{"id":59456,"date":"2024-02-28T05:59:00","date_gmt":"2024-02-28T05:59:00","guid":{"rendered":"https:\/\/medsname.com\/nimodip\/"},"modified":"2026-05-01T10:49:15","modified_gmt":"2026-05-01T10:49:15","slug":"nimodip","status":"publish","type":"product","link":"https:\/\/medsbase.com\/da\/nimodip\/","title":{"rendered":"Nimodip"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 Hurtigt svar \u2014 Hvad er Nimodip?<\/h3>\n<p style=\"margin:0;\"><strong>Nimodip<\/strong> er en oral <strong>nimodipine<\/strong> (30 mg) tablet \u2014 a <strong>cerebral-selective dihydropyridine calcium channel blocker<\/strong> specifically used to prevent and reduce the severity of <strong>cerebral vasospasm<\/strong> og <strong>delayed cerebral ischaemia (DCI)<\/strong> following <strong>aneurysmal subarachnoid haemorrhage (aSAH)<\/strong>. Dosing: <strong>60 mg every 4 hours (360 mg\/day) for 21 consecutive days<\/strong>, started within 96 hours of the bleed. Nimodipine preferentially dilates cerebral arteries over peripheral ones, reducing the incidence of vasospasm-related neurological deficits without causing significant systemic hypotension at standard doses. Common side effects: hypotension, headache, nausea, flushing.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Hvad du f\u00e5r med MedsBase:<\/strong> WHO-GMP certificeret producent \u00b7 Diskret emballage \u00b7 Verdensomsp\u00e6ndende forsendelse \u00b7 1.400+ verificerede <a href=\"https:\/\/medsbase.com\/da\/reviews\/\">kundeanmeldelser<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Hver ordre er d\u00e6kket af vores <a href=\"https:\/\/medsbase.com\/da\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 hvis din pakke ikke ankommer inden for 20 hverdage, sender vi en erstatning.<\/p>\n<h3>Hvorfor bestille fra MedsBase<\/h3>\n<p>Vores generiske medicin kommer fra WHO-GMP certificerede producenter og sendes verdensomsp\u00e6ndende i diskret, neutral emballage \u2014 ingen medicinnavn p\u00e5 pakkens ydre. Kortbetalinger h\u00e5ndteres af en reguleret processor (kontoudtogsbeskrivelser inkluderer en reguleret betalingsprocessor \u2014 aldrig \u201cMedsBase\u201d eller medicinnavn). Crypto og SEPA bankoverf\u00f8rsel accepteres ogs\u00e5. Hver ordre er d\u00e6kket af vores Reshipment Assurance Policy.<\/p>\n<h2 class=\"wp-block-heading\">Hvad Er Nimodip?<\/h2>\n<p>Nimodip is an oral tablet containing <strong>nimodipine 30 mg<\/strong>. Nimodipine is a <strong>cerebral-selective dihydropyridine calcium channel blocker<\/strong> &mdash; unlike other CCBs (amlodipine, nifedipine), it preferentially dilates cerebral arteries with minimal effect on peripheral blood pressure.<\/p>\n<p>Nimodipine is the <strong>only calcium channel blocker with a neurology indication<\/strong>: prevention of ischaemic neurological deficits (vasospasm) following aneurysmal <strong>subarachnoid haemorrhage (SAH)<\/strong>. The landmark BIDA trial (1983) demonstrated a ~40% reduction in cerebral infarction and improved neurological outcomes with the standard 21-day oral protocol. Nimodip is manufactured by a WHO-GMP certified facility and is bioequivalent to the originator brand <strong>Nimotop<\/strong> (Bayer).<\/p>\n<h2 class=\"wp-block-heading\">How Does Nimodip (Nimodipine) Work?<\/h2>\n<p>Nimodipine blocks <strong>L-type voltage-gated calcium channels<\/strong>, but unlike other calcium channel blockers (amlodipine, nifedipine), it has <strong>preferential affinity for cerebral vascular smooth muscle<\/strong>. This cerebral selectivity means it dilates brain arteries more than peripheral ones, making it uniquely suited for preventing vasospasm after subarachnoid haemorrhage.<\/p>\n<p>Beyond vasodilation, nimodipine may have <strong>neuroprotective effects<\/strong> \u2014 it reduces calcium influx into neurons during ischaemia, which attenuates excitotoxic cell death. Clinical trials (the landmark British Aneurysm Nimodipine Trial) demonstrated a significant reduction in poor outcomes, even though angiographic vasospasm rates were not dramatically different \u2014 suggesting the benefit is partly neuroprotective.<\/p>\n<h2 class=\"wp-block-heading\">Indikationer<\/h2>\n<ul>\n<li><strong>Prevention of cerebral vasospasm<\/strong> and delayed cerebral ischaemia after aneurysmal subarachnoid haemorrhage \u2014 the <strong>only approved indication<\/strong><\/li>\n<li><strong>Off-label uses:<\/strong> migraine prophylaxis, vascular dementia (limited evidence), traumatic subarachnoid haemorrhage<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Dosing \u2014 The 21-Day Protocol<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:0 0 24px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px 14px;\">Parameter<\/th>\n<th style=\"padding:10px 14px;\">Standard Protocol<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px 14px;\">Dosis<\/td>\n<td style=\"padding:10px 14px;\">60 mg (two 30 mg tablets)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px 14px;\">Hyppighed<\/td>\n<td style=\"padding:10px 14px;\">Every 4 hours<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px 14px;\">Total daily dose<\/td>\n<td style=\"padding:10px 14px;\">360 mg\/day<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px 14px;\">Varighed<\/td>\n<td style=\"padding:10px 14px;\">21 consecutive days<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px 14px;\">Start<\/td>\n<td style=\"padding:10px 14px;\">Within 96 hours of haemorrhage<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px 14px;\">Leversvigt<\/td>\n<td style=\"padding:10px 14px;\">30 mg every 4 hours (halved dose)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Kritisk:<\/strong> Nimodipine tablets must be <strong>swallowed whole<\/strong>, not crushed. For patients unable to swallow, the contents can be extracted via syringe and administered through a nasogastric tube \u2014 but <strong>never inject the oral solution intravenously<\/strong> (fatal cases of inadvertent IV administration of oral nimodipine have occurred). Take at least 1 hour before or 2 hours after meals for optimal absorption.<\/p>\n<h2 class=\"wp-block-heading\">Bivirkninger<\/h2>\n<p><strong>Almindelige:<\/strong> hypotension (dose-related, usually mild), headache, nausea, flushing, peripheral oedema.<\/p>\n<p><strong>Mindre almindelige:<\/strong> dizziness, tachycardia, rash, GI upset, bradycardia.<\/p>\n<p><strong>Alvorlige:<\/strong> severe hypotension (especially in patients with pre-existing low blood pressure or on other antihypertensives), ileus (in critically ill SAH patients), hepatotoxicity (rare \u2014 elevated transaminases).<\/p>\n<h2 class=\"wp-block-heading\">Advarsler og forholdsregler<\/h2>\n<ul>\n<li><strong>Hypotension.<\/strong> Nimodipine can cause significant blood pressure drops, particularly in hypovolaemic SAH patients or those on other antihypertensives. Monitor BP every 1&ndash;2 hours during the initial 48 hours. Reduce dose to 30 mg every 4 hours (from every 2 hours) if systolic drops below 90 mmHg.<\/li>\n<li><strong>Hepatic impairment.<\/strong> Nimodipine undergoes extensive first-pass hepatic metabolism. In cirrhosis, bioavailability increases markedly &mdash; halve the dose and monitor for hypotension and bradycardia.<\/li>\n<li><strong>Cerebral oedema \/ raised ICP.<\/strong> Use with caution in patients with cerebral oedema or severely elevated intracranial pressure.<\/li>\n<li><strong>Grapefruit juice.<\/strong> Inhibits CYP3A4 metabolism of nimodipine, doubling plasma levels. Avoid grapefruit products during the 21-day protocol.<\/li>\n<li><strong>Epilepsi.<\/strong> Use nimodipine cautiously in patients with epilepsy &mdash; although it is not epileptogenic, seizures are a common SAH complication and drug interactions with anticonvulsants (especially enzyme inducers like phenytoin and carbamazepine) are clinically significant.<\/li>\n<li><strong>Pregnancy category C.<\/strong> Teratogenic in animals at high doses. Use only if benefit outweighs risk.<\/li>\n<li><strong>Amning.<\/strong> Nimodipine is excreted in breast milk. The clinical significance is uncertain &mdash; use with caution.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Contraindications &mdash; Who Should NOT Take Nimodip<\/h2>\n<ul>\n<li>Known hypersensitivity to nimodipine, other dihydropyridines or any excipient<\/li>\n<li>Concurrent use with <strong>rifampicin<\/strong> (reduces nimodipine to subtherapeutic levels via CYP3A4 induction)<\/li>\n<li>Concurrent use with <strong>strong CYP3A4 inhibitors<\/strong> (ketoconazole, itraconazole, ritonavir) without dose reduction<\/li>\n<li>Unstable angina or recent MI (within 4 weeks)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">L\u00e6gemiddelinteraktioner<\/h2>\n<ul>\n<li><strong>Other antihypertensives &amp; calcium channel blockers:<\/strong> Additiv hypotension<\/li>\n<li><strong>CYP3A4-h\u00e6mmere<\/strong> (ketoconazole, fluconazole, macrolide antibiotics, grapefruit juice): Increase nimodipine levels significantly<\/li>\n<li><strong>CYP3A4-inducere<\/strong> (rifampicin, phenytoin, carbamazepine, phenobarbital): Reduce nimodipine levels, potentially to sub-therapeutic<\/li>\n<li><strong>Betablokkere:<\/strong> Additive negative chronotropic effect \u2014 monitor heart rate<\/li>\n<li><strong>Nephrotoxic drugs:<\/strong> Nimodipine may worsen renal function in SAH patients receiving concurrent nephrotoxics<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Opbevaringsvejledning<\/h2>\n<ul>\n<li>Opbevar ved stuetemperatur, <strong>15\u201325\u00b0C<\/strong>. <strong>Beskyt mod lys<\/strong> &mdash; nimodipine is light-sensitive.<\/li>\n<li>Keep in original amber blister packaging until use.<\/li>\n<li>Opbevar ikke i badev\u00e6relset.<\/li>\n<li>Opbevar utilg\u00e6ngeligt for b\u00f8rn.<\/li>\n<li>Brug ikke efter udl\u00f8bsdatoen.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Relaterede kategorier p\u00e5 MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/da\/neurological-conditions-and-epilepsy\/\">Se alle neurologiske og epilepsimediciner<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/heart-and-blood-pressure\/\">Browse heart &amp; blood pressure medications<\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">Ofte stillede sp\u00f8rgsm\u00e5l<\/h2>\n<h3 class=\"wp-block-heading\">What is Nimodip used for?<\/h3>\n<p>Nimodip contains <strong>nimodipine 30 mg<\/strong> and is used to prevent <strong>cerebral vasospasm<\/strong> og <strong>delayed cerebral ischaemia<\/strong> following aneurysmal subarachnoid haemorrhage (aSAH). It is the only drug proven to improve neurological outcomes after SAH.<\/p>\n<h3 class=\"wp-block-heading\">Why is nimodipine given every 4 hours and not twice daily?<\/h3>\n<p>Nimodipine has a short half-life (<strong>1\u20132 timer<\/strong> orally). The every-4-hour dosing ensures continuous therapeutic levels throughout the 21-day critical vasospasm period (days 3&ndash;14 are highest risk). Missing doses creates gaps in protection.<\/p>\n<h3 class=\"wp-block-heading\">Is nimodipine the same as nifedipine or amlodipine?<\/h3>\n<p>All three are dihydropyridine calcium channel blockers, but nimodipine is <strong>uniquely cerebral-selective<\/strong>. Nifedipine and amlodipine primarily target peripheral and coronary arteries and are used for hypertension\/angina. They are <strong>not interchangeable<\/strong> \u2014 only nimodipine has evidence for SAH outcomes.<\/p>\n<h3 class=\"wp-block-heading\">Why must nimodipine never be given intravenously?<\/h3>\n<p>Oral nimodipine formulations contain excipients not suitable for IV injection. Inadvertent IV administration has caused <strong>cardiovascular collapse and death<\/strong>. When oral dosing is impossible (unconscious patients), nimodipine should be given via nasogastric tube, not injected.<\/p>\n<h3 class=\"wp-block-heading\">Does nimodipine actually prevent vasospasm?<\/h3>\n<p>Interestingly, nimodipine does <strong>not significantly reduce angiographic vasospasm<\/strong>. Its benefit appears to be primarily <strong>neuroprotective<\/strong> \u2014 reducing ischaemic neuronal damage from vasospasm rather than preventing the spasm itself. The clinical result is fewer patients with permanent neurological deficits.<\/p>\n<h3 class=\"wp-block-heading\">Can I take nimodipine with grapefruit juice?<\/h3>\n<p><strong>Nej.<\/strong> Grapefruit juice inhibits CYP3A4, significantly increasing nimodipine levels and the risk of hypotension. Avoid grapefruit throughout treatment.<\/p>\n<h3 class=\"wp-block-heading\">What happens if a dose is missed?<\/h3>\n<p>Take the missed dose as soon as possible. If it is nearly time for the next dose, skip the missed one and continue the schedule. Given the short half-life, any gap reduces protection during the critical vasospasm window.<\/p>\n<h3 class=\"wp-block-heading\">Is nimodipine used for migraine?<\/h3>\n<p>Nimodipine has been studied for <strong>migr\u00e4neprofylakse<\/strong> with mixed results. Some patients benefit, but it is not a first-line migraine preventive \u2014 propranolol, topiramate, and valproate have stronger evidence. It is used off-label when other options have failed or are contraindicated.<\/p>\n<h3 class=\"wp-block-heading\">Can nimodipine lower blood pressure too much?<\/h3>\n<p>Yes \u2014 hypotension is the main clinical concern. In SAH patients, maintaining adequate cerebral perfusion pressure is critical. Blood pressure should be monitored regularly, and the dose may need to be halved (30 mg every 4 hours) in patients with hepatic impairment or significant hypotension.<\/p>\n<h3 class=\"wp-block-heading\">How long is the treatment course?<\/h3>\n<p>The standard protocol is <strong>21 consecutive days<\/strong>, regardless of whether vasospasm occurs. The highest-risk period is days 3&ndash;14, but treatment extends to day 21 to cover late vasospasm events.<\/p>\n<h3 class=\"wp-block-heading\">Is Nimodip the same as Nimotop?<\/h3>\n<p>Both contain nimodipine 30 mg. Nimotop is the original Bayer brand. Nimodip is a bioequivalent generic at a lower cost.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;font-size:13px;\"><strong>Medicinsk ansvarsfraskrivelse:<\/strong> Denne side er kun til informationsform\u00e5l og erstatter ikke professionel medicinsk r\u00e5dgivning. Konsult\u00e9r altid en kvalificeret sundhedsudbyder f\u00f8r du p\u00e5begynder, \u00e6ndrer eller stopper medicin. Doseringsinformation afspejler producentens m\u00e6rkning og publiceret klinisk vejledning \u2014 individuelle behov kan variere.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Relaterede alternativer<\/h3>\n<p>Andre produkter inden for <strong>Kroniske tilstande<\/strong> som kunder ogs\u00e5 ser:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/da\/glinil-m\/\">Glinil M<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/trinicalm-plus\/\">Trinicalm Plus<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/opiprol\/\">Opiprol<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/atrest\/\">Atrest<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/ramgee\/\">Ramgee<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Manages hypertension<br \/>\n\u2705 Prevents stroke<br \/>\n\u2705 Enhances blood flow<br \/>\n\u2705 Reduces migraine frequency<br \/>\n\u2705 Alleviates brain-related issues<\/p>\n<p>Nimodip contains Nimodipine.<\/p>","protected":false},"featured_media":59457,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3468],"product_tag":[3892,3893],"class_list":{"0":"post-59456","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-neurological-conditions-and-epilepsy","9":"product_tag-nimodip","10":"product_tag-nimodipine","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product\/59456","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/comments?post=59456"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/media\/59457"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/media?parent=59456"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product_brand?post=59456"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product_cat?post=59456"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product_tag?post=59456"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}