{"id":70740,"date":"2026-05-12T10:25:30","date_gmt":"2026-05-12T10:25:30","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&p=70740"},"modified":"2026-05-21T07:14:10","modified_gmt":"2026-05-21T07:14:10","slug":"ghrp-2","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/ghrp-2\/","title":{"rendered":"GHRP-2 Acetate"},"content":{"rendered":"

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Rychl\u00e1 odpov\u011b\u010f \u2014 Co je GHRP-2 Acet\u00e1t?<\/h3>\n

GHRP-2 Acetate<\/strong> (tak\u00e9 naz\u00fdvan\u00fd Pralmorelin nebo KP-102) je syntetick\u00fd hexapeptidov\u00fd sekretagog r\u016fstov\u00e9ho hormonu s 6 aminokyselinami a nej\u00fa\u010dinn\u011bj\u0161\u00ed z\u00e1stupce prvn\u00ed generace \u0159ady GHRP na z\u00e1klad\u011b \u00fa\u010dinku na mg. P\u016fsob\u00ed na receptor sekretagogu r\u016fstov\u00e9ho hormonu (GHS-R1a) \u2014 stejn\u00fd receptor jako endogenn\u00ed ghrelin a GHRP-6<\/a> \u2014 vyvol\u00e1v\u00e1 pulzn\u00ed uvol\u0148ov\u00e1n\u00ed r\u016fstov\u00e9ho hormonu s men\u0161\u00edm sign\u00e1lem zv\u00fd\u0161en\u00ed chuti k j\u00eddlu ne\u017e GHRP-6, ale s podobn\u00fdm profilem kortizolu\/prolaktinu. Dod\u00e1v\u00e1 se v lyofilizovan\u00fdch vialk\u00e1ch o obsahu 5 mg a 10 mg pouze pro laboratorn\u00ed v\u00fdzkum.<\/p>\n<\/div>\n

Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdzkumn\u00e9 lyofilizovan\u00e9 peptidy \u00b7 HPLC \u010distota \u226599% (COA na vy\u017e\u00e1d\u00e1n\u00ed) \u00b7 Diskr\u00e9tn\u00ed teplotn\u011b stabiln\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 p\u0159eprava peptid\u016f \u00b7 1,400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Specifikace<\/th>\nDetail<\/th>\n<\/tr>\n<\/thead>\n
CAS \u010d\u00edslo<\/strong><\/td>\n158861-67-7 (voln\u00e1 b\u00e1ze GHRP-2); dod\u00e1v\u00e1 se ve form\u011b acet\u00e1tov\u00e9 soli<\/td>\n<\/tr>\n
item2<\/strong><\/td>\nC45<\/sub>H55<\/sub>N9<\/sub>O6<\/sub> (voln\u00e1 b\u00e1ze; acet\u00e1tov\u00e1 s\u016fl p\u0159id\u00e1v\u00e1 CH3<\/sub>COOH protion)<\/td>\n<\/tr>\n
item7<\/strong><\/td>\n817,97 Da (voln\u00e1 b\u00e1ze)<\/td>\n<\/tr>\n
item9<\/strong><\/td>\nD-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2<\/sub> (6 aminokyselin; obsahuje D-Ala na pozici 1, D-2-naftylalanin na pozici 2 a D-Phe na pozici 5 pro proteolytickou stabilitu; C-termin\u00e1ln\u011b amidovan\u00fd). Tak\u00e9 zn\u00e1m\u00fd jako Pralmorelin \/ KP-102.<\/td>\n<\/tr>\n
item11<\/strong><\/td>\nLyofilizovan\u00e1 octanov\u00e1 s\u016fl (b\u00edl\u00fd a\u017e sv\u011btle \u017elut\u00fd pr\u00e1\u0161ek)<\/td>\n<\/tr>\n
item13<\/strong><\/td>\n\u226599% (HPLC ov\u011b\u0159eno, COA na vy\u017e\u00e1d\u00e1n\u00ed)<\/td>\n<\/tr>\n
Skladov\u00e1n\u00ed<\/strong><\/td>\nLyofilizovan\u00e9: 2\u20138 \u00b0C (lednice) pro pracovn\u00ed z\u00e1sobu; \u221220 \u00b0C pro dlouhodob\u00e9 skladov\u00e1n\u00ed neotev\u0159en\u00fdch vialek. Rekonstituovan\u00e9: 2\u20138 \u00b0C, pou\u017eijte do ~30 dn\u016f. Chra\u0148te p\u0159ed sv\u011btlem. Nefreeze\u2013thaw rekonstituovan\u00fd roztok.<\/td>\n<\/tr>\n
Rozpustnost<\/strong><\/td>\nBakteriostatick\u00e1 voda (doporu\u010deno) nebo steriln\u00ed voda pro krat\u0161\u00ed dobu pou\u017eit\u00ed<\/td>\n<\/tr>\n
Pouze pro v\u00fdzkum<\/strong><\/td>\nPouze pro laboratorn\u00ed v\u00fdzkum. Nen\u00ed ur\u010deno pro diagnostick\u00e9 nebo terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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Co je GHRP-2 Acet\u00e1t?<\/h2>\n

GHRP-2<\/strong> (Growth Hormone Releasing Peptide 2), tak\u00e9 zn\u00e1m\u00fd jako Pralmorelin<\/strong> nebo podle p\u016fvodn\u00edho v\u00fdvojov\u00e9ho k\u00f3du KP-102<\/strong>, je 6-aminokyselinov\u00fd syntetick\u00fd hexapeptid a jeden z kanonick\u00fdch z\u00e1stupc\u016f prvn\u00ed generace t\u0159\u00eddy peptid\u016f uvol\u0148uj\u00edc\u00edch r\u016fstov\u00fd hormon (GHS). Byl vyvinut kr\u00e1tce po GHRP-6 ve stejn\u00e9m programu studuj\u00edc\u00ed vztah mezi strukturou a aktivitou (SAR) na Tulane University, s c\u00edlem zv\u00fd\u0161it \u00fa\u010dinnost na mg ve srovn\u00e1n\u00ed s mate\u0159skou slou\u010deninou p\u0159i zachov\u00e1n\u00ed selektivity pro receptor GHS-R1a. Acet\u00e1tov\u00fd protion se pou\u017e\u00edv\u00e1 p\u0159i lyofilizaci pro v\u00fdzkumn\u00e9 \u00fa\u010dely, proto\u017ee zlep\u0161uje dlouhodobou stabilitu peptidu a jeho rozpustnost ve vod\u011b bez zm\u011bny farmakologie.<\/p>\n

Dob\u0159e charakterizovan\u00e1 sekvence je D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2<\/sub>, molekulov\u00e1 hmotnost 817,97 Da, empirick\u00fd vzorec C45<\/sub>H55<\/sub>N9<\/sub>O6<\/sub>. Strukturn\u00ed inovace oproti GHRP-6 je zaveden\u00ed D-2-naftylalaninu (D-2-Nal) na pozici 2 m\u00edsto D-Trp \u2014 v\u00edce lipofiln\u00ed naftylov\u00fd kruh zvy\u0161uje afinitu k GHS-R1a a podle publikovan\u00fdch v\u00fdzkum\u016f produkuje p\u0159ibli\u017en\u011b 2\u20133kr\u00e1t v\u011bt\u0161\u00ed \u00fa\u010dinnost na mg p\u0159i uvol\u0148ov\u00e1n\u00ed r\u016fstov\u00e9ho hormonu. Dv\u011b substituce D-aminokyselin (D-Ala na pozici 1, D-Phe na pozici 5) zaji\u0161\u0165uj\u00ed odolnost v\u016f\u010di prote\u00e1z\u00e1m. Pozoruhodn\u00e9 je, \u017ee v Japonsku byl GHRP-2 (pod n\u00e1zvem Pralmorelin Hydrochloride \/ GHRP Kaken) schv\u00e1len jako jednor\u00e1zov\u00fd intraven\u00f3zn\u00ed diagnostick\u00fd prost\u0159edek pro testov\u00e1n\u00ed deficitu r\u016fstov\u00e9ho hormonu u dosp\u011bl\u00fdch \u2014 jeden z m\u00e1la GHS peptid\u016f, kter\u00fd dos\u00e1hl jak\u00e9hokoli klinick\u00e9ho schv\u00e1len\u00ed. GHRP-2 nen\u00ed schv\u00e1len FDA, EMA, MHRA ani \u017e\u00e1dn\u00fdm jin\u00fdm v\u00fdznamn\u00fdm regul\u00e1torem pro terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed. V\u00fdzkumn\u00fd DSIP prod\u00e1van\u00fd zde je dod\u00e1v\u00e1n<\/strong> FDA, EMA, MHRA ani \u017e\u00e1dn\u00fdm jin\u00fdm z\u00e1padn\u00edm regul\u00e1torem pro terapeutick\u00e9 pou\u017eit\u00ed. V\u00fdzkumn\u00fd GHRP-2 acet\u00e1t prod\u00e1van\u00fd zde je dod\u00e1v\u00e1n ur\u010den pouze pro laboratorn\u00ed v\u00fdzkum<\/strong> a nen\u00ed ur\u010den pro lidsk\u00e9 ani veterin\u00e1rn\u00ed pod\u00e1v\u00e1n\u00ed.<\/p>\n

Mechanismus \u00fa\u010dinku \u2014 agonismus receptoru GHS-R1a se zv\u00fd\u0161enou \u00fa\u010dinnost\u00ed<\/h2>\n

Co \u010din\u00ed GHRP-2 mechanisticky v\u00fdjime\u010dn\u00fdm mezi prvn\u00ed generac\u00ed sekretagog\u016f r\u016fstov\u00e9ho hormonu, je kombinace vysok\u00e9 afinity k GHS-R1a s relativn\u011b kr\u00e1tk\u00fdm polo\u010dasem v plazm\u011b<\/strong>, co\u017e podle publikovan\u00fdch v\u00fdzkum\u016f vytv\u00e1\u0159\u00ed ost\u0159ej\u0161\u00ed a reprodukovateln\u011bj\u0161\u00ed pulz r\u016fstov\u00e9ho hormonu:<\/p>\n