{"id":59649,"date":"2024-02-28T06:08:49","date_gmt":"2024-02-28T06:08:49","guid":{"rendered":"https:\/\/medsname.com\/trazonil\/"},"modified":"2026-05-01T10:49:15","modified_gmt":"2026-05-01T10:49:15","slug":"trazonil","status":"publish","type":"product","link":"https:\/\/medsbase.com\/da\/trazonil\/","title":{"rendered":"Trazonil"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Trazonil?<\/h3>\n<div style=\"margin:0;\">\n<p style=\"margin:0;\"><strong>Trazonil<\/strong> indeholder <strong>trazodone hydrochloride (50 mg \/ 100 mg)<\/strong> from a WHO-GMP certified manufacturer (Intas Pharmaceuticals) &mdash; a <strong>SARI<\/strong> antidepressant whose primary modern use is <strong>insomnia at low dose (25&ndash;100 mg at bedtime)<\/strong> rather than depression. Mechanism: 5-HT<sub>2A<\/sub> antagonism plus weak SRI plus alpha-1 antagonism plus H<sub>1<\/sub> antagonism &mdash; the 5-HT<sub>2A<\/sub>\/H<sub>1<\/sub>\/alpha-1 combination drives sedation. <strong>Antidepressant doses (150&ndash;400 mg\/day)<\/strong> are uncommon today &mdash; SSRIs and SNRIs largely replaced trazodone for MDD. Off-label insomnia is its dominant use. Important warnings: <strong>priapism<\/strong> (rare, 1 in 1,000&ndash;10,000 &mdash; emergency if &gt; 4 h), orthostatic hypotension (alpha-1), QT prolongation at high doses. Very <strong>safe in overdose<\/strong> compared to TCAs.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Hvad du f\u00e5r med MedsBase:<\/strong> WHO-GMP certificeret producent \u00b7 Diskret emballage \u00b7 Verdensomsp\u00e6ndende forsendelse \u00b7 1.400+ verificerede <a href=\"https:\/\/medsbase.com\/da\/reviews\/\">kundeanmeldelser<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Hver ordre er d\u00e6kket af vores <a href=\"https:\/\/medsbase.com\/da\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 hvis din pakke ikke ankommer inden for 20 hverdage, sender vi en erstatning.<\/p>\n<h3>Hvorfor bestille fra MedsBase<\/h3>\n<p>Vores generiske medicin kommer fra WHO-GMP certificerede producenter og sendes verdensomsp\u00e6ndende i diskret, neutral emballage \u2014 ingen medicinnavn p\u00e5 pakkens ydre. Kortbetalinger h\u00e5ndteres af en reguleret processor (kontoudtogsbeskrivelser inkluderer en reguleret betalingsprocessor \u2014 aldrig \u201cMedsBase\u201d eller medicinnavn). Crypto og SEPA bankoverf\u00f8rsel accepteres ogs\u00e5. Hver ordre er d\u00e6kket af vores Reshipment Assurance Policy.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 22px 0;border-radius:4px;font-size:14px;\"><strong>Important &mdash; this is not a situational-anxiety medication.<\/strong> Trazonil is a <strong>serotonin antagonist and reuptake inhibitor (SARI)<\/strong>, prescribed and titrated over weeks for <strong>major depressive disorder (MDD); off-label widely used at low dose for chronic insomnia<\/strong>. It is <strong>ikke<\/strong> the right drug for acute, performance-related anxiety (flying, public speaking, exams) &mdash; for those use cases beta-blockers (propranolol), benzodiazepines, or hydroxyzine are clinically appropriate. If you do not have a diagnosed mood, anxiety, or psychiatric disorder, do not start this medication.<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 22px 0;border-radius:4px;font-size:14px;\"><strong>FDA black-box warning &mdash; suicidality.<\/strong> All antidepressants carry an FDA black-box warning for increased risk of suicidal thinking and behaviour in children, adolescents, and young adults under 25, particularly during the first weeks of treatment or after dose changes. Family members and prescribers should monitor closely for worsening mood, agitation, or suicidal ideation in this age group.<\/div>\n<h2 class=\"wp-block-heading\">What Is Trazonil?<\/h2>\n<p>Trazonil is an oral tablet of <strong>trazodone hydrochloride (50 mg \/ 100 mg)<\/strong> manufactured by Intas Pharmaceuticals. Trazodone (US brand <strong>Desyrel<\/strong>) is a <strong>serotonin antagonist and reuptake inhibitor (SARI)<\/strong> introduced in 1981. It blocks 5-HT<sub>2A<\/sub> receptors potently, weakly inhibits the serotonin transporter, and antagonises alpha-1 adrenergic and H<sub>1<\/sub> histamine receptors. The combination is heavily sedating &mdash; which is why trazodone has become predominantly an off-label hypnotic rather than an antidepressant in modern practice.<\/p>\n<h2 class=\"wp-block-heading\">Indikationer<\/h2>\n<ul>\n<li><strong>Major depressiv lidelse<\/strong> &mdash; on-label, but uncommon today (SSRIs \/ SNRIs are first-line)<\/li>\n<li><strong>Insomnia (off-label, low-dose)<\/strong> &mdash; the most common modern use; 25&ndash;100 mg at bedtime<\/li>\n<li>Off-label adjuncts: SSRI-induced insomnia, anxiety with insomnia, agitation in dementia (used with caution)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Dosering<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:0 0 22px 0;font-size:14px;\">\n<thead>\n<tr>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">Indikation<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">Start<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">Typical<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">Maksimum<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">Noter<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">S\u00f8vnl\u00f8shed (off-label)<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">25&ndash;50 mg at bedtime<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">50&ndash;100 mg at bedtime<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">150 mg ved sengetid<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Most commonly used dose range; effective hypnotic without significant antidepressant action<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">MDD (on-label)<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">50&ndash;75 mg\/day in divided doses<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">150&ndash;400 mg\/day<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">600 mg\/day inpatient<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Daytime divided doses for antidepressant effect; sedation often prohibitive<\/td>\n<\/tr>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Elderly insomnia<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">25 mg at bedtime<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">25&ndash;50 mg at bedtime<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">100 mg<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Caution &mdash; orthostasis and falls<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Leversvigt<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Reduce by 25&ndash;50%<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">\u2014<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">\u2014<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Langsommere titrering<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Bivirkninger<\/h2>\n<h2 class=\"wp-block-heading\">Side-effect profile<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:0 0 22px 0;font-size:14px;\">\n<thead>\n<tr>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">Hyppighed<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">Effekt<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">Noter<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Almindelige<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Sedation, drowsiness<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">The point of off-label hypnotic use; problematic for daytime dosing<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Almindelige<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Orthostatisk hypotoni, svimmelhed<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Alpha-1 blockade &mdash; falls risk in elderly<\/td>\n<\/tr>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Almindelige<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Dry mouth, blurred vision<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Mild anticholinergic<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Almindelige<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Kvalme, opkastning<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Tag sammen med mad<\/td>\n<\/tr>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Mindre almindeligt<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Headache, nasal congestion<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Alpha-1 blockade<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Mindre almindeligt<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Weight gain (modest)<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Less than mirtazapine or paroxetine<\/td>\n<\/tr>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Meget sj\u00e6lden<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Priapism (1 in 1,000&ndash;10,000)<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Persistent erection &gt; 4 h is a urological emergency &mdash; mechanism is alpha-1 blockade interfering with detumescence; men should be counselled and report immediately<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Meget sj\u00e6lden<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">QT-forl\u00e6ngelse<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Dose-related; caution with other QT-prolonging drugs<\/td>\n<\/tr>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Meget sj\u00e6lden<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Serotoninsyndrom<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">See interactions<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">L\u00e6gemiddelinteraktioner<\/h2>\n<p><strong>Absolute contraindications<\/strong>: MAOIs (14-day washout).<\/p>\n<p><strong>Additive sedation<\/strong>: alcohol, benzodiazepines, opioids, antihistamines, sedating antipsychotics &mdash; main interaction concern in older adults.<\/p>\n<p><strong>QT-forl\u00e6ngelse<\/strong>: caution with citalopram (high dose), ondansetron, methadone, fluoroquinolones.<\/p>\n<p><strong>CYP3A4-substrat<\/strong>: levels rise with strong inhibitors (ketoconazole, ritonavir, clarithromycin) &mdash; reduce dose or avoid.<\/p>\n<p><strong>Antihypertensiva<\/strong>: additive orthostasis with alpha-blockers, doxazosin, prazosin, terazosin.<\/p>\n<h2 class=\"wp-block-heading\">Why Trazodone for Insomnia?<\/h2>\n<p>Trazodone has become the most-prescribed off-label sleep medication in many countries despite very thin formal sleep-disorder evidence. The reasons are pragmatic:<\/p>\n<ul>\n<li>Heavy sedation at low dose (25&ndash;100 mg)<\/li>\n<li>No physiological dependence or rebound insomnia (unlike benzodiazepines \/ Z-drugs)<\/li>\n<li>No DEA scheduling<\/li>\n<li>Low overdose toxicity<\/li>\n<li>Generic and inexpensive<\/li>\n<li>Useful when SSRI-induced insomnia complicates depression treatment<\/li>\n<\/ul>\n<p>Limitations: orthostatic falls (especially in older adults), priapism risk in men, and limited objective data on sleep-architecture preservation. Daytime grogginess can persist with low-dose 100 mg use.<\/p>\n<h2 id=\"faqs\">Ofte stillede sp\u00f8rgsm\u00e5l<\/h2>\n<h3 class=\"wp-block-heading\">How long does Trazonil take to work for sleep?<\/h3>\n<p>Sedation begins within 1&ndash;2 hours of taking the dose. Take 30 minutes before intended bedtime.<\/p>\n<h3 class=\"wp-block-heading\">Will Trazonil help with depression at low dose?<\/h3>\n<p>No &mdash; antidepressant effect requires 150&ndash;400 mg\/day in divided doses. Bedtime 25&ndash;100 mg is purely a hypnotic dose.<\/p>\n<h3 class=\"wp-block-heading\">Is Trazonil safer than zolpidem (Ambien) or benzodiazepines for sleep?<\/h3>\n<p>Different risk profile. Trazodone has no dependence potential and far lower overdose risk, but more orthostasis, falls, priapism (rare), and daytime grogginess. The right choice depends on patient age, fall risk, sex (priapism in men), and history of substance use.<\/p>\n<h3 class=\"wp-block-heading\">What is priapism and how worried should I be?<\/h3>\n<p>Priapism is a persistent erection unrelieved by ejaculation, usually painful, lasting more than 4 hours. It is a urological emergency &mdash; without prompt treatment, permanent erectile dysfunction can result. Trazodone-related priapism is rare (1 in 1,000&ndash;10,000) but real. Men starting trazodone should be told to seek emergency care for any erection lasting more than 4 hours.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol on Trazonil?<\/h3>\n<p>Avoid &mdash; additive sedation and orthostasis. Combining trazodone with alcohol significantly increases sedation and fall risk.<\/p>\n<h3 class=\"wp-block-heading\">Does Trazonil cause sexual dysfunction?<\/h3>\n<p>Less than SSRIs. Mechanism is different &mdash; the 5-HT<sub>2A<\/sub> blockade does not cause SSRI-style sexual side effects. Priapism in men is the rare specific concern.<\/p>\n<h3 class=\"wp-block-heading\">Can I stop Trazonil abruptly?<\/h3>\n<p>Better to taper, but discontinuation syndrome is much milder than SSRIs \/ SNRIs. Tapering over 1&ndash;2 weeks is usually sufficient.<\/p>\n<h3 class=\"wp-block-heading\">Is Trazonil safe in pregnancy?<\/h3>\n<p>Limited data &mdash; not first-line. Discuss individually with the prescriber.<\/p>\n<h3 class=\"wp-block-heading\">Can Trazonil cause weight gain?<\/h3>\n<p>Modest weight gain over months &mdash; less than mirtazapine, paroxetine, or olanzapine. Not a major concern at hypnotic doses.<\/p>\n<h3 class=\"wp-block-heading\">How should Trazonil be stored?<\/h3>\n<p>Store at 15&ndash;30 &deg;C in the original blister packaging away from moisture and sunlight. Keep out of reach of children &mdash; trazodone is much safer in overdose than TCAs but still medically significant.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0 0 0;border-radius:4px;font-size:13.5px;line-height:1.55;\"><strong>Medicinsk ansvarsfraskrivelse:<\/strong> Information on this page is intended for adults using prescribed psychiatric medication and is not a substitute for individualised medical care. Antidepressants, antipsychotics, and related medications can interact with other drugs, alcohol, and pre-existing conditions. Discuss any new medication, dose change, or planned discontinuation with a qualified prescriber. If you experience suicidal thoughts, mania, severe akathisia, signs of serotonin syndrome (high fever, confusion, muscle rigidity, rapid heart rate), or neuroleptic malignant syndrome, seek emergency care immediately.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Relaterede alternativer<\/h3>\n<p>Andre produkter inden for <strong>Kroniske tilstande<\/strong> som kunder ogs\u00e5 ser:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/da\/encorate-chrono\/\">Encorate Chrono<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/budecort-rotacaps\/\">Budecort Rotacaps<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/nootropil-syrup\/\">Nootropil Syrup<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/l-thyroid\/\">L-Thyroid<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/duolin-inhaler\/\">Duolin Inhaler<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Eases depression symptoms<br \/>\n\u2705 Enhances sleep quality<br \/>\n\u2705 Alleviates anxiety<br \/>\n\u2705 Manages PTSD<br \/>\n\u2705 Reduces side effects<\/p>\n<p>Trazonil contains Trazodone Hydrochloride.<\/p>","protected":false},"featured_media":59650,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,4647],"product_tag":[4719,4720],"class_list":{"0":"post-59649","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-situational-anxiety-treatment","9":"product_tag-trazodone","10":"product_tag-trazonil","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product\/59649","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/comments?post=59649"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/media\/59650"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/media?parent=59649"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product_brand?post=59649"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product_cat?post=59649"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product_tag?post=59649"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}