{"id":71477,"date":"2026-05-20T10:00:00","date_gmt":"2026-05-20T10:00:00","guid":{"rendered":"https:\/\/medsbase.com\/hexarelin-acetate\/"},"modified":"2026-05-21T07:14:09","modified_gmt":"2026-05-21T07:14:09","slug":"hexarelin-acetate","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/hexarelin-acetate\/","title":{"rendered":"Hexarelin Acet\u00e1t (Examorelin)"},"content":{"rendered":"

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Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Hexarelin Acet\u00e1t?<\/h3>\n

Hexarelin Acetate<\/strong> (tak\u00e9 naz\u00fdvan\u00fd Examorelin<\/strong>) je syntetick\u00fd 6-aminokyselinov\u00fd sekretagog r\u016fstov\u00e9ho hormonu (GHS)<\/strong>: His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2<\/sub>, s bioaktivn\u00ed protijonovou sol\u00ed acet\u00e1tu. CAS 140703-51-1 (voln\u00fd peptid) \/ 171263-26-6 (acet\u00e1tov\u00e1 s\u016fl). MW 887,04 voln\u00fd \/ 947,07 g\/mol jako acet\u00e1t. Nejsiln\u011bj\u0161\u00ed mimikum ghrelinu v rodin\u011b GHRP-2 \/ GHRP-6 \/ Ipamorelin \u2014 siln\u011b aktivuje GHSR-1a na somatotrofech hypof\u00fdzy a na kardiomyocytech (ty druh\u00e9 p\u0159es receptor CD36 pro kardioprotektivn\u00ed \u00fa\u010dinky nez\u00e1visl\u00e9 na uvol\u0148ov\u00e1n\u00ed GH). Vyvol\u00e1v\u00e1 siln\u00e9 pulzn\u00ed uvol\u0148ov\u00e1n\u00ed GH bez akutn\u00edho zv\u00fd\u0161en\u00ed hladu, ale s prok\u00e1zan\u00fdm zv\u00fd\u0161en\u00edm kortizolu a prolaktinu p\u0159i vy\u0161\u0161\u00edch d\u00e1vk\u00e1ch. Pouze pro laboratorn\u00ed v\u00fdzkum. Syntetick\u00fd peptid \u2014 nikoli p\u0159\u00edrodn\u00ed ghrelin.<\/em><\/p>\n<\/div>\n

Co z\u00edsk\u00e1te s MedsBase:<\/strong> Lyofilizovan\u00fd Hexarelin Acet\u00e1t \u226599% HPLC-verifikovan\u00fd \u00b7 COA dostupn\u00fd na vy\u017e\u00e1d\u00e1n\u00ed \u00b7 Diskr\u00e9tn\u00ed teplotn\u011b stabiln\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 kur\u00fdrn\u00ed slu\u017eba pro v\u00fdzkumn\u00e9 pot\u0159eby \u00b7 1 400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Specifikace<\/th>\nDetail<\/th>\n<\/tr>\n<\/thead>\n
T\u0159\u00edda slou\u010denin<\/strong><\/td>\nSyntetick\u00fd 6-aa peptidov\u00fd sekretagog r\u016fstov\u00e9ho hormonu (rodina GHRP); mimikum ghrelinu; acet\u00e1tov\u00e1 s\u016fl<\/td>\n<\/tr>\n
Chemick\u00fd n\u00e1zev<\/strong><\/td>\nHexarelin Acet\u00e1t (synonyma: Examorelin, EP-23905, MF6003)<\/td>\n<\/tr>\n
CAS \u010d\u00edslo<\/strong><\/td>\n140703-51-1 (voln\u00fd peptid); 171263-26-6 (acet\u00e1tov\u00e1 s\u016fl)<\/td>\n<\/tr>\n
item9<\/strong><\/td>\nL-His-D-2-methyl-Trp-L-Ala-L-Trp-D-Phe-L-Lys-NH2<\/sub> (6 aminokyselin; D-2-Me-Trp na pozici 2 a D-Phe na pozici 5 zaji\u0161\u0165uj\u00ed proteolytickou stabilitu a selektivitu v\u016f\u010di receptoru; C-termin\u00e1ln\u00ed amid)<\/td>\n<\/tr>\n
Molekul\u00e1rn\u00ed vzorec \/ MW<\/strong><\/td>\nC47<\/sub>H58<\/sub>N12<\/sub>O6<\/sub> (voln\u00fd peptid, MW 887,04 g\/mol); + C2<\/sub>H4<\/sub>O2<\/sub> protijon acet\u00e1tu (acet\u00e1tov\u00e1 s\u016fl, MW 947,07 g\/mol)<\/td>\n<\/tr>\n
Mechanismus \u00fa\u010dinku<\/strong><\/td>\nDvojit\u00e1 receptorov\u00e1 farmakologie. (1) Prim\u00e1rn\u00ed: agonista GHSR-1a<\/strong> (receptoru pro sekretagog r\u016fstov\u00e9ho hormonu typ 1a, receptor ghrelinu) na somatotrofn\u00edch bu\u0148k\u00e1ch hypof\u00fdzy \u2013 vyvol\u00e1v\u00e1 siln\u00e9 pulzn\u00ed uvol\u0148ov\u00e1n\u00ed GH p\u0159es signalizaci Gq-PLC-IP3<\/sub>-Ca2+<\/sup> ; tak\u00e9 p\u016fsob\u00ed na GHSR v neuronech j\u00e1dra arcuatus. (2) Sekund\u00e1rn\u00ed: v\u00e1\u017ee se na CD36<\/strong> (scavenger receptor) na kardiomyocytech, c\u00e9vn\u00edm endotelu a makrof\u00e1z\u00edch \u2013 vykazuje kardioprotektivn\u00ed \u00fa\u010dinky v modelech isch\u00e9mie-reperf\u00faze nez\u00e1visle<\/em> na uvol\u0148ov\u00e1n\u00ed GH. Tento dvojit\u00fd mechanismus je u Hexarelinu unik\u00e1tn\u00ed v r\u00e1mci rodiny GHRP.<\/td>\n<\/tr>\n
Potence ve srovn\u00e1n\u00ed s rodinou<\/strong><\/td>\nNejsiln\u011bj\u0161\u00ed peptid uvol\u0148uj\u00edc\u00ed r\u016fstov\u00fd hormon v rodin\u011b GHRP-2 \/ GHRP-6 \/ Hexarelin \/ Ipamorelin na z\u00e1klad\u011b hmotnosti v mg \u2014 ale s odpov\u00eddaj\u00edc\u00edm zv\u00fd\u0161en\u00edm kortizolu a prolaktinu p\u0159i vy\u0161\u0161\u00edch d\u00e1vk\u00e1ch (na rozd\u00edl od Ipamorelin<\/a>, kter\u00fd zp\u016fsobuje pouze \u010dist\u00e9 uvoln\u011bn\u00ed r\u016fstov\u00e9ho hormonu).<\/td>\n<\/tr>\n
item11<\/strong><\/td>\nLyofilizovan\u00fd b\u00edl\u00fd a\u017e sv\u011btle \u017elut\u00fd pr\u00e1\u0161ek; jednor\u00e1zov\u00e9 v\u00fdzkumn\u00e9 lahvi\u010dky<\/td>\n<\/tr>\n
item13<\/strong><\/td>\n\u226599% (HPLC ov\u011b\u0159eno, COA na vy\u017e\u00e1d\u00e1n\u00ed)<\/td>\n<\/tr>\n
Skladov\u00e1n\u00ed<\/strong><\/td>\nLyofilizovan\u00fd: kr\u00e1tkodob\u011b 2\u20138 \u00b0C; dlouhodob\u011b \u221220 \u00b0C (\u226536 m\u011bs\u00edc\u016f). Rekonstituovan\u00fd: 2\u20138 \u00b0C, pou\u017e\u00edt do 30 dn\u016f. Vyvarujte se opakovan\u00e9ho zmrazov\u00e1n\u00ed a rozmrazov\u00e1n\u00ed.<\/td>\n<\/tr>\n
Pouze pro v\u00fdzkum<\/strong><\/td>\nPouze pro laboratorn\u00ed v\u00fdzkum. Nepou\u017e\u00edvat pro hum\u00e1nn\u00ed nebo veterin\u00e1rn\u00ed diagnostick\u00e9 \u010di terapeutick\u00e9 \u00fa\u010dely. Hexarelin \/ Examorelin je na seznamu zak\u00e1zan\u00fdch l\u00e1tek WADA (t\u0159\u00edda S2, peptidov\u00e9 hormony a r\u016fstov\u00e9 faktory) a je zak\u00e1z\u00e1n za v\u0161ech okolnost\u00ed v atletick\u00fdch sout\u011b\u017e\u00edch.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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Mechanismus \u00fa\u010dinku \u2014 dvoj\u00ed farmakologie GHSR-1a + CD36<\/h2>\n

Hexarelin je mezi rodinou GHRP unik\u00e1tn\u00ed t\u00edm, \u017ee m\u00e1 dob\u0159e zdokumentovanou aktivitu u dvou mechanisticky odli\u0161n\u00fdch receptor\u016f:<\/p>\n