{"id":60802,"date":"2024-02-28T07:09:25","date_gmt":"2024-02-28T07:09:25","guid":{"rendered":"https:\/\/medsname.com\/unicontin-e\/"},"modified":"2026-04-30T10:23:42","modified_gmt":"2026-04-30T10:23:42","slug":"unicontin-e","status":"publish","type":"product","link":"https:\/\/medsbase.com\/da\/unicontin-e\/","title":{"rendered":"Unicontin-E"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 28px 0;border-radius:4px;\">\n<h3 style=\"margin:0 0 10px 0;font-size:18px;color:#1a1a1a;\">\u26a1 Quick Answer \u2014 What is Unicontin-E?<\/h3>\n<p><strong>Unicontin-E<\/strong> indeholder <strong>theophylline<\/strong>, en <strong>methylxanthin bronkodilatator<\/strong> med antiinflammatorisk effekt, anvendt som till\u00e6gsterapi ved kronisk astma og KOL. Theophyllin virker p\u00e5 flere m\u00e5der \u2014 h\u00e6mning af fosfodiesterase (hvilket \u00f8ger cAMP), antagonisme af adenosinreceptorer og aktivering af HDAC2 (antiinflammatorisk). Det har en <strong>smal terapeutisk bredde<\/strong> (target serum 10\u201320 mg\/L; toxicity at 20+) and many drug interactions, requiring careful dosing and (in some patients) blood-level monitoring. Each controlled-release tablet contains <strong>400 mg<\/strong>, fremstillet af <strong>Modi-Mundipharma<\/strong> p\u00e5 WHO-GMP certificerede faciliteter.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Hvad du f\u00e5r med MedsBase:<\/strong> WHO-GMP certificeret producent \u00b7 Diskret emballage \u00b7 Verdensomsp\u00e6ndende forsendelse \u00b7 1.400+ verificerede <a href=\"https:\/\/medsbase.com\/da\/reviews\/\">kundeanmeldelser<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Hver ordre er d\u00e6kket af vores <a href=\"https:\/\/medsbase.com\/da\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 hvis din pakke ikke ankommer inden for 20 hverdage, sender vi en erstatning.<\/p>\n<h3>Hvorfor bestille fra MedsBase<\/h3>\n<p>Vores generiske medicin kommer fra WHO-GMP certificerede producenter og sendes verdensomsp\u00e6ndende i diskret, neutral emballage \u2014 ingen medicinnavn p\u00e5 pakkens ydre. Kortbetalinger h\u00e5ndteres af en reguleret processor (kontoudtogsbeskrivelser inkluderer en reguleret betalingsprocessor \u2014 aldrig \u201cMedsBase\u201d eller medicinnavn). Crypto og SEPA bankoverf\u00f8rsel accepteres ogs\u00e5. Hver ordre er d\u00e6kket af vores Reshipment Assurance Policy.<\/p>\n<div style=\"background:#f4f8fb;border:1px solid #e0e0e0;padding:12px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;text-align:center;\">\n<strong>\ud83d\udd12 Krypteret betaling<\/strong> \u00b7 <strong>\ud83d\udcb3 Verificeret betalingsprocessor<\/strong> \u00b7 <strong>\ud83d\ude9a Verdensomsp\u00e6ndende forsendelse<\/strong> \u00b7 <strong>\u2b50 4,9\/5 fra 1.400+ kunder<\/strong>\n<\/div>\n<h2>What Is Unicontin-E?<\/h2>\n<p>Unicontin-E is an oral methylxanthine bronchodilator. Methylxanthines are derived from natural alkaloids (theophylline is the dimethylxanthine present in tea). Their use has declined since the 1990s as inhaled \u03b22-agonists and corticosteroids became first-line \u2014 but they retain a role as third-line add-on therapy in difficult asthma and COPD.<\/p>\n<h2>How Does Unicontin-E Work?<\/h2>\n<ul>\n<li><strong>H\u00e6mning af fosfodiesterase (PDE3, PDE4)<\/strong> \u2014 \u00f8ger cyklisk AMP i luftvejernes glatte muskulatur og inflammatoriske celler; nettoresultatet er bronkodilatation og reduceret frigivelse af mediatorer.<\/li>\n<li><strong>Adenosinreceptorantagonisme<\/strong> \u2014 blokerer adenosinmedieret bronkokonstriktion og frigivelse af mediatorer fra mastceller.<\/li>\n<li><strong>HDAC2-aktivering<\/strong> (theophyllin ved lave serumkoncentrationer 5\u201310 mg\/L) \u2014 genopretter kortikosteroidrespons i KOL og sv\u00e6r astma, hvor steroidresistens delvis skyldes nedsat HDAC2.<\/li>\n<li><strong>Diafragmakontraktilitet<\/strong> \u2014 methylxanthiner reducerer diafragmatr\u00e6thed, nyttig ved KOL med sv\u00e6r luftvejsbegr\u00e6nsning.<\/li>\n<\/ul>\n<h2>\u2014 det forst\u00e6rker den normale fysiologiske respons snarere end at udl\u00f8se en kunstigt.<\/h2>\n<ul>\n<li><strong>Sv\u00e6r kronisk astma<\/strong> \u2014 till\u00e6g til h\u00f8j-dosis ICS-LABA hvor yderligere bronkodilatation er n\u00f8dvendig<\/li>\n<li><strong>KOL-underholdning<\/strong> \u2014 till\u00e6g til LAMA-LABA eller trippelterapi<\/li>\n<li><strong>Nattelig astma<\/strong> \u2014 depotformulering giver natlig bronkodilatation<\/li>\n<li><strong>For tidligt f\u00f8dselsapn\u00f8<\/strong> (teofyllin) \u2014 neonatal brug<\/li>\n<li><strong>Cor pulmonale og pulmonal hypertension<\/strong> \u2014 supplement<\/li>\n<\/ul>\n<h2>Unicontin-E Dosage<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Patient<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Dosis<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Hyppighed<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Voksne \u2014 initial<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>200 mg<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Twice daily; titrate to serum level 10\u201320 mg\/L<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Voksne \u2014 vedligeholdelse<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>400 mg<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Twice daily (or 600 mg once daily ER)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Elderly \/ heart failure \/ liver disease<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Halver dosis<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor serum level<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Side Effects of Unicontin-E<\/h2>\n<ul>\n<li>Kvalme, opkastning, dyspepsi<\/li>\n<li>Hovedpine<\/li>\n<li>Rystelser<\/li>\n<li>S\u00f8vnl\u00f8shed, uro<\/li>\n<li>Takykardi, hjertebanken<\/li>\n<li>Mild hypokalaemi ved h\u00f8je doser<\/li>\n<\/ul>\n<p><strong>Toksiske niveauer (&gt;20 mg\/L) - akut tilf\u00e6lde:<\/strong><\/p>\n<ul>\n<li>Kraftig kvalme, vedvarende opkastning<\/li>\n<li>Hjertearytmi (atrieflimren, supraventrikul\u00e6r takykardi)<\/li>\n<li>Krampeanfald (ofte uden forvarsel)<\/li>\n<li>Hypotension, hyperglyk\u00e6mi, hypokali\u00e6mi, hyperkalci\u00e6mi<\/li>\n<\/ul>\n<h2>Advarsler og forholdsregler<\/h2>\n<ul>\n<li><strong>Sn\u00e6vert terapeutisk indeks.<\/strong> M\u00e5lniveau i serum 10\u201320 mg\/L. Kontroller blodniveau 5 dage efter start, efter dosis\u00e6ndring, ved nyt interagerende l\u00e6gemiddel, ved rygestop og under sygdom\/feber (clearance falder).<\/li>\n<li><strong>Mange l\u00e6gemiddelinteraktioner<\/strong> \u2014 se interaktionstabel. St\u00f8rstedelen metaboliseres af CYP1A2; mange h\u00e6mmere og induktorer \u00e6ndrer niveauerne markant.<\/li>\n<li><strong>Rygning<\/strong> inducerer CYP1A2 og s\u00e6nker teofyllinniveauet med ~50% \u2014 omtitrer ved rygestop.<\/li>\n<li><strong>Hjertesygdom:<\/strong> anvend med forsigtighed ved arytmier, hjertesvigt, sv\u00e6r hypertension.<\/li>\n<li><strong>Hyperthyreose:<\/strong> \u00f8get clearance samt forst\u00e6rkede adrenerge effekter.<\/li>\n<li><strong>Graviditet og amning:<\/strong> generelt undg\u00e5s; kun anvend hvis fordel er tydelig.<\/li>\n<li><strong>Lidelse i leveren:<\/strong> reducer dosis \u2014 methylxanthiner metaboliseres i leveren.<\/li>\n<\/ul>\n<h2>Kontraindikationer<\/h2>\n<ul>\n<li>Overf\u00f8lsomhed over for theophyllin eller andre xanthiner (koffein, theobromin)<\/li>\n<li>Aktiv maves\u00e5rssygdom<\/li>\n<li>Ukontrollerede tachyarytmier<\/li>\n<li>Sv\u00e6rt hjertesvigt (NYHA IV)<\/li>\n<\/ul>\n<h2>L\u00e6gemiddelinteraktioner<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Interagerende l\u00e6gemiddel<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Effekt<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Hvad skal der g\u00f8res<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Ciprofloxacin, erythromycin, clarithromycin, fluvoxamin<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">H\u00e6mmer CYP1A2 \u2192 \u00f8ger theophyllinniveauet \u2192 toksicitet (kvalme, arytmi, kramper)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Undg\u00e5 eller reducer theophyllindosis med 50%; kontroller serumkoncentrationen<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Cimetidin, allopurinol<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u00d8ger theophyllinniveauet<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reducer dosis; overv\u00e5g niveauer<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Phenytoin, carbamazepine, rifampicin<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Inducerer CYP \u2014 lavere niveauer<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">H\u00f8jere dosis kan v\u00e6re n\u00f8dvendig<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Rygning<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Inducerer CYP1A2 \u2014 lavere niveauer<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Omtitrer dosis ved rygestop<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u03b2-agonister, diuretika<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additiv hypokali\u00e6mi<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Overv\u00e5g kalium<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Opbevaring<\/h2>\n<ul>\n<li>Opbevares under <strong>25\u00b0C<\/strong> p\u00e5 et k\u00f8ligt, t\u00f8rt sted v\u00e6k fra direkte sollys.<\/li>\n<li>Opbevar i originalemballage inden brug for at beskytte mod fugt og lys.<\/li>\n<li>Brug ikke efter den udl\u00f8bsdato, der er trykt p\u00e5 strimlen.<\/li>\n<li>Opbevar utilg\u00e6ngeligt for b\u00f8rn.<\/li>\n<\/ul>\n<h2>Relaterede alternativer p\u00e5 MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/da\/asthalin-inhaler\/\"><strong>Asthalin Inhalator \u2014 salbutamol lindrende<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/budecort-inhaler\/\"><strong>Budecort Inhalator \u2014 budesonide ICS forebyggende<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/foracort-inhaler\/\"><strong>Foracort Inhalator \u2014 budesonide + formoterol ICS-LABA<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/tiova-inhaler\/\"><strong>Tiova Inhalator \u2014 tiotropium LAMA til KOL<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/montair\/\"><strong>Montair \u2014 montelukast LTRA tablet<\/strong><\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">Ofte stillede sp\u00f8rgsm\u00e5l<\/h2>\n<h3>Is theophylline still used in modern asthma management?<\/h3>\n<p>Yes, but as third-line add-on. Inhaled \u03b22 agonists, ICS, ICS-LABA, LTRA, and LAMA are first-line; theophylline is added for refractory disease, particularly nocturnal asthma. The narrow therapeutic index and many drug interactions limit its use.<\/p>\n<h3>How is the dose decided?<\/h3>\n<p>Adjusted to serum theophylline level 10\u201320 mg\/L. Check 5 days after starting, after dose change, with new interacting drug, with smoking cessation, and during illness\/fever.<\/p>\n<h3>Why so many interactions?<\/h3>\n<p>Theophylline is metabolised by CYP1A2 \u2014 many drugs raise levels (ciprofloxacin, erythromycin, fluvoxamine, cimetidine) or lower levels (rifampicin, phenytoin, smoking).<\/p>\n<h3>How long does Unicontin-E last?<\/h3>\n<p>The controlled-release tablet provides 12-hour cover. Twice-daily dosing maintains stable serum levels.<\/p>\n<h3>What are the toxic symptoms?<\/h3>\n<p>Severe nausea, persistent vomiting, tachycardia, palpitations, tremor, hyperactivity, seizures (often without warning), arrhythmias, hypotension. Toxicity above 20 mg\/L is an emergency \u2014 withhold dose, check level, supportive care.<\/p>\n<h3>Can I take it with caffeine?<\/h3>\n<p>Caffeine and theophylline are both methylxanthines with overlapping effects. Heavy caffeine can amplify tremor, tachycardia, and insomnia. Reduce caffeine if symptomatic.<\/p>\n<h3>Why does smoking affect dose?<\/h3>\n<p>Smoking induces CYP1A2 (the enzyme that metabolises theophylline). Smokers need higher doses; on stopping, levels rise \u2014 re-titrate.<\/p>\n<h3>Is Unicontin-E safe in pregnancy?<\/h3>\n<p>Generally avoided unless benefit clear. Inhaled therapy is preferred.<\/p>\n<h3>Can I crush or split Unicontin-E tablets?<\/h3>\n<p>No \u2014 controlled-release tablets must be swallowed whole. Crushing destroys the release matrix and risks acute toxicity.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0;border-radius:4px;font-size:13px;\"><strong>Medicinsk ansvarsfraskrivelse:<\/strong> Denne side er uddannelsesm\u00e6ssig og erstatter ikke professionel medicinsk r\u00e5dgivning. Konsulter altid en kvalificeret sundhedsfaglig person, f\u00f8r du starter, stopper eller \u00e6ndrer enhver inhalator eller respirationsmedicin, is\u00e6r hvis du har andre medicinske tilstande, tager andre receptpligtige l\u00e6gemidler, er gravid eller ammer, eller er over 65 \u00e5r.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Relaterede alternativer<\/h3>\n<p>Andre produkter inden for <strong>Kroniske tilstande<\/strong> som kunder ogs\u00e5 ser:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/da\/topme-xl\/\">Topme XL<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/amifru\/\">Amifru<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/unibrom-eye-drops\/\">Unibrom Eye Drops<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/nise-gel\/\">Nise Gel<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/dynapar\/\">Dynapar<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Lindrer bronkospasme<br \/>\n\u2705 Enhances lung function<br \/>\n\u2705 Reduces shortness of breath<br \/>\n\u2705 Improves airway flow<br \/>\n\u2705 Manages asthma symptoms<\/p>\n<p>Unicontin-E contains Theophylline.<\/p>","protected":false},"featured_media":60803,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3681,3141,3223],"product_tag":[3731,4926],"class_list":{"0":"post-60802","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-asthma-copd-treatment","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-theophylline","10":"product_tag-unicontin-e","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product\/60802","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/comments?post=60802"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/media\/60803"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/media?parent=60802"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product_brand?post=60802"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product_cat?post=60802"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product_tag?post=60802"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}