{"id":70733,"date":"2026-05-12T10:13:05","date_gmt":"2026-05-12T10:13:05","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&p=70733"},"modified":"2026-05-21T07:14:10","modified_gmt":"2026-05-21T07:14:10","slug":"ghrp-6","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/ghrp-6\/","title":{"rendered":"GHRP-6 Acet\u00e1t"},"content":{"rendered":"

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Rychl\u00e1 odpov\u011b\u010f \u2014 Co je GHRP-6 Acetate?<\/h3>\n

GHRP-6 Acet\u00e1t<\/strong> (Growth Hormone Releasing Peptide 6) je syntetick\u00fd hexapeptid s 6 aminokyselinami a jeden z p\u016fvodn\u00edch sekretagog\u016f r\u016fstov\u00e9ho hormonu, vyvinut\u00fd Bowersem a kolegy jako \u010dlen druh\u00e9 generace \u0159ady GHRP. P\u016fsob\u00ed na receptor sekretagogu r\u016fstov\u00e9ho hormonu (GHS-R1a) \u2014 stejn\u00fd receptor jako endogenn\u00ed ghrelin \u2014 a zp\u016fsobuje pulzn\u00ed uvol\u0148ov\u00e1n\u00ed r\u016fstov\u00e9ho hormonu spolu se stimulac\u00ed chuti k j\u00eddlu. Dod\u00e1v\u00e1 se v lyofilizovan\u00fdch vialk\u00e1ch o obsahu 5 mg a 10 mg pouze pro laboratorn\u00ed v\u00fdzkum.<\/p>\n<\/div>\n

Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdzkumn\u00e9 lyofilizovan\u00e9 peptidy \u00b7 HPLC \u010distota \u226599% (COA na vy\u017e\u00e1d\u00e1n\u00ed) \u00b7 Diskr\u00e9tn\u00ed teplotn\u011b stabiln\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 p\u0159eprava peptid\u016f \u00b7 1,400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Specifikace<\/th>\nDetail<\/th>\n<\/tr>\n<\/thead>\n
CAS \u010d\u00edslo<\/strong><\/td>\n87616-84-0 (GHRP-6 voln\u00e1 b\u00e1ze); dod\u00e1v\u00e1 se ve form\u011b acet\u00e1tov\u00e9 soli<\/td>\n<\/tr>\n
item2<\/strong><\/td>\nC46<\/sub>H56<\/sub>N12<\/sub>O6<\/sub> (voln\u00e1 b\u00e1ze; acet\u00e1tov\u00e1 s\u016fl p\u0159id\u00e1v\u00e1 CH3<\/sub>COOH protion)<\/td>\n<\/tr>\n
item7<\/strong><\/td>\n873,02 Da (voln\u00e1 b\u00e1ze)<\/td>\n<\/tr>\n
item9<\/strong><\/td>\nHis-D-Trp-Ala-Trp-D-Phe-Lys-NH2<\/sub> (HwAWfK-NH2<\/sub>, 6 aminokyselin; obsahuje D-Trp na pozici 2 a D-Phe na pozici 5 pro proteolytickou stabilitu; C-koncov\u011b amidovan\u00fd)<\/td>\n<\/tr>\n
item11<\/strong><\/td>\nLyofilizovan\u00e1 octanov\u00e1 s\u016fl (b\u00edl\u00fd a\u017e sv\u011btle \u017elut\u00fd pr\u00e1\u0161ek)<\/td>\n<\/tr>\n
item13<\/strong><\/td>\n\u226599% (HPLC ov\u011b\u0159eno, COA na vy\u017e\u00e1d\u00e1n\u00ed)<\/td>\n<\/tr>\n
Skladov\u00e1n\u00ed<\/strong><\/td>\nLyofilizovan\u00e9: 2\u20138 \u00b0C (lednice) pro pracovn\u00ed z\u00e1sobu; \u221220 \u00b0C pro dlouhodob\u00e9 skladov\u00e1n\u00ed neotev\u0159en\u00fdch vialek. Rekonstituovan\u00e9: 2\u20138 \u00b0C, pou\u017eijte do ~30 dn\u016f. Chra\u0148te p\u0159ed sv\u011btlem. Nefreeze\u2013thaw rekonstituovan\u00fd roztok.<\/td>\n<\/tr>\n
Rozpustnost<\/strong><\/td>\nBakteriostatick\u00e1 voda (doporu\u010deno) nebo steriln\u00ed voda pro krat\u0161\u00ed dobu pou\u017eit\u00ed<\/td>\n<\/tr>\n
Pouze pro v\u00fdzkum<\/strong><\/td>\nPouze pro laboratorn\u00ed v\u00fdzkum. Nen\u00ed ur\u010deno pro diagnostick\u00e9 nebo terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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Co je GHRP-6 Acet\u00e1t?<\/h2>\n

GHRP-6<\/strong> (Growth Hormone Releasing Peptide 6) je syntetick\u00fd hexapeptid slo\u017een\u00fd z 6 aminokyselin a jeden z kanonick\u00fdch z\u00e1stupc\u016f t\u0159\u00eddy peptid\u016f uvol\u0148uj\u00edc\u00edch r\u016fstov\u00fd hormon (GHS). Byl vyvinut Cyril Y. Bowers a kolegy na Tulane University jako sou\u010d\u00e1st programu studuj\u00edc\u00edho vztah mezi strukturou a aktivitou, jeho\u017e c\u00edlem bylo identifikovat mal\u00e9 peptidy schopn\u00e9 stimulovat pulzn\u00ed uvol\u0148ov\u00e1n\u00ed r\u016fstov\u00e9ho hormonu z p\u0159edn\u00edho laloku hypof\u00fdzy. Tato pr\u00e1ce nakonec vedla k objevu receptoru pro sekretagogy r\u016fstov\u00e9ho hormonu a nep\u0159\u00edmo k identifikaci endogenn\u00edho ghrelinu jako jeho p\u0159irozen\u00e9ho ligandu v roce 1999 Kojimou a spol. (Nature). Acet\u00e1tov\u00fd protion se pou\u017e\u00edv\u00e1 p\u0159i lyofilizaci v\u00fdzkumn\u00fdch vzork\u016f, proto\u017ee zlep\u0161uje dlouhodobou stabilitu peptidu a jeho rozpustnost ve vod\u011b, ani\u017e by m\u011bnil jeho farmakologick\u00e9 vlastnosti.<\/p>\n

Dob\u0159e charakterizovan\u00e1 sekvence je HwAWfK-NH2<\/sub> (kde mal\u00e1 p\u00edsmena ozna\u010duj\u00ed D-aminokyselinov\u00e9 zbytky), molekulov\u00e1 hmotnost 873,02 Da, empirick\u00fd vzorec C46<\/sub>H56<\/sub>N12<\/sub>O6<\/sub>. Dv\u011b substituce D-aminokyselinami (D-Trp na pozici 2 a D-Phe na pozici 5) zaji\u0161\u0165uj\u00ed odolnost v\u016f\u010di endogenn\u00edm prote\u00e1z\u00e1m a prodlu\u017euj\u00ed polo\u010das in vivo ve srovn\u00e1n\u00ed s analogy obsahuj\u00edc\u00edmi pouze L-aminokyseliny. C-konec je amidov\u00e1n, co\u017e je nezbytn\u00e9 pro receptorovou aktivitu. GHRP-6 nen\u00ed FDA, EMA, MHRA ani \u017e\u00e1dn\u00fdm jin\u00fdm v\u00fdznamn\u00fdm regul\u00e1torem pro terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed. V\u00fdzkumn\u00fd DSIP prod\u00e1van\u00fd zde je dod\u00e1v\u00e1n<\/strong> FDA, EMA, MHRA ani \u017e\u00e1dn\u00fdm jin\u00fdm v\u00fdznamn\u00fdm regul\u00e1torem schv\u00e1len pro terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed. V\u00fdzkumn\u00fd GHRP-6 acet\u00e1t prod\u00e1van\u00fd zde je dod\u00e1v\u00e1n ur\u010den pouze pro laboratorn\u00ed v\u00fdzkum<\/strong> a nen\u00ed ur\u010den k pod\u00e1v\u00e1n\u00ed lidem nebo zv\u00ed\u0159at\u016fm. Pro nov\u011bj\u0161\u00ed generaci receptorov\u011b selektivn\u00edho analogu bez signalizace kortizolu\/prolaktinu viz n\u00e1\u0161 Ipamorelin<\/a> produktovou str\u00e1nku.<\/p>\n

Mechanismus \u00fa\u010dinku \u2014 agonismus receptoru GHS-R1a a pulz GH<\/h2>\n

Co \u010din\u00ed GHRP-6 mechanisticky v\u00fdjime\u010dn\u00fdm mezi v\u00fdzkumn\u00fdmi peptidy r\u016fstov\u00e9 osy, je jeho selektivn\u00ed p\u016fsoben\u00ed na receptor pro sekretagogy r\u016fstov\u00e9ho hormonu<\/strong> \u2014 stejn\u00fd receptor, kter\u00fd je aktivov\u00e1n endogenn\u00edm ghrelinem \u2014 na rozd\u00edl od receptoru GHRH vyu\u017e\u00edvan\u00e9ho sermorelinem a CJC-1295. Podle publikovan\u00fdch v\u00fdzkum\u016f je v\u00fdsledn\u00fdm efektem pulzn\u00ed sp\u00ed\u0161e ne\u017e tonick\u00fd vzorec uvol\u0148ov\u00e1n\u00ed GH:<\/p>\n