{"id":70699,"date":"2026-05-12T09:19:23","date_gmt":"2026-05-12T09:19:23","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&p=70699"},"modified":"2026-05-21T07:14:10","modified_gmt":"2026-05-21T07:14:10","slug":"selank","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/selank\/","title":{"rendered":"Selank"},"content":{"rendered":"

<\/p>\n

\n

Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Selank?<\/h3>\n

Selank<\/strong> je syntetick\u00fd heptapeptid vyvinut\u00fd Ruskou akademi\u00ed v\u011bd jako analog endogenn\u00edho imunomodula\u010dn\u00edho peptidu tuftsinu. Podle publikovan\u00fdch v\u00fdzkum\u016f p\u016fsob\u00ed jako anxiolytikum s nootropn\u00edmi \u00fa\u010dinky, moduluje GABAergn\u00ed, serotoninergn\u00ed a enkefalinovou signalizaci a zvy\u0161uje expresi BDNF bez sedativn\u00edch \u00fa\u010dink\u016f nebo rizika z\u00e1vislosti typick\u00e9ho pro benzodiazepiny. Dod\u00e1v\u00e1 se v lyofilizovan\u00fdch vialech o obsahu 5 mg a 10 mg v\u00fdhradn\u011b pro laboratorn\u00ed v\u00fdzkum.<\/p>\n<\/div>\n

Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdzkumn\u00e9 lyofilizovan\u00e9 peptidy \u00b7 HPLC \u010distota \u226599% (COA na vy\u017e\u00e1d\u00e1n\u00ed) \u00b7 Diskr\u00e9tn\u00ed teplotn\u011b stabiln\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 p\u0159eprava peptid\u016f \u00b7 1,400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Specifikace<\/th>\nDetail<\/th>\n<\/tr>\n<\/thead>\n
CAS \u010d\u00edslo<\/strong><\/td>\n129954-34-3<\/td>\n<\/tr>\n
item2<\/strong><\/td>\nC33<\/sub>H57<\/sub>N11<\/sub>O9<\/sub><\/td>\n<\/tr>\n
item7<\/strong><\/td>\n751,88 Da<\/td>\n<\/tr>\n
item9<\/strong><\/td>\nThr-Lys-Pro-Arg-Pro-Gly-Pro-NH2<\/sub> (TKPRPGP-NH2<\/sub>, 7 aminokyselin; C-termin\u00e1ln\u011b amidovan\u00fd analog tuftsinu)<\/td>\n<\/tr>\n
item11<\/strong><\/td>\nLyofilizovan\u00fd pr\u00e1\u0161ek (b\u00edl\u00fd a\u017e sv\u011btle \u017elut\u00fd)<\/td>\n<\/tr>\n
item13<\/strong><\/td>\n\u226599% (HPLC ov\u011b\u0159eno, COA na vy\u017e\u00e1d\u00e1n\u00ed)<\/td>\n<\/tr>\n
Skladov\u00e1n\u00ed<\/strong><\/td>\nLyofilizovan\u00e9: 2\u20138 \u00b0C (lednice) pro pracovn\u00ed z\u00e1sobu; \u221220 \u00b0C pro dlouhodob\u00e9 skladov\u00e1n\u00ed neotev\u0159en\u00fdch vialek. Rekonstituovan\u00e9: 2\u20138 \u00b0C, pou\u017eijte do ~30 dn\u016f. Chra\u0148te p\u0159ed sv\u011btlem. Nefreeze\u2013thaw rekonstituovan\u00fd roztok.<\/td>\n<\/tr>\n
Rozpustnost<\/strong><\/td>\nBakteriostatick\u00e1 voda (doporu\u010deno) nebo steriln\u00ed voda pro krat\u0161\u00ed pou\u017eit\u00ed. Kompatibiln\u00ed s v\u00fdzkumn\u00fdmi formulacemi pro intranaz\u00e1ln\u00ed pod\u00e1n\u00ed.<\/td>\n<\/tr>\n
Pouze pro v\u00fdzkum<\/strong><\/td>\nPouze pro laboratorn\u00ed v\u00fdzkum. Nen\u00ed ur\u010deno pro diagnostick\u00e9 nebo terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/p>\n

Co je Selank?<\/h2>\n

Selank<\/strong> je syntetick\u00fd heptapeptid vyvinut\u00fd v 90. letech 20. stolet\u00ed v \u00dastavu molekul\u00e1rn\u00ed genetiky Rusk\u00e9 akademie v\u011bd, ve stejn\u00e9 laborato\u0159i, kter\u00e1 vyvinula Semax<\/a>. Strukturn\u011b jde o analog endogenn\u00edho imunomodula\u010dn\u00edho tetrapeptidu tuftsinu (TKPR), roz\u0161\u00ed\u0159en\u00e9ho na C-konci o Pro-Gly-Pro ocas, kter\u00fd zaji\u0161\u0165uje proteolytickou stabilitu a amidovan\u00fd C-konec. Toto prodlou\u017een\u00ed v\u00fdrazn\u011b prodlu\u017euje polo\u010das v plazm\u011b oproti p\u0159irozen\u00e9mu tuftsinu, kter\u00fd se rozkl\u00e1d\u00e1 b\u011bhem minut, p\u0159i zachov\u00e1n\u00ed imunomodula\u010dn\u00ed aktivity p\u016fvodn\u00edho peptidu.<\/p>\n

Dob\u0159e charakterizovan\u00e1 sekvence Selanku je TKPRPGP-NH2<\/sub>, molekulov\u00e1 hmotnost 751,88 Da, empirick\u00fd vzorec C33<\/sub>H57<\/sub>N11<\/sub>O9<\/sub>. Dod\u00e1v\u00e1 se jako vysoce \u010dist\u00fd lyofilizovan\u00fd pr\u00e1\u0161ek pro rekonstituci s bakteriostatickou vodou. V Rusku je Selank schv\u00e1len jako anxiolytikum na p\u0159edpis pod n\u00e1zvem Selank (intranaz\u00e1ln\u00ed sprej); mimo postsov\u011btsk\u00fd blok nen\u00ed schv\u00e1len FDA, EMA, MHRA ani \u017e\u00e1dn\u00fdm jin\u00fdm v\u00fdznamn\u00fdm regul\u00e1torem. V\u00fdzkumn\u00fd Selank prod\u00e1van\u00fd zde je dod\u00e1v\u00e1n ur\u010den pouze pro laboratorn\u00ed v\u00fdzkum<\/strong> a nen\u00ed schv\u00e1len pro pod\u00e1v\u00e1n\u00ed lidem nebo zv\u00ed\u0159at\u016fm. Pro v\u00fdzkum souvisej\u00edc\u00edch peptid\u016f nav\u0161tivte na\u0161i Semax<\/a> produktovou str\u00e1nku.<\/p>\n

Mechanismus \u00fa\u010dinku \u2014 GABAergn\u00ed, serotoninergn\u00ed a BDNF dr\u00e1hy<\/h2>\n

Co \u010din\u00ed Selank v\u00fdjime\u010dn\u00fdm mezi v\u00fdzkumn\u00fdmi anxiolytick\u00fdmi slou\u010deninami, je jeho multidr\u00e1hov\u00fd neuromodula\u010dn\u00ed profil<\/strong> bez p\u0159\u00edm\u00e9 vazby na receptor GABAA<\/sub> benzodiazepinov\u00e9ho m\u00edsta \u2014 ka\u017ed\u00e1 z t\u011bchto drah p\u0159isp\u00edv\u00e1 k pozorovan\u00e9mu anxiolytick\u00e9mu a nootropn\u00edmu fenotypu v publikovan\u00fdch v\u00fdzkumech:<\/p>\n