{"id":70664,"date":"2026-05-12T08:56:17","date_gmt":"2026-05-12T08:56:17","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&p=70664"},"modified":"2026-05-21T07:14:10","modified_gmt":"2026-05-21T07:14:10","slug":"mots-c","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/mots-c\/","title":{"rendered":"MOTS-c"},"content":{"rendered":"

<\/p>\n

\n

Rychl\u00e1 odpov\u011b\u010f \u2014 Co je MOTS-c?<\/h3>\n

MOTS-c<\/strong> (Mitochondri\u00e1ln\u011b k\u00f3dovan\u00fd sign\u00e1ln\u00ed peptid z otev\u0159en\u00e9ho \u010dtec\u00edho r\u00e1mce 12S rRNA) je 16-aminokyselinov\u00fd peptid identifikovan\u00fd v roce 2015. Podle publikovan\u00fdch preklinick\u00fdch studi\u00ed p\u016fsob\u00ed jako imit\u00e1tor cvi\u010den\u00ed a metabolick\u00fd regul\u00e1tor aktivac\u00ed AMPK dr\u00e1hy, obnoven\u00edm citlivosti na inzul\u00edn a modulac\u00ed exprese gen\u016f v reakci na mitochondri\u00e1ln\u00ed stres. Dod\u00e1v\u00e1 se v lyofilizovan\u00fdch vial\u00e1ch o obsahu 10 mg a\u017e 40 mg v\u00fdhradn\u011b pro laboratorn\u00ed v\u00fdzkum.<\/p>\n<\/div>\n

Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdzkumn\u00e9 lyofilizovan\u00e9 peptidy \u00b7 HPLC \u010distota \u226599% (COA na vy\u017e\u00e1d\u00e1n\u00ed) \u00b7 Diskr\u00e9tn\u00ed teplotn\u011b stabiln\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 p\u0159eprava peptid\u016f \u00b7 1,400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Specifikace<\/th>\nDetail<\/th>\n<\/tr>\n<\/thead>\n
CAS \u010d\u00edslo<\/strong><\/td>\n1627580-64-6<\/td>\n<\/tr>\n
item2<\/strong><\/td>\nC100<\/sub>H152<\/sub>N28<\/sub>O22<\/sub>S2<\/sub><\/td>\n<\/tr>\n
item7<\/strong><\/td>\n2174.62 Da<\/td>\n<\/tr>\n
item9<\/strong><\/td>\nMet-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR, 16 aminokyselin; k\u00f3dov\u00e1no v mitochondri\u00e1ln\u00edm genu 12S rRNA)<\/td>\n<\/tr>\n
item11<\/strong><\/td>\nLyofilizovan\u00fd pr\u00e1\u0161ek (b\u00edl\u00fd a\u017e sv\u011btle \u017elut\u00fd)<\/td>\n<\/tr>\n
item13<\/strong><\/td>\n\u226599% (HPLC ov\u011b\u0159eno, COA na vy\u017e\u00e1d\u00e1n\u00ed)<\/td>\n<\/tr>\n
Skladov\u00e1n\u00ed<\/strong><\/td>\nLyofilizovan\u00e9: 2\u20138 \u00b0C (lednice) pro pracovn\u00ed z\u00e1sobu; \u221220 \u00b0C pro dlouhodob\u00e9 skladov\u00e1n\u00ed neotev\u0159en\u00fdch vialek. Rekonstituovan\u00e9: 2\u20138 \u00b0C, pou\u017eijte do ~30 dn\u016f. Chra\u0148te p\u0159ed sv\u011btlem. Nefreeze\u2013thaw rekonstituovan\u00fd roztok.<\/td>\n<\/tr>\n
Rozpustnost<\/strong><\/td>\nBakteriostatick\u00e1 voda (doporu\u010deno) nebo steriln\u00ed voda pro krat\u0161\u00ed dobu pou\u017eit\u00ed<\/td>\n<\/tr>\n
Pouze pro v\u00fdzkum<\/strong><\/td>\nPouze pro laboratorn\u00ed v\u00fdzkum. Nen\u00ed ur\u010deno pro diagnostick\u00e9 nebo terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/p>\n

Co je MOTS-c?<\/h2>\n

MOTS-c<\/strong> (Mitochondri\u00e1ln\u011b k\u00f3dovan\u00fd peptid z otev\u0159en\u00e9ho \u010dtec\u00edho r\u00e1mce 12S rRNA) je 16-aminokyselinov\u00fd peptid poprv\u00e9 identifikovan\u00fd Lee et al. v Cell Metabolism<\/em> (2015) jako z\u00e1stupce nov\u011b rozpoznan\u00e9 t\u0159\u00eddy mitochondri\u00e1ln\u011b odvozen\u00fdch peptid\u016f (MDPs). Na rozd\u00edl od v\u0161ech ostatn\u00edch peptid\u016f v katalogu v\u00fdzkumn\u00fdch l\u00e1tek \u2014 kter\u00e9 jsou k\u00f3dov\u00e1ny jadernou DNA a syntetizov\u00e1ny v cytoplazm\u011b \u2014 je MOTS-c k\u00f3dov\u00e1n v mitochondri\u00e1ln\u00edm genu 12S rRNA a translatov\u00e1n mitochondri\u00e1ln\u00edmi ribozomy. Tento neobvykl\u00fd biologick\u00fd p\u016fvod z n\u011bj \u010din\u00ed p\u0159\u00edm\u00fd intracelul\u00e1rn\u00ed sign\u00e1l stavu mitochondri\u00ed a nej\u010dast\u011bji citovan\u00e9ho z\u00e1stupce t\u0159\u00eddy peptid\u016f, kter\u00e1 zahrnuje humanin a rodinu SHLP peptid\u016f.<\/p>\n

Peptidov\u00e1 sekvence je MRWQEMGYIFYPRKLR, molekulov\u00e1 hmotnost p\u0159ibli\u017en\u011b 2 175 Da, empirick\u00fd vzorec C100<\/sub>H152<\/sub>N28<\/sub>O22<\/sub>S2<\/sub>. Endogenn\u00ed MOTS-c se p\u0159i metabolick\u00e9m a oxida\u010dn\u00edm stresu p\u0159esouv\u00e1 z mitochondri\u00ed do j\u00e1dra, kde reguluje genov\u00fd program fol\u00e1tov\u00e9ho cyklu a metabolismu methioninu \u2014 mechanismus, kter\u00fd nem\u00e1 obdoby mezi jadern\u011b k\u00f3dovan\u00fdmi peptidy. MOTS-c je dod\u00e1v\u00e1n jako vysoce \u010dist\u00fd lyofilizovan\u00fd pr\u00e1\u0161ek pro rekonstituci s bakteriostatickou vodou a je ur\u010den pouze pro laboratorn\u00ed v\u00fdzkum<\/strong>. Nen\u00ed schv\u00e1len FDA, EMA ani MHRA pro terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at. Pro souvisej\u00edc\u00ed metabolick\u00e9 a dlouhov\u011bkostn\u00ed peptidy viz na\u0161e pln\u00e9 katalog v\u00fdzkumn\u00fdch peptid\u016f<\/a>.<\/p>\n

Mechanismus \u00fa\u010dinku \u2014 AMPK, metabolismus gluk\u00f3zy a nukle\u00e1rn\u00ed translokace<\/h2>\n

Co odli\u0161uje MOTS-c od star\u0161\u00edch metabolick\u00fdch peptid\u016f, je jeho t\u0159\u00edmod\u00e1ln\u00ed mechanismus \u00fa\u010dinku<\/strong> kter\u00fd zahrnuje mitochondrie, cytoplazmu a j\u00e1dro \u2014 ka\u017ed\u00fd z nich p\u0159isp\u00edv\u00e1 k pozorovan\u00e9mu metabolick\u00e9mu fenotypu v publikovan\u00e9m v\u00fdzkumu:<\/p>\n