{"id":70705,"date":"2026-05-12T09:29:41","date_gmt":"2026-05-12T09:29:41","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&#038;p=70705"},"modified":"2026-05-21T07:14:10","modified_gmt":"2026-05-21T07:14:10","slug":"oxytocin-acetate","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/oxytocin-acetate\/","title":{"rendered":"Oxytocin Acetate"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background: #fff8e1; border-left: 4px solid #f5a623; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<h3 style=\"margin: 0 0 8px 0; font-size: 16px; color: #1a4a6b;\">Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Oxytocin Acet\u00e1t?<\/h3>\n<p style=\"margin: 0;\"><strong>Oxytocin Acetate<\/strong> je acet\u00e1t-soln\u00e1 forma oxytocinu, 9-aminokyselinov\u00e9ho cyklick\u00e9ho neuropeptidu s jedn\u00edm disulfidov\u00fdm m\u016fstkem mezi Cys1 a Cys6. Jeden z nejstar\u0161\u00edch a nejv\u00edce studovan\u00fdch neuropeptid\u016f ve v\u00fdzkumn\u00e9 literatu\u0159e, p\u016fsob\u00ed jako hypotalamick\u00fd hormon (kontrakce d\u011blohy, ejekce ml\u00e9ka) i jako centr\u00e1ln\u00ed neuromodul\u00e1tor soci\u00e1ln\u00ed vazby, d\u016fv\u011bry a afiliativn\u00edho chov\u00e1n\u00ed. Dod\u00e1v\u00e1 se v lyofilizovan\u00fdch vialk\u00e1ch 5 mg a 10 mg pouze pro laboratorn\u00ed v\u00fdzkum.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background: #f4f8fb; border: 1px solid #d8e3eb; padding: 12px 16px; margin: 16px 0; border-radius: 4px; font-size: 14px;\"><strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdzkumn\u00e9 lyofilizovan\u00e9 peptidy \u00b7 HPLC \u010distota \u226599% (COA na vy\u017e\u00e1d\u00e1n\u00ed) \u00b7 Diskr\u00e9tn\u00ed teplotn\u011b stabiln\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 p\u0159eprava peptid\u016f \u00b7 1,400+ ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size: 14px; color: #444; margin: 8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<table class=\"medsbase-spec-table\" style=\"width: 100%; border-collapse: collapse; margin: 18px 0; font-size: 14px;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 8px 12px; text-align: left; width: 30%;\">Specifikace<\/th>\n<th style=\"padding: 8px 12px; text-align: left;\">Detail<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>CAS \u010d\u00edslo<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">50-56-6 (voln\u00e1 b\u00e1ze oxytocinu); dod\u00e1v\u00e1 se jako acet\u00e1t-soln\u00e1 forma<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>item2<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">C<sub>43<\/sub>H<sub>66<\/sub>N<sub>12<\/sub>O<sub>12<\/sub>S<sub>2<\/sub> (voln\u00e1 b\u00e1ze; acet\u00e1tov\u00e1 s\u016fl p\u0159id\u00e1v\u00e1 CH<sub>3<\/sub>COOH protion)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>item7<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">1007.19 Da (voln\u00e1 b\u00e1ze)<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>item9<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH<sub>2<\/sub> (CYIQNCPLG-NH<sub>2<\/sub>, 9 aminokyselin; intramolekul\u00e1rn\u00ed disulfidov\u00fd m\u016fstek Cys<sup>1<\/sup>\u2013Cys<sup>6<\/sup> tvo\u0159\u00edc\u00ed 6-\u010dlenn\u00fd makrocyklick\u00fd kruh s 3-\u010dlenn\u00fdm C-koncov\u00fdm ocasem; C-konec amidov\u00e1n)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>item11<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Lyofilizovan\u00e1 octanov\u00e1 s\u016fl (b\u00edl\u00fd a\u017e sv\u011btle \u017elut\u00fd pr\u00e1\u0161ek)<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>item13<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u226599% (HPLC ov\u011b\u0159eno, COA na vy\u017e\u00e1d\u00e1n\u00ed)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Skladov\u00e1n\u00ed<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Lyofilizovan\u00e9: 2\u20138 \u00b0C (lednice) pro pracovn\u00ed z\u00e1sobu; \u221220 \u00b0C pro dlouhodob\u00e9 skladov\u00e1n\u00ed neotev\u0159en\u00fdch vialek. Rekonstituovan\u00e9: 2\u20138 \u00b0C, pou\u017eijte do ~30 dn\u016f. Chra\u0148te p\u0159ed sv\u011btlem. Nefreeze\u2013thaw rekonstituovan\u00fd roztok.<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Rozpustnost<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Bakteriostatick\u00e1 voda (doporu\u010deno) nebo steriln\u00ed voda pro krat\u0161\u00ed pou\u017eit\u00ed. Kompatibiln\u00ed s v\u00fdzkumn\u00fdmi formulacemi pro intranaz\u00e1ln\u00ed pod\u00e1n\u00ed.<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Pouze pro v\u00fdzkum<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Pouze pro laboratorn\u00ed v\u00fdzkum. Nen\u00ed ur\u010deno pro diagnostick\u00e9 nebo terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><!-- \/medsbase-tldr-answer --><\/p>\n<h2>Co je Oxytocin Acetate?<\/h2>\n<p><strong>Oxytocin Acetate<\/strong> je octanov\u00e1 s\u016fl oxytocinu, 9-aminokyselinov\u00e9ho cyklick\u00e9ho neuropeptidu, kter\u00fd byl poprv\u00e9 izolov\u00e1n sirem Henrym Dalem v roce 1906 a chemicky syntetizov\u00e1n Vincentem du Vigneaudem v roce 1953 \u2013 prvn\u00ed peptidov\u00fd hormon v\u016fbec vyroben\u00fd tot\u00e1ln\u00ed synt\u00e9zou, pr\u00e1ce, kter\u00e1 vynesla du Vigneaudovi Nobelovu cenu za chemii v roce 1955. Octanov\u00fd protiont se pou\u017e\u00edv\u00e1 ve v\u00fdzkumn\u00e9 lyofilizaci, proto\u017ee zlep\u0161uje dlouhodobou stabilitu peptidu a rozpustnost ve vod\u011b ve srovn\u00e1n\u00ed s volnou b\u00e1z\u00ed oxytocinu, ani\u017e by m\u011bnil farmakologii \u2013 octan se rychle disociuje ve fyziologick\u00e9m roztoku.<\/p>\n<p>Dob\u0159e charakterizovan\u00e1 sekvence je CYIQNCPLG-NH<sub>2<\/sub> s intramolekul\u00e1rn\u00ed disulfidovou vazbou mezi Cys1 a Cys6, kter\u00e1 vytv\u00e1\u0159\u00ed 6-\u010dlenn\u00fd makrocyklick\u00fd kruh a 3-\u010dlenn\u00fd C-koncov\u00fd ocas. Molekulov\u00e1 hmotnost je 1007,19 Da (voln\u00e1 b\u00e1ze); empirick\u00fd vzorec C<sub>43<\/sub>H<sub>66<\/sub>N<sub>12<\/sub>O<sub>12<\/sub>S<sub>2<\/sub>. Oxytocin je dod\u00e1v\u00e1n jako vysoce \u010dist\u00fd lyofilizovan\u00fd pr\u00e1\u0161ek pro rekonstituci s bakteriostatickou vodou. Farmaceutick\u00fd oxytocin je schv\u00e1len FDA jako injek\u010dn\u00ed porodnick\u00fd l\u00e9k (Pitocin, Syntocinon) pro indukci porodu a kontrolu poporodn\u00edho krv\u00e1cen\u00ed; v\u00fdzkumn\u00fd oxytocin acet\u00e1t prod\u00e1van\u00fd zde je dod\u00e1v\u00e1n <strong>ur\u010den pouze pro laboratorn\u00ed v\u00fdzkum<\/strong> a nen\u00ed schv\u00e1len FDA pro pod\u00e1v\u00e1n\u00ed lidem nebo zv\u00ed\u0159at\u016fm. Pro souvisej\u00edc\u00ed v\u00fdzkum mal\u00fdch peptid\u016f CNS viz na\u0161e <a href=\"https:\/\/medsbase.com\/cs\/selank\/\">Selank<\/a> a <a href=\"https:\/\/medsbase.com\/cs\/pt-141\/\">PT-141<\/a> produktov\u00e9 str\u00e1nky.<\/p>\n<h2>Mechanismus \u00fa\u010dinku \u2013 perifern\u00ed endokrinn\u00ed a centr\u00e1ln\u00ed neuromodula\u010dn\u00ed role<\/h2>\n<p>Co \u010din\u00ed oxytocin neobvykl\u00fdm mezi v\u00fdzkumn\u00fdmi peptidy, je jeho <strong>dvoj\u00ed identita<\/strong> jako perifern\u00edho endokrinn\u00edho hormonu a centr\u00e1ln\u00edho neuromodul\u00e1toru. Stejn\u00e1 molekula, uvoln\u011bn\u00e1 z r\u016fzn\u00fdch anatomick\u00fdch odd\u00edl\u016f, produkuje z\u00e1sadn\u011b odli\u0161n\u00e9 fyziologick\u00e9 \u00fa\u010dinky:<\/p>\n<ul>\n<li><strong>Perifern\u00ed endokrinn\u00ed uvoln\u011bn\u00ed \u2013 d\u011blo\u017en\u00ed a ml\u00e9\u010dn\u00e9 \u00fa\u010dinky<\/strong> \u2013 Oxytocin je syntetizov\u00e1n v magnocelul\u00e1rn\u00edch neuronech supraoptick\u00fdch a paraventrikul\u00e1rn\u00edch jader hypotalamu a uvol\u0148ov\u00e1n do syst\u00e9mov\u00e9ho ob\u011bhu z zadn\u00edho laloku hypof\u00fdzy. Perifern\u00ed oxytocin se v\u00e1\u017ee na receptory OXTR na hladk\u00e9m svalstvu d\u011blohy (stimuluje kontrakce b\u011bhem porodu) a na myoepitelov\u00fdch bu\u0148k\u00e1ch ml\u00e9\u010dn\u00fdch alveol\u016f (vyvol\u00e1v\u00e1 reflex vypuzov\u00e1n\u00ed ml\u00e9ka). Perifern\u00ed polo\u010das je kr\u00e1tk\u00fd (~3\u20135 minut IV) kv\u016fli rychl\u00e9mu metabolismu oxytocin\u00e1zou a dal\u0161\u00edmi peptid\u00e1zami.<\/li>\n<li><strong>Centr\u00e1ln\u00ed uvol\u0148ov\u00e1n\u00ed \u2014 soci\u00e1ln\u00ed, afilia\u010dn\u00ed a stres tlum\u00edc\u00ed chov\u00e1n\u00ed<\/strong> \u2014 Samostatn\u00e1 populace parvocelul\u00e1rn\u00edch oxytocinov\u00fdch neuron\u016f vys\u00edl\u00e1 axony do mozkov\u00fdch oblast\u00ed v\u010detn\u011b amygdaly, nucleus accumbens, ventr\u00e1ln\u00ed tegment\u00e1ln\u00ed oblasti a prefront\u00e1ln\u00ed k\u016fry. Centr\u00e1ln\u00ed uvol\u0148ov\u00e1n\u00ed oxytocinu nevstupuje do syst\u00e9mov\u00e9ho ob\u011bhu a nen\u00ed m\u011b\u0159eno plazmatick\u00fdmi testy. V publikovan\u00fdch v\u00fdzkumech moduluje p\u00e1rov\u00e9 vazby, skupinovou p\u0159\u00edslu\u0161nost, d\u016fv\u011bru, extinkci strachu a reakci na stres. Literatura o p\u00e1rov\u00fdch vazb\u00e1ch u hrabo\u0161\u016f pr\u00e9riov\u00fdch je kanonick\u00fdm mechanistick\u00fdm datasetem pro centr\u00e1ln\u00ed oxytocinovou signalizaci.<\/li>\n<li><strong>Farmakologie receptor\u016f a signalizace<\/strong> \u2014 Oxytocin p\u016fsob\u00ed na jedin\u00fd G-proteinem v\u00e1zan\u00fd receptor (OXTR), kter\u00fd se prim\u00e1rn\u011b v\u00e1\u017ee na G\u03b1<sub>q\/11<\/sub> a aktivuje fosfolip\u00e1zu C, IP<sub>3<\/sub>, a uvol\u0148ov\u00e1n\u00ed intracelul\u00e1rn\u00edho v\u00e1pn\u00edku v hladk\u00e9m svalstvu. V CNS je signalizace OXTR slo\u017eit\u011bj\u0161\u00ed a zahrnuje vazbu na G\u03b1<sub>i\/o<\/sub> , modulaci GABAergn\u00edch interneuron\u016f a k\u0159\u00ed\u017eovou komunikaci s bl\u00edzce p\u0159\u00edbuzn\u00fdm vasopresinov\u00fdm receptorem V1a. Selektivn\u00ed agonist\u00e9 a antagonist\u00e9 OXTR jsou hojn\u011b vyu\u017e\u00edv\u00e1ni v sou\u010dasn\u00e9m v\u00fdzkumu k rozli\u0161en\u00ed p\u0159\u00edsp\u011bvk\u016f oxytocinu a vasopresinu k chov\u00e1n\u00ed.<\/li>\n<\/ul>\n<p>Intranaz\u00e1ln\u00ed pod\u00e1n\u00ed je jednou z nej\u010dast\u011bji citovan\u00fdch v\u00fdzkumn\u00fdch metod pod\u00e1n\u00ed, proto\u017ee vyvol\u00e1v\u00e1 m\u011b\u0159iteln\u00e9 \u00fa\u010dinky na soci\u00e1ln\u00ed chov\u00e1n\u00ed v CNS, ani\u017e by zv\u00fd\u0161ilo perifern\u00ed plazmatickou hladinu oxytocinu na fyziologicky v\u00fdznamn\u00e9 \u00farovn\u011b. P\u0159esn\u00fd mechanismus, kter\u00fdm intranaz\u00e1ln\u00ed oxytocin dos\u00e1hne kompartment\u016f CNS \u2014 zda transportem p\u0159es \u010dichov\u00fd a trigemin\u00e1ln\u00ed nerv, dif\u00faz\u00ed p\u0159es cribriformn\u00ed plot\u00e9nku nebo perifern\u00edm zp\u011btn\u00fdm sign\u00e1lem \u2014 z\u016fst\u00e1v\u00e1 p\u0159edm\u011btem aktivn\u00edho v\u00fdzkumu. Behavior\u00e1ln\u00ed \u00fa\u010dinky jsou dostate\u010dn\u011b reprodukovateln\u00e9, aby se intranaz\u00e1ln\u00ed pod\u00e1n\u00ed stalo standardn\u00ed cestou v behavior\u00e1ln\u00edm v\u00fdzkumu oxytocinu u lid\u00ed a hlodavc\u016f.<\/p>\n<h2>Publikovan\u00e9 v\u00fdzkumn\u00e9 aplikace<\/h2>\n<p>Oxytocin Acetate se pou\u017e\u00edv\u00e1 v laboratorn\u00edch v\u00fdzkumn\u00fdch kontextech, kter\u00e9 zkoumaj\u00ed:<\/p>\n<ul>\n<li><strong>Soci\u00e1ln\u00ed chov\u00e1n\u00ed a p\u00e1rov\u00e9 vazby<\/strong> \u2014 testy partner preference u hrabo\u0161\u016f pr\u00e9riov\u00fdch, formov\u00e1n\u00ed partner preference u monogamn\u00edch vs. polygamn\u00edch hrabo\u0161\u016f, paradigmata soci\u00e1ln\u00edho rozpozn\u00e1v\u00e1n\u00ed u hlodavc\u016f (Insel &amp; Hulihan, Behav Neurosci 1995; Young &amp; Wang, Nat Neurosci 2004)<\/li>\n<li><strong>V\u00fdzkum autismu a soci\u00e1ln\u00edho pozn\u00e1n\u00ed<\/strong> \u2014 preklinick\u00e9 modely fenotyp\u016f soci\u00e1ln\u00edho deficitu, kohortov\u00e9 studie variant OXTR, behavior\u00e1ln\u00ed koncov\u00e9 body intranaz\u00e1ln\u00edho oxytocinu; jedna z nejaktivn\u011bj\u0161\u00edch oblast\u00ed sou\u010dasn\u00e9ho klinick\u00e9ho v\u00fdzkumu oxytocinu<\/li>\n<li><strong>V\u00fdzkum chov\u00e1n\u00ed t\u00fdkaj\u00edc\u00ed se d\u016fv\u011bry a spolupr\u00e1ce<\/strong> \u2014 ekonomick\u00e9 paradigmaty hry na d\u016fv\u011bru, kooperativn\u00ed rozhodov\u00e1n\u00ed v podm\u00ednk\u00e1ch nejistoty; modulace p\u0159edsudk\u016f v\u016f\u010di vlastn\u00ed vs. ciz\u00ed skupin\u011b<\/li>\n<li><strong>Stres, \u00fazkost a extinkce strachu<\/strong> \u2014 amygdala-dependentn\u00ed podmi\u0148ov\u00e1n\u00ed strachu, stresem indukovan\u00e1 aktivace osy HPA, modulace kortizolov\u00e9 odpov\u011bdi v publikovan\u00fdch studi\u00edch<\/li>\n<li><strong>Mate\u0159sk\u00e9 chov\u00e1n\u00ed a rodi\u010dovsk\u00e1 p\u00e9\u010de<\/strong> \u2014 indukce poporodn\u00edho mate\u0159sk\u00e9ho chov\u00e1n\u00ed u hlodavc\u016f, v\u00fdzkum otcovsk\u00e9 p\u00e9\u010de u monogamn\u00edch druh\u016f hrabo\u0161\u016f, allorodi\u010dovsk\u00e9 chov\u00e1n\u00ed<\/li>\n<li><strong>V\u00fdzkum reproduk\u010dn\u00ed fyziologie<\/strong> \u2014 testy kontraktility d\u011blohy, v\u00fdzkum myoepiteli\u00e1ln\u00edch bun\u011bk ml\u00e9\u010dn\u00e9 \u017el\u00e1zy, studie mechanism\u016f porodu a porodn\u00edch proces\u016f<\/li>\n<li><strong>Hojen\u00ed ran a regenerace tk\u00e1n\u00ed<\/strong> \u2014 exprese OXTR na derm\u00e1ln\u00edch fibroblastech a keratinocytech; nov\u00e9 v\u00fdzkumy lok\u00e1ln\u00ed oxytocinov\u00e9 signalizace p\u0159i hojen\u00ed ko\u017en\u00edch ran<\/li>\n<li><strong>Srovn\u00e1vac\u00ed v\u00fdzkum neuropeptid\u016f<\/strong> \u2014 srovn\u00e1n\u00ed s vazopresinem (bl\u00edzce p\u0159\u00edbuzn\u00fd 9-aminokyselinov\u00fd cyklick\u00fd neuropeptid s jednou aminokyselinovou odchylkou) a s dal\u0161\u00edmi mal\u00fdmi CNS-aktivn\u00edmi peptidy, jako jsou <a href=\"https:\/\/medsbase.com\/cs\/selank\/\">Selank<\/a>.<\/li>\n<\/ul>\n<p>Pro \u0161ir\u0161\u00ed kontext, kam oxytocin zapad\u00e1 v r\u00e1mci krajiny mal\u00fdch peptidov\u00fdch neuromodul\u00e1tor\u016f, viz <a href=\"https:\/\/medsbase.com\/cs\/selank\/\">Selank<\/a> (anxiolytick\u00fd heptapeptid), <a href=\"https:\/\/medsbase.com\/cs\/pt-141\/\">PT-141<\/a> (CNS-aktivn\u00ed agonista melanokortinu), a <a href=\"https:\/\/medsbase.com\/cs\/semax\/\">Semax<\/a> (nootropn\u00ed heptapeptid). Prohl\u00e9dn\u011bte si cel\u00fd <a href=\"https:\/\/medsbase.com\/cs\/peptides\/\">katalog v\u00fdzkumn\u00fdch peptid\u016f<\/a> pro p\u0159\u00edbuzn\u00e9 slou\u010deniny.<\/p>\n<h2>Dostupn\u00e9 s\u00edly a koncentrace<\/h2>\n<p>MedsBase nab\u00edz\u00ed Oxytocin Acetate ve dvou velikostech lyofilizovan\u00fdch vialek kalibrovan\u00fdch na typick\u00e9 d\u00e9lky v\u00fdzkumn\u00fdch protokol\u016f. Ka\u017ed\u00e1 s\u00edla je dostupn\u00e1 v balen\u00ed po 10 nebo 20 vialk\u00e1ch s \u00fapln\u00fdmi pokyny pro rekonstituci:<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">S\u00edla vialky<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Typick\u00fd v\u00fdzkumn\u00fd p\u0159\u00edpad u\u017eit\u00ed<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Velikosti balen\u00ed<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>5 mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Standardn\u00ed v\u00fdzkumn\u00e1 s\u00edla, intranaz\u00e1ln\u00ed formulace, protokoly behavior\u00e1ln\u00edch test\u016f<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10 nebo 20 vialek<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>10 mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">V\u00fdzkum s prodlou\u017een\u00fdm cyklem, nejni\u017e\u0161\u00ed cena za mg, behavior\u00e1ln\u00ed studie s v\u00edce kohortami<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10 nebo 20 vialek<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Ob\u011b s\u00edly jsou stejn\u00e9 chemick\u00e9 formy (lyofilizovan\u00fd pr\u00e1\u0161ek acet\u00e1tov\u00e9 soli, \u010distota 99%+ HPLC). Proto\u017ee v\u00fdzkumn\u00e9 d\u00e1vkov\u00e1n\u00ed oxytocinu je v re\u017eimu n\u00edzk\u00fdch mikrogram\u016f na aplikaci, jedna vialka 5 mg podporuje mnoho t\u00fddn\u016f behavior\u00e1ln\u00edho v\u00fdzkumu p\u0159i typick\u00fdch intranaz\u00e1ln\u00edch d\u00e1vk\u00e1ch (24 IU \u2248 40 mcg na aplikaci u lidsk\u00e9ho v\u00fdzkumu, s ni\u017e\u0161\u00edmi d\u00e1vkami u hlodavc\u016f).<\/p>\n<h2>Jak se porovn\u00e1v\u00e1 \u2014 Oxytocin Acetate vs Selank<\/h2>\n<p>Oxytocin a <a href=\"https:\/\/medsbase.com\/cs\/selank\/\">Selank<\/a> jsou oba mal\u00e9 CNS-aktivn\u00ed peptidy pou\u017e\u00edvan\u00e9 ve v\u00fdzkumu chov\u00e1n\u00ed a n\u00e1lady, ale c\u00edl\u00ed na r\u016fzn\u00e9 receptory a behavior\u00e1ln\u00ed dom\u00e9ny. N\u011bkdy jsou ve v\u00fdzkumu srovn\u00e1v\u00e1ny, proto\u017ee oba jsou intranaz\u00e1ln\u011b biologicky dostupn\u00e9 a oba produkuj\u00ed m\u011b\u0159iteln\u00e9 behavior\u00e1ln\u00ed efekty v publikovan\u00fdch studi\u00edch na hlodavc\u00edch a lidech, p\u0159esto\u017ee jsou strukturn\u011b a farmakologicky nep\u0159\u00edbuzn\u00e9.<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Krit\u00e9rium<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Oxytocin Acetate<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Selank<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>D\u00e9lka<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">9 aminokyselin (cyklick\u00fd nonapeptid)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">7 aminokyselin (line\u00e1rn\u00ed heptapeptid)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Struktura<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Disulfidem propojen\u00fd makrocyklus<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Line\u00e1rn\u00ed s amidovan\u00fdm C-koncem<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Prim\u00e1rn\u00ed receptor<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">OXTR (G-proteinov\u00fd receptor)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Neklasick\u00fd (modulace GABA, BDNF)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Behavior\u00e1ln\u00ed sign\u00e1l<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Soci\u00e1ln\u00ed vazba, d\u016fv\u011bra, afiliativn\u00ed chov\u00e1n\u00ed<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Anxiolytikum, odolnost v\u016f\u010di stresu<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Typick\u00e1 v\u00fdzkumn\u00e1 d\u00e1vka (intranaz\u00e1ln\u00ed)<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">24\u201340 IU (~40\u201365 mcg)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">300\u2013900 mcg<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Polo\u010das v plazm\u011b<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">~3\u20135 min (IV)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">~15\u201330 min (intranaz\u00e1ln\u00ed)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Schv\u00e1len\u00e9 klinick\u00e9 pou\u017eit\u00ed<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Indukce porodu, poporodn\u00ed krv\u00e1cen\u00ed<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Anxiolytic (pouze v Rusku)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Pro behavior\u00e1ln\u00ed v\u00fdzkum a kombinov\u00e1n\u00ed maj\u00ed tyto dva peptidy neprot\u00ednaj\u00edc\u00ed se mechanismy (oxytocin p\u016fsob\u00ed na vlastn\u00ed GPCR; Selank p\u016fsob\u00ed modulac\u00ed GABA\/BDNF), tak\u017ee spole\u010dn\u00e1 administrace nen\u00ed farmakologicky redundantn\u00ed. V\u00fdzkumn\u00e9 protokoly studuj\u00edc\u00ed stres a soci\u00e1ln\u00ed chov\u00e1n\u00ed jako spole\u010dn\u00e9 c\u00edle n\u011bkdy vyu\u017e\u00edvaj\u00ed ob\u011b slo\u017eky.<\/p>\n<h2>Skladov\u00e1n\u00ed a rekonstituce<\/h2>\n<p><strong>P\u0159ed rekonstituci:<\/strong> lyofilizovan\u00e9 lahvi\u010dky skladujte v chladni\u010dce p\u0159i 2\u20138 \u00b0C v p\u016fvodn\u00edm obalu pro kr\u00e1tkodob\u00e9 pracovn\u00ed z\u00e1soby. Pro dlouhodob\u00e9 skladov\u00e1n\u00ed neotev\u0159en\u00fdch lahvi\u010dek zmrazte p\u0159i \u221220 \u00b0C. Lyofilizovan\u00fd oxytocin acet\u00e1t je stabiln\u00ed v chladni\u010dce a\u017e 24 m\u011bs\u00edc\u016f a p\u0159i \u221220 \u00b0C a\u017e 36 m\u011bs\u00edc\u016f. Vyvarujte se cykl\u016fm zmrazov\u00e1n\u00ed a rozmrazov\u00e1n\u00ed lyofilizovan\u00e9ho pr\u00e1\u0161ku. Forma acet\u00e1tov\u00e9 soli je hygroskopicky stabiln\u011bj\u0161\u00ed ne\u017e voln\u00e1 b\u00e1ze, ale lahvi\u010dky by m\u011bly b\u00fdt st\u00e1le chr\u00e1n\u011bny p\u0159ed vlhkost\u00ed vzduchu.<\/p>\n<p><strong>Postup rekonstituce:<\/strong> injektujte bakteriostatickou vodu po bo\u010dn\u00ed st\u011bn\u011b peptidov\u00e9 lahvi\u010dky (ne p\u0159\u00edmo na lyofilizovan\u00fd kol\u00e1\u010d). Pro lahvi\u010dku 5 mg, 5,0 ml bakteriostatick\u00e9 vody vytvo\u0159\u00ed pracovn\u00ed koncentraci 1 mg\/ml; 0,04 ml pod\u00e1v\u00e1 v\u00fdzkumnou d\u00e1vku 40 mcg (~24 IU). Jemn\u011b zakru\u017ete \u2013 ne <strong>ne<\/strong> prot\u0159epejte \u2014 a nechte 2\u20135 minut pro \u00fapln\u00e9 rozpu\u0161t\u011bn\u00ed. Spr\u00e1vn\u011b rekonstituovan\u00fd roztok by m\u011bl b\u00fdt \u010dir\u00fd a bezbarv\u00fd. Pro v\u00fdzkumn\u00e9 formulace s intranaz\u00e1ln\u00edm vehikulem lze rekonstituovan\u00fd roztok p\u0159en\u00e9st do kalibrovan\u00e9 lahvi\u010dky s nosn\u00edm sprejem, kter\u00e1 dod\u00e1v\u00e1 ~100 \u03bcL na jedno stisknut\u00ed.<\/p>\n<p><strong>Po rekonstituci:<\/strong> skladujte v chladni\u010dce p\u0159i 2\u20138 \u00b0C a pou\u017eijte do 30 dn\u016f pro optim\u00e1ln\u00ed stabilitu. Nepou\u017e\u00edvejte zmrazen\u00fd rekonstituovan\u00fd roztok \u2013 cykly zmrazov\u00e1n\u00ed a rozmrazov\u00e1n\u00ed degraduj\u00ed integritu peptidu a naru\u0161uj\u00ed disulfidovou vazbu Cys1\u2013Cys6. Zlikvidujte jakoukoli lahvi\u010dku vykazuj\u00edc\u00ed z\u00e1kal, sra\u017eeninu nebo zm\u011bnu barvy.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3>K \u010demu se pou\u017e\u00edv\u00e1 Oxytocin Acetate ve v\u00fdzkumu?<\/h3>\n<p>Oxytocin Acetate se pou\u017e\u00edv\u00e1 v laboratorn\u00edm v\u00fdzkumu p\u0159i studiu soci\u00e1ln\u00edho chov\u00e1n\u00ed a p\u00e1rov\u00fdch vazeb, autismu a soci\u00e1ln\u00edho pozn\u00e1v\u00e1n\u00ed, paradigmat d\u016fv\u011bry a spolupr\u00e1ce, stresu a extinkce strachu, mate\u0159sk\u00e9 a rodi\u010dovsk\u00e9 p\u00e9\u010de, reproduk\u010dn\u00ed fyziologie a hojen\u00ed ran. Je jedn\u00edm z nejv\u00edce studovan\u00fdch neuropeptid\u016f v odborn\u00e9 literatu\u0159e a slou\u017e\u00ed jako kanonick\u00e1 v\u00fdzkumn\u00e1 slou\u010denina osy OXTR. V\u00fdzkumn\u00fd oxytocin acet\u00e1t prod\u00e1van\u00fd zde je <strong>ne<\/strong> schv\u00e1len FDA pro neklinick\u00e9 pou\u017eit\u00ed u lid\u00ed a je dod\u00e1v\u00e1n v\u00fdhradn\u011b pro laboratorn\u00ed v\u00fdzkum.<\/p>\n<h3>Jak\u00fd je rozd\u00edl mezi oxytocin acet\u00e1tem a volnou b\u00e1z\u00ed oxytocinu?<\/h3>\n<p>Acet\u00e1tov\u00fd protion nem\u011bn\u00ed farmakologii \u2013 rychle se disociuje ve fyziologick\u00e9m roztoku. Acet\u00e1tov\u00e1 s\u016fl se pou\u017e\u00edv\u00e1 p\u0159i lyofilizaci v\u00fdzkumn\u00fdch peptid\u016f, proto\u017ee zlep\u0161uje dlouhodobou stabilitu peptidu, sni\u017euje hygroskopi\u010dnost a zlep\u0161uje rozpustnost ve vod\u011b ve srovn\u00e1n\u00ed s volnou b\u00e1z\u00ed oxytocinu. V\u0161echny publikovan\u00e9 behavior\u00e1ln\u00ed a endokrinn\u00ed \u00fa\u010dinky oxytocinu plat\u00ed pro acet\u00e1tovou s\u016fl p\u0159i ekvivalentn\u00edm obsahu oxytocinu.<\/p>\n<h3>Jak se Oxytocin li\u0161\u00ed od Selanku?<\/h3>\n<p>Oba jsou mal\u00e9 peptidy aktivn\u00ed v CNS pou\u017e\u00edvan\u00e9 ve v\u00fdzkumu chov\u00e1n\u00ed, ale c\u00edl\u00ed na r\u016fzn\u00e9 receptory a behavior\u00e1ln\u00ed dom\u00e9ny. Oxytocin je 9-aminokyselinov\u00fd makrocyklick\u00fd peptid s disulfidov\u00fdm m\u016fstkem, kter\u00fd se v\u00e1\u017ee na G-proteinov\u00fd receptor OXTR, s prim\u00e1rn\u00edm v\u00fdzkumn\u00fdm sign\u00e1lem v paradigmatech soci\u00e1ln\u00ed vazby a d\u016fv\u011bry. Selank je 7-aminokyselinov\u00fd line\u00e1rn\u00ed heptapeptid p\u016fsob\u00edc\u00ed prost\u0159ednictv\u00edm modulace GABA a exprese BDNF, s prim\u00e1rn\u00edm v\u00fdzkumn\u00fdm sign\u00e1lem v anxiol\u00fdze a odolnosti v\u016f\u010di stresu. Tyto dva peptidy nejsou farmakologicky p\u0159\u00edbuzn\u00e9.<\/p>\n<h3>Jak\u00e1 je typick\u00e1 v\u00fdzkumn\u00e1 d\u00e1vka Oxytocinu?<\/h3>\n<p>Publikovan\u00e9 v\u00fdzkumn\u00e9 protokoly pro intranaz\u00e1ln\u00ed pod\u00e1n\u00ed u lid\u00ed obvykle pou\u017e\u00edvaj\u00ed 24\u201340 IU na d\u00e1vku (1 IU \u2248 1,7 mcg, tak\u017ee 24 IU \u2248 40 mcg). D\u00e1vky pro hlodavce jsou ni\u017e\u0161\u00ed v absolutn\u00ed hmotnosti, ale vy\u0161\u0161\u00ed v mg\/kg. 5 mg lahvi\u010dka rekonstituovan\u00e1 s 5,0 mL bakteriostatick\u00e9 vody poskytne koncentraci 1 mg\/mL \u2014 40 mcg v 0,04 mL.<\/p>\n<h3>Je Oxytocin Acetate schv\u00e1len FDA?<\/h3>\n<p>Farmaceutick\u00fd injek\u010dn\u00ed oxytocin (Pitocin, Syntocinon) je schv\u00e1len FDA pro specifick\u00e9 porodnick\u00e9 indikace \u2014 indukci porodu, kontrolu poporodn\u00edho krv\u00e1cen\u00ed a usnadn\u011bn\u00ed vypuzov\u00e1n\u00ed ml\u00e9ka \u2014 vyr\u00e1b\u011bn\u00fd podle standard\u016f GMP schv\u00e1len\u00fdmi farmaceutick\u00fdmi v\u00fdrobci. V\u00fdzkumn\u00fd oxytocin acet\u00e1t prod\u00e1van\u00fd zde je samostatn\u00fd produkt ur\u010den\u00fd pouze pro laboratorn\u00ed v\u00fdzkum a nen\u00ed <strong>ne<\/strong> schv\u00e1len FDA pro lidsk\u00e9 nebo veterin\u00e1rn\u00ed pou\u017eit\u00ed mimo tyto porodnick\u00e9 indikace.<\/p>\n<h3>Jak by m\u011bl b\u00fdt Oxytocin Acetate skladov\u00e1n?<\/h3>\n<p>Lyofilizovan\u00e9 lahvi\u010dky: kr\u00e1tkodob\u011b uchov\u00e1vejte v chladni\u010dce p\u0159i 2\u20138 \u00b0C, nebo dlouhodob\u011b p\u0159i \u221220 \u00b0C pro neotev\u0159en\u00e9 lahvi\u010dky. Rekonstituovan\u00fd roztok: uchov\u00e1vejte v chladni\u010dce p\u0159i 2\u20138 \u00b0C, pou\u017eijte do 30 dn\u016f. Nep\u0159emrazujte rekonstituovan\u00fd roztok \u2014 cykly mrazen\u00ed a rozmrazov\u00e1n\u00ed degraduj\u00ed peptid a mohou naru\u0161it disulfidov\u00fd m\u016fstek. V\u017edy chra\u0148te p\u0159ed p\u0159\u00edm\u00fdm sv\u011btlem.<\/p>\n<h3>Jak rekonstituovat Oxytocin Acetate?<\/h3>\n<p>Postupujte podle v\u00fd\u0161e uveden\u00e9ho rekonstitu\u010dn\u00edho postupu. P\u0159idejte bakteriostatickou vodu po st\u011bn\u011b lahvi\u010dky (ne p\u0159\u00edmo na lyofilizovan\u00fd pr\u00e1\u0161ek), jemn\u011b prot\u0159epejte a nechte 2\u20135 minut pro \u00fapln\u00e9 rozpu\u0161t\u011bn\u00ed. Ne <strong>ne<\/strong> Net\u0159epejte lahvi\u010dkou \u2014 energick\u00e9 m\u00edch\u00e1n\u00ed m\u016f\u017ee naru\u0161it disulfidovou vazbu. Spr\u00e1vn\u011b rekonstituovan\u00fd roztok je \u010dir\u00fd a bezbarv\u00fd. Pro lahvi\u010dku 5 mg + 5,0 mL rozpou\u0161t\u011bdla je pracovn\u00ed koncentrace 1 mg\/mL.<\/p>\n<h3>Jak\u00e9 s\u00edly nab\u00edz\u00ed MedsBase?<\/h3>\n<p>MedsBase nab\u00edz\u00ed Oxytocin Acetate v lyofilizovan\u00fdch lahvi\u010dk\u00e1ch 5 mg a 10 mg. Ka\u017ed\u00e9 balen\u00ed je dostupn\u00e9 v balen\u00ed po 10 nebo 20 lahvi\u010dk\u00e1ch. V\u0161echny lahvi\u010dky jsou dod\u00e1v\u00e1ny s \u010distotou 99%+ HPLC a certifik\u00e1tem anal\u00fdzy na vy\u017e\u00e1d\u00e1n\u00ed.<\/p>\n<h3>Lze Oxytocin pod\u00e1vat intranaz\u00e1ln\u011b ve v\u00fdzkumu?<\/h3>\n<p>Ano \u2014 intranaz\u00e1ln\u00ed pod\u00e1n\u00ed je jedn\u00edm z nej\u010dast\u011bji uv\u00e1d\u011bn\u00fdch zp\u016fsob\u016f pod\u00e1n\u00ed oxytocinu ve studi\u00edch chov\u00e1n\u00ed. Intranaz\u00e1ln\u00ed oxytocin vyvol\u00e1v\u00e1 m\u011b\u0159iteln\u00e9 \u00fa\u010dinky na CNS v oblasti soci\u00e1ln\u00edho chov\u00e1n\u00ed, d\u016fv\u011bry a reakce na stres, ani\u017e by zv\u00fd\u0161il perifern\u00ed plazmatickou hladinu oxytocinu na fyziologicky v\u00fdznamn\u00e9 \u00farovn\u011b. P\u0159esn\u00fd mechanismus vstupu do CNS z\u016fst\u00e1v\u00e1 p\u0159edm\u011btem aktivn\u00edho v\u00fdzkumu (transport p\u0159es \u010dichov\u00fd a trojklann\u00fd nerv, difuze p\u0159es cribriformn\u00ed plot\u00e9nku nebo perifern\u00ed zp\u011btn\u00e1 vazba). Subkut\u00e1nn\u00ed a intracerebroventrikul\u00e1rn\u00ed cesty jsou tak\u00e9 dokumentov\u00e1ny ve v\u00fdzkumu na hlodavc\u00edch.<\/p>\n<h3>Jak\u00fd je polo\u010das rozpadu Oxytocinu?<\/h3>\n<p>Podle publikovan\u00fdch v\u00fdzkum\u016f m\u00e1 oxytocin v plazm\u011b polo\u010das rozpadu p\u0159ibli\u017en\u011b 3\u20135 minut po intraven\u00f3zn\u00edm pod\u00e1n\u00ed. Kr\u00e1tk\u00fd perifern\u00ed polo\u010das je zp\u016fsoben rychl\u00fdm metabolismem oxytocin\u00e1zou (tak\u00e9 naz\u00fdvanou cystinyl aminopeptid\u00e1za) a dal\u0161\u00edmi peptid\u00e1zami. Behavior\u00e1ln\u00ed \u00fa\u010dinky po intranaz\u00e1ln\u00edm pod\u00e1n\u00ed p\u0159etrv\u00e1vaj\u00ed d\u00e9le ne\u017e clearance z plazmy, proto\u017ee centr\u00e1ln\u00ed kompartmenty oxytocinu jsou odd\u011blen\u00e9 od perifern\u00edho ob\u011bhu.<\/p>\n<h3>Pro\u010d je disulfidov\u00fd m\u016fstek d\u016fle\u017eit\u00fd?<\/h3>\n<p>Disulfidov\u00e1 vazba Cys1\u2013Cys6 uzamyk\u00e1 oxytocin do cyklick\u00e9 konformace pot\u0159ebn\u00e9 pro vazbu na receptor. Redukce disulfidov\u00e9 vazby p\u0159em\u011b\u0148uje oxytocin na neaktivn\u00ed line\u00e1rn\u00ed formu \u2014 proto postupy rekonstituce specificky vylu\u010duj\u00ed prudk\u00e9 prot\u0159ep\u00e1v\u00e1n\u00ed a cykly zmrazov\u00e1n\u00ed-rozmrazov\u00e1n\u00ed, kter\u00e9 mohou naru\u0161it m\u016fstek a degradovat peptidovou aktivitu. Bl\u00edzce p\u0159\u00edbuzn\u00fd neuropeptid vasopresin m\u00e1 stejnou architekturu disulfidov\u00e9ho m\u016fstku s pouze jednou aminokyselinovou odchylkou na pozici 3 (Phe u vasopresinu vs Ile u oxytocinu).<\/p>\n<h3>M\u00e1 Oxytocin ve v\u00fdzkumu vedlej\u0161\u00ed \u00fa\u010dinky?<\/h3>\n<p>Nejkonzistentn\u011bj\u0161\u00edm zji\u0161t\u011bn\u00edm ve v\u00fdzkumu oxytocinu je d\u00e1vkov\u00e1 z\u00e1vislost behavior\u00e1ln\u00edch \u00fa\u010dink\u016f \u2014 odpov\u011b\u010f nen\u00ed monot\u00f3nn\u00ed p\u0159i vysok\u00fdch d\u00e1vk\u00e1ch a velmi vysok\u00e9 d\u00e1vky mohou vyvolat paradoxn\u00ed efekty. Akutn\u00ed perifern\u00ed \u00fa\u010dinky mohou zahrnovat d\u011blo\u017en\u00ed kontrakce (relevantn\u00ed ve v\u00fdzkumn\u00fdch modelech t\u011bhotenstv\u00ed) a m\u00edrn\u00e9 vazokonstrik\u010dn\u00ed efekty p\u0159i suprafyziologick\u00fdch d\u00e1vk\u00e1ch. Dlouhodob\u00e9 behavior\u00e1ln\u00ed studie popsaly kontextov\u011b z\u00e1visl\u00e9 efekty \u2014 nap\u0159. zv\u00fd\u0161enou afiliaci ve skupin\u011b m\u016f\u017ee doprov\u00e1zet zv\u00fd\u0161en\u00e1 preference vlastn\u00ed skupiny v n\u011bkter\u00fdch soci\u00e1ln\u011b-kognitivn\u00edch paradigmatech.<\/p>\n<h3>Jak dlouho trv\u00e1, ne\u017e se projev\u00ed \u00fa\u010dinky Oxytocinu v preklinick\u00e9m v\u00fdzkumu?<\/h3>\n<p>Akutn\u00ed behavior\u00e1ln\u00ed \u00fa\u010dinky na soci\u00e1ln\u00ed rozpozn\u00e1v\u00e1n\u00ed, preference partnera a paradigmata d\u016fv\u011bry jsou detekovateln\u00e9 do 30\u201360 minut po intranaz\u00e1ln\u00edm pod\u00e1n\u00ed u lidsk\u00e9ho i hlodav\u010d\u00edho v\u00fdzkumu. Perifern\u00ed \u00fa\u010dinky (d\u011blo\u017en\u00ed kontrakce, vypuzov\u00e1n\u00ed ml\u00e9ka) nastupuj\u00ed b\u011bhem sekund po intraven\u00f3zn\u00edm pod\u00e1n\u00ed d\u00edky p\u0159\u00edm\u00e9mu spojen\u00ed OXTR s PLC\/IP<sub>3<\/sub>\/Ca<sup>2+<\/sup> signalizac\u00ed.<\/p>\n<h3>Mohu objednat Oxytocin Acetate pro mezin\u00e1rodn\u00ed p\u0159epravu?<\/h3>\n<p>Ano. MedsBase expeduje Oxytocin Acetate celosv\u011btov\u011b prost\u0159ednictv\u00edm na\u0161\u00ed specializovan\u00e9 s\u00edt\u011b pro p\u0159epravu peptid\u016f. Objedn\u00e1vky obsahuj\u00edc\u00ed pouze peptidy kvalifikuj\u00ed pro na\u0161i samostatnou slu\u017ebu peptidov\u00e9 p\u0159epravy. V\u0161echny z\u00e1silky jsou expedov\u00e1ny v teplotn\u011b kontrolovan\u00e9m balen\u00ed s pln\u00fdm sledov\u00e1n\u00edm a jsou kryty na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a>.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Dal\u0161\u00ed peptidy pro v\u00fdzkum CNS, behavior\u00e1ln\u00ed a afektivn\u00ed v\u00fdzkum<\/h2>\n<ul>\n<li><a href=\"\/cs\/selank\/\"><strong>Selank<\/strong><\/a> \u2014 Anxiolytick\u00fd heptapeptidov\u00fd analog tuftsinu \u2014 v\u00fdzkum odolnosti v\u016f\u010di stresu GABA\/BDNF<\/li>\n<li><a href=\"\/cs\/semax\/\"><strong>Semax<\/strong><\/a> \u2014 Rusk\u00fd vyvinut\u00fd nootropn\u00ed heptapeptid \u2014 modulace melanokortinu a dopaminergn\u00edho syst\u00e9mu<\/li>\n<li><a href=\"\/cs\/pt-141\/\"><strong>PT-141 (Bremelanotid)<\/strong><\/a> \u2014 Agonista melanokortinov\u00e9ho receptoru \u2014 mal\u00fd CNS-aktivn\u00ed peptid pro v\u00fdzkum sexu\u00e1ln\u00edho chov\u00e1n\u00ed<\/li>\n<li><a href=\"\/cs\/epitalon\/\"><strong>Epitalon<\/strong><\/a> \u2014 AEDG pine\u00e1ln\u00ed tetrapeptid \u2014 v\u00fdzkum dlouhov\u011bkosti a cirkadi\u00e1nn\u00edch rytm\u016f<\/li>\n<li><a href=\"\/cs\/bpc-157\/\"><strong>BPC-157<\/strong><\/a> \u2014 Body Protection Compound \u2014 v\u00fdzkum regenerace tk\u00e1n\u00ed<\/li>\n<\/ul>\n<p><!-- medsbase-peptide-guide-cta --><\/p>\n<h2>Dal\u0161\u00ed \u010dten\u00ed<\/h2>\n<div style=\"background: #f4f8fb; border-left: 4px solid #2c7cb0; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<p style=\"margin: 0 0 8px 0;\"><strong>\ud83d\udcd6 Prozkoumejte CNS-aktivn\u00ed v\u00fdzkumn\u00e9 peptidy<\/strong><\/p>\n<p style=\"margin: 0;\">Prohl\u00e9dn\u011bte si celou <a href=\"https:\/\/medsbase.com\/cs\/peptides\/\"><strong>katalog v\u00fdzkumn\u00fdch peptid\u016f<\/strong><\/a>, v\u010detn\u011b p\u0159\u00edbuzn\u00fdch slou\u010denin jako <a href=\"https:\/\/medsbase.com\/cs\/selank\/\">Selank<\/a> pro v\u00fdzkum GABA osy s anxiolytick\u00fdm \u00fa\u010dinkem, <a href=\"https:\/\/medsbase.com\/cs\/semax\/\">Semax<\/a> pro nootropick\u00fd v\u00fdzkum melanokortinov\u00e9 osy a <a href=\"https:\/\/medsbase.com\/cs\/pt-141\/\">PT-141<\/a> pro v\u00fdzkum sexu\u00e1ln\u00edho chov\u00e1n\u00ed zalo\u017een\u00e9ho na melanokortinu.<\/p>\n<\/div>\n<p><!-- pep-seo-v1 --><\/p>","protected":false},"excerpt":{"rendered":"<p>\u2705 9-aminokyselinov\u00fd cyklick\u00fd neuropeptid<br \/>\n\u2705 Agonista OXTR receptoru<br \/>\n\u2705 V\u00fdzkum soci\u00e1ln\u00edho pouta a afilia\u010dn\u00edho chov\u00e1n\u00ed<br \/>\n\u2705 Intranas\u00e1ln\u011b biologicky dostupn\u00fd peptid<br \/>\n\u2705 Acet\u00e1tov\u00e1 forma \u2014 vy\u0161\u0161\u00ed stabilita<\/p>\n<p><strong>Oxytocin Acetate<\/strong> obsahuje syntetickou peptidovou slou\u010deninu.<\/p>","protected":false},"featured_media":70970,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[5426],"product_tag":[6274,5441],"class_list":{"0":"post-70705","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptides","7":"product_tag-oxytocin","8":"product_tag-peptide","10":"first","11":"instock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/70705","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=70705"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/70970"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=70705"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=70705"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=70705"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=70705"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}