{"id":71400,"date":"2026-05-20T09:01:36","date_gmt":"2026-05-20T09:01:36","guid":{"rendered":"https:\/\/medsbase.com\/pinealon\/"},"modified":"2026-05-21T07:14:09","modified_gmt":"2026-05-21T07:14:09","slug":"pinealon","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/pinealon\/","title":{"rendered":"Pinealon"},"content":{"rendered":"

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Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Pinealon?<\/h3>\n

Pinealon<\/strong> je syntetick\u00fd tripeptid (sekvence Glu-Asp-Arg, EDR) pat\u0159\u00edc\u00ed do rodiny Khavinsonov\u00fdch kr\u00e1tk\u00fdch peptidov\u00fdch bioregul\u00e1tor\u016f vyvinut\u00fdch v Petrohradsk\u00e9m institutu biorregulace a gerontologie. P\u016fvodn\u011b odvozen\u00fd z v\u00fdzkumu extrakt\u016f z epif\u00fdzy skotu je Pinealon studov\u00e1n pro neuroprotektivn\u00ed, antioxida\u010dn\u00ed a \u00fa\u010dinky na kognitivn\u00ed st\u00e1rnut\u00ed v laboratorn\u00edch modelech \u2014 s navrhovan\u00fdm mechanismem zahrnuj\u00edc\u00edm p\u0159\u00edm\u00fd p\u0159\u00edstup k j\u00e1dru a regulaci genov\u00e9 exprese na \u00farovni chromatinu. P\u0159\u00edbuzn\u00fd peptid s Epitalon<\/a> v r\u00e1mci Khavinsonovy \u0159ady. Dod\u00e1v\u00e1 se v lyofilizovan\u00fdch vial\u00e1ch o obsahu 5 mg, 10 mg a 20 mg pouze pro laboratorn\u00ed v\u00fdzkum.<\/p>\n<\/div>\n

Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdzkumn\u00e9 lyofilizovan\u00e9 peptidy \u00b7 HPLC \u010distota \u226599% (COA na vy\u017e\u00e1d\u00e1n\u00ed) \u00b7 Diskr\u00e9tn\u00ed teplotn\u011b stabiln\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 p\u0159eprava peptid\u016f \u00b7 1,400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Specifikace<\/th>\nDetail<\/th>\n<\/tr>\n<\/thead>\n
CAS \u010d\u00edslo<\/strong><\/td>\n308067-43-8 (b\u011b\u017en\u011b uv\u00e1d\u011bno; ne v\u0161echny zdroje dodavatel\u016f peptid\u016f publikuj\u00ed registra\u010dn\u00ed \u010d\u00edslo)<\/td>\n<\/tr>\n
Typ<\/strong><\/td>\nSyntetick\u00fd tripeptidov\u00fd bioregul\u00e1tor (rodina Khavinsonov\u00fdch kr\u00e1tk\u00fdch peptid\u016f) \u2014 vyvinut v Petrohradsk\u00e9m institutu biorregulace a gerontologie Vladimirem Khavinsonem; p\u016fvodn\u011b zalo\u017een na v\u00fdzkumu extrakt\u016f z epif\u00fdzy skotu. Pinealon je kognitivn\u00ed\/neuroprotektivn\u00ed \u010dlen Khavinsonovy \u0159ady, sp\u00e1rovan\u00fd s Epitalon<\/a> (dlouhov\u011bkost\/telomer\u00e1za) jako dva nejv\u00edce studovan\u00e9 slou\u010deniny.<\/td>\n<\/tr>\n
item2<\/strong><\/td>\nC15<\/sub>H26<\/sub>N6<\/sub>O8<\/sub><\/td>\n<\/tr>\n
item7<\/strong><\/td>\n~418,4 Da<\/td>\n<\/tr>\n
item9<\/strong><\/td>\nH-Glu-Asp-Arg-OH (EDR) \u2014 line\u00e1rn\u00ed sekvence 3 aminokyselin. Voln\u00e9 N- a C-konce; \u017e\u00e1dn\u00fd disulfidov\u00fd m\u016fstek, \u017e\u00e1dn\u00e1 acylace, \u017e\u00e1dn\u00e1 PEGylace. \u010cist\u00fd n\u00e1boj +1 p\u0159i neutr\u00e1ln\u00edm pH (jeden kationtov\u00fd Arg vyv\u00e1\u017een karboxyl\u00e1tov\u00fdmi skupinami Glu\/Asp).<\/td>\n<\/tr>\n
item11<\/strong><\/td>\nLyofilizovan\u00fd pr\u00e1\u0161ek (b\u00edl\u00fd a\u017e sv\u011btle \u017elut\u00fd)<\/td>\n<\/tr>\n
item13<\/strong><\/td>\n\u226599% (HPLC ov\u011b\u0159eno, COA na vy\u017e\u00e1d\u00e1n\u00ed)<\/td>\n<\/tr>\n
Skladov\u00e1n\u00ed<\/strong><\/td>\nLyofilizovan\u00fd: 2\u20138 \u00b0C (lednice) pro pracovn\u00ed z\u00e1sobu; \u221220 \u00b0C pro dlouhodob\u00e9 skladov\u00e1n\u00ed neotev\u0159en\u00fdch vialek. Rekonstituovan\u00fd: 2\u20138 \u00b0C, pou\u017e\u00edt do ~14\u201328 dn\u016f. Chr\u00e1nit p\u0159ed sv\u011btlem. Vyvarovat se opakovan\u00e9ho zmrazov\u00e1n\u00ed a rozmrazov\u00e1n\u00ed rekonstituovan\u00e9ho roztoku.<\/td>\n<\/tr>\n
Rozpustnost<\/strong><\/td>\nVysoce rozpustn\u00fd v bakteriostatick\u00e9 vod\u011b nebo steriln\u00ed vod\u011b \u2014 kr\u00e1tk\u00e9 nabit\u00e9 tripeptidy se rychle rozpou\u0161t\u011bj\u00ed p\u0159i jemn\u00e9m prot\u0159ep\u00e1v\u00e1n\u00ed. Nejsou pot\u0159eba speci\u00e1ln\u00ed rozpou\u0161t\u011bdla.<\/td>\n<\/tr>\n
Pouze pro v\u00fdzkum<\/strong><\/td>\nPouze pro laboratorn\u00ed v\u00fdzkum. Nen\u00ed ur\u010deno pro diagnostick\u00e9 nebo terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/p>\n

Co je Pinealon?<\/h2>\n

Pinealon<\/strong> je syntetick\u00fd tripeptid slo\u017een\u00fd z L-glutamov\u00e9 kyseliny, L-asparagov\u00e9 kyseliny a L-argininu (sekvence Glu-Asp-Arg, jednop\u00edsmenn\u00fd k\u00f3d EDR). Pat\u0159\u00ed do rodiny Khavinsonov\u00fdch kr\u00e1tk\u00fdch peptidov\u00fdch bioregul\u00e1tor\u016f \u2014 skupiny 2- a\u017e 4-aminokyselinov\u00fdch peptid\u016f vyvinut\u00fdch v Petrohradsk\u00e9m institutu bioreguace a gerontologie pod veden\u00edm Vladimira Khavinsona, p\u016fvodn\u011b zalo\u017een\u00fdch na frakcionaci a charakterizaci bioaktivn\u00edho materi\u00e1lu extrahovan\u00e9ho z hov\u011bz\u00ed \u0161i\u0161inky a dal\u0161\u00edch tk\u00e1n\u00ed. V r\u00e1mci Khavinsonovy \u0159ady je Pinealon slou\u010deninou nejv\u00edce spojovanou s kognitivn\u00ed funkc\u00ed a neuroprotekc\u00ed v publikovan\u00e9m v\u00fdzkumu, zat\u00edmco jeho sourozeneck\u00fd tetrapeptid Epitalon<\/a> (Ala-Glu-Asp-Gly, AEDG) je nejv\u00edce studovanou slou\u010deninou v kontextu dlouhov\u011bkosti\/telomer\u00e1zy.<\/p>\n

Khavinsonovy kr\u00e1tk\u00e9 peptidy se struktur\u00e1ln\u011b li\u0161\u00ed od v\u011bt\u0161iny ostatn\u00edch v\u00fdzkumn\u00fdch peptid\u016f ve dvou d\u016fle\u017eit\u00fdch ohledech: jsou extr\u00e9mn\u011b kr\u00e1tk\u00e9<\/strong> (Pinealon m\u00e1 jen t\u0159i aminokyseliny, MW ~418 Da, men\u0161\u00ed ne\u017e typick\u00e1 n\u00edzkomolekul\u00e1rn\u00ed l\u00e9\u010diva) a jejich navrhovan\u00fd mechanismus se soust\u0159ed\u00ed na p\u0159\u00edm\u00fd p\u0159\u00edstup do j\u00e1dra<\/strong> m\u00edsto vazby na receptory v plazmatick\u00e9 membr\u00e1n\u011b. Publikovan\u00fd Khavinson\u016fv model p\u0159edpokl\u00e1d\u00e1, \u017ee kr\u00e1tk\u00e9 nabit\u00e9 peptidy mohou p\u0159ekro\u010dit jak bun\u011b\u010dnou membr\u00e1nu, tak jadern\u00fd obal, dos\u00e1hnout chromatinu a modulovat genovou expresi prost\u0159ednictv\u00edm sekven\u010dn\u011b specifick\u00fdch interakc\u00ed s DNA \u2014 mechanismus odli\u0161n\u00fd od kanonick\u00e9 farmakologie vazby na receptory u v\u011bt\u0161\u00edch peptid\u016f. Tento model je podlo\u017een publikovan\u00fdm v\u00fdzkumem Khavinsonovy skupiny sahaj\u00edc\u00edm n\u011bkolik desetilet\u00ed a je p\u0159edm\u011btem pokra\u010duj\u00edc\u00edho mechanistick\u00e9ho zkoum\u00e1n\u00ed nez\u00e1visl\u00fdmi v\u00fdzkumn\u00edky.<\/p>\n

Pinealon byl zkoum\u00e1n v laboratorn\u00edch v\u00fdzkumn\u00fdch kontextech zam\u011b\u0159en\u00fdch na kognitivn\u00ed st\u00e1rnut\u00ed, ochranu neuron\u00e1ln\u00edch kultur p\u0159ed oxida\u010dn\u00edm stresem, modely cerebr\u00e1ln\u00ed ischemie a v\u00fdzkum cirkadi\u00e1nn\u00edho\/pine\u00e1ln\u00edho osy. Je FDA, EMA, MHRA ani \u017e\u00e1dn\u00fdm jin\u00fdm v\u00fdznamn\u00fdm regul\u00e1torem pro terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed. V\u00fdzkumn\u00fd DSIP prod\u00e1van\u00fd zde je dod\u00e1v\u00e1n<\/strong> schv\u00e1len FDA, EMA, MHRA nebo jak\u00fdmkoli jin\u00fdm v\u00fdznamn\u00fdm regul\u00e1torem pro terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed. Zde prod\u00e1van\u00fd v\u00fdzkumn\u00fd Pinealon je dod\u00e1v\u00e1n ur\u010den pouze pro laboratorn\u00ed v\u00fdzkum<\/strong> a nen\u00ed ur\u010den pro lidsk\u00e9 ani veterin\u00e1rn\u00ed pod\u00e1v\u00e1n\u00ed.<\/p>\n

Mechanismus \u00fa\u010dinku \u2014 Khavinsonova kr\u00e1tkopeptidov\u00e1 bioregulace<\/h2>\n

Publikovan\u00fd mechanistick\u00fd model pro Khavinsonovy kr\u00e1tk\u00e9 peptidy \u2014 podlo\u017een\u00fd v\u00fdzkumem Khavinsonovy skupiny a testovan\u00fd v nez\u00e1visl\u00fdch laborato\u0159\u00edch \u2014 navrhuje t\u0159i hlavn\u00ed mechanismy \u00fa\u010dinku:<\/p>\n