{"id":70711,"date":"2026-05-12T09:38:54","date_gmt":"2026-05-12T09:38:54","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&p=70711"},"modified":"2026-05-21T07:14:10","modified_gmt":"2026-05-21T07:14:10","slug":"dsip","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/dsip\/","title":{"rendered":"DSIP"},"content":{"rendered":"

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Rychl\u00e1 odpov\u011b\u010f \u2014 Co je DSIP?<\/h3>\n

DSIP<\/strong> (Delta Sleep-Inducing Peptide) je neuropeptid slo\u017een\u00fd z 9 aminokyselin, poprv\u00e9 izolovan\u00fd z ven\u00f3zn\u00ed krve mozku kr\u00e1l\u00edk\u016f b\u011bhem elektrick\u00e9 stimulace thalamick\u00fdch oblast\u00ed podporuj\u00edc\u00edch sp\u00e1nek v roce 1977. Podle publikovan\u00fdch v\u00fdzkum\u016f moduluje architekturu sp\u00e1nku \u2014 konkr\u00e9tn\u011b pomal\u00fd (delta) sp\u00e1nek \u2014 spolu s prok\u00e1zan\u00fdmi \u00fa\u010dinky na stresovou reaktivitu, abstinen\u010dn\u00ed syndromy a nocicepci. Dod\u00e1v\u00e1 se v lyofilizovan\u00fdch vialk\u00e1ch o obsahu 5 mg a\u017e 15 mg v\u00fdhradn\u011b pro laboratorn\u00ed v\u00fdzkum.<\/p>\n<\/div>\n

Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdzkumn\u00e9 lyofilizovan\u00e9 peptidy \u00b7 HPLC \u010distota \u226599% (COA na vy\u017e\u00e1d\u00e1n\u00ed) \u00b7 Diskr\u00e9tn\u00ed teplotn\u011b stabiln\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 p\u0159eprava peptid\u016f \u00b7 1,400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Specifikace<\/th>\nDetail<\/th>\n<\/tr>\n<\/thead>\n
CAS \u010d\u00edslo<\/strong><\/td>\n62568-57-4<\/td>\n<\/tr>\n
item2<\/strong><\/td>\nC35<\/sub>H48<\/sub>N10<\/sub>O15<\/sub><\/td>\n<\/tr>\n
item7<\/strong><\/td>\n848.81 Da<\/td>\n<\/tr>\n
item9<\/strong><\/td>\nTrp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE, 9 aminokyselin; line\u00e1rn\u00ed, nemodifikovan\u00e9 konce)<\/td>\n<\/tr>\n
item11<\/strong><\/td>\nLyofilizovan\u00fd pr\u00e1\u0161ek (b\u00edl\u00fd a\u017e sv\u011btle \u017elut\u00fd)<\/td>\n<\/tr>\n
item13<\/strong><\/td>\n\u226599% (HPLC ov\u011b\u0159eno, COA na vy\u017e\u00e1d\u00e1n\u00ed)<\/td>\n<\/tr>\n
Skladov\u00e1n\u00ed<\/strong><\/td>\nLyofilizovan\u00e9: 2\u20138 \u00b0C (lednice) pro pracovn\u00ed z\u00e1sobu; \u221220 \u00b0C pro dlouhodob\u00e9 skladov\u00e1n\u00ed neotev\u0159en\u00fdch vialek. Rekonstituovan\u00e9: 2\u20138 \u00b0C, pou\u017eijte do ~30 dn\u016f. Chra\u0148te p\u0159ed sv\u011btlem. Nefreeze\u2013thaw rekonstituovan\u00fd roztok.<\/td>\n<\/tr>\n
Rozpustnost<\/strong><\/td>\nBakteriostatick\u00e1 voda (doporu\u010deno) nebo steriln\u00ed voda pro krat\u0161\u00ed dobu pou\u017eit\u00ed<\/td>\n<\/tr>\n
Pouze pro v\u00fdzkum<\/strong><\/td>\nPouze pro laboratorn\u00ed v\u00fdzkum. Nen\u00ed ur\u010deno pro diagnostick\u00e9 nebo terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/p>\n

Co je DSIP?<\/h2>\n

DSIP<\/strong> (Delta Sleep-Inducing Peptide) je line\u00e1rn\u00ed neuropeptid slo\u017een\u00fd z 9 aminokyselin, poprv\u00e9 izolovan\u00fd Schoenenbergerem a Monnierem na Univerzit\u011b v Basileji v roce 1977. Peptid byl identifikov\u00e1n dial\u00fdzou ven\u00f3zn\u00ed krve mozku kr\u00e1l\u00edk\u016f b\u011bhem elektrick\u00e9 stimulace intralamin\u00e1rn\u00edho thalamu \u2014 oblasti zn\u00e1m\u00e9 pro vyvol\u00e1v\u00e1n\u00ed delta-vln (pomal\u00fdch vln) v k\u016f\u0159e \u2014 a koncentrac\u00ed bioaktivn\u00ed frakce. DSIP byl pojmenov\u00e1n podle dominantn\u00edho elektroencefalografick\u00e9ho sign\u00e1lu, kter\u00fd vyvol\u00e1val p\u0159i pod\u00e1n\u00ed pokusn\u00fdm zv\u00ed\u0159at\u016fm: zv\u00fd\u0161en\u00fd pod\u00edl delta-vln b\u011bhem sp\u00e1nku.<\/p>\n

Dob\u0159e charakterizovan\u00e1 sekvence je WAGGDASGE, molekulov\u00e1 hmotnost 848,81 Da, empirick\u00fd vzorec C35<\/sub>H48<\/sub>N10<\/sub>O15<\/sub>. DSIP je strukturn\u011b neobvykl\u00fd mezi mal\u00fdmi peptidy aktivn\u00edmi v CNS \u2014 je line\u00e1rn\u00ed, nemodifikovan\u00fd na obou konc\u00edch a neobsahuje prolin ani cystein. Peptid je dod\u00e1v\u00e1n jako lyofilizovan\u00fd pr\u00e1\u0161ek vysok\u00e9 \u010distoty pro rekonstituci s bakteriostatickou vodou. DSIP nen\u00ed schv\u00e1len FDA, EMA, MHRA ani \u017e\u00e1dn\u00fdm jin\u00fdm v\u00fdznamn\u00fdm regul\u00e1torem pro terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed. V\u00fdzkumn\u00fd DSIP prod\u00e1van\u00fd zde je dod\u00e1v\u00e1n<\/strong> a nen\u00ed ur\u010den pro pod\u00e1v\u00e1n\u00ed lidem nebo zv\u00ed\u0159at\u016fm. Pro souvisej\u00edc\u00ed v\u00fdzkum peptid\u016f cirkadi\u00e1nn\u00edho rytmu a sp\u00e1nkov\u00e9 osy viz na\u0161e ur\u010den pouze pro laboratorn\u00ed v\u00fdzkum<\/strong> Mechanismus \u00fa\u010dinku \u2014 Architektura sp\u00e1nku, stresov\u00e1 reaktivita a neuroprotekce Epitalon<\/a> a Selank<\/a> produktov\u00e9 str\u00e1nky.<\/p>\n

Mechanismus \u00fa\u010dinku \u2014 sp\u00e1nkov\u00e1 architektura, reaktivita na stres a neuroprotekce<\/h2>\n

Co \u010din\u00ed DSIP neobvykl\u00fdm mezi v\u00fdzkumn\u00fdmi peptidy, je \u0161\u00ed\u0159e \u00fa\u010dink\u016f zdokumentovan\u00fdch pro tak mal\u00fd, line\u00e1rn\u00ed peptid bez jasn\u011b identifikovan\u00e9ho prim\u00e1rn\u00edho receptoru. Publikovan\u00fd v\u00fdzkum zmapoval jeho aktivitu nap\u0159\u00ed\u010d t\u0159i p\u0159ekr\u00fdvaj\u00edc\u00ed se dom\u00e9ny<\/strong>, z nich\u017e ka\u017ed\u00e1 p\u0159isp\u00edv\u00e1 k pozorovan\u00e9mu fenotypu:<\/p>\n