{"id":61309,"date":"2024-02-28T07:34:47","date_gmt":"2024-02-28T07:34:47","guid":{"rendered":"https:\/\/medsname.com\/kenadion-injection\/"},"modified":"2026-04-30T10:23:36","modified_gmt":"2026-04-30T10:23:36","slug":"kenadion-injection","status":"publish","type":"product","link":"https:\/\/medsbase.com\/da\/kenadion-injection\/","title":{"rendered":"Kenadion Injection"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">Hurtigt svar<\/h3>\n<p><strong>Kenadion Injektion (fytomenadion (vitamin K1) 10 mg ampul)<\/strong> er vitamin K1 (fytomenadion) til intraven\u00f8s eller intramuskul\u00e6r injektion. Det bruges som modgift ved warfarin-forgiftning, til forebyggelse og behandling af h\u00e6morragisk sygdom hos nyf\u00f8dte samt ved vitamin K-mangel p\u00e5 grund af malabsorption eller kolestase.<\/p>\n<ul style=\"margin-bottom:0;\">\n<li>Fytomenadion (vitamin K1) 10 mg pr. ampul<\/li>\n<li>Indikationer: warfarin-modvirkning, neonatal vitamin K-profilakse, malabsorptionsrelateret mangel<\/li>\n<li>Intraven\u00f8s (langsomt) eller intramuskul\u00e6r administration \u2013 specialistmilj\u00f8<\/li>\n<li>WHO-GMP certificeret producent<\/li>\n<\/ul>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f6f8;border:1px solid #e0e4e7;padding:12px 16px;margin:18px 0;border-radius:4px;font-size:14px;color:#444;\">\n<strong>WHO-GMP certificeret producent<\/strong> \u00b7 Diskret emballage \u00b7 Verdensomsp\u00e6ndende forsendelse \u00b7 <a href=\"https:\/\/medsbase.com\/da\/reviews\/\" style=\"color:#2c7cb0;\">1.400+ verificerede kundeanmeldelser<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Hver ordre er d\u00e6kket af vores <a href=\"https:\/\/medsbase.com\/da\/medsbase-re-shipment-assurance-policy\/\"><strong>Reshipment Assurance Policy<\/strong><\/a> \u2014 hvis din pakke ikke ankommer inden for 20 hverdage, sender vi en erstatning.<\/p>\n<p style=\"font-size:13px;color:#666;margin:4px 0 18px;\">Hver ordre er d\u00e6kket af vores <a href=\"https:\/\/medsbase.com\/da\/medsbase-re-shipment-assurance-policy\/\" style=\"color:#2c7cb0;\">Reshipment Assurance Policy<\/a>.<\/p>\n<h3>Hvorfor bestille fra MedsBase<\/h3>\n<p>Kenadion Injektion kommer fra en WHO-GMP-certificeret producent. Hver ordre sendes i diskret, unbrandet emballage over hele verden og er d\u00e6kket af vores Reshipment Assurance Policy. Betal sikkert med kreditkort, SEPA bankoverf\u00f8rsel eller kryptovaluta. Se vores <a href=\"https:\/\/medsbase.com\/da\/reviews\/\">1.400+ verificerede kundeanmeldelser<\/a>.<\/p>\n<h2>Hvad er Kenadion Injektion?<\/h2>\n<p>Kenadion er parenteral fytomenadion (vitamin K1) \u2014 den naturlige form for vitamin K, der er essentiel for den hepatiske syntese af koagulationsfaktor II, VII, IX, X samt protein C og S. Vitamin K1 er antidotet ved warfarinforgiftning, den rutinem\u00e6ssige profylaxe, der gives til nyf\u00f8dte for at forebygge h\u00e6morragisk sygdom hos nyf\u00f8dte, og erstatningsterapien for vitamin K-mangel for\u00e5rsaget af kronisk malabsorption eller galdevejsobstruktion.<\/p>\n<h2>Indikationer<\/h2>\n<ul>\n<li><strong>Warfarinforgiftning \/ overantikoagulering<\/strong> \u2014 INR-styret dosis<\/li>\n<li><strong>Vitamin K-mangelbl\u00f8dning (VKDB) hos nyf\u00f8dte<\/strong> \u2014 rutinem\u00e6ssig 1 mg IM ved f\u00f8dslen (eller oral 2 mg ved f\u00f8dslen og opf\u00f8lgende doser)<\/li>\n<li><strong>Vitamin K-mangel pga. malabsorption<\/strong> \u2014 c\u00f8liaki, inflammatorisk tarmsygdom, cystisk fibrose, kort tarmsyndrom<\/li>\n<li><strong>Kolestatisk leversygdom<\/strong> \u2014 galdevejsobstruktion forhindrer galdesalt-afh\u00e6ngig optagelse af fedtopl\u00f8selige vitaminer<\/li>\n<li><strong>Kronisk brug af bredspektret antibiotika<\/strong> \u2014 tarmflora \u00f8delagt, vitamin K2-produktion tabt<\/li>\n<li><strong>Total parenteral ern\u00e6ring<\/strong> uden tilstr\u00e6kkelig vitamin K-tilskud<\/li>\n<li><strong>Pr\u00e6procedurel reversering<\/strong> hos warfariniserede patienter (sammen med 4F-PCC til akut reversering)<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>IV phytomenadione: risiko for anafylaktoide reaktioner \u2014 langsom administration er obligatorisk<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Hurtig IV phytomenadione har for\u00e5rsaget d\u00f8delige anafylaktoide reaktioner (is\u00e6r med de \u00e6ldre Cremophor-indeholdende formuleringer). Moderne emulsionformuleringer er sikrere, men IV vitamin K1 skal gives langsomt \u2014 over mindst 30 sekunder for sm\u00e5 doser, ideelt som en 30-minutters infusion i 50 ml saltvand for h\u00f8jere doser. IM er generelt sikrere end IV men har langsommere virkning.<\/p>\n<\/div>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;\">\n<thead>\n<tr>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px;text-align:left;\">Indikation<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px;text-align:left;\">Dosis &amp; administrationsvej<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px;text-align:left;\">Starttidspunkt<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Profylakse mod neonatal VKDB<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">1 mg IM ved f\u00f8dslen (eller 2 mg oral ved f\u00f8dslen + opf\u00f8lgning)<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Timer<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Warfarin INR &gt; 8 (ingen bl\u00f8dning)<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">1\u20135 mg oral eller 0,5\u20131 mg langsom IV<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">IV: 6\u201312 timer; oral: 24 timer<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Alvorlig bl\u00f8dning ved warfarin<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">5\u201310 mg langsom IV + 4F-PCC<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">IV: 6\u201312 timer (PCC: minutter)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Etableret vitamin K-mangel<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">5\u201310 mg IV\/IM, kan gentages<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">6\u201312 timer<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Vedligeholdelse ved kolestatisk sygdom<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">10 mg IM m\u00e5nedligt (eller oral phytomenadione dagligt)<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Timer til dage<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">TPN-tilskud<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">If\u00f8lge parenteral ern\u00e6ringsprotokol<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Vedligeholdelse<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Bivirkninger<\/h2>\n<ul>\n<li><strong>Anafylaktoid reaktion<\/strong> med hurtig intraven\u00f8s administration \u2014 den dominerende sikkerhedsbekymring; langsom administration er obligatorisk<\/li>\n<li><strong>Ubehag ved injektionssted<\/strong><\/li>\n<li><strong>Overf\u00f8lsomhedsreaktion<\/strong> \u2014 sj\u00e6lden men rapporteret<\/li>\n<li><strong>Warfarin-resistens<\/strong> \u2014 h\u00f8j dosis K1 kan g\u00f8re efterf\u00f8lgende re-antikoagulering vanskeligere; mindre doser foretr\u00e6kkes, n\u00e5r der forventes en overgangsperiode<\/li>\n<\/ul>\n<h2>L\u00e6gemiddelinteraktioner<\/h2>\n<ul>\n<li><strong>Warfarin<\/strong> \u2014 vitamin K1 modvirker antikoagulering; dette er intentionelt ved overdosering, men problematisk, hvis antikoagulering er terapeutisk n\u00f8dvendig. V\u00e6lg dosis omhyggeligt ved modvirkning.<\/li>\n<li><strong>Andre vitamin K-antagonister<\/strong> (acenocoumarol, phenprocoumon) &mdash; same antagonism<\/li>\n<li><strong>Direct oral anticoagulants (apixaban, rivaroxaban, dabigatran)<\/strong> &mdash; vitamin K1 has NO effect on these; reversal needs different agents (andexanet, idarucizumab, 4F-PCC)<\/li>\n<\/ul>\n<h2>Kontraindikationer<\/h2>\n<ul>\n<li>Hypersensitivity to phytomenadione<\/li>\n<li>Caution in severe hepatic impairment (response may be limited if hepatic synthesis itself is failing)<\/li>\n<\/ul>\n<h2>Opbevaring<\/h2>\n<p>Opbevares under 25\u00b0C, beskyttes mod lys. Brug ampullen efter \u00e5bning.<\/p>\n<h2 id=\"faqs\">Ofte stillede sp\u00f8rgsm\u00e5l<\/h2>\n<h3>Why is it given to newborns?<\/h3>\n<p>Newborns are vitamin K-deficient at birth (poor placental transfer, sterile gut at birth, low K1 in breast milk). Vitamin K deficiency bleeding (VKDB) of the newborn was a major cause of catastrophic intracranial bleeding before routine prophylaxis. WHO and national guidelines recommend 1 mg IM at birth (or oral 2 mg at birth followed by additional doses); IM is more reliable than oral for prevention.<\/p>\n<h3>Why is rapid IV dangerous?<\/h3>\n<p>Older Cremophor-containing formulations of phytomenadione caused anaphylactoid reactions (acute hypotension, bronchospasm, rarely fatal). Modern aqueous-emulsion formulations are safer but slow administration is still mandatory. Where possible, oral or IM is preferred.<\/p>\n<h3>How does it reverse warfarin?<\/h3>\n<p>Warfarin blocks vitamin-K-epoxide reductase in the liver, preventing recycling of reduced vitamin K needed to gamma-carboxylate clotting factors II, VII, IX, X. Phytomenadione bypasses this block by providing reduced vitamin K1, allowing fresh clotting factor synthesis. Onset is hours-to-days; emergency reversal needs 4F-PCC for the immediate factor replacement.<\/p>\n<h3>Will it work for DOAC bleeding?<\/h3>\n<p>No. Apixaban, rivaroxaban, edoxaban, dabigatran do NOT involve vitamin K. Phytomenadione has no effect on them. Reversal needs andexanet alfa (Xa inhibitors) or idarucizumab (dabigatran), with 4F-PCC as backup.<\/p>\n<h3>Can patients on warfarin take vitamin K?<\/h3>\n<p>Vitamin K-rich foods (leafy greens, broccoli) are not forbidden &mdash; the rule is consistency. Patients on warfarin should keep vitamin K intake stable so the warfarin dose can be matched. Sudden multivitamin starts\/stops or major dietary swings cause INR instability. Multivitamins with vitamin K should be discussed with the warfarin clinic.<\/p>\n<h3>How quickly does INR drop after vitamin K?<\/h3>\n<p>Oral vitamin K1: INR begins falling at 6&ndash;12 hours, normalises by 24&ndash;48 hours. IV vitamin K1: faster, INR begins falling at 6&ndash;12 hours. Emergency reversal (active bleeding) needs 4F-PCC for immediate factor replacement &mdash; vitamin K is supportive but slow.<\/p>\n<h3>Er det sikkert under graviditet?<\/h3>\n<p>Yes &mdash; commonly given in malabsorption \/ cholestasis-of-pregnancy. Crosses placenta poorly so does not cause fetal effects acutely.<\/p>\n<h3>Why does cholestatic liver disease cause vitamin K deficiency?<\/h3>\n<p>Vitamin K is fat-soluble. Bile salts are needed for fat absorption. Biliary obstruction (gallstone, primary biliary cholangitis, cholangiocarcinoma) blocks bile flow, preventing fat-soluble vitamin absorption. Vitamin K deficiency causes elevated INR even before clinical bleeding.<\/p>\n<h3>Can I take vitamin K orally instead?<\/h3>\n<p>Yes &mdash; oral phytomenadione tablets exist for non-emergency replacement (e.g. cholestatic-disease maintenance, mild warfarin over-anticoagulation without bleeding). The injection is for emergencies, neonatal prophylaxis, severe malabsorption, or when oral cannot be tolerated.<\/p>\n<h3>Will it interact with my other medicines?<\/h3>\n<p>Mainly warfarin and other vitamin K antagonists. No clinically significant interactions with most other drugs &mdash; including antibiotics, statins, antihypertensives, or oral contraceptives.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Andre vitaminer og mineraler<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/da\/vitamin-b12-1500-mcg-tablets-nerve-health-energy\/\">Vitamin B12 1500 mcg<\/a> &mdash; oral cyanocobalamin<\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/walcobal-injection\/\">Walcobal Injektion<\/a> \u2014 methylcobalamin IM<\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/polybion-ampoule\/\">Polybion Ampul<\/a> \u2014 B-kompleks parenteral<\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/celin\/\">Celin<\/a> &mdash; vitamin C 500 mg<\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/arachitol-6l-injection\/\">Arachitol 6L Injektion<\/a> \u2014 cholecalciferol IM-depot<\/li>\n<li><a href=\"https:\/\/medsbase.com\/da\/multivite-gold\/\">Multivite Gold<\/a> \u2014 omfattende multivitamin<\/li>\n<\/ul>\n<h2>Medicinsk ansvarsfraskrivelse<\/h2>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;font-size:14px;color:#444;\">\nDenne side er kun til undervisningsform\u00e5l og er ikke en erstatning for professionel medicinsk r\u00e5dgivning. Vitamin- og mineraltilskud b\u00f8r ideelt set vejledes af laboratorietests, hvor der mist\u00e6nkes mangel. Megadosistilskud er ikke harml\u00f8se \u2014 vitamin A er teratogent, vitamin E \u00f8ger bl\u00f8dningsrisiko, beta-caroten \u00f8ger lungekr\u00e6ftrisiko hos rygere, og h\u00f8jdosis calcium har en kardiovaskul\u00e6r signalering. Gravide eller ammende patienter b\u00f8r f\u00f8lge obstetrisk vejledning til pr\u00e6natal supplering. Patienter p\u00e5 warfarin skal opretholde stabilt vitamin K-indtag. Patienter p\u00e5 levothyroxin, fluoroquinoloner eller tetracycliner skal adskille jern og calcium med 4 timer. Opgiv altid alle kosttilskud til din l\u00e6ge og apoteker.\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u2705 Fremmer blodets koagulering<br \/>\n\u2705 Forebygger bl\u00f8dning<br \/>\n\u2705 Behandler vitamin K-mangel<br \/>\n\u2705 St\u00f8tter knoglesundhed<br \/>\n\u2705 Vigtig for nyf\u00f8dte<\/p>\n<p>Kenadion Injection indeholder vitamin K.<\/p>","protected":false},"featured_media":61310,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3863],"product_tag":[5012,5013,5014],"class_list":{"0":"post-61309","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-vitamins-and-minerals","9":"product_tag-kenadion","10":"product_tag-kenadion-injection","11":"product_tag-vitamin-k","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product\/61309","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/comments?post=61309"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/media\/61310"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/media?parent=61309"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product_brand?post=61309"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product_cat?post=61309"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/da\/wp-json\/wp\/v2\/product_tag?post=61309"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}