{"id":71500,"date":"2026-05-20T10:25:00","date_gmt":"2026-05-20T10:25:00","guid":{"rendered":"https:\/\/medsbase.com\/thymosin-alpha-1\/"},"modified":"2026-05-21T07:14:09","modified_gmt":"2026-05-21T07:14:09","slug":"thymosin-alpha-1","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/thymosin-alpha-1\/","title":{"rendered":"Thymosin Alfa-1 (T\u03b11 \/ Thymalfasin)"},"content":{"rendered":"

<\/p>\n

\n

Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Thymosin Alpha-1?<\/h3>\n

Thymosin Alpha-1<\/strong> (T\u03b11; klinicky Thymalfasin \/ Zadaxin<\/strong>) je syntetick\u00fd peptid o 28 aminokyselin\u00e1ch (CAS 62304-98-7 voln\u00e1 forma, 62304-94-3 acet\u00e1t; MW 3 108,3 g\/mol) odpov\u00eddaj\u00edc\u00ed N-termin\u00e1ln\u00edm 28 zbytk\u016fm p\u0159irozen\u00e9ho prekurzoru prothymosinu odvozen\u00e9ho z brzl\u00edku. Sekvence: Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH. Mechanismus: aktivuje TLR9 a TLR2<\/strong> na dendritick\u00fdch bu\u0148k\u00e1ch a makrof\u00e1z\u00edch, podporuje Th1-polarizovan\u00e9 zr\u00e1n\u00ed T-lymfocyt\u016f, zvy\u0161uje proliferaci CD4+ a CD8+ T-lymfocyt\u016f a zvy\u0161uje produkci cytokin\u016f IFN-\u03b3 \/ IL-2. Klinicky schv\u00e1len ve v\u00edce ne\u017e 35 zem\u00edch (pod zna\u010dkou Zadaxin) pro chronickou hepatitidu B a C a pou\u017e\u00edv\u00e1n jako imunostimula\u010dn\u00ed adjuvant v onkologick\u00e9m v\u00fdzkumu. Pouze pro laboratorn\u00ed v\u00fdzkum. Definovan\u00fd jednosekven\u010dn\u00ed peptid o 28 aminokyselin\u00e1ch<\/em> \u2014 odli\u0161n\u00fd od v\u00edceslo\u017ekov\u00e9 Thymalin<\/a> polypeptidov\u00e9 p\u0159\u00edpravy.<\/p>\n<\/div>\n

Co z\u00edsk\u00e1te s MedsBase:<\/strong> Lyofilizovan\u00fd \u226599% HPLC-verifikovan\u00fd Thymosin Alpha-1 acet\u00e1t \u00b7 COA dostupn\u00fd na vy\u017e\u00e1d\u00e1n\u00ed \u00b7 Diskr\u00e9tn\u00ed teplotn\u011b stabiln\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 kur\u00fdrn\u00ed doprava pro v\u00fdzkumn\u00e9 \u00fa\u010dely \u00b7 1 400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Specifikace<\/th>\nDetail<\/th>\n<\/tr>\n<\/thead>\n
T\u0159\u00edda slou\u010denin<\/strong><\/td>\nSyntetick\u00fd imunomodula\u010dn\u00ed peptid o 28 aminokyselin\u00e1ch (N-termin\u00e1ln\u00ed fragment prothymosinu \u03b1); agonista TLR9\/TLR2; definovan\u00fd jednosekven\u010dn\u00ed thymick\u00fd peptid<\/td>\n<\/tr>\n
Chemick\u00fd n\u00e1zev<\/strong><\/td>\nThymosin Alpha-1 (synonyma: T\u03b11, Thymalfasin, Zadaxin)<\/td>\n<\/tr>\n
CAS \u010d\u00edslo<\/strong><\/td>\n62304-98-7 (voln\u00fd peptid); 62304-94-3 (acet\u00e1tov\u00e1 s\u016fl)<\/td>\n<\/tr>\n
item9<\/strong><\/td>\nAc-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH (28 aminokyselin; N-termin\u00e1ln\u00ed acetylace; odpov\u00edd\u00e1 zbytk\u016fm 2\u201329 prothymosinu \u03b1)<\/td>\n<\/tr>\n
item7<\/strong><\/td>\n3 108,3 g\/mol<\/td>\n<\/tr>\n
item2<\/strong><\/td>\nC129<\/sub>H215<\/sub>N33<\/sub>O55<\/sub>; MW 3108,32 g\/mol (28-aa N-termin\u00e1ln\u011b acetylovan\u00fd peptid, voln\u00e1 kyselina C-terminus).<\/td>\n<\/tr>\n
Mechanismus \u00fa\u010dinku<\/strong><\/td>\nAktivuje TLR9<\/strong> (toll-like receptor 9) na dendritick\u00fdch bu\u0148k\u00e1ch a plazmacytoidn\u00edch DC, s n\u00e1sledn\u00fdm TLR2<\/strong> zapojen\u00edm. N\u00e1sledn\u00e9 efekty: signaliza\u010dn\u00ed kask\u00e1da MyD88-IRAK-NF-\u03baB; polarizace T-bun\u011bk sm\u011brem k Th1; zv\u00fd\u0161en\u00e1 proliferace CD4+ \/ CD8+ T-bun\u011bk; zv\u00fd\u0161en\u00e1 produkce IFN-\u03b3 a IL-2; aktivovan\u00e1 cytotoxicita NK bun\u011bk; modulace rovnov\u00e1hy regula\u010dn\u00edch T-bun\u011bk (Treg). Celkov\u00fd efekt je \u0161irok\u00e1 imunitn\u00ed restaurace \/ pos\u00edlen\u00ed Th1 odpov\u011bdi.<\/td>\n<\/tr>\n
Forma \/ \u010cistota \/ Skladov\u00e1n\u00ed<\/strong><\/td>\nLyofilizovan\u00fd b\u00edl\u00fd a\u017e sv\u011btle \u017elut\u00fd pr\u00e1\u0161ek, \u226599% HPLC. Skladov\u00e1n\u00ed kr\u00e1tkodob\u011b 2\u20138 \u00b0C, dlouhodob\u011b \u221220 \u00b0C. Rekonstituovan\u00fd roztok: 2\u20138 \u00b0C, pou\u017e\u00edt do 30 dn\u016f. Vyvarujte se opakovan\u00e9ho zmrazov\u00e1n\u00ed.<\/td>\n<\/tr>\n
Pouze pro v\u00fdzkum<\/strong><\/td>\nPouze pro laboratorn\u00ed v\u00fdzkum. Zadaxin (klinick\u00fd T\u03b11) je schv\u00e1len ve 35+ zem\u00edch pro chronickou HBV a HCV (nen\u00ed schv\u00e1len FDA v USA). Nen\u00ed na seznamu zak\u00e1zan\u00fdch l\u00e1tek WADA.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/p>\n

Mechanismus \u00fa\u010dinku \u2014 aktivace TLR9 \/ TLR2 + polarizace Th1<\/h2>\n

Thymosin Alpha-1 je p\u0159esn\u011b definovan\u00fd imunomodula\u010dn\u00ed peptid s detailn\u011b popsan\u00fdm mechanismem \u00fa\u010dinku v publikovan\u00fdch studi\u00edch:<\/p>\n