{"id":58833,"date":"2024-02-28T05:30:07","date_gmt":"2024-02-28T05:30:07","guid":{"rendered":"https:\/\/medsname.com\/pexep\/"},"modified":"2026-04-30T10:24:07","modified_gmt":"2026-04-30T10:24:07","slug":"pexep","status":"publish","type":"product","link":"https:\/\/medsbase.com\/da\/pexep\/","title":{"rendered":"Pexep"},"content":{"rendered":"

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\u26a1 Hurtigt svar<\/h3>\n

Pexep (Paroxetine 12.5 \/ 25 \/ 37.5 mg) is a selective serotonin reuptake inhibitor used for depression, anxiety, and related disorders. Strong serotonin reuptake blockade \u2014 effective but with the worst discontinuation profile of any SSRI; taper carefully.<\/p>\n<\/div>\n

\nHvad du f\u00e5r med MedsBase:<\/strong> WHO-GMP certificeret producent \u00b7 Diskret emballage \u00b7 Verdensomsp\u00e6ndende forsendelse \u00b7 1.400+ verificerede kundeanmeldelser<\/a>\n<\/div>\n

\ud83d\udce6 Hver ordre er d\u00e6kket af vores Reshipment Assurance Policy<\/strong><\/a> \u2014 hvis din pakke ikke ankommer inden for 20 hverdage, sender vi en erstatning.<\/p>\n

Hvorfor bestille fra MedsBase<\/h3>\n

Pexep at MedsBase is supplied directly from a WHO-GMP certified manufacturer in plain, discreet packaging. Every order is covered by our Reshipment Assurance Policy<\/a> \u2014 20-hverdages leveringsvindue eller vi gensender uden ekstra omkostninger \u2014 og kvalificerer sig til vores kundeloyalitetsprogram<\/a>. Verdensomsp\u00e6ndende forsendelse er tilg\u00e6ngelig til de fleste destinationer.<\/p>\n

How Pexep works<\/h2>\n

Pexep<\/strong> is a Paroxetine-containing SSRI tablet supplied by Sun Pharma. Available strengths: 12.5 \/ 25 \/ 37.5 mg<\/strong>. Tag med eller uden mad, p\u00e5 samme tidspunkt hver dag for stabile plasmakoncentrationer.<\/p>\n

SSRI'er h\u00e6mmer genoptagelsen af serotonin (5-HT) ved den pr\u00e6synaptiske serotonin-transporter (SERT), hvilket \u00f8ger den synaptiske serotonin-tilg\u00e6ngelighed. Den terapeutiske effekt f\u00f8lger transporterblokeringen med 2\u20136 ugers forsinkelse \u2014 forsinkelsen afspejler nedstr\u00f8ms tilpasninger i 5-HT-autoreceptor f\u00f8lsomhed, BDNF-ekspression og hippocampal neurogenese, ikke direkte receptorvirkninger. Patienter, der ikke m\u00e6rker \u201cnogen effekt\u201d efter 2 uger, b\u00f8r ikke stoppe tidligt; vurder respons efter 4\u20136 uger med en tilstr\u00e6kkelig dosis.<\/p>\n

Paroxetine is also the only SSRI with a clear pregnancy signal<\/strong> \u2014 first-trimester exposure has been linked to a small increase in cardiac malformations (FDA Category D \/ pregnancy risk increased). Do not start paroxetine in women planning pregnancy or in early pregnancy; if already on it, do not abruptly stop \u2014 a careful risk-benefit conversation with the prescriber is required. Other SSRIs (sertraline, citalopram) are preferred for women of reproductive age.<\/p>\n

Indikationer og dosering<\/h2>\n\n\n\n\n\n\n\n\n\n
Indikation<\/th>\nStartdosis<\/th>\nM\u00e5ldosis<\/th>\nMaksimal dosis<\/th>\n<\/tr>\n<\/thead>\n
Major depression<\/td>\n20 mg \u00e9n gang dagligt<\/td>\n20\u201340 mg \u00e9n gang dagligt<\/td>\n50 mg<\/td>\n<\/tr>\n
OCD<\/td>\n20 mg \u00e9n gang dagligt<\/td>\n40\u201360 mg OD<\/td>\n60 mg<\/td>\n<\/tr>\n
Panikangst<\/td>\n10 mg \u00e9n gang dagligt i 1 uge<\/td>\n40 mg OD<\/td>\n60 mg<\/td>\n<\/tr>\n
Social anxiety \/ GAD \/ PTSD<\/td>\n20 mg \u00e9n gang dagligt<\/td>\n20\u201350 mg OD<\/td>\n50 mg<\/td>\n<\/tr>\n
Older adults \/ hepatic \/ renal<\/td>\n10 mg \u00e9n gang dagligt<\/td>\n10\u201320 mg \u00e9n gang dagligt<\/td>\n40 mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Vigtige sikkerhedsovervejelser<\/h2>\n
\nWorst discontinuation syndrome of any SSRI<\/strong><\/p>\n

Paroxetine has a short half-life (~21 hours, no active metabolite) plus potent SERT binding plus anticholinergic action<\/strong> \u2014 the combination produces the worst withdrawal of any antidepressant. Symptoms (dizziness, “brain zaps”, flu-like malaise, irritability, nausea) appear within 24\u201348 h of a missed dose. Always taper<\/strong> over at least 4 weeks (often 8\u201312 weeks for long-term users), going as slowly as 1\u20132 mg\/week at the bottom end. Consider switching to fluoxetine for the taper.<\/p>\n<\/div>\n

\nSelvmordstendens sortboks (under 25 \u00e5r)<\/strong><\/p>\n

Alle SSRI-pr\u00e6parater b\u00e6rer en FDA-sortboksadvarsel om \u00f8get selvmordstanker hos patienter under 25, is\u00e6r i de f\u00f8rste 4 uger og ved dosis\u00e6ndringer. Dette betyder ikke<\/em> ikke, at SSRI er netto-skadelige for unge mennesker \u2014 metaanalyser viser nettofordel \u2014 men det betyder t\u00e6t klinisk overv\u00e5gning under indledning og titrering hos unge og unge voksne.<\/p>\n<\/div>\n

\nSerotoninsyndrom<\/strong><\/p>\n

Combining Pexep with other serotonergic agents can cause serotonin syndrome (tremor, hyperreflexia, clonus, hyperthermia, agitation). Avoid concurrent: MAOIs (14-day washout each direction; fluoxetine needs 5 weeks), tramadol, pethidine, dextromethorphan, linezolid, methylene blue, St John’s wort, MDMA. Triptan + SSRI is generally tolerated for migraine \u2014 the absolute risk is low.<\/p>\n<\/div>\n

Almindelige bivirkninger<\/h2>\n