \u00fa\u010dinku \u2014 stabilizace mitochondri\u00ed c\u00edlen\u00e1 na kardiolipin<\/h2>\n

Mechanismus SS-31 je mezi v\u00fdzkumn\u00fdmi peptidy unik\u00e1tn\u00ed, proto\u017ee jeho c\u00edlem je fosfolipid, nikoli receptorov\u00fd protein. T\u0159i vz\u00e1jemn\u011b propojen\u00e9 efekty definuj\u00ed jeho farmakologii:<\/p>\n