{"id":70723,"date":"2026-05-12T09:57:27","date_gmt":"2026-05-12T09:57:27","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&#038;p=70723"},"modified":"2026-05-21T07:14:10","modified_gmt":"2026-05-21T07:14:10","slug":"kisspeptin-10","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/kisspeptin-10\/","title":{"rendered":"Kisspeptin-10"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background: #fff8e1; border-left: 4px solid #f5a623; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<h3 style=\"margin: 0 0 8px 0; font-size: 16px; color: #1a4a6b;\">Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Kisspeptin-10?<\/h3>\n<p style=\"margin: 0;\"><strong>Kisspeptin-10<\/strong> (KP-10) je 10-aminokyselinov\u00fd peptid s C-termin\u00e1ln\u00ed amidac\u00ed a nejv\u00edce studovan\u00fd aktivn\u00ed fragment produktu genu KISS1. Je hlavn\u00edm endogenn\u00edm regul\u00e1torem aktivity neuron\u016f GnRH \u2014 publikovan\u00fd v\u00fdzkum jej stanovil jako spou\u0161t\u011b\u010d puberty a pulsn\u00edho uvol\u0148ov\u00e1n\u00ed gonadotropin\u016f. P\u016fsob\u00ed prost\u0159ednictv\u00edm receptoru GPR54 (KISS1R) v\u00e1zan\u00e9ho na G-protein. Dod\u00e1v\u00e1 se v lyofilizovan\u00fdch vialk\u00e1ch o obsahu 5 mg a 10 mg pouze pro laboratorn\u00ed v\u00fdzkum.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background: #f4f8fb; border: 1px solid #d8e3eb; padding: 12px 16px; margin: 16px 0; border-radius: 4px; font-size: 14px;\"><strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdzkumn\u00e9 lyofilizovan\u00e9 peptidy \u00b7 HPLC \u010distota \u226599% (COA na vy\u017e\u00e1d\u00e1n\u00ed) \u00b7 Diskr\u00e9tn\u00ed teplotn\u011b stabiln\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 p\u0159eprava peptid\u016f \u00b7 1,400+ ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size: 14px; color: #444; margin: 8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<table class=\"medsbase-spec-table\" style=\"width: 100%; border-collapse: collapse; margin: 18px 0; font-size: 14px;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 8px 12px; text-align: left; width: 30%;\">Specifikace<\/th>\n<th style=\"padding: 8px 12px; text-align: left;\">Detail<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>CAS \u010d\u00edslo<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">374675-21-5 (kisspeptin-10, lidsk\u00fd)<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>item2<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">C<sub>63<\/sub>H<sub>83<\/sub>N<sub>17<\/sub>O<sub>14<\/sub><\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>item7<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">1302.45 Da<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>item9<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH<sub>2<\/sub> (YNWNSFGLRF-NH<sub>2<\/sub>, 10 aminokyselin; C-termin\u00e1ln\u011b amidovan\u00fd aktivn\u00ed fragment 54-aminokyselinov\u00e9ho zral\u00e9ho kisspeptinu)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>item11<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Lyofilizovan\u00fd pr\u00e1\u0161ek (b\u00edl\u00fd a\u017e sv\u011btle \u017elut\u00fd)<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>item13<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u226599% (HPLC ov\u011b\u0159eno, COA na vy\u017e\u00e1d\u00e1n\u00ed)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Skladov\u00e1n\u00ed<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Lyofilizovan\u00e9: 2\u20138 \u00b0C (lednice) pro pracovn\u00ed z\u00e1sobu; \u221220 \u00b0C pro dlouhodob\u00e9 skladov\u00e1n\u00ed neotev\u0159en\u00fdch vialek. Rekonstituovan\u00e9: 2\u20138 \u00b0C, pou\u017eijte do ~30 dn\u016f. Chra\u0148te p\u0159ed sv\u011btlem. Nefreeze\u2013thaw rekonstituovan\u00fd roztok.<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Rozpustnost<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Bakteriostatick\u00e1 voda (doporu\u010deno) nebo steriln\u00ed voda pro krat\u0161\u00ed dobu pou\u017eit\u00ed<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Pouze pro v\u00fdzkum<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Pouze pro laboratorn\u00ed v\u00fdzkum. Nen\u00ed ur\u010deno pro diagnostick\u00e9 nebo terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><!-- \/medsbase-tldr-answer --><\/p>\n<h2>Co je Kisspeptin-10?<\/h2>\n<p><strong>Kisspeptin-10<\/strong> (KP-10) je 10-aminokyselinov\u00fd peptid a nejv\u00edce studovan\u00fd aktivn\u00ed fragment produktu genu KISS1, co\u017e je 145-aminokyselinov\u00fd preprokisspeptin, kter\u00fd je zpracov\u00e1n na 54-aminokyselinov\u00fd zral\u00fd kisspeptin a n\u011bkolik krat\u0161\u00edch C-termin\u00e1ln\u00edch aktivn\u00edch fragment\u016f (kisspeptin-14, kisspeptin-13, kisspeptin-10). V\u0161echny krat\u0161\u00ed fragmenty sd\u00edlej\u00ed C-termin\u00e1ln\u00ed 10-aminokyselinov\u00e9 aktivn\u00ed j\u00e1dro a maj\u00ed srovnatelnou \u00fa\u010dinnost na receptor kisspeptinu \u2014 kisspeptin-10 je nejkrat\u0161\u00ed pln\u011b aktivn\u00ed forma a zdaleka nej\u010dast\u011bji studovan\u00fd peptid v literatu\u0159e o kisspeptinu.<\/p>\n<p>Dob\u0159e charakterizovan\u00e1 sekvence je YNWNSFGLRF-NH<sub>2<\/sub>, molekulov\u00e1 hmotnost 1302,45 Da, empirick\u00fd vzorec C<sub>63<\/sub>H<sub>83<\/sub>N<sub>17<\/sub>O<sub>14<\/sub>. C-termin\u00e1ln\u00ed amidace je nezbytn\u00e1 pro plnou receptorovou aktivitu. KISS1 byl p\u016fvodn\u011b identifikov\u00e1n jako gen potla\u010duj\u00edc\u00ed metast\u00e1zy Leeem et al. (Cancer Res 1996) a byl p\u0159ejmenov\u00e1n na kisspeptin na po\u010dest Hershey v Pensylv\u00e1nii (domov \u010dokol\u00e1d Hershey\u2019s Kisses), kde byl gen poprv\u00e9 naklonov\u00e1n. Reproduk\u010dn\u00ed role \u2014 KISS1\/GPR54 jako vrcholov\u00fd regul\u00e1tor neuron\u016f GnRH a molekul\u00e1rn\u00ed str\u00e1\u017ece puberty \u2014 byla stanovena dv\u011bma nez\u00e1visl\u00fdmi studiemi v roce 2003 (Seminara et al., NEJM; de Roux et al., PNAS), kter\u00e9 prok\u00e1zaly, \u017ee ztr\u00e1tov\u00e9 mutace GPR54 zp\u016fsobuj\u00ed idiopatick\u00fd hypogonadotropn\u00ed hypogonadismus u lid\u00ed. Kisspeptin-10 je dod\u00e1v\u00e1n jako vysoce \u010dist\u00fd lyofilizovan\u00fd pr\u00e1\u0161ek pro rekonstituci s bakteriostatickou vodou. Nen\u00ed <strong>FDA, EMA, MHRA ani \u017e\u00e1dn\u00fdm jin\u00fdm v\u00fdznamn\u00fdm regul\u00e1torem pro terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed. V\u00fdzkumn\u00fd DSIP prod\u00e1van\u00fd zde je dod\u00e1v\u00e1n<\/strong> schv\u00e1len FDA, EMA, MHRA ani \u017e\u00e1dn\u00fdm jin\u00fdm v\u00fdznamn\u00fdm regul\u00e1torem pro terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed, a\u010dkoli prob\u00edhaj\u00edc\u00ed v\u00fdzkum IVF a neplodnosti zkoum\u00e1 klinick\u00e9 aplikace. V\u00fdzkumn\u00fd kisspeptin-10 prod\u00e1van\u00fd zde je dod\u00e1v\u00e1n <strong>ur\u010den pouze pro laboratorn\u00ed v\u00fdzkum<\/strong> a nen\u00ed ur\u010den pro lidsk\u00e9 ani veterin\u00e1rn\u00ed pod\u00e1v\u00e1n\u00ed.<\/p>\n<h2>Mechanismus \u00fa\u010dinku \u2014 signalizace GPR54 \/ KISS1R a osa HPG<\/h2>\n<p>Co \u010din\u00ed kisspeptin-10 mechanisticky v\u00fdjime\u010dn\u00fdm mezi reproduk\u010dn\u00edmi v\u00fdzkumn\u00fdmi peptidy, je jeho pozice jako <strong>vrcholov\u00e9ho upstream regul\u00e1toru<\/strong> cel\u00e9 osy hypothalamo-hypofyz\u00e1rn\u011b-gonad\u00e1ln\u00ed (HPG). Tento peptid p\u016fsob\u00ed na jedin\u00fd receptor \u2014 GPR54 (tak\u00e9 naz\u00fdvan\u00fd KISS1R) \u2014 ale n\u00e1sledn\u00e1 kask\u00e1da ovl\u00e1d\u00e1 cel\u00fd reproduk\u010dn\u00ed endokrinn\u00ed syst\u00e9m podle publikovan\u00fdch v\u00fdzkum\u016f:<\/p>\n<ul>\n<li><strong>Aktivace GPR54 (KISS1R) na neuronech GnRH<\/strong> \u2014 Kisspeptin-10 se v\u00e1\u017ee na GPR54, receptor t\u0159\u00eddy A sp\u0159a\u017een\u00fd s G-proteinem, kter\u00fd je hust\u011b exprimov\u00e1n na t\u011blech neuron\u016f GnRH v hypothalamick\u00fdch j\u00e1drech arcuatus a anteroventr\u00e1ln\u00edho periventrikul\u00e1rn\u00edho j\u00e1dra. Aktivace receptoru se sp\u0159ahuje s G\u03b1<sub>q\/11<\/sub> a fosfolip\u00e1zou C, zvy\u0161uje intracelul\u00e1rn\u00ed v\u00e1pn\u00edk a spou\u0161t\u00ed depolarizaci neuron\u016f GnRH a pulzn\u00ed uvol\u0148ov\u00e1n\u00ed GnRH do hypofyz\u00e1rn\u00edho port\u00e1ln\u00edho syst\u00e9mu. Toto je nejp\u0159\u00edm\u011bj\u0161\u00ed mechanismus \u2014 aktivita neuron\u016f GnRH je limituj\u00edc\u00edm krokem aktivity osy HPG a kisspeptin je hlavn\u00edm endogenn\u00edm stimulem.<\/li>\n<li><strong>Pulzn\u00ed vs. surge re\u017eim regulace osy HPG<\/strong> \u2014 Kisspeptinov\u00e9 neurony v j\u00e1d\u0159e arcuatus \u0159\u00edd\u00ed pulzn\u00ed vzorec GnRH\/LH, kter\u00fd udr\u017euje gonad\u00e1ln\u00ed funkci po celou dobu reproduk\u010dn\u00edho \u017eivota. Samostatn\u00e1 populace kisspeptinov\u00fdch neuron\u016f v anteroventr\u00e1ln\u00edm periventrikul\u00e1rn\u00edm j\u00e1d\u0159e (u hlodavc\u016f) generuje preovula\u010dn\u00ed LH surge u samic. V\u00fdzkum vyu\u017e\u00edvaj\u00edc\u00ed selektivn\u00ed stimulaci nebo knockout t\u011bchto populac\u00ed rozli\u0161il dva re\u017eimy v\u00fdstupu osy HPG v publikovan\u00fdch studi\u00edch.<\/li>\n<li><strong>Iniciace puberty a \u201ckisspeptinov\u00fd p\u0159ep\u00edna\u010d\u201d<\/strong> \u2014 Ztr\u00e1tov\u00e9 mutace GPR54 zp\u016fsobuj\u00ed \u00fapln\u00e9 selh\u00e1n\u00ed n\u00e1stupu puberty u lid\u00ed a zv\u00ed\u0159ec\u00edch model\u016f; ziskov\u00e9 mutace zp\u016fsobuj\u00ed centr\u00e1ln\u00ed p\u0159ed\u010dasnou pubertu. Hypot\u00e9za \u201ckisspeptinov\u00e9ho p\u0159ep\u00edna\u010de\u201d \u2014 \u017ee puberta je zah\u00e1jena, kdy\u017e kisspeptinov\u00e9 neurony v j\u00e1d\u0159e arcuatus dos\u00e1hnou kritick\u00e9 prahov\u00e9 aktivity \u2014 je dominantn\u00edm modelem n\u00e1stupu puberty v sou\u010dasn\u00e9m v\u00fdzkumu reproduk\u010dn\u00ed neurov\u011bdy.<\/li>\n<\/ul>\n<p>Kisspeptin-10 m\u00e1 relativn\u011b kr\u00e1tk\u00fd plazmatick\u00fd polo\u010das (~5\u201310 minut) kv\u016fli rychl\u00e9 proteolytick\u00e9 degradaci, zejm\u00e9na na centr\u00e1ln\u00edm RF amidov\u00e9m motivu matrixov\u00fdmi metaloprotein\u00e1zami. Subkut\u00e1nn\u00ed, intraven\u00f3zn\u00ed a intracerebroventrikul\u00e1rn\u00ed pod\u00e1n\u00ed jsou v\u0161echny dokumentov\u00e1ny v publikovan\u00fdch v\u00fdzkumech; centr\u00e1ln\u00ed pod\u00e1n\u00ed je vyhrazeno pro studie mechanismu \u00fa\u010dinku u hlodavc\u016f, kde je relevantn\u00ed ot\u00e1zka p\u0159ekon\u00e1n\u00ed hematoencefalick\u00e9 bari\u00e9ry. Pro syst\u00e9mov\u00fd v\u00fdzkum osy HPG produkuje perifern\u00ed pod\u00e1n\u00ed m\u011b\u0159iteln\u00e9 odpov\u011bdi GnRH\/LH b\u011bhem minut po bolusov\u00e9 injekci.<\/p>\n<h2>Publikovan\u00e9 v\u00fdzkumn\u00e9 aplikace<\/h2>\n<p>Kisspeptin-10 se pou\u017e\u00edv\u00e1 v laboratorn\u00edm v\u00fdzkumu, kter\u00fd zkoum\u00e1:<\/p>\n<ul>\n<li><strong>Reproduk\u010dn\u00ed endokrinologie a farmakologie HPG osy<\/strong> \u2014 pulzn\u00ed dynamika GnRH\/LH\/FSH, regulace gon\u00e1d\u00e1ln\u00ed zp\u011btn\u00e9 vazby, vliv pohlavn\u00edch steroid\u016f na aktivitu kisspeptinov\u00fdch neuron\u016f (Seminara et al., NEJM 2003; de Roux et al., PNAS 2003)<\/li>\n<li><strong>V\u00fdzkum puberty<\/strong> \u2014 na\u010dasov\u00e1n\u00ed n\u00e1stupu puberty u hlodavc\u016f, vzorce aktivace kisspeptinov\u00fdch neuron\u016f b\u011bhem pubert\u00e1ln\u00edho p\u0159echodu, mechanistick\u00e1 anal\u00fdza centr\u00e1ln\u00ed p\u0159ed\u010dasn\u00e9 puberty<\/li>\n<li><strong>V\u00fdzkum hypogonadotropn\u00edho hypogonadismu<\/strong> \u2014 preklinick\u00e9 modely ztr\u00e1ty funkce GPR54, protokoly n\u00e1hrady kisspeptinu, v\u00fdzkum mechanismu \u00fa\u010dinku nov\u00fdch terapi\u00ed hypogonadismu<\/li>\n<li><strong>V\u00fdzkum IVF a indukce ovulace<\/strong> \u2014 alternativy k hCG triggeru v IVF protokolech, srovn\u00e1vac\u00ed indukce LH vzestupu; klinick\u00fd v\u00fdzkum dos\u00e1hl f\u00e1ze 2 v n\u011bkter\u00fdch programech, a\u010dkoli samotn\u00fd kisspeptin-10 nen\u00ed schv\u00e1len<\/li>\n<li><strong>V\u00fdzkum syndromu polycystick\u00fdch ovari\u00ed (PCOS)<\/strong> \u2014 zm\u011bn\u011bn\u00e1 hladina kisspeptinu v preklinick\u00fdch modelech PCOS, abnormality frekvence LH pulz\u016f, v\u00fdzkum folikul\u00e1rn\u00edho zr\u00e1n\u00ed<\/li>\n<li><strong>Suprese metast\u00e1z a biologie rakoviny<\/strong> \u2014 KISS1 byl p\u016fvodn\u011b identifikov\u00e1n jako gen supresoru metast\u00e1z; publikovan\u00fd v\u00fdzkum st\u00e1le zkoum\u00e1 antimetastatickou aktivitu kisspeptinu v modelech rakoviny prsu, melanomu a pankreatu<\/li>\n<li><strong>Kardiovaskul\u00e1rn\u00ed a metabolick\u00fd v\u00fdzkum<\/strong> \u2014 objevuj\u00edc\u00ed se exprese KISS1R na kardiomyocytech a pankreatick\u00fdch \u03b2-bu\u0148k\u00e1ch; zkoumaj\u00ed se \u00fa\u010dinky na gluk\u00f3zovou homeost\u00e1zu a srde\u010dn\u00ed kontraktilitu<\/li>\n<li><strong>Srovn\u00e1vac\u00ed v\u00fdzkum reproduk\u010dn\u00edch peptid\u016f<\/strong> \u2014 benchmarkov\u00e1n\u00ed v\u016f\u010di <a href=\"https:\/\/medsbase.com\/cs\/pt-141\/\">PT-141 (Bremelanotid)<\/a> pro v\u00fdzkum sexu\u00e1ln\u00edho chov\u00e1n\u00ed na ose melanokortinu a proti <a href=\"https:\/\/medsbase.com\/cs\/oxytocin-acetate\/\">Oxytocin Acetate<\/a> pro afiliativn\u00ed a soci\u00e1ln\u011b-vazebn\u00e9 \u00fa\u010dely.<\/li>\n<\/ul>\n<p>Pro \u0161ir\u0161\u00ed kontext, kam kisspeptin-10 zapad\u00e1 v r\u00e1mci reproduk\u010dn\u00ed a CNS-aktivn\u00ed peptidov\u00e9 krajiny, viz <a href=\"https:\/\/medsbase.com\/cs\/pt-141\/\">PT-141<\/a> (agonist\u00e9 melanokortinu pro v\u00fdzkum sexu\u00e1ln\u00edho chov\u00e1n\u00ed), <a href=\"https:\/\/medsbase.com\/cs\/oxytocin-acetate\/\">Oxytocin Acetate<\/a> (afiliativn\u011b-behavior\u00e1ln\u00ed neuropeptid), a <a href=\"https:\/\/medsbase.com\/cs\/sermorelin\/\">Sermorelin<\/a> (v\u00fdzkum hypotalamo-hypofyz\u00e1rn\u00ed osy GHRH). Prohl\u00e9dn\u011bte si cel\u00fd <a href=\"https:\/\/medsbase.com\/cs\/peptides\/\">katalog v\u00fdzkumn\u00fdch peptid\u016f<\/a> pro p\u0159\u00edbuzn\u00e9 slou\u010deniny.<\/p>\n<h2>Dostupn\u00e9 s\u00edly a koncentrace<\/h2>\n<p>MedsBase nab\u00edz\u00ed Kisspeptin-10 ve dvou velikostech lyofilizovan\u00fdch vialek kalibrovan\u00fdch na typick\u00e9 d\u00e9lky v\u00fdzkumn\u00fdch protokol\u016f. Ka\u017ed\u00e1 s\u00edla je dostupn\u00e1 v balen\u00ed po 10 nebo 20 vialk\u00e1ch s \u00fapln\u00fdmi pokyny pro rekonstituci:<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">S\u00edla vialky<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Typick\u00fd v\u00fdzkumn\u00fd p\u0159\u00edpad u\u017eit\u00ed<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Velikosti balen\u00ed<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>5 mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Standardn\u00ed v\u00fdzkumn\u00e1 s\u00edla \u2013 pilotn\u00ed d\u00e1vkov\u00e1n\u00ed, pulzn\u00ed protokoly HPG osy, studie s jednou kohortou<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10 nebo 20 vialek<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>10 mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Protokoly s prodlou\u017een\u00fdm cyklem, studie s v\u00edce kohortami, nejni\u017e\u0161\u00ed cena za mg<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10 nebo 20 vialek<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Ob\u011b s\u00edly jsou stejn\u00e9 chemick\u00e9 formy (lyofilizovan\u00fd pr\u00e1\u0161ek, \u010distota 99 %+ HPLC). Vialky s vy\u0161\u0161\u00edm obsahem mg vy\u017eaduj\u00ed men\u0161\u00ed objemy rekonstituce na jednotku d\u00e1vky, co\u017e je u\u017eite\u010dn\u00e9, kdy\u017e cht\u011bj\u00ed v\u00fdzkumn\u00edci minimalizovat objem injekce v protokolech pro hlodavce. Proto\u017ee d\u00e1vkov\u00e9 rozmez\u00ed kisspeptinu-10 je v re\u017eimu n\u00edzk\u00fdch mikrogram\u016f na pod\u00e1n\u00ed, jedna vialka 5 mg podporuje mnoho t\u00fddn\u016f pulzn\u00edho v\u00fdzkumu p\u0159i typick\u00fdch d\u00e1vk\u00e1ch.<\/p>\n<h2>Srovn\u00e1n\u00ed \u2013 Kisspeptin-10 vs PT-141<\/h2>\n<p>Kisspeptin-10 a <a href=\"https:\/\/medsbase.com\/cs\/pt-141\/\">PT-141 (Bremelanotid)<\/a> jsou oba mal\u00e9 CNS-aktivn\u00ed peptidy pou\u017e\u00edvan\u00e9 ve v\u00fdzkumu reproduk\u010dn\u00edho a sexu\u00e1ln\u00edho chov\u00e1n\u00ed, ale p\u016fsob\u00ed na z\u00e1sadn\u011b odli\u0161n\u00fdch drah\u00e1ch. Kisspeptin-10 p\u016fsob\u00ed na endokrinn\u00ed HPG osu na \u00farovni neuron\u016f GnRH; PT-141 p\u016fsob\u00ed na melanokortinovou osu behavior\u00e1ln\u011b-sexu\u00e1ln\u00ed na \u00farovni MC4R. Tyto dva jsou mechanisticky komplement\u00e1rn\u00ed sp\u00ed\u0161e ne\u017e konkuren\u010dn\u00ed ve v\u00fdzkumn\u00fdch modelech.<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Krit\u00e9rium<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Kisspeptin-10<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">PT-141 (Bremelanotid)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>D\u00e9lka<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10 aminokyselin (dekapeptid)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">7 aminokyselin (cyklick\u00fd heptapeptid)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Prim\u00e1rn\u00ed receptor<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">GPR54 \/ KISS1R<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">MC3R \/ MC4R melanokortinov\u00e9 receptory<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Prim\u00e1rn\u00ed \u00fa\u010dinek<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Uvol\u0148ov\u00e1n\u00ed GnRH\/LH\/FSH (endokrinn\u00ed)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Sexu\u00e1ln\u00ed chov\u00e1n\u00ed zprost\u0159edkovan\u00e9 CNS (behavior\u00e1ln\u00ed)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Oblast v\u00fdzkumu<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Osa HPG, puberta, hypogonadismus, IVF<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Sexu\u00e1ln\u00ed touha, vzru\u0161en\u00ed, erektiln\u00ed funkce<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Polo\u010das v plazm\u011b<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">~5\u201310 min<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">~2 hodiny (SC)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Schv\u00e1len\u00e9 klinick\u00e9 pou\u017eit\u00ed<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">\u017d\u00e1dn\u00e9 (f\u00e1ze 2 ve v\u00fdzkumu IVF)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Schv\u00e1leno FDA jako Vyleesi pro HSDD (jin\u00e1 molekula ne\u017e v\u00fdzkumn\u00e1 kvalita)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Typick\u00e1 v\u00fdzkumn\u00e1 d\u00e1vka<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10\u2013200 mcg, bolus nebo pulz<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">0,25\u20132 mg, jednor\u00e1zov\u00e9 pod\u00e1n\u00ed<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Tyto dva peptidy p\u016fsob\u00ed na r\u016fzn\u00e9 \u00farovni reproduk\u010dn\u00ed biologie \u2014 kisspeptin-10 na endokrinn\u00ed osu HPG, PT-141 na behavior\u00e1ln\u00ed osu zprost\u0159edkovanou CNS \u2014 nejsou tedy p\u0159\u00edm\u00fdmi alternativami. V\u00fdzkum zam\u011b\u0159en\u00fd na pulzn\u00ed dynamiku GnRH\/LH, na\u010dasov\u00e1n\u00ed puberty nebo hypogonadismus vyu\u017e\u00edv\u00e1 kisspeptin-10. V\u00fdzkum zam\u011b\u0159en\u00fd na dr\u00e1hy sexu\u00e1ln\u00edho vzru\u0161en\u00ed zprost\u0159edkovan\u00e9 CNS vyu\u017e\u00edv\u00e1 PT-141.<\/p>\n<h2>Skladov\u00e1n\u00ed a rekonstituce<\/h2>\n<p><strong>P\u0159ed rekonstituci:<\/strong> lyofilizovan\u00e9 lahvi\u010dky skladujte v chladni\u010dce p\u0159i 2\u20138 \u00b0C v p\u016fvodn\u00edm obalu pro kr\u00e1tkodob\u00e9 pou\u017eit\u00ed. Pro dlouhodob\u00e9 skladov\u00e1n\u00ed neotev\u0159en\u00fdch lahvi\u010dek zmrazte p\u0159i \u221220 \u00b0C. Lyofilizovan\u00fd kisspeptin-10 je stabiln\u00ed v chladni\u010dce a\u017e 24 m\u011bs\u00edc\u016f a p\u0159i \u221220 \u00b0C a\u017e 36 m\u011bs\u00edc\u016f. Vyvarujte se cykl\u016f rozmrazov\u00e1n\u00ed a zmrazov\u00e1n\u00ed lyofilizovan\u00e9ho pr\u00e1\u0161ku.<\/p>\n<p><strong>Postup rekonstituce:<\/strong> injektujte bakteriostatickou vodu po bo\u010dn\u00ed st\u011bn\u011b lahvi\u010dky s peptidem (ne p\u0159\u00edmo na lyofilizovanou hmotu). Pro lahvi\u010dku 5 mg odpov\u00edd\u00e1 2,0 ml bakteriostatick\u00e9 vody pracovn\u00ed koncentraci 2,5 mg\/ml \u2014 0,04 ml dod\u00e1 v\u00fdzkumnou d\u00e1vku 100 mcg. Pro pr\u00e1ci s ni\u017e\u0161\u00edmi d\u00e1vkami lze pou\u017e\u00edt dal\u0161\u00ed \u0159ed\u011bn\u00ed do bakteriostatick\u00e9 vody (s voliteln\u00fdm nosn\u00fdm proteinem BSA v koncentraci 0,1%). Jemn\u011b zam\u00edchejte \u2014 ne <strong>ne<\/strong> net\u0159epejte \u2013 a nechte 2\u20135 minut pro \u00fapln\u00e9 rozpu\u0161t\u011bn\u00ed. Spr\u00e1vn\u011b rekonstituovan\u00fd roztok by m\u011bl b\u00fdt \u010dir\u00fd a bezbarv\u00fd.<\/p>\n<p><strong>Po rekonstituci:<\/strong> skladujte v chladni\u010dce p\u0159i 2\u20138 \u00b0C a pou\u017e\u00edvejte do 30 dn\u016f pro optim\u00e1ln\u00ed stabilitu. Nerozmrazujte rekonstituovan\u00fd roztok \u2014 cykly rozmrazov\u00e1n\u00ed a zmrazov\u00e1n\u00ed degraduj\u00ed integritu peptidu. Vyho\u010fte jakoukoli lahvi\u010dku projevuj\u00edc\u00ed z\u00e1kal, sra\u017eeniny nebo zm\u011bnu barvy. Kisspeptin-10 je n\u00e1chyln\u00fd k proteolytick\u00e9mu \u0161t\u011bpen\u00ed na C-termin\u00e1ln\u00edm RF-amidov\u00e9m motivu; rekonstituovan\u00fd roztok by m\u011bl b\u00fdt pou\u017eit v\u010das v r\u00e1mci 30denn\u00edho okna pro protokoly vy\u017eaduj\u00edc\u00ed p\u0159esnou kalibraci d\u00e1vkov\u00e9 odpov\u011bdi.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3>K \u010demu se pou\u017e\u00edv\u00e1 Kisspeptin-10 ve v\u00fdzkumu?<\/h3>\n<p>Kisspeptin-10 se pou\u017e\u00edv\u00e1 v laboratorn\u00edm v\u00fdzkumu zam\u011b\u0159en\u00e9m na hypotalamo-hypofyz\u00e1rno-gonad\u00e1ln\u00ed (HPG) osu, aktivitu neuron\u016f GnRH, pulzn\u00ed uvol\u0148ov\u00e1n\u00ed gonadotropin\u016f, n\u00e1stup puberty, hypogonadotropn\u00ed hypogonadismus, syndrom polycystick\u00fdch ovari\u00ed (PCOS), alternativy k hCG p\u0159i IVF a indukci ovulace, potla\u010den\u00ed metast\u00e1z rakoviny (KISS1 byl p\u016fvodn\u011b identifikov\u00e1n jako gen potla\u010duj\u00edc\u00ed metast\u00e1zy) a nov\u011b objeven\u00e9 kardio-metabolick\u00e9 signalizace kisspeptinu. Je to kanonick\u00fd v\u00fdzkumn\u00fd n\u00e1stroj pro farmakologii KISS1R \/ GPR54. V\u00fdzkumn\u00fd kisspeptin-10 prod\u00e1van\u00fd zde je <strong>ne<\/strong> schv\u00e1len\u00fd FDA a je dod\u00e1v\u00e1n v\u00fdhradn\u011b pro laboratorn\u00ed v\u00fdzkumn\u00e9 \u00fa\u010dely.<\/p>\n<h3>Jak se li\u0161\u00ed Kisspeptin-10 od PT-141?<\/h3>\n<p>Oba jsou mal\u00e9 CNS-aktivn\u00ed reproduk\u010dn\u00ed peptidy, ale c\u00edl\u00ed na r\u016fzn\u00e9 receptory a biologick\u00e9 \u00farovn\u011b. Kisspeptin-10 p\u016fsob\u00ed na receptor GPR54\/KISS1R na neuronech GnRH a ovliv\u0148uje endokrinn\u00ed osu HPG (LH, FSH, produkci gon\u00e1d\u00e1ln\u00edch steroid\u016f). PT-141 p\u016fsob\u00ed na melanokortinov\u00e9 receptory MC3R\/MC4R v CNS a ovliv\u0148uje behavior\u00e1ln\u011b-sexu\u00e1ln\u00ed reakce (touha, vzru\u0161en\u00ed, erektiln\u00ed funkce). Tyto dva peptidy jsou mechanisticky komplement\u00e1rn\u00ed a \u0159e\u0161\u00ed r\u016fzn\u00e9 v\u00fdzkumn\u00e9 ot\u00e1zky.<\/p>\n<h3>Jak\u00fd je rozd\u00edl mezi Kisspeptin-10 a Kisspeptin-54?<\/h3>\n<p>Oba jsou aktivn\u00ed fragmenty produktu genu KISS1. Kisspeptin-54 (tak\u00e9 zvan\u00fd metastin) je pln\u011b zral\u00fd 54-aminokyselinov\u00fd peptid secernovan\u00fd in vivo. Kisspeptin-10 je C-termin\u00e1ln\u00ed 10-aminokyselinov\u00e9 aktivn\u00ed j\u00e1dro, kter\u00e9 si zachov\u00e1v\u00e1 prakticky plnou receptorovou \u00fa\u010dinnost a je nej\u010dast\u011bji pou\u017e\u00edvan\u00fdm v\u00fdzkumn\u00fdm peptidem, proto\u017ee jeho men\u0161\u00ed velikost zlev\u0148uje synt\u00e9zu, usnad\u0148uje ov\u011b\u0159en\u00ed \u010distoty a zjednodu\u0161uje rekonstituci. Kisspeptin-13 a kisspeptin-14 jsou intermedi\u00e1ln\u00ed \u0161t\u011bpn\u00e9 produkty, kter\u00e9 tak\u00e9 sd\u00edlej\u00ed aktivn\u00ed C-termin\u00e1ln\u00ed j\u00e1dro. V\u0161echny \u010dty\u0159i maj\u00ed srovnatelnou \u00fa\u010dinnost na GPR54.<\/p>\n<h3>Jak\u00e1 je typick\u00e1 v\u00fdzkumn\u00e1 d\u00e1vka Kisspeptin-10?<\/h3>\n<p>Publikovan\u00e9 preklinick\u00e9 protokoly obvykle pou\u017e\u00edvaj\u00ed 10\u2013200 mcg na d\u00e1vku u hlodavc\u016f, pod\u00e1van\u00fdch subkut\u00e1nn\u011b nebo intraven\u00f3zn\u011b pro v\u00fdzkum bolusov\u00fdch pulz\u016f, nebo jako kontinu\u00e1ln\u00ed infuzi pro studie chronick\u00e9 stimulace. V\u00fdzkum lidsk\u00e9ho IVF pou\u017eil 6,4\u201312,8 \u03bcg\/kg jako jednu subkut\u00e1nn\u00ed spou\u0161t\u011bc\u00ed d\u00e1vku. 5 mg lahvi\u010dka rekonstituovan\u00e1 s 2,0 ml bakteriostatick\u00e9 vody poskytuje 2,5 mg\/ml \u2014 0,04 ml odpov\u00edd\u00e1 100 mcg.<\/p>\n<h3>Je Kisspeptin-10 schv\u00e1len FDA?<\/h3>\n<p>Ne. Kisspeptin-10 nen\u00ed schv\u00e1len FDA, EMA, MHRA ani \u017e\u00e1dn\u00fdm jin\u00fdm v\u00fdznamn\u00fdm regul\u00e1torem pro terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed. F\u00e1ze 2 klinick\u00e9ho v\u00fdzkumu v indukci ovulace IVF prob\u00edh\u00e1, ale kisspeptin-10 nebyl schv\u00e1len pro \u017e\u00e1dn\u00e9 klinick\u00e9 indikace. Ve\u0161ker\u00fd kisspeptin-10 prod\u00e1van\u00fd dodavateli pouze pro v\u00fdzkumn\u00e9 \u00fa\u010dely je ur\u010den pro laboratorn\u00ed v\u00fdzkum a nem\u011bl by b\u00fdt pod\u00e1v\u00e1n lidem.<\/p>\n<h3>Jak by m\u011bl b\u00fdt Kisspeptin-10 skladov\u00e1n?<\/h3>\n<p>Lyofilizovan\u00e9 lahvi\u010dky: chlazen\u00e9 p\u0159i 2\u20138 \u00b0C pro kr\u00e1tkodob\u00e9 pracovn\u00ed z\u00e1soby, nebo \u221220 \u00b0C pro dlouhodob\u00e9 skladov\u00e1n\u00ed neotev\u0159en\u00fdch lahvi\u010dek. Rekonstituovan\u00fd roztok: chlazen\u00fd p\u0159i 2\u20138 \u00b0C, pou\u017e\u00edvejte do 30 dn\u016f. Nefreezujte rekonstituovan\u00fd roztok \u2014 cykly zmrazen\u00ed a rozmrazen\u00ed degraduj\u00ed peptid. V\u017edy chra\u0148te p\u0159ed p\u0159\u00edm\u00fdm sv\u011btlem. Pro pracovn\u00ed \u0159ed\u011bn\u00ed s n\u00edzkou koncentrac\u00ed se doporu\u010duje nosn\u00fd protein BSA (0,1%), aby se minimalizovaly ztr\u00e1ty adsorpc\u00ed.<\/p>\n<h3>Jak rekonstituovat Kisspeptin-10?<\/h3>\n<p>Postupujte podle v\u00fd\u0161e uveden\u00e9ho rekonstitu\u010dn\u00edho postupu. P\u0159idejte bakteriostatickou vodu po st\u011bn\u011b lahvi\u010dky (ne p\u0159\u00edmo na lyofilizovan\u00fd pr\u00e1\u0161ek), jemn\u011b prot\u0159epejte a nechte 2\u20135 minut pro \u00fapln\u00e9 rozpu\u0161t\u011bn\u00ed. Ne <strong>ne<\/strong> Prot\u0159epejte lahvi\u010dku. Spr\u00e1vn\u011b rekonstituovan\u00fd roztok je \u010dir\u00fd a bezbarv\u00fd. Pro lahvi\u010dku 5 mg + 2,0 mL rozpou\u0161t\u011bdla je pracovn\u00ed koncentrace 2,5 mg\/mL.<\/p>\n<h3>Jak\u00e9 s\u00edly nab\u00edz\u00ed MedsBase?<\/h3>\n<p>MedsBase nab\u00edz\u00ed Kisspeptin-10 v lyofilizovan\u00fdch lahvi\u010dk\u00e1ch 5 mg a 10 mg. Ka\u017ed\u00e9 balen\u00ed je dostupn\u00e9 ve velikostech 10 nebo 20 lahvi\u010dek. V\u0161echny lahvi\u010dky jsou dod\u00e1v\u00e1ny s \u010distotou 99%+ HPLC a certifik\u00e1tem anal\u00fdzy na vy\u017e\u00e1d\u00e1n\u00ed.<\/p>\n<h3>Pro\u010d byl KISS1 p\u016fvodn\u011b pojmenov\u00e1n kisspeptin?<\/h3>\n<p>Gen KISS1 byl objeven jako supresor metast\u00e1z Lee et al. v Hershey, Pensylv\u00e1nie (Cancer Res 1996). N\u00e1zev \u201ckisspeptin\u201d byl \u017eertovnou nar\u00e1\u017ekou na Hershey\u2019s Kisses, ikonickou \u010dokol\u00e1du vyr\u00e1b\u011bnou ve stejn\u00e9m m\u011bst\u011b. Reproduk\u010dn\u00ed role byla charakterizov\u00e1na a\u017e v roce 2003 sou\u010dasnou publikac\u00ed studi\u00ed o hypogonadismu zp\u016fsoben\u00e9m mutac\u00ed GPR54 u lid\u00ed v NEJM (Seminara et al.) a PNAS (de Roux et al.). Peptid m\u00e1 tedy neobvykl\u00e9 postaven\u00ed, kdy byl nez\u00e1visle charakterizov\u00e1n jak jako supresor metast\u00e1z rakoviny, tak jako vrcholov\u00fd regul\u00e1tor puberty \u2014 dv\u011b role, kter\u00e9 z\u016fst\u00e1vaj\u00ed mechanisticky ne zcela propojeny.<\/p>\n<h3>Zp\u016fsobuje Kisspeptin-10 vedlej\u0161\u00ed \u00fa\u010dinky ve v\u00fdzkumu?<\/h3>\n<p>Publikovan\u00fd preklinick\u00fd a klinick\u00fd v\u00fdzkum f\u00e1ze 1\/2 dokumentuje dobrou sn\u00e1\u0161enlivost p\u0159i typick\u00fdch v\u00fdzkumn\u00fdch d\u00e1vk\u00e1ch. Hlavn\u00ed c\u00edlen\u00e9 \u00fa\u010dinky jsou aktivace HPG osy \u2014 vzestup LH, FSH, testosteronu (u mu\u017e\u016f) nebo estradiolu (u \u017een) a n\u00e1sledn\u00e9 \u00fa\u010dinky gon\u00e1d\u00e1ln\u00edch steroid\u016f. Nec\u00edlen\u00e9 \u00fa\u010dinky zahrnuj\u00ed m\u00edrn\u00e9 kardiovaskul\u00e1rn\u00ed \u00fa\u010dinky zprost\u0159edkovan\u00e9 expres\u00ed KISS1R na c\u00e9vn\u00ed tk\u00e1ni a \u00fa\u010dinek zarudnut\u00ed\/vasodilatace pozorovan\u00fd u n\u011bkter\u00fdch lidsk\u00fdch v\u00fdzkum\u016f p\u0159i vy\u0161\u0161\u00edch d\u00e1vk\u00e1ch. \u00dadaje o dlouhodob\u00e9 bezpe\u010dnosti mimo v\u00fdzkumn\u00e9 kontexty jsou omezen\u00e9.<\/p>\n<h3>Jak\u00fd je polo\u010das rozpadu Kisspeptinu-10?<\/h3>\n<p>V preklinick\u00e9m a klinick\u00e9m v\u00fdzkumu m\u00e1 kisspeptin-10 plazmatick\u00fd polo\u010das rozpadu p\u0159ibli\u017en\u011b 5\u201310 minut po intraven\u00f3zn\u00edm nebo subkut\u00e1nn\u00edm pod\u00e1n\u00ed. Kr\u00e1tk\u00fd polo\u010das je zp\u016fsoben rychlou proteolytickou \u0161t\u011bpenou matrix metaloprotein\u00e1zami na centr\u00e1ln\u00edm RF-amidov\u00e9m motivu. Pro v\u00fdzkum chronick\u00e9 stimulace se pou\u017e\u00edvaj\u00ed kontinu\u00e1ln\u00ed infuze nebo opakovan\u00e9 pulzn\u00ed d\u00e1vkovac\u00ed protokoly k udr\u017een\u00ed obsazen\u00ed receptor\u016f.<\/p>\n<h3>Jak dlouho trv\u00e1, ne\u017e se \u00fa\u010dinky Kisspeptinu-10 projev\u00ed v preklinick\u00e9m v\u00fdzkumu?<\/h3>\n<p>Akutn\u00ed odpov\u011bdi LH na bolusov\u00e9 pod\u00e1n\u00ed kisspeptinu-10 jsou detekovateln\u00e9 b\u011bhem 5\u201315 minut ve v\u00fdzkumu na hlodavc\u00edch a lidech. Odpov\u011bdi FSH a n\u00e1sledn\u00e9 gon\u00e1d\u00e1ln\u00ed steroidn\u00ed \u00fa\u010dinky se vyv\u00edjej\u00ed v pr\u016fb\u011bhu hodin a\u017e dn\u016f. Chronick\u00e9 stimula\u010dn\u00ed \u00fa\u010dinky na na\u010dasov\u00e1n\u00ed puberty u mlad\u00fdch hlodavc\u016f se projevuj\u00ed b\u011bhem p\u0159irozen\u00e9ho pubert\u00e1ln\u00edho obdob\u00ed \u2014 dny a\u017e t\u00fddny v z\u00e1vislosti na druhu a v\u00fdvojov\u00e9m st\u00e1diu p\u0159i intervenci.<\/p>\n<h3>Mohu si objednat Kisspeptin-10 pro mezin\u00e1rodn\u00ed dopravu?<\/h3>\n<p>Ano. MedsBase expeduje Kisspeptin-10 do cel\u00e9ho sv\u011bta prost\u0159ednictv\u00edm na\u0161\u00ed specializovan\u00e9 s\u00edt\u011b pro dopravu peptid\u016f. Objedn\u00e1vky obsahuj\u00edc\u00ed pouze peptidy se kvalifikuj\u00ed pro na\u0161i samostatnou slu\u017ebu dopravy peptid\u016f. V\u0161echny objedn\u00e1vky jsou odes\u00edl\u00e1ny v termoregulovan\u00e9m balen\u00ed s kompletn\u00edm sledov\u00e1n\u00edm a jsou kryty na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a>.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Dal\u0161\u00ed peptidy pro v\u00fdzkum reprodukce, CNS a chov\u00e1n\u00ed<\/h2>\n<ul>\n<li><a href=\"\/cs\/pt-141\/\"><strong>PT-141 (Bremelanotid)<\/strong><\/a> \u2014 Cyklick\u00fd heptapeptidov\u00fd agonista melanokortinu \u2014 v\u00fdzkum sexu\u00e1ln\u00edho chov\u00e1n\u00ed zprost\u0159edkovan\u00e9ho CNS<\/li>\n<li><a href=\"\/cs\/oxytocin-acetate\/\"><strong>Oxytocin Acetate<\/strong><\/a> \u2014 9-aa cyklick\u00fd neuropeptid \u2014 v\u00fdzkum soci\u00e1ln\u00edho p\u0159ilnut\u00ed a afiliativn\u00edho chov\u00e1n\u00ed<\/li>\n<li><a href=\"\/cs\/sermorelin\/\"><strong>Sermorelin<\/strong><\/a> \u2014 Analog GHRH(1-29) \u2014 v\u00fdzkum hypothalamo-hypofyz\u00e1rn\u00ed osy<\/li>\n<li><a href=\"\/cs\/cjc-1295-with-dac\/\"><strong>CJC-1295 with DAC<\/strong><\/a> \u2014 Dlouhodob\u011b p\u016fsob\u00edc\u00ed analog GHRH \u2014 v\u00fdzkum r\u016fstov\u00e9 osy<\/li>\n<li><a href=\"\/cs\/selank\/\"><strong>Selank<\/strong><\/a> \u2014 Anxiolytick\u00fd heptapeptid \u2014 v\u00fdzkum odolnosti v\u016f\u010di stresu GABA\/BDNF<\/li>\n<\/ul>\n<p><!-- medsbase-peptide-guide-cta --><\/p>\n<h2>Dal\u0161\u00ed \u010dten\u00ed<\/h2>\n<div style=\"background: #f4f8fb; border-left: 4px solid #2c7cb0; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<p style=\"margin: 0 0 8px 0;\"><strong>\ud83d\udcd6 Prozkoumejte peptidy pro v\u00fdzkum reprodukce a CNS<\/strong><\/p>\n<p style=\"margin: 0;\">Prohl\u00e9dn\u011bte si celou <a href=\"https:\/\/medsbase.com\/cs\/peptides\/\"><strong>katalog v\u00fdzkumn\u00fdch peptid\u016f<\/strong><\/a>, v\u010detn\u011b p\u0159\u00edbuzn\u00fdch slou\u010denin jako <a href=\"https:\/\/medsbase.com\/cs\/pt-141\/\">PT-141 (Bremelanotid)<\/a> pro v\u00fdzkum sexu\u00e1ln\u00edho chov\u00e1n\u00ed melanokortinu, <a href=\"https:\/\/medsbase.com\/cs\/oxytocin-acetate\/\">Oxytocin Acetate<\/a> pro v\u00fdzkum afiliativn\u00edho chov\u00e1n\u00ed a <a href=\"https:\/\/medsbase.com\/cs\/sermorelin\/\">Sermorelin<\/a> pro v\u00fdzkum hypotalamo-hypofyz\u00e1rn\u00ed osy.<\/p>\n<\/div>\n<p><!-- pep-seo-v1 --><\/p>","protected":false},"excerpt":{"rendered":"<p>\u2705 Hlavn\u00ed regul\u00e1tor aktivity neuron\u016f GnRH<br \/>\n\u2705 Agonista receptoru KISS1R \/ GPR54<br \/>\n\u2705 V\u00fdzkumn\u00e1 l\u00e1tka pro osu HPG a pubertu<br \/>\n\u2705 V\u00fdzkum IVF a indukce ovulace<br \/>\n\u2705 P\u016fvodn\u011b identifikov\u00e1n jako supresor metast\u00e1z<\/p>\n<p><strong>Kisspeptin-10<\/strong> obsahuje syntetickou peptidovou slou\u010deninu.<\/p>","protected":false},"featured_media":70963,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[5426],"product_tag":[6277,5441],"class_list":{"0":"post-70723","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptides","7":"product_tag-kisspeptin","8":"product_tag-peptide","10":"first","11":"instock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/70723","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=70723"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/70963"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=70723"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=70723"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=70723"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=70723"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}