{"id":58795,"date":"2024-02-28T05:28:23","date_gmt":"2024-02-28T05:28:23","guid":{"rendered":"https:\/\/medsname.com\/leetrexate\/"},"modified":"2026-04-30T10:24:07","modified_gmt":"2026-04-30T10:24:07","slug":"leetrexate","status":"publish","type":"product","link":"https:\/\/medsbase.com\/da\/leetrexate\/","title":{"rendered":"Leetrexate"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Leetrexate?<\/h3>\n<p style=\"margin:0;\"><strong>Leetrexate<\/strong> is an oral tablet from Leeford Healthcare containing <strong>methotrexate 2.5 mg<\/strong> &mdash; an antimetabolite (dihydrofolate reductase inhibitor) used for <strong>maintenance therapy of acute lymphoblastic leukaemia (ALL)<\/strong>, <strong>some lymphomas<\/strong>, <strong>severe rheumatoid arthritis<\/strong>, <strong>severe psoriasis<\/strong>, and other immune-mediated disease. Oncology maintenance dose: typically <strong>15&ndash;30 mg\/m&sup2; per WEEK<\/strong> (NOT daily) &mdash; weekly dosing is the most critical safety point. <strong>Daily dosing of methotrexate by mistake is one of the most common preventable serious medication errors and can be fatal.<\/strong> Obligatorisk: <strong>folic acid 5 mg weekly<\/strong> on a different day; baseline + ongoing FBC, LFTs, U&#038;E, CXR. Absolute contraindication in pregnancy and breastfeeding (potent teratogen).<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Hvad du f\u00e5r med MedsBase:<\/strong> WHO-GMP certificeret producent \u00b7 Diskret emballage \u00b7 Verdensomsp\u00e6ndende forsendelse \u00b7 1.400+ verificerede <a href=\"https:\/\/medsbase.com\/da\/reviews\/\">kundeanmeldelser<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Hver ordre er d\u00e6kket af vores <a href=\"https:\/\/medsbase.com\/da\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 hvis din pakke ikke ankommer inden for 20 hverdage, sender vi en erstatning.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;\"><strong>\u26a0 Specialistvejledning p\u00e5kr\u00e6vet.<\/strong> Kr\u00e6ftmedicin skal ordineres af en behandlende onkolog med en bekr\u00e6ftet diagnose, baseline-stadieinddeling og en defineret behandlingsplan. Start, stop eller \u00e6ndr aldrig dosis eller brug kr\u00e6ftmedicin uden for en onkolog-ledet behandlingsplan. De fleste kr\u00e6ftl\u00e6gemidler kr\u00e6ver regelm\u00e6ssig blodpr\u00f8veoverv\u00e5gning (FBC, LFT, nyrefunktion), er absolut kontraindicerede under graviditet og har betydelige l\u00e6gemiddelinteraktioner.<\/div>\n<div style=\"background:#f4f8fb;border:1px solid #d6e4ec;padding:12px 18px;margin:14px 0;border-radius:4px;font-size:14px;color:#3a5160;text-align:center;\">\n<strong>\ud83d\udd12 Krypteret Checkout<\/strong> \u00b7 <strong>\ud83d\udcb3 Verificeret processor<\/strong> \u00b7 <strong>\ud83d\ude9a Verdensomsp\u00e6ndende forsendelse<\/strong> \u00b7 <strong>\u2b50 4,9\/5 fra 1.400+ kunder<\/strong>\n<\/div>\n<h2 class=\"wp-block-heading\">What Is Leetrexate?<\/h2>\n<p>Leetrexate is an oral tablet from Leeford Healthcare containing <strong>methotrexate 2.5 mg<\/strong>. Methotrexate is a folate antagonist (dihydrofolate reductase inhibitor) used at low doses for <strong>maintenance therapy of acute lymphoblastic leukaemia (ALL)<\/strong>, several lymphomas, certain solid tumours, and at similar low doses for severe rheumatoid arthritis, psoriasis, Crohn&#39;s disease and other immune-mediated conditions.<\/p>\n<h2 class=\"wp-block-heading\">\u2014 det forst\u00e6rker den normale fysiologiske respons snarere end at udl\u00f8se en kunstigt.<\/h2>\n<ul>\n<li><strong>Maintenance phase of acute lymphoblastic leukaemia<\/strong> (oral methotrexate weekly with mercaptopurine daily)<\/li>\n<li><strong>Trophoblastic disease (gestational choriocarcinoma)<\/strong> &mdash; specialist oncology<\/li>\n<li><strong>Cutaneous T-cell lymphoma, mycosis fungoides<\/strong><\/li>\n<li><strong>Sv\u00e6r leddegigt<\/strong> &mdash; first-line DMARD<\/li>\n<li><strong>Severe psoriasis, psoriatic arthritis<\/strong><\/li>\n<li><strong>Severe Crohn&#39;s disease maintenance<\/strong><\/li>\n<li><strong>Several other immune-mediated conditions:<\/strong> ANCA vasculitis, dermatomyositis, juvenile idiopathic arthritis<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Dosage and How to Take &mdash; CRITICAL<\/h2>\n<p>Standard <strong>oncology maintenance<\/strong> dose: <strong>15&ndash;30 mg\/m&sup2; per WEEK<\/strong> (typically 20&ndash;25 mg\/week for an adult). Standard <strong>rheumatology \/ dermatology<\/strong> dose: 7.5&ndash;25 mg per week.<\/p>\n<ol>\n<li><strong>WEEKLY DOSING ONLY.<\/strong> Methotrexate is dosed once a week, NOT daily. Choose one fixed day of the week (e.g. Monday) and take all tablets together that day. <strong>Daily dosing by mistake is potentially fatal.<\/strong> This is the most common preventable serious medication error involving methotrexate.<\/li>\n<li><strong>Folic acid 5 mg weekly<\/strong> on a different day (e.g. Friday) reduces nausea, mouth ulcers and LFT rise without significantly reducing efficacy.<\/li>\n<li>Tag med eller uden mad.<\/li>\n<li><strong>Obligatorisk overv\u00e5gning:<\/strong> baseline FBC, LFTs (AST, ALT), U&#038;E + creatinine, CXR. Repeat FBC + LFTs every 2 weeks for first 3 months, then monthly. Annual cumulative-dose tracking for hepatic fibrosis risk (specialist).<\/li>\n<li>Stop and seek same-day review for: severe mouth ulcers, severe diarrhoea, new dyspnoea or cough, fever, jaundice, easy bruising or bleeding, or unusual rash.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Bivirkninger<\/h2>\n<p><strong>Almindelige:<\/strong> nausea, mouth ulcers, fatigue, hair thinning, mild LFT rise, mild cytopenia.<\/p>\n<p><strong>Vigtigt:<\/strong><\/p>\n<ul>\n<li><strong>Myelodepression<\/strong> &mdash; neutropenia, thrombocytopenia, anaemia. Severe pancytopenia can occur with daily-dosing errors.<\/li>\n<li><strong>Hepatotoksicitet<\/strong> &mdash; LFT rises common; cumulative-dose hepatic fibrosis with long-term use<\/li>\n<li><strong>Pneumonitis<\/strong> &mdash; idiosyncratic; new dyspnoea or dry cough warrants stopping and review<\/li>\n<li>Renal impairment &mdash; accumulation toxicity<\/li>\n<li>Mucositis &mdash; often the rate-limiting side effect at higher doses<\/li>\n<li>Fotosensitivitet<\/li>\n<li>Severe skin reactions (Stevens-Johnson syndrome) &mdash; rare but documented<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Warnings &mdash; CRITICAL<\/h2>\n<ul>\n<li><strong>Pregnancy: ABSOLUTE CONTRAINDICATION (FDA Pregnancy Category X).<\/strong> Methotrexate is a potent teratogen and abortifacient. Reliable contraception throughout treatment AND for at least <strong>3 months after the last dose in women, 6 months in men<\/strong> (some guidelines require 6 months in both).<\/li>\n<li><strong>Breastfeeding: contraindicated<\/strong> &mdash; methotrexate excreted in breast milk.<\/li>\n<li><strong>Nedsat nyrefunktion:<\/strong> reduce dose for eGFR &lt; 60 mL\/min; avoid if eGFR &lt; 30. Methotrexate is renally cleared and accumulates rapidly in renal failure with severe toxicity.<\/li>\n<li><strong>Severe hepatic impairment, active alcoholism, hepatitis B\/C:<\/strong> avoid &mdash; high risk of severe hepatotoxicity.<\/li>\n<li><strong>Aktiv infektion:<\/strong> hold methotrexate during serious infection.<\/li>\n<li><strong>Levende vacciner<\/strong> (MMR, yellow fever, BCG, oral polio): contraindicated during methotrexate therapy.<\/li>\n<li><strong>Pleural effusion or ascites:<\/strong> methotrexate accumulates in third-space fluid and re-releases, causing prolonged toxicity. Drain effusions before starting.<\/li>\n<li><strong>NSAID interaction risk:<\/strong> see drug interaction table.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">L\u00e6gemiddelinteraktioner<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;\">Kombiner med<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Effekt<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Hvad skal der g\u00f8res<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">NSAIDs (ibuprofen, naproxen, diclofenac), aspirin (analgesic dose)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduce methotrexate clearance &mdash; toxicity risk; severe at high MTX doses, modest at low maintenance doses<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Generally OK at stable low oral MTX doses with monitoring; avoid with high-dose IV MTX. Paracetamol is safer.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Trimethoprim, co-trimoxazole (Septrin)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additive antifolate effect &mdash; severe pancytopenia<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">AVOID. Use alternative antibiotic.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Live vaccines (MMR, yellow fever, BCG, varicella)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Disseminated infection from live vaccine<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Kontraindiceret.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">PPIs (omeprazole) at high-dose IV methotrexate<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduce MTX clearance<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Hold PPIs around high-dose IV MTX (specialist). Generally OK at low oral doses.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Alkohol<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additiv levertoksicitet<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Limit to occasional small amounts. No more than 1&ndash;2 drinks per week.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Probenecid, penicillins (high dose)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduce MTX renal clearance &mdash; toxicity<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Undg\u00e5 kombination.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Folic acid 5 mg weekly<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduces toxicity (mucositis, GI, LFT rise) without significantly reducing efficacy<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">STANDARD &mdash; take 5 mg weekly on a different day from MTX.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Opbevaring<\/h2>\n<ul>\n<li>Stuetemperatur, 15\u201325\u00b0C, original blister.<\/li>\n<li>Keep out of reach of children, women of childbearing potential, and pets &mdash; methotrexate is a potent teratogen.<\/li>\n<li>Wash hands after handling tablets.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Relaterede alternativer p\u00e5 MedsBase<\/h2>\n<p>Andre onkologiske l\u00e6gemidler p\u00e5 lager sammen med dette produkt:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/da\/folitrax\/\"><strong>Folitrax (methotrexate 7.5 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/imutrex\/\"><strong>Imutrex (methotrexate 2.5 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/noltrexate\/\"><strong>Noltrexate (methotrexate 2.5 mg)<\/strong><\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/medsbase.com\/da\/anti-cancer-medication\/\">Se alle antikr\u00e6ftl\u00e6gemidler \u2192<\/a><\/p>\n<h2 id=\"faqs\">Ofte stillede sp\u00f8rgsm\u00e5l<\/h2>\n<h3 class=\"wp-block-heading\">Why is methotrexate dosed weekly, not daily?<\/h3>\n<p><strong>Methotrexate is dosed once a week (not daily) at low oncology-maintenance and rheumatology doses.<\/strong> Daily dosing of methotrexate by mistake is potentially fatal &mdash; it has caused multiple inquest-level adverse events worldwide and is one of the most common preventable serious medication errors. Pick one fixed day of the week (e.g. Monday), take all tablets together that day, and never dose more frequently. Tell every doctor and pharmacist about your weekly schedule.<\/p>\n<h3 class=\"wp-block-heading\">Why do I take folic acid?<\/h3>\n<p>Folic acid 5 mg once weekly (on a different day from methotrexate, e.g. Friday) reduces the most common methotrexate side effects &mdash; nausea, mouth ulcers, GI upset, LFT rise &mdash; without significantly reducing efficacy. It is a standard part of every long-term methotrexate regimen.<\/p>\n<h3 class=\"wp-block-heading\">Hvilke blodpr\u00f8ver har jeg brug for?<\/h3>\n<p>Baseline: FBC, LFTs (AST, ALT), U&#038;E + creatinine, CXR. Then FBC + LFTs every 2 weeks for the first 3 months, then monthly. Annual cumulative-dose review for hepatic fibrosis risk (specialist). Tell your doctor about any infection, mouth ulcers, easy bruising, or jaundice.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol on methotrexate?<\/h3>\n<p>Limit alcohol to 1&ndash;2 standard drinks per week or less &mdash; both alcohol and methotrexate are hepatotoxic. Heavier drinking significantly raises the risk of methotrexate-induced liver damage and hepatic fibrosis on long-term therapy.<\/p>\n<h3 class=\"wp-block-heading\">Can I get pregnant on methotrexate?<\/h3>\n<p><strong>No &mdash; methotrexate is FDA Pregnancy Category X.<\/strong> Methotrexate is teratogenic and abortifacient. Reliable contraception is mandatory throughout treatment and for at least <strong>3 months after the last dose in women<\/strong> and at least <strong>6 months in men<\/strong> (some guidelines extend the female window to 6 months also). Discuss family planning with your specialist before starting; switch to a non-teratogenic alternative (azathioprine, sulfasalazine in some indications) if pregnancy planned.<\/p>\n<h3 class=\"wp-block-heading\">Can I have live vaccines on methotrexate?<\/h3>\n<p>Live vaccines (MMR, yellow fever, BCG, oral polio, varicella) are contraindicated during methotrexate therapy &mdash; risk of disseminated infection from the vaccine virus. Inactivated vaccines (annual flu shot, pneumococcal, COVID-19, hepatitis B) are not only safe but recommended. Plan live vaccines at least 4 weeks before starting methotrexate, or 3 months after stopping.<\/p>\n<h3 class=\"wp-block-heading\">What antibiotics are unsafe with methotrexate?<\/h3>\n<p><strong>Trimethoprim and co-trimoxazole (Septrin\/Bactrim)<\/strong> are the most dangerous &mdash; they have additive antifolate effects with methotrexate and have caused fatal pancytopenia. AVOID. Use alternative antibiotics &mdash; amoxicillin, doxycycline, cefalexin etc are safe. Tell every doctor about your methotrexate before any antibiotic is prescribed.<\/p>\n<h3 class=\"wp-block-heading\">Why must I tell my doctor before any surgery?<\/h3>\n<p>Methotrexate impairs wound healing and increases infection risk. For elective major surgery, methotrexate is sometimes held for 1&ndash;2 weeks pre-op and resumed once the wound has healed. For minor surgery (skin biopsy, dental work) it can usually be continued. Specialist guidance.<\/p>\n<p><!-- medsbase-why-order --><\/p>\n<h3>Hvorfor bestille fra MedsBase<\/h3>\n<p>Hver batch er indk\u00f8bt fra en <strong>WHO-GMP certificeret producent<\/strong>. Ordre sendes i neutral, um\u00e6rket emballage fra vores opfyldningspartnere og d\u00e6kket af vores <a href=\"\/da\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance Policy<\/a>: hvis en forsendelse ikke ankommer inden for 20 hverdage sender vi en gratis genforsendelse, ingen sp\u00f8rgsm\u00e5l stillet.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Relaterede anti-kr\u00e6ftl\u00e6gemidler<\/h3>\n<p>Andre onkologiske l\u00e6gemidler p\u00e5 lager sammen med dette produkt:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/da\/folitrax\/\">Folitrax (methotrexat 2,5\/7,5\/10 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/imutrex\/\">Imutrex (methotrexat 2,5\/7,5\/10 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/noltrexate\/\">Noltrexate (methotrexate 2.5\/7.5\/10 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/endoxan\/\">Endoxan (cyclophosphamid 50 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/hydrosar\/\">Hydrosar (hydroxyurea 500 mg)<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Behandler leddegigt<br \/>\n\u2705 Reducerer ledbet\u00e6ndelse<br \/>\n\u2705 Bremser sygdomsudvikling<br \/>\n\u2705 Kontrollerer autoimmunsygdomme<br \/>\n\u2705 Improves symptoms<\/p>\n<p>Leetrexate contains Methotrexate.<\/p>","protected":false},"featured_media":58796,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[4571,4466],"class_list":{"0":"post-58795","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-leetrexate","10":"product_tag-methotrexate","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product\/58795","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/comments?post=58795"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/media\/58796"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/media?parent=58795"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product_brand?post=58795"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product_cat?post=58795"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product_tag?post=58795"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}