{"id":59484,"date":"2024-02-28T06:00:08","date_gmt":"2024-02-28T06:00:08","guid":{"rendered":"https:\/\/medsname.com\/angiplat\/"},"modified":"2026-05-01T10:49:15","modified_gmt":"2026-05-01T10:49:15","slug":"angiplat","status":"publish","type":"product","link":"https:\/\/medsbase.com\/da\/angiplat\/","title":{"rendered":"Angiplat"},"content":{"rendered":"

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⚡ Quick Answer — What is Angiplat?<\/h3>\n

Angiplat<\/strong> er en nitroglycerin (glyceryl trinitrate) 2.5 mg sustained-release capsule<\/strong>, used for the profylakse<\/em> (prevention) of chronic stable angina pectoris. A usual starting dose is one capsule two to three times a day<\/strong> with an 8–12 hour nitrate-free interval<\/strong> overnight. Angiplat is ikke<\/strong> suitable for aborting an acute angina attack — use sublingual nitroglycerin or isosorbide dinitrate for that purpose.<\/p>\n<\/div>\n

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Angiplat 2.5 mg<\/strong> is an oral, sustained-release (SR) nitroglycerin capsule manufactured for daily use in patients with chronic stable angina pectoris. Each capsule contains 2.5 mg of glyceryl trinitrate (nitroglycerin)<\/strong> in a controlled-release matrix that slowly releases the active drug over 6–8 hours. This extended release profile allows twice- or thrice-daily dosing rather than the very short action of sublingual nitroglycerin.<\/p>\n

Angiplat is widely prescribed in cardiology practice as part of a long-term anti-anginal regimen — usually alongside a beta-blocker (atenolol, metoprolol, bisoprolol) or a calcium channel blocker (amlodipine, diltiazem), plus aspirin and a statin for secondary prevention of coronary events. It reduces the number and severity of angina episodes, improves exercise tolerance, and can reduce the need for short-acting rescue medication during the day.<\/p>\n

What Is Angiplat Used For?<\/h2>\n

Angiplat is indicated for:<\/p>\n

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  • Langtidsprofylakse af kronisk stabil angina<\/strong> — reducing the frequency of chest pain episodes<\/li>\n
  • Effort-induced angina<\/strong> — pre-medication before predictable strain (walking uphill, climbing stairs)<\/li>\n
  • Mixed angina<\/strong> (combination of effort and spasm) — as add-on therapy<\/li>\n
  • Left ventricular failure with angina<\/strong> — reducing preload and ischaemia<\/li>\n<\/ul>\n

    Angiplat is ikke<\/em> indicated for acute angina attacks. Sustained-release oral nitroglycerin has an onset of 30–45 minutes — too slow to abort a live ischaemic episode. For that indication, use a sublingual nitroglycerin tablet or spray, or a sublingual isosorbide dinitrate 5 mg tablet.<\/p>\n

    Hvordan virker nitrater?<\/h2>\n

    Alle nitratmedicin har den samme grundl\u00e6ggende virkem\u00e5de. N\u00e5r de er optaget, omdannes de enzymatisk til nitric oxide (NO)<\/strong> inde i vaskul\u00e6re glatmuskelceller. NO aktiverer guanylatcyklase, hvilket \u00f8ger intracellul\u00e6rt cGMP og afslapper blodkarrenes glatte muskulatur. De kliniske effekter er:<\/p>\n

      \n
    • Ven\u00f8s udvidelse<\/strong> (dominerende ved lave doser) \u2014 reducerer ven\u00f8s retur til hjertet, hvilket s\u00e6nker forbelastning<\/em>. Det er s\u00e5dan, nitrater reducerer hjertets oxygenbehov.<\/li>\n
    • Arteriel udvidelse<\/strong> (h\u00f8jere doser) \u2014 reducerer systemisk vaskul\u00e6r modstand og efterbelastning<\/em>, hvilket yderligere reducerer hjertets arbejdsbyrde.<\/li>\n
    • Udvidelse af kranskaren<\/strong> \u2014 forbedrer blodgennemstr\u00f8mningen til isk\u00e6miske omr\u00e5der af hjertemusklen, is\u00e6r ved koronar spasme.<\/li>\n<\/ul>\n

      Den samlede effekt er mindre brystsmerter, f\u00e6rre anginaepisoder og forbedret fysisk udholdenhed hos patienter med stabil koronar hjertesygdom.<\/p>\n

      Nitrattolerance \u2014 den kritiske doseringsregel<\/h2>\n

      Nitrattolerance er det absolut vigtigste koncept for enhver patient, der tager nitrat. Hvis nitrat gives d\u00f8gnet rundt \u2014 med konstante blodniveauer i 24 timer i d\u00f8gnet \u2014 aftager den anti-angin\u00f8se effekt inden for 48 til 72 timer. Dette er et veldokumenteret, reproducerbart farmakologisk f\u00e6nomen, ikke en indbildt effekt.<\/p>\n

      L\u00f8sningen er enkel og ikke til diskussion: hver 24-timers cyklus skal indeholde en nitratfri periode p\u00e5 mindst 8\u201312 timer<\/strong>, normalt om natten. De standardstrategier er:<\/p>\n

        \n
      • Asymmetrisk to gange daglig dosering (f.eks. kl. 7 om morgenen og kl. 15, intet efter det indtil n\u00e6ste morgen)<\/li>\n
      • Engangs daglige depotformuleringer designet til at levere et lavt bundniveau<\/li>\n
      • Fjernelse af et transdermalt plaster efter 12\u201314 timers p\u00e5f\u00f8ring<\/li>\n<\/ul>\n

        G\u00f8r ikke<\/em> tag ikke ekstra doser \u201cved sengetid\u201d eller om natten, medmindre din l\u00e6ge udtrykkeligt har ordineret d\u00f8gnbehandling af en specifik \u00e5rsag.<\/p>\n

        Angiplat Dosing<\/h2>\n

        Til kronisk stabil angina hos voksne:<\/p>\n

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        • Startdosis:<\/strong> 2.5 mg (one capsule) two to three times daily, with meals<\/li>\n
        • Titration:<\/strong> If angina remains uncontrolled after 1–2 weeks, doctors may increase to 5 mg (two capsules) twice or three times daily, or switch to Angispan-TR 6.5 mg<\/li>\n
        • Nitrate-free interval:<\/strong> Leave at least 8–12 hours between the last dose of one day and the first dose of the next. The easiest way: take at 7 a.m. and 3 p.m., then nothing until the following morning<\/li>\n
        • Maksimum:<\/strong> 26 mg\/day in divided doses (rarely needed)<\/li>\n<\/ul>\n

          Capsules should be swallowed whole with water; do not crush, chew, or open them — this destroys the sustained-release matrix and causes a rapid burst of nitroglycerin with a bad headache and hypotension.<\/p>\n

          Missed dose: take it as soon as you remember, unless it is within 3 hours of the next scheduled dose — in that case skip the missed dose. Never double up.<\/p>\n

          Who Should Not Take Angiplat?<\/h2>\n

          Der er \u00e9n absolut kontraindikation, som alle patienter skal forst\u00e5 f\u00f8r den f\u00f8rste dosis:<\/p>\n

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          Kombiner aldrig nitrat med en PDE5-h\u00e6mmer.<\/strong> Sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra) og avanafil (Stendra) forst\u00e6rker nitraters vasodilaterende effekt og kan for\u00e5rsage livstruende hypotoni, kollaps, slagtilf\u00e6lde eller myokardieinfarkt. Vent mindst 24 timer efter sildenafil\/vardenafil<\/strong> og 48 timer efter tadalafil<\/strong> f\u00f8r du tager en nitratdosis. Dette g\u00e6lder for alle former \u2014 orale, sublinguale, transdermale og spray.<\/p>\n<\/div>\n

          Andre vigtige kontraindikationer:<\/p>\n