{"id":58731,"date":"2024-02-28T05:25:22","date_gmt":"2024-02-28T05:25:22","guid":{"rendered":"https:\/\/medsname.com\/endace\/"},"modified":"2026-04-30T10:24:09","modified_gmt":"2026-04-30T10:24:09","slug":"endace","status":"publish","type":"product","link":"https:\/\/medsbase.com\/da\/endace\/","title":{"rendered":"Endace"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Endace?<\/h3>\n<p style=\"margin:0;\"><strong>Endace<\/strong> er en oral tablet fra Cipla, der indeholder <strong>megestrol acetate<\/strong> p\u00e5 <strong>40 mg and 160 mg<\/strong> &mdash; a synthetic progestin used as <strong>appetite stimulant<\/strong> in cancer cachexia and HIV-related anorexia, and as palliative endocrine therapy in advanced hormone-receptor-positive breast cancer and endometrial cancer. Standard appetite-stimulant dose: <strong>400&ndash;800 mg\/day<\/strong> (typically 800 mg\/day in cancer cachexia). Onset of appetite improvement at 1&ndash;2 weeks; weight gain (mostly fat, not muscle) at 4&ndash;6 weeks. <strong>Increased venous thromboembolism risk<\/strong> &mdash; caution in immobilised cancer patients; consider DVT prophylaxis. Other warnings: adrenal suppression with prolonged use (mineralocorticoid effect), hyperglycaemia, fluid retention.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Hvad du f\u00e5r med MedsBase:<\/strong> WHO-GMP certificeret producent \u00b7 Diskret emballage \u00b7 Verdensomsp\u00e6ndende forsendelse \u00b7 1.400+ verificerede <a href=\"https:\/\/medsbase.com\/da\/reviews\/\">kundeanmeldelser<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Hver ordre er d\u00e6kket af vores <a href=\"https:\/\/medsbase.com\/da\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 hvis din pakke ikke ankommer inden for 20 hverdage, sender vi en erstatning.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;\"><strong>\u26a0 Specialistvejledning p\u00e5kr\u00e6vet.<\/strong> Kr\u00e6ftmedicin skal ordineres af en behandlende onkolog med en bekr\u00e6ftet diagnose, baseline-stadieinddeling og en defineret behandlingsplan. Start, stop eller \u00e6ndr aldrig dosis eller brug kr\u00e6ftmedicin uden for en onkolog-ledet behandlingsplan. De fleste kr\u00e6ftl\u00e6gemidler kr\u00e6ver regelm\u00e6ssig blodpr\u00f8veoverv\u00e5gning (FBC, LFT, nyrefunktion), er absolut kontraindicerede under graviditet og har betydelige l\u00e6gemiddelinteraktioner.<\/div>\n<div style=\"background:#f4f8fb;border:1px solid #d6e4ec;padding:12px 18px;margin:14px 0;border-radius:4px;font-size:14px;color:#3a5160;text-align:center;\">\n<strong>\ud83d\udd12 Krypteret Checkout<\/strong> \u00b7 <strong>\ud83d\udcb3 Verificeret processor<\/strong> \u00b7 <strong>\ud83d\ude9a Verdensomsp\u00e6ndende forsendelse<\/strong> \u00b7 <strong>\u2b50 4,9\/5 fra 1.400+ kunder<\/strong>\n<\/div>\n<h2 class=\"wp-block-heading\">What Is Endace?<\/h2>\n<p>Endace is an oral tablet from Cipla containing <strong>megestrol acetate<\/strong> (40 mg and 160 mg). Megestrol is a synthetic progestin with potent appetite-stimulant effects. The dominant modern use is as supportive care for <strong>cancer cachexia<\/strong> &mdash; the involuntary weight loss that affects most patients with advanced cancer and significantly worsens quality of life and treatment tolerance. It also retains a niche role in palliative endocrine therapy for advanced hormone-receptor-positive breast and endometrial cancer.<\/p>\n<h2 class=\"wp-block-heading\">\u2014 det forst\u00e6rker den normale fysiologiske respons snarere end at udl\u00f8se en kunstigt.<\/h2>\n<ul>\n<li><strong>Cancer cachexia<\/strong> &mdash; appetite stimulation and weight gain<\/li>\n<li><strong>HIV-related anorexia and weight loss<\/strong> (less commonly used in 2026 with modern ART)<\/li>\n<li><strong>Palliative endocrine therapy in advanced HR+ breast cancer<\/strong> &mdash; later-line after AI and tamoxifen<\/li>\n<li><strong>Advanced endometrial cancer<\/strong> palliation<\/li>\n<li><strong>Off-label:<\/strong> hot flushes in patients who cannot use HRT<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Dosering og indtagelse<\/h2>\n<ul>\n<li><strong>Cancer cachexia \/ HIV anorexia:<\/strong> 400&ndash;800 mg\/day (often 800 mg\/day) of suspension or tablet equivalent<\/li>\n<li><strong>Breast cancer palliation:<\/strong> 160 mg\/day in divided doses<\/li>\n<li><strong>Endometrial cancer palliation:<\/strong> 80&ndash;320 mg\/day in divided doses<\/li>\n<\/ul>\n<ol>\n<li>Take with food to improve absorption and reduce nausea.<\/li>\n<li>Once daily or in divided doses depending on indication.<\/li>\n<li><strong>Obligatorisk overv\u00e5gning:<\/strong> baseline weight, blood glucose (megestrol commonly raises glucose); BP; signs of DVT; symptoms of adrenal suppression. Periodic FBC.<\/li>\n<li>For cachexia, expect appetite improvement at 1&ndash;2 weeks and weight gain at 4&ndash;6 weeks. Most weight gain is fat (not muscle), and adding nutritional support and resistance exercise where possible amplifies benefit.<\/li>\n<li><strong>Stop ikke pludseligt<\/strong> after prolonged use &mdash; risk of adrenal crisis from progestin-mediated adrenal suppression. Taper under specialist guidance.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Bivirkninger<\/h2>\n<p><strong>Almindelige:<\/strong> weight gain (the desired effect in cachexia), increased appetite, fluid retention, hyperglycaemia, breakthrough vaginal bleeding, mood changes, insomnia, sweating, hot flushes (paradoxically, in some patients).<\/p>\n<p><strong>Vigtigt:<\/strong><\/p>\n<ul>\n<li><strong>Venous thromboembolism (DVT, PE)<\/strong> &mdash; consider prophylactic anticoagulation in immobilised cancer patients<\/li>\n<li>Adrenal suppression with prolonged high-dose use<\/li>\n<li>New-onset diabetes or worsening glycaemic control<\/li>\n<li>Hypertension<\/li>\n<li>Cushingoid features at high doses<\/li>\n<li>Menstrual irregularities<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Advarsler<\/h2>\n<ul>\n<li><strong>Graviditet:<\/strong> contraindicated. Reliable contraception throughout treatment.<\/li>\n<li><strong>Amning:<\/strong> undg\u00e5.<\/li>\n<li><strong>Active VTE or recent thrombosis:<\/strong> avoid; alternatives include corticosteroids for cachexia (short-term) or omega-3.<\/li>\n<li><strong>Diabetes:<\/strong> monitor glucose carefully; insulin or hypoglycaemic dose adjustment likely.<\/li>\n<li><strong>Adrenal insufficiency:<\/strong> taper, do not stop abruptly after prolonged use.<\/li>\n<li><strong>Cardiovascular risk factors:<\/strong> caution &mdash; fluid retention, hypertension.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">L\u00e6gemiddelinteraktioner<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;\">Kombiner med<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Effekt<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Hvad skal der g\u00f8res<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Insulin or oral hypoglycaemics<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Megestrol raises blood glucose &mdash; reduced control<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor glucose; adjust diabetic medication.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Warfarin<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Possible INR change<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor INR.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Other progestins, oestrogens<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Stacked progestin \/ VTE effects<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Undg\u00e5 kombination.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Aromataseh\u00e6mmere<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Megestrol provides exogenous progestin &mdash; rarely used together; sequence appropriately<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Specialist judgment.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Opbevaring<\/h2>\n<ul>\n<li>Stuetemperatur, 15\u201325\u00b0C, original blister.<\/li>\n<li>Out of reach of children and pets.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Relaterede alternativer p\u00e5 MedsBase<\/h2>\n<p>Andre onkologiske l\u00e6gemidler p\u00e5 lager sammen med dette produkt:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/da\/endoxan\/\"><strong>Endoxan (cyclophosphamid 50 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/celkeran\/\"><strong>Celkeran (chlorambucil 2 \/ 5 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/temotero\/\"><strong>Temotero (temozolomid 20\/100 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/temozol-20\/\"><strong>Temozol (temozolomid 20 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/lomoother\/\"><strong>Lomoother (lomustin 40 mg)<\/strong><\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/medsbase.com\/da\/anti-cancer-medication\/\">Se alle antikr\u00e6ftl\u00e6gemidler \u2192<\/a><\/p>\n<h2 id=\"faqs\">Ofte stillede sp\u00f8rgsm\u00e5l<\/h2>\n<h3 class=\"wp-block-heading\">When will I notice the appetite-stimulant effect?<\/h3>\n<p>Improved appetite typically starts at <strong>1\u20132 uger<\/strong>. Measurable weight gain (mostly fat, with smaller fluid component) at <strong>4\u20136 uger<\/strong>. Most weight gain is fat &mdash; megestrol does not significantly increase lean muscle mass. Adding nutritional support and gentle resistance exercise where possible amplifies the benefit.<\/p>\n<h3 class=\"wp-block-heading\">Why is venous thromboembolism a risk?<\/h3>\n<p>Megestrol is a progestin and shares the VTE risk of all hormonal contraceptives + progestins, particularly in cancer patients (who already carry a 5&ndash;10&times; increased baseline VTE risk). Be alert for unilateral leg swelling, sudden chest pain or breathlessness; seek same-day care if these occur. Consider prophylactic anticoagulation in immobilised cancer patients on megestrol.<\/p>\n<h3 class=\"wp-block-heading\">Will Endace raise my blood sugar?<\/h3>\n<p>Yes &mdash; commonly. Megestrol mimics some of the metabolic effects of corticosteroids (impairs insulin action, raises hepatic glucose output). Diabetic patients usually need their hypoglycaemic medication adjusted upward; new-onset diabetes can occur in non-diabetic patients on long-term high-dose megestrol. Monitor capillary glucose weekly initially.<\/p>\n<h3 class=\"wp-block-heading\">Why must I taper rather than stop Endace?<\/h3>\n<p>Long-term high-dose megestrol suppresses the adrenal axis (mineralocorticoid effect on the hypothalamic-pituitary-adrenal axis). Abrupt discontinuation after &gt; 4&ndash;6 weeks of high-dose use risks <strong>adrenal crisis<\/strong> &mdash; nausea, vomiting, hypotension, hypoglycaemia. Taper down over 2&ndash;4 weeks under specialist supervision.<\/p>\n<h3 class=\"wp-block-heading\">Are there alternatives to Endace for cancer cachexia?<\/h3>\n<p>Limited options with strong evidence. <strong>Kortikosteroider<\/strong> (dexamethasone 4 mg\/day) provide short-term appetite stimulation but have severe long-term toxicity. <strong>Cannabinoids<\/strong> (dronabinol where legal) have modest evidence. <strong>Anamorelin<\/strong> (ghrelin agonist) is approved in Japan and some other markets. <strong>Olanzapine<\/strong> low-dose has emerging supportive evidence. <strong>Nutritional and exercise interventions<\/strong> remain first-line. Discuss with the palliative care team.<\/p>\n<h3 class=\"wp-block-heading\">Can Endace treat my breast cancer?<\/h3>\n<p>Megestrol has a niche role in palliative endocrine therapy for HR+ advanced breast cancer &mdash; usually <strong>later-line after aromatase inhibitor and tamoxifen failure<\/strong>. It is no longer a first or second-line endocrine choice in most modern practice; CDK4\/6 inhibitors + AI \/ fulvestrant have largely replaced it. Specialist oncology decision.<\/p>\n<h3 class=\"wp-block-heading\">Is Endace safe in pregnancy?<\/h3>\n<p>No &mdash; contraindicated. Megestrol is a progestin and may cause fetal masculinisation and other developmental effects. Reliable contraception throughout treatment.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol on Endace?<\/h3>\n<p>Occasional small amounts are tolerable but heavy drinking compounds the metabolic side effects (hyperglycaemia, hypertension, fluid retention). Discuss with the supportive care team in the context of overall cancer care.<\/p>\n<p><!-- medsbase-why-order --><\/p>\n<h3>Hvorfor bestille fra MedsBase<\/h3>\n<p>Hver batch er indk\u00f8bt fra en <strong>WHO-GMP certificeret producent<\/strong>. Ordre sendes i neutral, um\u00e6rket emballage fra vores opfyldningspartnere og d\u00e6kket af vores <a href=\"\/da\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance Policy<\/a>: hvis en forsendelse ikke ankommer inden for 20 hverdage sender vi en gratis genforsendelse, ingen sp\u00f8rgsm\u00e5l stillet.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Relaterede anti-kr\u00e6ftl\u00e6gemidler<\/h3>\n<p>Andre onkologiske l\u00e6gemidler p\u00e5 lager sammen med dette produkt:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/da\/cytomid\/\">Cytomid (flutamide 250 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/bicalumutide\/\">Bicalumutid (bicalutamide 50 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/bdenza\/\">Bdenza (enzalutamide 40 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/tamilong\/\">Tamilong (tamoxifen 10\/20 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/xtane\/\">Xtane (exemestan 25 mg)<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Manages appetite loss<br \/>\n\u2705 Treats breast cancer<br \/>\n\u2705 Kontrollerer endometriecancer<br \/>\n\u2705 Aids weight gain<br \/>\n\u2705 Forbedrer livskvalitet<\/p>\n<p>Endace contains Megestrol Acetate.<\/p>","protected":false},"featured_media":58732,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[4556,4557],"class_list":{"0":"post-58731","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-endace","10":"product_tag-megestrol","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product\/58731","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/comments?post=58731"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/media\/58732"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/media?parent=58731"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product_brand?post=58731"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product_cat?post=58731"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product_tag?post=58731"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}