{"id":61084,"date":"2024-02-28T07:23:46","date_gmt":"2024-02-28T07:23:46","guid":{"rendered":"https:\/\/medsname.com\/thioril\/"},"modified":"2026-04-30T10:23:39","modified_gmt":"2026-04-30T10:23:39","slug":"thioril","status":"publish","type":"product","link":"https:\/\/medsbase.com\/da\/thioril\/","title":{"rendered":"Thioril"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div class=\"medsbase-tldr-answer\" style=\"background:#fff8d6;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">\u26a1 Hurtigt svar<\/h3>\n<p style=\"margin-bottom:0;\">Thioril (Thioridazine 10 \/ 25 \/ 100 mg) is a first-generation phenothiazine antipsychotic. Reserved as last-resort second-line because of the FDA black-box QT warning.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Hvad du f\u00e5r med MedsBase:<\/strong> WHO-GMP certificeret producent \u00b7 Diskret emballage \u00b7 Verdensomsp\u00e6ndende forsendelse \u00b7 1.400+ verificerede <a href=\"https:\/\/medsbase.com\/da\/reviews\/\">kundeanmeldelser<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Hver ordre er d\u00e6kket af vores <a href=\"https:\/\/medsbase.com\/da\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 hvis din pakke ikke ankommer inden for 20 hverdage, sender vi en erstatning.<\/p>\n<h3>Hvorfor bestille fra MedsBase<\/h3>\n<p>Thioril at MedsBase is supplied directly from a WHO-GMP certified manufacturer in plain, discreet packaging. Every order is covered by our <a href=\"https:\/\/medsbase.com\/da\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance Policy<\/a> \u2014 20-hverdages leveringsvindue eller vi gensender uden ekstra omkostninger \u2014 og kvalificerer sig til vores <a href=\"https:\/\/medsbase.com\/da\/loyalty-points\/\">kundeloyalitetsprogram<\/a>. Verdensomsp\u00e6ndende forsendelse er tilg\u00e6ngelig til de fleste destinationer.<\/p>\n<h2>What Thioril is and how it works<\/h2>\n<p>Thioril is a Thioridazine tablet supplied by Sun Pharma. Available strengths: <strong>10 \/ 25 \/ 100 mg<\/strong>.<\/p>\n<p>Thioridazine is a piperidine phenothiazine. <strong>It carries an FDA black-box warning for fatal QT prolongation and torsades de pointes<\/strong> and is now reserved as a last-resort second-line antipsychotic \u2014 it was withdrawn or restricted in many jurisdictions in 2000\u20132005. Atypical antipsychotics are preferred for nearly all current indications.<\/p>\n<h2>Indikationer og dosering<\/h2>\n<p>Reserved for treatment-refractory schizophrenia where atypicals and other typicals have failed. Adult: 50\u2013100 mg TID, max 800 mg\/day. Pre-treatment ECG and electrolyte correction required. Some jurisdictions now require continuous QT monitoring during the first weeks.<\/p>\n<h2>Vigtige sikkerhedsovervejelser<\/h2>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>FDA black-box \u2014 fatal QT and torsades<\/strong><\/p>\n<p style=\"margin-bottom:0;\"><strong>Thioridazine carries an FDA black-box warning for dose-dependent QT prolongation and torsades de pointes.<\/strong> Reports of sudden cardiac death at therapeutic doses. <strong>Pre-treatment ECG mandatory.<\/strong> Contraindicated in known long QT, conduction abnormality, hypokalaemia, hypomagnesaemia, on other QT-prolonging therapy, in CYP2D6 poor metabolisers, and in concurrent strong CYP2D6 inhibitors (paroxetine, fluoxetine, bupropion, quinidine \u2014 all dramatically raise thioridazine levels). Many regulatory agencies have withdrawn thioridazine from the market or restricted to last-resort use; <strong>switch to a safer atypical wherever clinically possible<\/strong>.<\/p>\n<\/div>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>Antikolinerg byrde, sedation, ortostatisk hypotension<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Alle fenotiaziner har betydelig antikolinerg, antihistamin og \u03b11-blokerende aktivitet. S\u00e6rligt problematisk hos \u00e6ldre \u2014 fald, delirium, urinretention og forstoppelse er almindelige. Undg\u00e5 ved demens, BPH, sn\u00e6vervinklet glaukom, sv\u00e6r leversygdom.<\/p>\n<\/div>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>F\u00f8lsomhed over for lys og hudpigmentering<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Fenotiaziner for\u00e5rsager lysf\u00f8lsomhed (alvorlige solskoldninger) og ved langtidsbrug bl\u00e5-gr\u00e5 hudpigmentering og sj\u00e6ldent linse-\/hornhindepigmentering (is\u00e6r chlorpromazin). Solbeskyttelse er obligatorisk.<\/p>\n<\/div>\n<h2>Almindelige bivirkninger<\/h2>\n<ul>\n<li><strong>Sedering<\/strong> \u2014 universel.<\/li>\n<li><strong>Ortostatisk hypotension<\/strong> \u2014 st\u00e6rk \u03b11-blokering.<\/li>\n<li><strong>Antikolinerg<\/strong> \u2014 t\u00f8r mund, forstoppelse, vandladningsbesv\u00e6r, sl\u00f8ret syn.<\/li>\n<li><strong>EPS \/ tardiv dyskinesi<\/strong> \u2014 betydningsfuld.<\/li>\n<li><strong>Hyperprolaktin\u00e6mi<\/strong> \u2014 st\u00e6rk.<\/li>\n<li><strong>V\u00e6gt\u00f8gning<\/strong> \u2014 moderat.<\/li>\n<li><strong>QT-forl\u00e6ngelse<\/strong> \u2014 tilstede i begge, sv\u00e6r ved thioridazin.<\/li>\n<li><strong>Fotosensitivitet<\/strong> \u2014 universel.<\/li>\n<li><strong>Kolestatisk hepatitis (sj\u00e6lden, idiosynkratisk)<\/strong> \u2014 is\u00e6r chlorpromazin.<\/li>\n<\/ul>\n<h2>L\u00e6gemiddelinteraktioner<\/h2>\n<ul>\n<li><strong>Andre QT-forl\u00e6ngende l\u00e6gemidler<\/strong> \u2014 additiv risiko; undg\u00e5 kombinationer.<\/li>\n<li><strong>St\u00e6rke CYP2D6-h\u00e6mmere<\/strong> (paroxetin, fluoxetin, bupropion, kinidin) \u2014 \u00f8ger niveauerne betydeligt; absolut kontraindikation for thioridazin.<\/li>\n<li><strong>Antihypertensiva<\/strong> \u2014 st\u00e6rk additiv hypotension.<\/li>\n<li><strong>Antikolinergika<\/strong> \u2014 additiv belastning.<\/li>\n<li><strong>CNS-depressiva<\/strong> \u2014 additiv sedering.<\/li>\n<li><strong>Levodopa<\/strong> \u2014 antagonisme; undg\u00e5 ved Parkinsons sygdom.<\/li>\n<\/ul>\n<h2>Graviditet, amning, p\u00e6diatrisk<\/h2>\n<p>Graviditet: begr\u00e6nsede data; chlorpromazin er historisk blevet brugt ved hyperemesis med forsigtighed. Amning: passerer over i m\u00e6lk; normalt undg\u00e5s. P\u00e6diatri: ikke f\u00f8rstevalg; chlorpromazin bruges lejlighedsvis i lave doser til sv\u00e6r p\u00e6diatrisk agitation under specialistvejledning.<\/p>\n<h2>Opbevaring<\/h2>\n<p>Opbevares ved 15\u201330 \u00b0C, v\u00e6k fra lys, i original emballage.<\/p>\n<h2 id=\"faqs\">Ofte stillede sp\u00f8rgsm\u00e5l<\/h2>\n<h3>Why is thioridazine considered second-line now?<\/h3>\n<p>Thioridazine carries an FDA black-box warning for dose-dependent fatal QT prolongation. Atypical antipsychotics achieve similar antipsychotic effect with much less cardiac risk, less anticholinergic burden, and lower TD rates. Thioridazine is therefore reserved for treatment-refractory schizophrenia where atypicals and other typicals have failed.<\/p>\n<h3>Is thioridazine safe in older adults?<\/h3>\n<p>Generelt ikke foretrukket \u2014 antikolinerg byrde, fald, ortostase og TD-risiko stiger alle med alderen. Beers-kriterierne markerer begge som potentielt upassende medicin for \u00e6ldre voksne. Hvis det bruges, start med en lav dosis og gennemg\u00e5 ugentligt.<\/p>\n<h3>Will thioridazine cause tardive dyskinesia?<\/h3>\n<p>Kumulativ TD-risiko for typiske antipsykotika er cirka 5%\/\u00e5r af eksponering (atypiske cirka 1%\/\u00e5r). Efter 5 \u00e5rs eksponering for typiske antipsykotika udvikler cirka 25% af patienterne nogle TD-tegn. Risikoen er h\u00f8jere med alder og kvindelig k\u00f8n. TD kan v\u00e6re irreversibel \u2014 skift til clozapine eller et lav-EPS atypisk middel ved de f\u00f8rste tegn.<\/p>\n<h3>Why does thioridazine cause sun sensitivity?<\/h3>\n<p>Fenothiaziner aflejres i huden og gennemg\u00e5r fotokemisk skade ved UV-eksponering \u2014 hvilket producerer sv\u00e6re solskoldninger og, ved langtidsbrug, bl\u00e5-gr\u00e5 pigmentation. Solcreme, beskyttende t\u00f8j og begr\u00e6nset UV-eksponering er obligatorisk.<\/p>\n<h3>Can thioridazine be stopped abruptly?<\/h3>\n<p>Trap over 2\u20134 uger. Brutalt oph\u00f8r for\u00e5rsager kolinerg rebound (kvalme, svedtendens, s\u00f8vnl\u00f8shed) og antipsykotisk tilbagefald. Tilbagetr\u00e6kningsdyskinesi kan ogs\u00e5 afsl\u00f8re TD, der blev undertrykt af medicinen.<\/p>\n<h3>Will thioridazine interact with my other medications?<\/h3>\n<p>Flere vigtige interaktioner: (1) andre QT-forl\u00e6ngende l\u00e6gemidler (additiv effekt); (2) st\u00e6rke CYP2D6-h\u00e6mmere som paroxetin og fluoxetin (for\u00f8ger niveauer betydeligt); (3) antihypertensiva (additiv ortostase). Gennemg\u00e5 altid den fulde medicinliste med den ordinerede l\u00e6ge.<\/p>\n<h3>Why thioridazine for hiccups?<\/h3>\n<p>Not commonly used for hiccups \u2014 chlorpromazine is the phenothiazine of choice for that off-label indication.<\/p>\n<h3>How long until thioridazine works?<\/h3>\n<p>Beroligende og sedativ effekt inden for timer. Antipsykotisk effekt over 1\u20132 uger for positive symptomer. Fuld effekt ved 4\u20136 uger.<\/p>\n<h3>Can thioridazine be used for short-term severe agitation?<\/h3>\n<p>No \u2014 thioridazine is not used for acute agitation. The QT risk and slower onset make it unsuitable.<\/p>\n<h3>Will thioridazine affect my driving?<\/h3>\n<p>St\u00e6rk sedering i de f\u00f8rste 1\u20132 uger. De fleste patienter p\u00e5 stabile doser k\u00f8rer normalt, men den ortostatiske hypotension og sedering kan vedvare.<\/p>\n<h2>Andre Mental Sundhedsmedicin<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/da\/aripicon\/\">Aripicon (Aripiprazol - atypisk, lav EPS)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/risdone\/\">Risdone (Risperidon)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/olanzap\/\">Olanzap (Olanzapin)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/sulpitac\/\">Sulpitac (Amisulprid)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/skizoril\/\">Skizoril (Klozapin - refrakt\u00e6r sygdom)<\/a><\/li>\n<\/ul>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;font-size:0.9em;\">\n<strong>Medicinsk ansvarsfraskrivelse.<\/strong> Denne side er udelukkende til informationsform\u00e5l og er ikke erstatning for individuel l\u00e6gevejledning. Behandling med psykofarmaka b\u00f8r iv\u00e6rks\u00e6ttes, overv\u00e5ges og tilpasses af en kvalificeret kliniker. Hvis du eller nogen du kender er i akut selvmordskrise, skal du kontakte lokale akutteams eller ringe til din lands selvmordsforebyggende kriselinje (US\/Canada: 988; UK: Samaritans 116 123; international liste: <a href=\"https:\/\/findahelpline.com\/\" rel=\"nofollow noopener\" target=\"_blank\">findahelpline.com<\/a>).\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Thioril (Thioridazine 10\/25\/100 mg) \u2014 piperidine phenothiazine for treatment-refractory schizophrenia. last-resort second-line \u2014 FDA black-box for fatal QT prolongation.<\/p>","protected":false},"featured_media":61085,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3906],"product_tag":[4974,4975,4976],"class_list":{"0":"post-61084","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-mental-health-and-psychiatric-medications","9":"product_tag-thioridazine","10":"product_tag-thioridazine-hydrochloride","11":"product_tag-thioril","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product\/61084","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/comments?post=61084"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/media\/61085"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/media?parent=61084"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product_brand?post=61084"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product_cat?post=61084"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product_tag?post=61084"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}