{"id":58603,"date":"2024-02-27T18:46:43","date_gmt":"2024-02-27T18:46:43","guid":{"rendered":"https:\/\/medsname.com\/olanzoop\/"},"modified":"2026-04-30T10:24:11","modified_gmt":"2026-04-30T10:24:11","slug":"olanzoop","status":"publish","type":"product","link":"https:\/\/medsbase.com\/da\/olanzoop\/","title":{"rendered":"Olanzoop"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div class=\"medsbase-tldr-answer\" style=\"background:#fff8d6;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">\u26a1 Hurtigt svar<\/h3>\n<p style=\"margin-bottom:0;\">Olanzoop (Olanzapine 5 \/ 10 mg) is an atypical antipsychotic for schizophrenia, bipolar mania and maintenance, treatment-resistant depression (with fluoxetine), and acute agitation. The most robust antipsychotic effect of the atypicals \u2014 but the heaviest metabolic burden.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Hvad du f\u00e5r med MedsBase:<\/strong> WHO-GMP certificeret producent \u00b7 Diskret emballage \u00b7 Verdensomsp\u00e6ndende forsendelse \u00b7 1.400+ verificerede <a href=\"https:\/\/medsbase.com\/da\/reviews\/\">kundeanmeldelser<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Hver ordre er d\u00e6kket af vores <a href=\"https:\/\/medsbase.com\/da\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 hvis din pakke ikke ankommer inden for 20 hverdage, sender vi en erstatning.<\/p>\n<h3>Hvorfor bestille fra MedsBase<\/h3>\n<p>Olanzoop at MedsBase is supplied directly from a WHO-GMP certified manufacturer in plain, discreet packaging. Every order is covered by our <a href=\"https:\/\/medsbase.com\/da\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance Policy<\/a> \u2014 20-hverdages leveringsvindue eller vi gensender uden ekstra omkostninger \u2014 og kvalificerer sig til vores <a href=\"https:\/\/medsbase.com\/da\/loyalty-points\/\">kundeloyalitetsprogram<\/a>. Verdensomsp\u00e6ndende forsendelse er tilg\u00e6ngelig til de fleste destinationer.<\/p>\n<h2>What Olanzoop is and how it works<\/h2>\n<p>Olanzoop is an olanzapine tablet supplied by Cipla. Available strengths: <strong>5 \/ 10 mg<\/strong>. Olanzapine is a thienobenzodiazepine atypical antipsychotic with strong D2 antagonism, strong 5-HT2A antagonism, and substantial H1 (sedation, weight gain), M1 (anticholinergic), and \u03b11 (orthostasis) blockade. The H1+M1 receptor profile is responsible both for its calming\/sedative effect (useful in acute agitation) and for its metabolic burden.<\/p>\n<h2>Indikationer og dosering<\/h2>\n<table>\n<thead>\n<tr>\n<th>Indikation<\/th>\n<th>Startdosis<\/th>\n<th>M\u00e5ldosis<\/th>\n<th>Maksimal dosis<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Skizofreni (voksen)<\/td>\n<td>5\u201310 mg \u00e9n gang dagligt<\/td>\n<td>10\u201320 mg \u00e9n gang dagligt<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>Skizofreni (ungdom \u2265 13 \u00e5r)<\/td>\n<td>2.5\u20135 mg OD<\/td>\n<td>10 mg \u00e9n gang dagligt<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>Bipolar mani (voksen)<\/td>\n<td>10\u201315 mg \u00e9n gang dagligt<\/td>\n<td>10\u201320 mg \u00e9n gang dagligt<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>Acute agitation (IM)<\/td>\n<td>10 mg IM<\/td>\n<td>\u2014<\/td>\n<td>3 doser\/24 timer<\/td>\n<\/tr>\n<tr>\n<td>Treatment-resistant depression (with fluoxetine)<\/td>\n<td>5 mg + 20 mg fluoxetine<\/td>\n<td>5\u201318 mg<\/td>\n<td>18 mg<\/td>\n<\/tr>\n<tr>\n<td>\u00c6ldre voksne<\/td>\n<td>2.5\u20135 mg OD<\/td>\n<td>5\u201310 mg \u00e9n gang dagligt<\/td>\n<td>efter tolerabilitet<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Vigtige sikkerhedsovervejelser<\/h2>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>FDA black-box \u2014 demensrelateret psykose<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Alle atypiske antipsykotika b\u00e6rer en FDA black-box advarsel om \u00f8get d\u00f8delighed (prim\u00e6rt kardiovaskul\u00e6r og infektionsrelateret) ved brug til behandling af adf\u00e6rdsforstyrrelser hos \u00e6ldre med demens. <strong>Atypiske antipsykotika er ikke godkendt til demensrelateret psykose eller agitation.<\/strong>. Brug i denne population er off-label, sidste udvej, tidsbegr\u00e6nset og kr\u00e6ver en eksplicit risici-fordel samtale.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Heaviest metabolic burden of the atypicals<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Olanzapine produces the most weight gain (typically 4\u201310 kg in the first 6 months, sometimes far more), the most insulin resistance, and the most lipid disturbance of any commonly-used antipsychotic. Patients can develop type 2 diabetes within months of initiation. <strong>Mandatory monitoring: weight at every visit; fasting glucose \/ HbA1c and fasting lipids at baseline, 12 weeks, then 6-monthly.<\/strong> Counsel about diet and exercise from initiation.<\/p>\n<\/div>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Sedation and anticholinergic burden<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Strong sedation in the first 1\u20132 weeks. Anticholinergic effects (dry mouth, constipation, urinary hesitancy) are universal. Both lessen but do not disappear.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Olanzapine + benzodiazepine IM \u2014 caution<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Combining IM olanzapine with parenteral benzodiazepines has produced cases of severe hypotension, respiratory depression, and death. If both are clinically necessary in acute agitation, separate by \u2265 1 hour and monitor closely.<\/p>\n<\/div>\n<h2>Almindelige bivirkninger<\/h2>\n<ul>\n<li><strong>V\u00e6gt\u00f8gning og metabolt syndrom<\/strong> \u2014 the dominant long-term concern.<\/li>\n<li><strong>Sedering<\/strong> \u2014 universal at initiation.<\/li>\n<li><strong>Ortostatisk hypotension<\/strong> \u2014 common at initiation; titrate slowly in older adults.<\/li>\n<li><strong>Antikolinerg<\/strong> \u2014 dry mouth, constipation, urinary hesitancy.<\/li>\n<li><strong>Akathisia, EPS<\/strong> \u2014 less common than risperidone, more common than aripiprazole.<\/li>\n<li><strong>Prolaktin<\/strong> \u2014 modest rise; less than risperidone.<\/li>\n<li><strong>Hepatic<\/strong> \u2014 transient AST\/ALT rises common.<\/li>\n<\/ul>\n<h2>L\u00e6gemiddelinteraktioner<\/h2>\n<ul>\n<li><strong>CYP1A2-h\u00e6mmere<\/strong> (fluvoxamine, ciprofloxacin) \u2014 raise olanzapine levels markedly.<\/li>\n<li><strong>Rygning<\/strong> \u2014 induces CYP1A2; smokers have lower levels and need higher doses; smoking cessation can produce toxicity.<\/li>\n<li><strong>Carbamazepin<\/strong> \u2014 strong CYP1A2 induction; raises olanzapine clearance.<\/li>\n<li><strong>CNS-depressiva<\/strong> \u2014 additiv sedering.<\/li>\n<li><strong>Antikolinergika<\/strong> \u2014 additiv belastning.<\/li>\n<\/ul>\n<h2>Graviditet, amning, p\u00e6diatrisk<\/h2>\n<p>Pregnancy: limited data; weigh against untreated illness; late-pregnancy exposure can produce neonatal EPS or withdrawal. Breastfeeding: passes into milk; usually requires alternative or close monitoring. Paediatric: licensed from 13 (schizophrenia, bipolar).<\/p>\n<h2>Opbevaring<\/h2>\n<p>Opbevares ved 15\u201330 \u00b0C i original emballage.<\/p>\n<h2 id=\"faqs\">Ofte stillede sp\u00f8rgsm\u00e5l<\/h2>\n<h3>Why does Olanzoop cause so much weight gain?<\/h3>\n<p>Olanzapine&rsquo;s combined H1 antihistamine, 5-HT2C antagonism, and other receptor effects produce strong appetite stimulation, slowed satiety, and shifted carbohydrate preference. Weight gain is dose-related but real even at low doses. Counselling about diet and exercise from week 1, plus regular weight monitoring, is mandatory.<\/p>\n<h3>How is Olanzoop different from risperidone or aripiprazole?<\/h3>\n<p>Olanzapine has the strongest acute antipsychotic effect and the fastest calming action \u2014 useful in acute agitation. The trade-off is the heaviest metabolic burden. Risperidone is more efficacious for some positive symptoms but raises prolactin substantially. Aripiprazole is metabolically cleanest but produces more akathisia.<\/p>\n<h3>Should I monitor my blood sugar on Olanzoop?<\/h3>\n<p>Yes \u2014 fasting glucose or HbA1c at baseline, 12 weeks, and then 6-monthly. Olanzapine can produce diabetes within months of initiation, sometimes presenting with diabetic ketoacidosis. Don&rsquo;t skip the monitoring.<\/p>\n<h3>Can Olanzoop be used long-term?<\/h3>\n<p>Yes \u2014 particularly for schizophrenia maintenance where olanzapine often outperforms other atypicals on relapse rate. The metabolic burden is the main reason long-term use requires careful weight, glucose, and lipid monitoring, plus active management of cardiometabolic risk.<\/p>\n<h3>How long until Olanzoop works?<\/h3>\n<p>Calming effect within 1\u20132 hours of the first oral dose. Antipsychotic effect builds over 1\u20132 weeks; full antipsychotic and mood-stabilising effect at 4\u20136 weeks.<\/p>\n<h3>What about driving on Olanzoop?<\/h3>\n<p>Avoid driving in the first 1\u20132 weeks of titration. Most patients on stable doses drive normally, but the sedation can be persistent at higher doses.<\/p>\n<h3>Is the orodispersible form different?<\/h3>\n<p>Yes \u2014 orodispersible (ODT) versions of olanzapine exist (Zyprexa Zydis, Olimelt) and dissolve on the tongue without water. Bioequivalent to standard tablets but useful in adherence-uncertain or dysphagia patients.<\/p>\n<h3>Can Olanzoop be combined with fluoxetine?<\/h3>\n<p>Yes \u2014 the olanzapine-fluoxetine combination (OFC, Symbyax) is FDA-approved for treatment-resistant depression and bipolar depression. The fluoxetine partly addresses olanzapine&rsquo;s lack of antidepressant effect; olanzapine adds a strong mood-stabilising component.<\/p>\n<h3>Why does smoking matter?<\/h3>\n<p>Smoking strongly induces CYP1A2, which is olanzapine&rsquo;s main metabolic enzyme. Smokers metabolise olanzapine faster and need higher doses; abrupt cessation of smoking (e.g. hospital admission) can produce olanzapine toxicity if the dose isn&rsquo;t adjusted. Tell the prescriber if smoking status changes.<\/p>\n<h3>Can Olanzoop be stopped abruptly?<\/h3>\n<p>Generally not \u2014 taper over 2\u20134 weeks. Abrupt cessation can produce cholinergic rebound (nausea, sweating, insomnia) and an antipsychotic relapse. Never stop without prescriber agreement.<\/p>\n<h2>Andre Mental Sundhedsmedicin<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/da\/aripicon\/\">Aripicon (Aripiprazol \u2014 D2-partiel agonist)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/olanzap\/\">Olanzap (Olanzapin \u2014 robust antipsykotikum)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/risdone\/\">Risdone (Risperidon)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/seroquit\/\">Seroquit (Quetiapine \u2014 bipolar depression)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/atlura\/\">Atlura (Lurasidone \u2014 metabolisk neutral)<\/a><\/li>\n<\/ul>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;font-size:0.9em;\">\n<strong>Medicinsk ansvarsfraskrivelse.<\/strong> Denne side er udelukkende til informationsform\u00e5l og er ikke erstatning for individuel l\u00e6gevejledning. Behandling med psykofarmaka b\u00f8r iv\u00e6rks\u00e6ttes, overv\u00e5ges og tilpasses af en kvalificeret kliniker. Hvis du eller nogen du kender er i akut selvmordskrise, skal du kontakte lokale akutteams eller ringe til din lands selvmordsforebyggende kriselinje (US\/Canada: 988; UK: Samaritans 116 123; international liste: <a href=\"https:\/\/findahelpline.com\/\" rel=\"nofollow noopener\" target=\"_blank\">findahelpline.com<\/a>).\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Olanzoop (Olanzapine 5\/10 mg) \u2014 thienobenzodiazepine atypical for schizophrenia and bipolar mania. mandatory weight, glucose and lipid monitoring.<\/p>","protected":false},"featured_media":58604,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3906],"product_tag":[4527,4528],"class_list":{"0":"post-58603","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-mental-health-and-psychiatric-medications","9":"product_tag-olanzapine","10":"product_tag-olanzoop","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product\/58603","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/comments?post=58603"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/media\/58604"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/media?parent=58603"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product_brand?post=58603"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product_cat?post=58603"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product_tag?post=58603"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}