{"id":71421,"date":"2026-05-20T10:30:00","date_gmt":"2026-05-20T10:30:00","guid":{"rendered":"https:\/\/medsbase.com\/5-amino-1mq\/"},"modified":"2026-05-21T07:14:08","modified_gmt":"2026-05-21T07:14:08","slug":"5-amino-1mq","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/5-amino-1mq\/","title":{"rendered":"5-Amino-1MQ (5-Amino-1-Methylquinolinium Iodide)"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background: #fff8e1; border-left: 4px solid #f5a623; padding: 18px 22px; margin: 18px 0; border-radius: 4px;\">\n<h3 style=\"margin: 0 0 8px 0; font-size: 16px; color: #1a4a6b;\">Rychl\u00e1 odpov\u011b\u010f \u2014 Co je 5-Amino-1MQ?<\/h3>\n<p style=\"margin: 0;\"><strong>5-Amino-1MQ<\/strong> (5-amino-1-methylquinolinium iodide, CAS 42464-96-0) je mal\u00e1 molekula selektivn\u00ed na substr\u00e1tov\u00e9 m\u00edsto <strong>Inhibitor NNMT (nikotinamid N-methyltransfer\u00e1zy)<\/strong> s publikovanou IC<sub>50<\/sub> 1,2 \u00b5M. Blokov\u00e1n\u00edm NNMT \u2013 cytosolidn\u00edho enzymu, kter\u00fd spot\u0159ebov\u00e1v\u00e1 jak nikotinamid (prekurzor NAD<sup>+<\/sup>) tak S-adenosyl-L-methionin (SAM, univerz\u00e1ln\u00edho methylov\u00e9ho donoru) \u2013 bylo u 5-Amino-1MQ v recenzovan\u00fdch studi\u00edch prok\u00e1z\u00e1no zv\u00fd\u0161en\u00ed intracelul\u00e1rn\u00edch hladin NAD<sup>+<\/sup> a SAM, sn\u00ed\u017een\u00ed lipogeneze v adipocytech 3T3-L1 a in-vivo \u00fa\u010dinnost v my\u0161\u00edch modelech dietou indukovan\u00e9 obezity (20 mg\/kg\/den), opravy svalov\u00fdch kmenov\u00fdch bun\u011bk a metast\u00e1z ovari\u00e1ln\u00edho karcinomu bez ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f a\u017e do d\u00e1vky 60 mg\/kg\/den. Jedn\u00e1 se o malou molekulu (<em>nen\u00ed peptid<\/em>) dod\u00e1vanou jako lyofilizovan\u00fd pr\u00e1\u0161ek ur\u010den\u00fd v\u00fdhradn\u011b pro laboratorn\u00ed v\u00fdzkum.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background: #f4f8fb; border: 1px solid #d8e3eb; padding: 12px 16px; margin: 16px 0; border-radius: 4px; font-size: 14px;\"><strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> Lyofilizovan\u00fd pr\u00e1\u0161ek \u226599% HPLC-verifikovan\u00fd \u00b7 COA dostupn\u00fd na vy\u017e\u00e1d\u00e1n\u00ed \u00b7 Diskr\u00e9tn\u00ed teplotn\u011b stabiln\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 dod\u00e1vka v\u00fdzkumn\u00fdch materi\u00e1l\u016f \u00b7 1,400+ ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size: 14px; color: #444; margin: 8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<table class=\"medsbase-spec-table\" style=\"width: 100%; border-collapse: collapse; margin: 18px 0; font-size: 14px;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 8px 12px; text-align: left; width: 30%;\">Specifikace<\/th>\n<th style=\"padding: 8px 12px; text-align: left;\">Detail<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>T\u0159\u00edda slou\u010denin<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Mal\u00e1 molekula kvart\u00e9rn\u00ed amoniov\u00e9 soli chinolinia; selektivn\u00ed inhibitor NNMT; <em>nen\u00ed peptid<\/em><\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Chemick\u00fd n\u00e1zev<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">5-Amino-1-methylchinolinium jodid<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>CAS \u010d\u00edslo<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">42464-96-0<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>item2<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">C<sub>10<\/sub>H<sub>11<\/sub>IN<sub>2<\/sub> (jodidov\u00e1 s\u016fl)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>item7<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">286.11 g\/mol<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Mechanismus \u00fa\u010dinku<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Selektivn\u00ed inhibitor nikotinamid N-methyltransfer\u00e1zy (NNMT) v\u00e1zaj\u00edc\u00ed se na substr\u00e1t; IC<sub>50<\/sub> = 1,2 \u00b5M (test: 50 \u00b5M SAM, 100 \u00b5M nikotinamid). Neinhibuje p\u0159\u00edbuzn\u00e9 methyltransfer\u00e1zy (GNMT, PNMT, COMT) ani enzymy z\u00e1chrany NAD<sup>+<\/sup>-salvage (NAMPT, NMNAT).<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>item9<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">n\/a (mal\u00e1 molekula chinolinium soli \u2014 nikoliv peptid)<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>item11<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Lyofilizovan\u00fd krystalick\u00fd\/pr\u00e1\u0161ek (sv\u011btle \u017elut\u00fd a\u017e b\u00edl\u00fd); dod\u00e1v\u00e1no v jednor\u00e1zov\u00fdch v\u00fdzkumn\u00fdch vialk\u00e1ch<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>item13<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">\u226599 % (ov\u011b\u0159eno HPLC, COA na vy\u017e\u00e1d\u00e1n\u00ed) \u2014 odpov\u00edd\u00e1 referen\u010dn\u00edmu standardu Sigma-Aldrich SML2832<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Rozpustnost<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Vysoce rozpustn\u00fd ve vod\u011b (kvart\u00e9rn\u00ed amonn\u00e1 s\u016fl je hydrofiln\u00ed). Snadno se rekonstituuje v bakteriostatick\u00e9 vod\u011b, steriln\u00ed vod\u011b nebo PBS p\u0159i koncentrac\u00edch a\u017e ~50 mg\/ml bez sr\u00e1\u017een\u00ed. Tak\u00e9 rozpustn\u00fd v DMSO pro p\u0159\u00edpravu z\u00e1sobn\u00edho roztoku pro in-vitro bun\u011b\u010dn\u00e9 kultury.<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Skladov\u00e1n\u00ed<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Lyofilizovan\u00fd: 2\u20138 \u00b0C pro kr\u00e1tkodob\u00e9 pracovn\u00ed z\u00e1soby; \u221220 \u00b0C pro dlouhodob\u00e9 skladov\u00e1n\u00ed neotev\u0159en\u00fdch vialek (stabiln\u00ed \u226536 m\u011bs\u00edc\u016f p\u0159i \u221220 \u00b0C). Rekonstituovan\u00fd: 2\u20138 \u00b0C, pou\u017e\u00edt do ~30 dn\u016f. Chra\u0148te p\u0159ed dlouhodob\u00fdm vystaven\u00edm sv\u011btlu. Vyvarujte se opakovan\u00e9ho zmrazov\u00e1n\u00ed a rozmrazov\u00e1n\u00ed pracovn\u00edch roztok\u016f.<\/td>\n<\/tr>\n<tr style=\"background: #fff;\">\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0; width: 30%;\"><strong>Pouze pro v\u00fdzkum<\/strong><\/td>\n<td style=\"padding: 8px 12px; border-bottom: 1px solid #e0e0e0;\">Pouze pro laboratorn\u00ed v\u00fdzkum. Nen\u00ed ur\u010deno pro diagnostick\u00e9 nebo terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><!-- \/medsbase-tldr-answer --><\/p>\n<h2>Co je 5-Amino-1MQ?<\/h2>\n<p><strong>5-Amino-1MQ<\/strong> (5-amino-1-methylchinolinium jodid, CAS 42464-96-0) je mal\u00e1 molekula selektivn\u00edho inhibitoru <strong>nikotinamid N-methyltransfer\u00e1zy (NNMT)<\/strong>, cytosolic\u00e9 methyltransfer\u00e1zov\u00e9ho enzymu, jeho\u017e biologie se v posledn\u00edm desetilet\u00ed uk\u00e1zala jako uzel spojuj\u00edc\u00ed metabolismus NAD<sup>+<\/sup>-osy, lipogenezi adipocyt\u016f, biologii svalov\u00fdch kmenov\u00fdch bun\u011bk a strom\u00e1ln\u00ed metabolismus rakoviny. Je to <em>nen\u00ed peptid<\/em> \u2014 jde o syntetickou chinolinium kvart\u00e9rn\u00ed amonnou s\u016fl s molekul\u00e1rn\u00edm vzorcem C<sub>10<\/sub>H<sub>11<\/sub>IN<sub>2<\/sub> a molekulov\u00e1 hmotnost 286,11 g\/mol (jodidov\u00e1 s\u016fl). MedsBase ji skladuje ve stejn\u00e9m lyofilizovan\u00e9m form\u00e1tu jako n\u00e1\u0161 v\u00fdzkumn\u00fd peptidov\u00fd katalog pro snadn\u00e9 p\u0159eformulov\u00e1n\u00ed a d\u00e1vkov\u00e1n\u00ed ve sm\u00ed\u0161en\u00fdch protokolov\u00fdch studi\u00edch.<\/p>\n<p>NNMT katalyzuje p\u0159enos methylov\u00e9 skupiny z <strong>S-adenosyl-L-methioninu (SAM)<\/strong> \u2014 univerz\u00e1ln\u00edho bun\u011b\u010dn\u00e9ho methylov\u00e9ho donoru \u2014 na <strong>nikotinamid<\/strong>, generating 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine (SAH). The reaction terminally consumes both substrates: nicotinamide (which would otherwise be re-salvaged into NAD<sup>+<\/sup> a SAM (kter\u00fd by jinak byl dostupn\u00fd pro stovky bun\u011b\u010dn\u00fdch methyla\u010dn\u00edch reakc\u00ed prov\u00e1d\u011bn\u00fdch jin\u00fdmi methyltransfer\u00e1zami). NNMT proto stoj\u00ed na pr\u016fse\u010d\u00edku dvou nejv\u00edce studovan\u00fdch os bun\u011b\u010dn\u00e9 biochemie \u2014 dr\u00e1hy z\u00e1chrany NAD<sup>+<\/sup> a metabolismu jednoho uhl\u00edku \/ methylace \u2014 a jeho exprese je v\u00fdrazn\u011b zv\u00fd\u0161ena v obezitou asociovan\u00e9 tukov\u00e9 tk\u00e1ni, stromatu rakoviny a st\u00e1rnut\u00edm kostern\u00edho svalu.<\/p>\n<p>5-Amino-1MQ je nejv\u00edce publikovan\u00fd <strong>mal\u00e1 molekula, substr\u00e1tov\u011b c\u00edlen\u00fd<\/strong> Inhibitor NNMT v dan\u00e9m oboru. Byl charakterizov\u00e1n Neelakantanem et al. (2017\u20132018) jako selektivn\u00ed inhibitor s IC50 1,2 \u00b5M<sub>50<\/sub> pro rekombinantn\u00ed NNMT, bez ne\u017e\u00e1douc\u00ed aktivity v\u016f\u010di p\u0159\u00edbuzn\u00fdm methyltransfer\u00e1z\u00e1m (GNMT, PNMT, COMT) nebo NAD<sup>+<\/sup>-salvage enzym\u016fm (NAMPT, NMNAT) a s peror\u00e1ln\u00ed biologickou dostupnost\u00ed dostate\u010dnou pro podporu in-vivo d\u00e1vkovac\u00edch protokol\u016f u hlodavc\u016f. N\u00e1sledn\u00fd in-vivo v\u00fdzkum dokumentoval aktivitu ve t\u0159ech nez\u00e1visl\u00fdch modelech relevantn\u00edch pro onemocn\u011bn\u00ed: dietou indukovan\u00e1 obezita, oprava po\u0161kozen\u00ed kostern\u00edho svalstva a intraperitone\u00e1ln\u00ed metast\u00e1zy ovari\u00e1ln\u00edho karcinomu \u2014 v\u0161e bez ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f a\u017e do d\u00e1vky 60 mg\/kg\/den.<\/p>\n<h2>Mechanismus \u00fa\u010dinku \u2014 inhibice NNMT a osa NAD<sup>+<\/sup>\/SAM<\/h2>\n<p>Mechanismus 5-Amino-1MQ je nejl\u00e9pe charakterizov\u00e1n ze v\u0161ech mal\u00fdch molekul\u00e1rn\u00edch inhibitor\u016f NNMT v publikovan\u00e9 literatu\u0159e:<\/p>\n<ul>\n<li><strong>Kompetitivn\u00ed inhibice v m\u00edst\u011b substr\u00e1tu NNMT<\/strong> \u2014 5-Amino-1MQ se v\u00e1\u017ee na kapsu substr\u00e1tu nikotinamidu v NNMT, sout\u011b\u017e\u00ed s p\u0159irozen\u00fdm substr\u00e1tem nikotinamidu a br\u00e1n\u00ed SAM-\u0159\u00edzen\u00e9mu p\u0159enosu methylu. Krystalov\u00e9 struktury publikovan\u00e9 v roce 2018 potvrdily p\u0159\u00edmou obsazenost substr\u00e1tov\u00e9ho kan\u00e1lu. IC50 = 1,2 \u00b5M p\u0159i fyziologicky relevantn\u00edch koncentrac\u00edch kofaktor\u016f (50 \u00b5M SAM, 100 \u00b5M nikotinamid).<sub>50<\/sub> = 1.2 \u00b5M p\u0159i fyziologicky relevantn\u00edch koncentrac\u00edch kofaktor\u016f (50 \u00b5M SAM, 100 \u00b5M nicotinamide).<\/li>\n<li><strong>\u2014 Nikotinamid, kter\u00fd nen\u00ed methylov\u00e1n NNMT, z\u016fst\u00e1v\u00e1 dostupn\u00fd pro salvage pathway NAMPT-NMNAT, kde je p\u0159em\u011bn\u011bn na NMN a n\u00e1sledn\u011b na NAD<sup>+<\/sup> . Bu\u0148ky s vysokou expres\u00ed NNMT vykazuj\u00ed depleci NAD<\/strong> , kterou podle publikovan\u00fdch studi\u00ed l\u00e9\u010dba 5-Amino-1MQ \u010d\u00e1ste\u010dn\u011b reverzuje \u2014 co\u017e \u010din\u00ed slou\u010deninu mechanisticky odli\u0161nou od prekurzor\u016f NAD<sup>+<\/sup>. Bu\u0148ky s vysokou expres\u00ed NNMT vykazuj\u00ed NAD<sup>+<\/sup> vy\u010derp\u00e1n\u00ed, kter\u00e9 l\u00e9\u010dba 5-Amino-1MQ podle publikovan\u00fdch studi\u00ed \u010d\u00e1ste\u010dn\u011b zvrac\u00ed \u2014 co\u017e \u010din\u00ed tuto slou\u010deninu mechanisticky odli\u0161nou od NAD<sup>+<\/sup> prekurzory (NMN, NR, niacinamide), kter\u00e9 dopl\u0148uj\u00ed z\u00e1sobu shora, sp\u00ed\u0161e ne\u017e aby sni\u017eovaly rychlost spot\u0159eby nicotinamide.<\/li>\n<li><strong>\u0160et\u0159en\u00ed z\u00e1sob SAM a n\u00e1sledn\u00e9 \u00fa\u010dinky na methylaci<\/strong> \u2014 Ka\u017ed\u00e1 reakce katalyzovan\u00e1 NNMT tak\u00e9 spot\u0159ebuje jednu molekulu SAM, \u010d\u00edm\u017e vznik\u00e1 SAH. Inhibice NNMT tedy zvy\u0161uje intracelul\u00e1rn\u00ed hladinu SAM a sni\u017euje SAH, co\u017e zvy\u0161uje pom\u011br SAM:SAH \u2013 tzv. bun\u011b\u010dn\u00fd methyla\u010dn\u00ed potenci\u00e1l. Podle publikovan\u00e9ho v\u00fdzkumu na 3T3-L1 adipocytech je to spojeno se zm\u011bnami histonov\u00fdch methyla\u010dn\u00edch vzorc\u016f u gen\u016f pod\u00edlej\u00edc\u00edch se na lipogenezi a se sn\u00ed\u017een\u00edm de-novo lipogeneze.<\/li>\n<li><strong>Sn\u00ed\u017een\u00ed produkce 1-methylnikotinamidu (1-MNA)<\/strong> \u2014 1-MNA je p\u0159\u00edm\u00fdm produktem reakce katalyzovan\u00e9 NNMT. Podle publikovan\u00fdch studi\u00ed hladiny 1-MNA v plazm\u011b a tk\u00e1n\u00edch rychle klesaj\u00ed po pod\u00e1n\u00ed 5-Amino-1MQ, co\u017e poskytuje vhodn\u00fd farmakodynamick\u00fd biomarker pro sledov\u00e1n\u00ed c\u00edlov\u00e9 interakce in vivo.<\/li>\n<li><strong>Profil selektivity<\/strong> \u2014 5-Amino-1MQ neinhibuje p\u0159\u00edbuzn\u00e9 methyltransfer\u00e1zy GNMT (glycine N-methyltransferase), PNMT (phenylethanolamine N-methyltransferase) ani COMT (catechol-O-methyltransferase) a neinterferuje s NAD<sup>+<\/sup>-z\u00e1chrann\u00e9 enzymy NAMPT nebo NMNAT. Tento profil selektivity odli\u0161uje 5-Amino-1MQ od \u0161irokospektr\u00fdch inhibitor\u016f methyltransfer\u00e1z a \u010din\u00ed z n\u011bj standardn\u00ed farmakologick\u00fd n\u00e1stroj pro zkoum\u00e1n\u00ed NNMT-specifick\u00e9 biologie.<\/li>\n<\/ul>\n<p>\u00da\u010dinky slou\u010deniny se z t\u011bchto prim\u00e1rn\u00edch biochemick\u00fdch \u00fa\u010dink\u016f p\u0159en\u00e1\u0161ej\u00ed do mal\u00e9ho souboru dob\u0159e charakterizovan\u00fdch bun\u011b\u010dn\u00fdch fenotyp\u016f: sn\u00ed\u017een\u00e1 diferenciace a lipogeneze adipocyt\u016f 3T3-L1 (nejcitovan\u011bj\u0161\u00ed in-vitro parametr); zv\u00fd\u0161en\u00e1 proliferace satelitn\u00edch bun\u011bk sval\u016f a urychlen\u00e1 oprava poran\u011bn\u00ed u model\u016f st\u00e1rnouc\u00edch my\u0161\u00ed; sn\u00ed\u017een\u00e1 z\u00e1t\u011b\u017e peritone\u00e1ln\u00edmi n\u00e1dory u model\u016f metast\u00e1z rakoviny vaje\u010dn\u00edk\u016f. V\u00fdzkumn\u00edci by m\u011bli konzultovat prim\u00e1rn\u00ed literaturu (Neelakantan et al. 2017\u20132019, Sampath et al. 2018, n\u00e1sledn\u00e9 p\u0159ehledy dr\u00e1hy NNMT) ohledn\u011b parametr\u016f z\u00e1visl\u00fdch na d\u00e1vce, kinetick\u00fdch a druhov\u011b specifick\u00fdch parametr\u016f relevantn\u00edch pro konkr\u00e9tn\u00ed protokoly.<\/p>\n<h2>Publikovan\u00e9 v\u00fdzkumn\u00e9 aplikace<\/h2>\n<p>5-Amino-1MQ se pou\u017e\u00edv\u00e1 v laboratorn\u00edm v\u00fdzkumu, kter\u00fd zkoum\u00e1:<\/p>\n<ul>\n<li><strong>Biochemie a farmakologie osy NNMT<\/strong> \u2014 kanonick\u00fd farmakologick\u00fd n\u00e1stroj pro selektivn\u00ed inhibici NNMT v bezbun\u011b\u010dn\u00fdch testech, prim\u00e1rn\u00edch bun\u011b\u010dn\u00fdch kultur\u00e1ch a in-vivo studi\u00edch na hlodavc\u00edch; standardn\u00ed referen\u010dn\u00ed slou\u010denina pro studie mechanismu \u00fa\u010dinku nov\u011bj\u0161\u00edch inhibitor\u016f NNMT<\/li>\n<li><strong>NAD<sup>+<\/sup>-osov\u00e1 farmakologie \u2014 substr\u00e1tov\u011b \u0161et\u0159\u00edc\u00ed p\u0159\u00edstup<\/strong> \u2014 mechanisticky odli\u0161n\u00fd od NAD<sup>+<\/sup>-prekurzorov\u00fdch p\u0159\u00edstup\u016f (NMN, NR, suplementace nikotinamidem), kter\u00e9 dopl\u0148uj\u00ed pool shora; 5-Amino-1MQ naopak sni\u017euje spot\u0159ebu NAD<sup>+<\/sup>-prekurzor\u016f zdola blokov\u00e1n\u00edm nejv\u011bt\u0161\u00edho neobnoviteln\u00e9ho \u00faniku (NNMT)<\/li>\n<li><strong>Biologie adipocyt\u016f a v\u00fdzkum obezity<\/strong> \u2014 publikovan\u00e9 d\u00e1vkov\u00e1n\u00ed 20 mg\/kg\/den u dietou indukovan\u00fdch obezitou my\u0161\u00edch model\u016f prok\u00e1zalo sn\u00ed\u017een\u00ed tukov\u00e9 hmoty, zlep\u0161en\u00ed gluk\u00f3zov\u00e9 tolerance a sn\u00ed\u017een\u00ed jatern\u00ed akumulace lipid\u016f; kanonick\u00fd diferencia\u010dn\u00ed model 3T3-L1 vykazuje sn\u00ed\u017eenou lipogenezi<\/li>\n<li><strong>Biologie kmenov\u00fdch bun\u011bk kostern\u00edho svalstva a v\u00fdzkum st\u00e1rnut\u00ed<\/strong> \u2014 publikovan\u00e9 d\u00e1vkov\u00e1n\u00ed 5\u201310 mg\/kg u kardiotoxinem indukovan\u00fdch svalov\u00fdch poran\u011bn\u00ed my\u0161\u00edch model\u016f prok\u00e1zalo zrychlen\u00ed proliferace satelitn\u00edch bun\u011bk a zlep\u0161en\u00ed regenera\u010dn\u00ed kapacity, zejm\u00e9na u star\u0161\u00edch zv\u00ed\u0159at s elevovanou expres\u00ed NNMT<\/li>\n<li><strong>V\u00fdzkum strom\u00e1ln\u00edho metabolismu u n\u00e1dor\u016f<\/strong> \u2014 5-Amino-1MQ bylo pou\u017eito v publikovan\u00fdch intraperitone\u00e1ln\u00edch my\u0161\u00edch modelech metast\u00e1z ovari\u00e1ln\u00edho karcinomu HeyA8 (a\u017e 60 mg\/kg\/den) ke sn\u00ed\u017een\u00ed strom\u00e1ln\u00ed aktivity NNMT a peritone\u00e1ln\u00ed n\u00e1dorov\u00e9 z\u00e1t\u011b\u017ee; tak\u00e9 zkoum\u00e1no ve strom\u00e1ln\u011b c\u00edlen\u00e9m v\u00fdzkumu u pankreatick\u00fdch, prostatick\u00fdch a ren\u00e1ln\u00edch karcinom\u016f, kde je exprese NNMT vysok\u00e1 ve strom\u00e1ln\u00ed kompartmentu<\/li>\n<li><strong>V\u00fdzkum metyla\u010dn\u00edho potenci\u00e1lu a metabolismu jednouhl\u00edkat\u00fdch jednotek<\/strong> \u2014 v\u00fdzkumn\u00edci studuj\u00edc\u00ed pom\u011br SAM:SAH, glob\u00e1ln\u00ed metylaci histon\u016f nebo DNA metylaci mohou pou\u017e\u00edt 5-Amino-1MQ jako n\u00e1stroj k ovlivn\u011bn\u00ed bun\u011b\u010dn\u00e9ho metyla\u010dn\u00edho potenci\u00e1lu bez p\u0159\u00edm\u00e9 inhibice jak\u00e9koli DNA nebo histonov\u00e9 metyltransfer\u00e1zy<\/li>\n<li><strong>V\u00fdzkum kombinac\u00ed mitochondri\u00e1ln\u00ed bioenergetiky<\/strong> \u2014 protokoly n\u011bkdy kombinuj\u00ed 5-Amino-1MQ (NAD<sup>+<\/sup>-precursor sparing) s <a href=\"https:\/\/medsbase.com\/cs\/nad\/\">NAD<sup>+<\/sup><\/a> (p\u0159\u00edm\u00e1 suplementace prekurzoru) nebo <a href=\"https:\/\/medsbase.com\/cs\/ss-31-elamipretide\/\">SS-31<\/a> (kardiolipin-v\u00e1zaj\u00edc\u00ed mitochondri\u00e1ln\u011b c\u00edlen\u00fd peptid) pro zkoum\u00e1n\u00ed p\u0159\u00edsp\u011bvk\u016f substr\u00e1t\u016f v upstreamu vs. elektronov\u00e9ho toku v downstreamu k mitochondri\u00e1ln\u00ed bioenergetick\u00e9 v\u00fdkonnosti<\/li>\n<\/ul>\n<p>Pro \u0161ir\u0161\u00ed kontext o NAD<sup>+<\/sup>-ose a mitochondri\u00e1ln\u00edch\/metabolick\u00fdch v\u00fdzkumn\u00fdch slou\u010denin\u00e1ch v tomto katalogu viz <a href=\"https:\/\/medsbase.com\/cs\/nad\/\">NAD<sup>+<\/sup><\/a> (oxidovan\u00fd dinukleotidov\u00fd koenzym, centr\u00e1ln\u00ed substr\u00e1t elektronov\u00e9ho transportu), <a href=\"https:\/\/medsbase.com\/cs\/mots-c\/\">MOTS-c<\/a> (mitochondri\u00e1ln\u011b odvozen\u00fd metabolicky regula\u010dn\u00ed peptid), <a href=\"https:\/\/medsbase.com\/cs\/ss-31-elamipretide\/\">SS-31 (Elamipretide)<\/a> (mitochondri\u00e1ln\u011b c\u00edlen\u00fd peptid v\u00e1zaj\u00edc\u00ed kardiolipin), a <a href=\"https:\/\/medsbase.com\/cs\/l-carnitine\/\">L-Karnitin<\/a> (mitochondri\u00e1ln\u00ed transport\u00e9r dlouh\u00fdch mastn\u00fdch kyselin). Proch\u00e1zejte cel\u00fd <a href=\"https:\/\/medsbase.com\/cs\/peptides\/\">katalog v\u00fdzkumn\u00fdch peptid\u016f a slou\u010denin<\/a> pro souvisej\u00edc\u00ed slou\u010deniny, nebo se pod\u00edvejte na kur\u00e1torsk\u00fd <a href=\"https:\/\/medsbase.com\/cs\/best-longevity-peptides\/\">v\u00fdzkumn\u00e9 slou\u010deniny pro dlouhov\u011bkost<\/a> a <a href=\"https:\/\/medsbase.com\/cs\/best-peptides-for-fat-loss\/\">hub v\u00fdzkumn\u00fdch peptid\u016f pro \u00fabytek tuku<\/a> huby.<\/p>\n<h2>Dostupn\u00e9 s\u00edly a koncentrace<\/h2>\n<p>MedsBase nab\u00edz\u00ed 5-Amino-1MQ ve t\u0159ech lyofilizovan\u00fdch velikostech vial\u016f kalibrovan\u00fdch na typick\u00e9 d\u00e9lky v\u00fdzkumn\u00fdch protokol\u016f. Ka\u017ed\u00e1 s\u00edla je dostupn\u00e1 v balen\u00ed po 10 nebo 20 vialech:<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">S\u00edla vialky<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Typick\u00fd v\u00fdzkumn\u00fd p\u0159\u00edpad u\u017eit\u00ed<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Velikosti balen\u00ed<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>5 mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">In-vitro bun\u011b\u010dn\u00e9 kultury a kr\u00e1tkodob\u00e9 in-vivo titrace \u2014 3T3-L1 diferencia\u010dn\u00ed testy, farmakologie prim\u00e1rn\u00edch bun\u011bk, pr\u00e1ce s d\u00e1vkovou odpov\u011bd\u00ed v jedn\u00e9 kohort\u011b<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10 nebo 20 vialek<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>10 mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Standardn\u00ed st\u0159edn\u00ed s\u00edla \u2014 in-vivo protokoly u hlodavc\u016f s dietou indukovanou obezitou (20 mg\/kg\/den po dobu 4\u20138 t\u00fddn\u016f), \u010dasov\u00e9 studie regenerace svalov\u00e9ho po\u0161kozen\u00ed, st\u0159edn\u011b velk\u00e9 vzorky kohort<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10 nebo 20 vialek<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>50 mg<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Vysokokapacitn\u00ed\/prodlou\u017een\u00e9 protokoly \u2014 rozs\u00e1hl\u00e9 metabolick\u00e9 studie, v\u00fdzkum rakoviny-stromy s v\u00edce rameny (a\u017e 60 mg\/kg\/den v modelu ovari\u00e1ln\u00edho karcinomu HeyA8), dlouhodob\u00e9 pod\u00e1v\u00e1n\u00ed; nejni\u017e\u0161\u00ed cena za mg<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">10 nebo 20 vialek<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>V\u0161echny t\u0159i s\u00edly jsou stejn\u00e1 chemick\u00e1 entita (lyofilizovan\u00fd 5-amino-1-methylchinolinium jodid, \u226599% HPLC \u010distoty). Vial 50 mg poskytuje nejni\u017e\u0161\u00ed cenu za mg pro rozs\u00e1hl\u00e9 in-vivo protokoly (jedin\u00fd vial 50 mg pokryje p\u0159ibli\u017en\u011b dva t\u00fddny d\u00e1vkov\u00e1n\u00ed 20 mg\/kg\/den u 20g my\u0161i, nebo asi t\u0159i dny p\u0159i 60 mg\/kg\/den u 30g krysy). V\u00fdzkumn\u00edci by m\u011bli ur\u010dit konkr\u00e9tn\u00ed d\u00e1vkov\u00e9 rozsahy z recenzovan\u00e9 literatury vhodn\u00e9 pro protokol.<\/p>\n<h2>Srovn\u00e1n\u00ed \u2014 5-Amino-1MQ vs NAD<sup>+<\/sup><\/h2>\n<p>5-Amino-1MQ a <a href=\"https:\/\/medsbase.com\/cs\/nad\/\">NAD<sup>+<\/sup><\/a> jsou ob\u011b v\u00fdzkumn\u00e9 l\u00e1tky p\u016fsob\u00edc\u00ed na NAD osu, ale zasahuj\u00ed na zcela odli\u0161n\u00fdch m\u00edstech stejn\u00e9 metabolick\u00e9 smy\u010dky. NAD<sup>+<\/sup> p\u0159\u00edmo dopl\u0148uje z\u00e1soby dinukleotid\u016f \u2014 co\u017e je u\u017eite\u010dn\u00e9, kdy\u017e je c\u00edlem zv\u00fd\u0161it dostupnost substr\u00e1t\u016f pro redoxn\u00ed reakce, sirtuiny nebo PARP. 5-Amino-1MQ blokuje termin\u00e1ln\u00ed spot\u0159ebu nikotinamidu katalyzovanou NNMT \u2014 co\u017e je u\u017eite\u010dn\u00e9, kdy\u017e je c\u00edlem zpomalit vy\u010derp\u00e1n\u00ed z\u00e1sob prekurzor\u016f NAD<sup>+<\/sup> v d\u016fsledku k\u0159\u00ed\u017eov\u00e9 interakce s bun\u011b\u010dnou methyla\u010dn\u00ed osou. Tyto dv\u011b l\u00e1tky se mechanicky dopl\u0148uj\u00ed a v\u00fdzkumn\u00e9 protokoly je n\u011bkdy kombinuj\u00ed, aby odd\u011blily p\u0159\u00ednos zv\u00fd\u0161en\u00ed substr\u00e1tu (NAD<sup>+<\/sup>) od \u00faspory prekurzor\u016f (5-Amino-1MQ) pro v\u00fdstup NAD osy.<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 16px 0;\">\n<thead>\n<tr style=\"background: #2c7cb0; color: #fff;\">\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">Krit\u00e9rium<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">5-Amino-1MQ<\/th>\n<th style=\"padding: 10px; border: 1px solid #ddd; text-align: left;\">NAD<sup>+<\/sup><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Chemick\u00e1 t\u0159\u00edda<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Mal\u00e1 molekula chinolinium kvart\u00e9rn\u00ed amonn\u00e9 soli<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Dinukleotidov\u00fd koenzym (adenin + nikotinamidov\u00e9 nukleotidy spojen\u00e9 p\u0159es difosf\u00e1t)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Molekulov\u00e1 hmotnost<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">286.11 g\/mol<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">663.43 g\/mol<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>M\u00edsto z\u00e1sahu v ose NAD<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Blokuje spot\u0159ebu nikotinamidu NNMT (zpomaluje vy\u010derp\u00e1n\u00ed prekurzor\u016f zezdola)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">P\u0159\u00edmo p\u0159id\u00e1v\u00e1 do z\u00e1sob dinukleotid\u016f (zvy\u0161uje substr\u00e1t shora)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Nejl\u00e9pe prostudovan\u00fd v\u00fdzkumn\u00fd z\u00e1m\u011br<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Lipogeneze adipocyt\u016f, oprava svalov\u00fdch satelitn\u00edch bun\u011bk, metabolismus stromatu n\u00e1dor\u016f, farmakologie osy NNMT<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Biologie sirtuin\u016f, dlouhov\u011bkost, bun\u011b\u010dn\u00e9 st\u00e1rnut\u00ed, redox regulace NAD osy<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Selektivita<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Vysok\u00e1 \u2014 neinhibuje GNMT, PNMT, COMT, NAMPT ani NMNAT<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">n\/a (NAD<sup>+<\/sup> je p\u0159irozen\u00fd substr\u00e1t)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Stabilita v plazm\u011b<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Stabiln\u00ed \u2014 polo\u010das v hodin\u00e1ch; vhodn\u00e9 pro peror\u00e1ln\u00ed, intraperitone\u00e1ln\u00ed a intraven\u00f3zn\u00ed pod\u00e1n\u00ed<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Nestabiln\u00ed \u2014 polo\u010das v minut\u00e1ch v roztoku; rychle oxiduje a degraduje<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Typick\u00e1 v\u00fdzkumn\u00e1 d\u00e1vka<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">5\u201360 mg\/kg\/den v publikovan\u00fdch protokolech pro my\u0161i (20 mg\/kg\/den nej\u010dast\u011bj\u0161\u00ed pro DIO; 60 mg\/kg\/den nejvy\u0161\u0161\u00ed testovan\u00e1 d\u00e1vka bez ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f)<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Des\u00edtky a\u017e stovky mg (bun\u011b\u010dn\u00e1 kultura: \u00b5M koncentrace)<\/td>\n<\/tr>\n<tr style=\"background: #f9f9f9;\">\n<td style=\"padding: 10px; border: 1px solid #ddd;\"><strong>Schv\u00e1len\u00ed FDA<\/strong><\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Ne \u2014 pouze v\u00fdzkumn\u00e1 slou\u010denina<\/td>\n<td style=\"padding: 10px; border: 1px solid #ddd;\">Ne \u2014 pouze v\u00fdzkumn\u00e1 slou\u010denina<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Pro v\u00fdzkum zam\u011b\u0159en\u00fd na NAD<sup>+<\/sup>-osov\u00fd p\u0159\u00edjem prekurzor\u016f NNMT, lipogenezi adipocyt\u016f nebo biologii svalov\u00fdch kmenov\u00fdch bun\u011bk je 5-Amino-1MQ kanonick\u00fdm farmakologick\u00fdm n\u00e1strojem. Pro v\u00fdzkum zam\u011b\u0159en\u00fd na p\u0159\u00edmou suplementaci NAD<sup>+<\/sup>-poolu, biologii sirtuin\u016f nebo NAD-dependentn\u00ed redoxn\u00ed regulaci, <a href=\"https:\/\/medsbase.com\/cs\/nad\/\">NAD<sup>+<\/sup><\/a> je c\u00edlen\u011bj\u0161\u00ed slou\u010denina. Viz tak\u00e9 <a href=\"https:\/\/medsbase.com\/cs\/mots-c\/\">MOTS-c<\/a> pro v\u00fdzkum signalizace mitochondri\u00e1ln\u00edch peptid\u016f a <a href=\"https:\/\/medsbase.com\/cs\/ss-31-elamipretide\/\">SS-31 (Elamipretide)<\/a> pro v\u00fdzkum mitochondri\u00e1ln\u011b c\u00edlen\u00fdch l\u00e1tek v\u00e1zaj\u00edc\u00edch se na kardiolipin.<\/p>\n<div style=\"background: #f4f8fb; border-left: 4px solid #2c7cb0; padding: 14px 18px; margin: 18px 0;\"><strong class=\"mb-bac-water-callout\">\ud83d\udca7 Pot\u0159ebujete BAC vodu?<\/strong> Rekonstituce jak\u00e9hokoli lyofilizovan\u00e9ho vialu vy\u017eaduje steriln\u00ed bakteriostatickou vodu. Sp\u00e1rujte tento produkt s na\u0161\u00edm <a href=\"\/cs\/bac-water\/\"><strong>BAC Water (Bakteriostatick\u00e1 voda)<\/strong><\/a> \u2014 30 mL multid\u00e1vkov\u00fdm vialem, 0,9% benzylalkoholem konzervovan\u00fdm, USP-grade.<\/div>\n<h2>Skladov\u00e1n\u00ed a rekonstituce<\/h2>\n<p><strong>P\u0159ed rekonstituci:<\/strong> lyofilizovan\u00e9 lahvi\u010dky skladujte v chladni\u010dce p\u0159i 2\u20138 \u00b0C v p\u016fvodn\u00edm obalu pro kr\u00e1tkodob\u00e9 pracovn\u00ed z\u00e1soby. Pro dlouhodob\u00e9 skladov\u00e1n\u00ed zmrazte neotev\u0159en\u00e9 lahvi\u010dky p\u0159i \u221220 \u00b0C (stabilita \u226536 m\u011bs\u00edc\u016f p\u0159i \u221220 \u00b0C; \u226512 m\u011bs\u00edc\u016f p\u0159i 2\u20138 \u00b0C). Lyofilizovan\u00e9 5-Amino-1MQ je v\u00fdrazn\u011b stabiln\u011bj\u0161\u00ed ne\u017e v\u011bt\u0161ina lyofilizovan\u00fdch peptid\u016f, proto\u017ee mal\u00e1 molekula chinolinium-soli nem\u00e1 \u017e\u00e1dn\u00e9 amidov\u00e9 vazby ani disulfidov\u00e9 m\u016fstky, kter\u00e9 by mohly hydrolyzovat. Chra\u0148te p\u0159ed dlouhodob\u00fdm vystaven\u00edm p\u0159\u00edm\u00e9mu sv\u011btlu.<\/p>\n<p><strong>Postup rekonstituce:<\/strong> injektujte bakteriostatickou vodu, steriln\u00ed vodu nebo steriln\u00ed PBS po bo\u010dn\u00ed st\u011bn\u011b lahvi\u010dky (ne p\u0159\u00edmo na lyofilizovan\u00fd kol\u00e1\u010d). Pro lahvi\u010dku 5 mg poskytne 1,0 ml \u0159edidla pracovn\u00ed koncentraci 5 mg\/ml; 0,5 ml poskytne 10 mg\/ml. Pro lahvi\u010dku 10 mg poskytne 1,0 ml 10 mg\/ml; 2,0 ml poskytne 5 mg\/ml. Pro lahvi\u010dku 50 mg poskytne 1,0 ml 50 mg\/ml (praktick\u00fd limit rozpustnosti ve vodn\u00e9m pufru); 5,0 ml poskytne \u0159id\u0161\u00ed pracovn\u00ed z\u00e1sobu 10 mg\/ml. 5-Amino-1MQ se rozpou\u0161t\u00ed velmi rychle p\u0159i jemn\u00e9m krou\u017een\u00ed \u2014 obvykle do 10\u201330 sekund \u2014 proto\u017ee kvart\u00e9rn\u00ed amonn\u00e1 s\u016fl je vysoce hydrofiln\u00ed a nem\u00e1 \u017e\u00e1dnou slo\u017eenou strukturu, kter\u00e1 by se naru\u0161ila. Pro pr\u00e1ci s bun\u011b\u010dn\u00fdmi kulturami in vitro je tak\u00e9 vhodn\u00fdm rozpou\u0161t\u011bdlem pro rekonstituci DMSO (z\u00e1soba a\u017e 100 mM); pracovn\u00ed roztoky na\u0159e\u010fte do vodn\u00fdch m\u00e9di\u00ed t\u011bsn\u011b p\u0159ed pou\u017eit\u00edm. Po rekonstituci ve vodn\u00e9m pufru skladujte lahvi\u010dku p\u0159i 2\u20138 \u00b0C a pou\u017eijte do 30 dn\u016f. Chra\u0148te p\u0159ed sv\u011btlem. Zlikvidujte, pokud se objev\u00ed z\u00e1kal, \u010d\u00e1stice nebo v\u00fdrazn\u00e1 zm\u011bna barvy.<\/p>\n<h2>\u010casto kladen\u00e9 dotazy<\/h2>\n<h3>Je 5-Amino-1MQ peptid?<\/h3>\n<p>Ne. 5-Amino-1MQ je mal\u00e1 molekula chinoliniumov\u00e9ho kvart\u00e9rn\u00edho amonn\u00e9 soli (MW 286,11 g\/mol jako jodid), <em>ne<\/em> peptid. M\u00e1me jej v na\u0161em katalogu v\u00fdzkumn\u00fdch peptid\u016f vedle <a href=\"https:\/\/medsbase.com\/cs\/nad\/\">NAD<sup>+<\/sup><\/a> a <a href=\"https:\/\/medsbase.com\/cs\/l-carnitine\/\">L-Karnitin<\/a> proto\u017ee pln\u00ed dopl\u0148kovou roli ve v\u00fdzkumu mitochondri\u00ed\/metabolismu\/NAD osy a je dod\u00e1v\u00e1n ve stejn\u00e9m lyofilizovan\u00e9m form\u00e1tu v lahvi\u010dce. V tabulce specifikac\u00ed je \u0159\u00e1dek Sekvence ozna\u010den jako \u201cn\/a\u201d z tohoto d\u016fvodu.<\/p>\n<h3>Co vlastn\u011b inhibice NNMT d\u011bl\u00e1 v bu\u0148k\u00e1ch?<\/h3>\n<p>NNMT (nikotinamid N-methyltransfer\u00e1za) spot\u0159ebov\u00e1v\u00e1 jak nikotinamid (prekurzor NAD<sup>+<\/sup>) tak S-adenosyl-L-methionin (SAM, univerz\u00e1ln\u00ed donor methylu) za vzniku 1-methylnikotinamidu (1-MNA) a S-adenosylhomocysteinu (SAH). Kdy\u017e je NNMT inhibov\u00e1n 5-Amino-1MQ, oba substr\u00e1ty jsou u\u0161et\u0159eny: dostupnost prekurzor\u016f intracelul\u00e1rn\u00edho NAD<sup>+<\/sup> se zvy\u0161uje (proto\u017ee nikotinamid je nyn\u00ed voln\u00fd pro z\u00e1chranu p\u0159es NAMPT-NMNAT do NMN a NAD<sup>+<\/sup>) a intracelul\u00e1rn\u00ed SAM stoup\u00e1, zat\u00edmco SAH kles\u00e1 (zvy\u0161uje se bun\u011b\u010dn\u00fd methyla\u010dn\u00ed potenci\u00e1l \u2013 pom\u011br SAM:SAH). Tyto dva biochemick\u00e9 prim\u00e1rn\u00ed efekty se p\u0159en\u00e1\u0161ej\u00ed do bun\u011b\u010dn\u00fdch fenotyp\u016f dokumentovan\u00fdch v publikovan\u00e9m v\u00fdzkumu: sn\u00ed\u017een\u00e1 lipogeneze adipocyt\u016f, zrychlen\u00e1 oprava svalov\u00fdch kmenov\u00fdch bun\u011bk a sn\u00ed\u017een\u00e1 podp\u016frn\u00e1 metabolick\u00e1 aktivita n\u00e1dorov\u00e9ho stromatu u rakoviny.<\/p>\n<h3>Jak se 5-Amino-1MQ li\u0161\u00ed od NMN, NR nebo nikotinamidu?<\/h3>\n<p>NMN, NR a nikotinamid jsou v\u0161echny prekurzory NAD<sup>+<\/sup>-prekurzorov\u00e9 slou\u010deniny \u2014 zvy\u0161uj\u00ed hladinu NAD<sup>+<\/sup> pool shora dod\u00e1vkou z\u00e1chraniteln\u00fdch prekurzor\u016f. 5-Amino-1MQ d\u011bl\u00e1 opak: blokuje termin\u00e1ln\u00ed spot\u0159ebu nikotinamidu NNMT, \u010d\u00edm\u017e \u0161et\u0159\u00ed prekurzorov\u00fd pool zdola. Mechanicky jsou tyto dva p\u0159\u00edstupy komplement\u00e1rn\u00ed \u2013 publikovan\u00fd kombinovan\u00fd v\u00fdzkum zkoumal, zda spole\u010dn\u00e1 administrace prekurzoru (NMN nebo NR) se \u0161et\u0159\u00edc\u00edm \u010dinidlem (5-Amino-1MQ) vytv\u00e1\u0159\u00ed aditivn\u00ed nebo superaditivn\u00ed efekt na hladiny NAD<sup>+<\/sup> ve srovn\u00e1n\u00ed s ka\u017edou intervenc\u00ed samostatn\u011b.<\/p>\n<h3>Jak\u00e9 d\u00e1vkov\u00e9 rozsahy byly pou\u017eity ve v\u00fdzkumu na my\u0161\u00edch?<\/h3>\n<p>Nej\u010dast\u011bji citovan\u00e1 d\u00e1vka v protokolech pro my\u0161i je 20 mg\/kg\/den u studi\u00ed dietou indukovan\u00e9 obezity (4\u20138 t\u00fddn\u016f denn\u00ed intraperitone\u00e1ln\u00ed nebo or\u00e1ln\u00ed aplikace). V\u00fdzkum opravy sval\u016f po poran\u011bn\u00ed pou\u017e\u00edval 5\u201310 mg\/kg. V\u00fdzkum metast\u00e1z ovari\u00e1ln\u00edho karcinomu HeyA8 pou\u017eil a\u017e 60 mg\/kg\/den bez hl\u00e1\u0161en\u00fdch ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f v publikovan\u00fdch studi\u00edch. V\u00fdzkumn\u00edci by se m\u011bli obr\u00e1tit na prim\u00e1rn\u00ed literaturu (Neelakantan et al. 2017\u20132019, Sampath et al. 2018, n\u00e1sledn\u00e9 p\u0159ehledy NNMT dr\u00e1hy) pro druhov\u011b, modelov\u011b a endpointov\u011b specifick\u00e9 d\u00e1vkovac\u00ed doporu\u010den\u00ed.<\/p>\n<h3>Jak\u00e9 zp\u016fsoby pod\u00e1n\u00ed jsou pou\u017e\u00edv\u00e1ny v publikovan\u00e9m v\u00fdzkumu?<\/h3>\n<p>Intraperitone\u00e1ln\u00ed (IP) pod\u00e1n\u00ed u hlodavc\u016f je nej\u010dast\u011bj\u0161\u00ed cestou v publikovan\u00e9m in-vivo v\u00fdzkumu, proto\u017ee poskytuje spolehlivou syst\u00e9movou expozici a je vhodn\u00e9 pro opakovan\u00e9 denn\u00ed d\u00e1vkov\u00e1n\u00ed. Or\u00e1ln\u00ed pod\u00e1n\u00ed (sondou nebo v pitn\u00e9 vod\u011b) bylo tak\u00e9 pou\u017eito v chronick\u00fdch d\u00e1vkovac\u00edch protokolech. Subkut\u00e1nn\u00ed a intraven\u00f3zn\u00ed cesty jsou m\u00e9n\u011b \u010dast\u00e9, ale jsou dokumentov\u00e1ny. Pro in-vitro pr\u00e1ci je slou\u010denina p\u0159id\u00e1v\u00e1na p\u0159\u00edmo do kultiva\u010dn\u00edho m\u00e9dia v mikromol\u00e1rn\u00edch koncentrac\u00edch.<\/p>\n<h3>Lze 5-Amino-1MQ kombinovat s NAD<sup>+<\/sup>, MOTS-c, nebo SS-31 ve v\u00fdzkumn\u00fdch protokolech?<\/h3>\n<p>Ano \u2014 tyto \u010dty\u0159i slou\u010deniny c\u00edl\u00ed na r\u016fzn\u00e9 vrstvy mitochondri\u00e1ln\u00ed a NAD-osov\u00e9 biologie a b\u011b\u017en\u011b se kombinuj\u00ed ve v\u00fdzkumu zam\u011b\u0159en\u00e9m na rozli\u0161en\u00ed p\u0159\u00edsp\u011bvk\u016f upstream-substr\u00e1tu vs. downstream-elektronov\u00e9ho toku vs. kardiolipinu \/ struktury vnit\u0159n\u00ed membr\u00e1ny k mitochondri\u00e1ln\u00edmu v\u00fdkonu. Jsou chemicky stabiln\u00ed spole\u010dn\u011b v roztoku. Ka\u017edou rekonstituujte zvl\u00e1\u0161\u0165, abyste zajistili stabilitu a p\u0159esnost koncentrace, a pot\u00e9 je t\u011bsn\u011b p\u0159ed pou\u017eit\u00edm sm\u00edchejte, m\u00edsto abyste rekonstituovan\u00e9 lahvi\u010dky skladovali spole\u010dn\u011b. Nejstudovan\u011bj\u0161\u00ed kombinac\u00ed v publikovan\u00e9 literatu\u0159e je 5-Amino-1MQ s<sup>+<\/sup> prekurzory (NMN nebo NR), jak je pops\u00e1no v\u00fd\u0161e; kombinace s peptidov\u00fdmi slou\u010deninami jsou m\u00e9n\u011b publikovan\u00e9, ale mechanisticky racion\u00e1ln\u00ed.<\/p>\n<h3>Pro\u010d nen\u00ed 5-Amino-1MQ FDA-approved?<\/h3>\n<p>5-Amino-1MQ je relativn\u011b nov\u00e1 v\u00fdzkumn\u00e1 slou\u010denina (selektivita k vazebn\u00e9mu m\u00edstu substr\u00e1tu byla poprv\u00e9 publikov\u00e1na Neelakantanem et al. v roce 2017) a dosud nepostoupila do klinick\u00e9ho v\u00fdvoje na lidech. Oblast inhibitor\u016f NNMT je aktivn\u00ed v ran\u00e9 f\u00e1zi objevov\u00e1n\u00ed l\u00e9\u010div \u2013 n\u011bkolik skafold\u016f inhibitor\u016f NNMT druh\u00e9 generace je v preklinick\u00e9m v\u00fdvoji \u2013 av\u0161ak \u017e\u00e1dn\u00e1 slou\u010denina z t\u00e9to t\u0159\u00eddy zat\u00edm nedokon\u010dila klinick\u00e9 studie na lidech. 5-Amino-1MQ z\u016fst\u00e1v\u00e1 nejpublikovan\u011bj\u0161\u00edm referen\u010dn\u00edm n\u00e1strojem pro selektivn\u00ed inhibici NNMT v laboratorn\u00edm v\u00fdzkumu.<\/p>\n<h3>Jak se selektivita 5-Amino-1MQ srovn\u00e1v\u00e1 se \u0161irokospektr\u00fdmi inhibitory methyltransfer\u00e1z?<\/h3>\n<p>5-Amino-1MQ je inhibitor c\u00edlen\u00fd na vazebn\u00e9 m\u00edsto substr\u00e1tu \u2014 v\u00e1\u017ee se do vazebn\u00e9 kapsy pro nikotinamidov\u00fd substr\u00e1t NNMT a nezasahuje do vazebn\u00e9 kapsy pro kofaktor SAM. To je mechanisticky odli\u0161n\u00e9 od inhibitor\u016f methyltransfer\u00e1z kompetitivn\u00edch se SAM (jako jsou sinefungin nebo analogy methylthioadenosine), kter\u00e9 c\u00edl\u00ed na kofaktorovou kapsu, a proto inhibuj\u00ed \u0161irok\u00e9 spektrum methyltransfer\u00e1z. P\u0159\u00edstup c\u00edlen\u00fd na vazebn\u00e9 m\u00edsto substr\u00e1tu poskytuje 5-Amino-1MQ selektivitu v\u016f\u010di GNMT, PNMT, COMT a dal\u0161\u00edm enzym\u016fm z\u00e1visl\u00fdm na SAM, a pr\u00e1v\u011b to jej \u010din\u00ed u\u017eite\u010dn\u00fdm jako n\u00e1stroj pro zkoum\u00e1n\u00ed biologie specifick\u00e9 pro NNMT sp\u00ed\u0161e ne\u017e jako pan-methyltransfer\u00e1zov\u00fd inhibitor.<\/p>\n<div class=\"medsbase-trust-strip\" style=\"background: #f4f8fb; border: 1px solid #d8e3eb; padding: 12px 16px; margin: 20px 0 8px; border-radius: 4px; font-size: 14px;\"><strong>Pro\u010d objedn\u00e1vat v\u00fdzkumn\u00e9 slou\u010deniny od MedsBase:<\/strong> Lyofilizovan\u00e9 peptidy a slou\u010deniny HPLC \u226599% \u00b7 COA dostupn\u00e9 na vy\u017e\u00e1d\u00e1n\u00ed \u00b7 Diskr\u00e9tn\u00ed teplotn\u011b stabiln\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 p\u0159eprava \u00b7 <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance<\/a> na ka\u017edou objedn\u00e1vku \u00b7 1,400+ ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Dal\u0161\u00ed v\u00fdzkumn\u00e9 slou\u010deniny pro v\u00fdzkum NAD osy a metabolismu<\/h2>\n<ul>\n<li><a href=\"\/cs\/nad\/\"><strong>NAD\u207a<\/strong><\/a> \u2014 Oxidovan\u00fd dinukleotidov\u00fd koenzym \u2014 p\u0159\u00edm\u00fd v\u00fdzkum dopl\u0148ov\u00e1n\u00ed NAD poolu<\/li>\n<li><a href=\"\/cs\/mots-c\/\"><strong>MOTS-c<\/strong><\/a> \u2014 Mitochondri\u00e1ln\u00ed peptid \u2014 v\u00fdzkum metabolismu a inzulinov\u00e9 senzitivity<\/li>\n<li><a href=\"\/cs\/ss-31-elamipretide\/\"><strong>SS-31 (Elamipretide)<\/strong><\/a> \u2014 Peptid v\u00e1zaj\u00edc\u00ed kardiolipin s mitochondri\u00e1ln\u00edm c\u00edlen\u00edm<\/li>\n<li><a href=\"\/cs\/epitalon\/\"><strong>Epitalon<\/strong><\/a> \u2014 Tetrapeptidov\u00fd bioregul\u00e1tor pine\u00e1ln\u00ed osy \u2014 v\u00fdzkum telomer\u00e1zy \/ dlouhov\u011bkosti<\/li>\n<li><a href=\"\/cs\/l-carnitine\/\"><strong>L-Karnitin<\/strong><\/a> \u2014 Mitochondri\u00e1ln\u00ed transport\u00e9r dlouh\u00fdch mastn\u00fdch kyselin \u2014 doprovodn\u00e1 mal\u00e1 molekula<\/li>\n<li><a href=\"\/cs\/bac-water\/\"><strong>BAC Water (Bakteriostatick\u00e1 voda)<\/strong><\/a> \u2014 Nezbytn\u00e9 pro rekonstituci jak\u00e9hokoli lyofilizovan\u00e9ho vialu \u2014 steriln\u00ed \u0159edidlo s 0,9% konzervantem benzylalkoholu<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Selektivn\u00ed malomolekul\u00e1rn\u00ed inhibitor NNMT (nikotinamid N-methyltransfer\u00e1zy)<br \/>\n\u2705 C\u00edleno na vazebn\u00e9 m\u00edsto substr\u00e1tu; IC\u2085\u2080 1,2 \u00b5M; neovliv\u0148uje GNMT\/PNMT\/COMT\/NAMPT\/NMNAT<br \/>\n\u2705 Zvy\u0161uje intracelul\u00e1rn\u00ed hladiny NAD\u207a a SAM \u0161et\u0159en\u00edm spot\u0159eby prekurzor\u016f<br \/>\n\u2705 Sni\u017euje lipogenezi v adipocytech 3T3-L1; publikovan\u00e1 \u00fa\u010dinnost v modelech my\u0161\u00ed s dietou indukovanou obezitou<br \/>\n\u2705 Malomolekul\u00e1rn\u00ed v\u00fdzkumn\u00e1 slou\u010denina \u2014 nikoli peptid (MW 286,11, CAS 42464-96-0)<\/p>\n<p><strong>5-Amino-1MQ<\/strong> obsahuje v\u00fdzkumnou slou\u010deninu 5-amino-1-methylquinolinium iodide.<\/p>","protected":false},"featured_media":71430,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[5426],"product_tag":[6479,6483,6484,6481,6480,6482],"class_list":{"0":"post-71421","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptides","7":"product_tag-5-amino-1mq","8":"product_tag-longevity-research","9":"product_tag-metabolic-research","10":"product_tag-nad-precursor-sparing","11":"product_tag-nnmt-inhibitor","12":"product_tag-research-compound","14":"first","15":"instock","16":"shipping-taxable","17":"purchasable","18":"product-type-variable","19":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/71421","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=71421"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/71430"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=71421"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=71421"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=71421"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=71421"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}