{"id":51442,"date":"2023-09-20T09:21:39","date_gmt":"2023-09-20T09:21:39","guid":{"rendered":"https:\/\/medsname.com\/arkamin\/"},"modified":"2026-09-12T04:33:28","modified_gmt":"2026-09-12T04:33:28","slug":"arkamin","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/arkamin\/","title":{"rendered":"Arkamin"},"content":{"rendered":"

<\/p>\n

\n

\u26a1 Quick Answer \u2014 What is Arkamin?<\/h3>\n

Arkamin<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u0394\u03b9\u03c3\u03ba\u03af\u03bf \u03ba\u03bb\u03bf\u03bd\u03b9\u03b4\u03af\u03bd\u03b7\u03c2 100 mcg<\/strong> from Torrent Pharma \u2014 a \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ac \u03b4\u03c1\u03ce\u03bd\u03c4\u03b1\u03c2 \u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ae\u03c2 \u03b1-2 \u03b1\u03b4\u03c1\u03b5\u03bd\u03bf\u03cb\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd (\u03b9\u03bc\u03b9\u03b4\u03b1\u03b6\u03bf\u03bb\u03af\u03bd\u03b7) \u03c0\u03bf\u03c5 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03c5\u03bc\u03c0\u03b1\u03b8\u03b7\u03c4\u03b9\u03ba\u03ae \u03c1\u03bf\u03ae<\/strong>, \u03b4\u03c1\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c3\u03b5 \u03c0\u03c1\u03bf\u03c3\u03c5\u03bd\u03b1\u03c0\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b1-2 \u03b1\u03b4\u03c1\u03b5\u03bd\u03b5\u03c1\u03b3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 (\u03ba\u03b1\u03b9 \u03b9\u03bc\u03b9\u03b4\u03b1\u03b6\u03bf\u03bb\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd\u03c2-1 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2) \u03c3\u03c4\u03bf\u03bd \u03c1\u03bf\u03c3\u03c4\u03c1\u03b1\u03bb\u03b9\u03ba\u03cc \u03b2\u03b5\u03bd\u03c4\u03c1\u03bf\u03bb\u03b1\u03c4\u03b5\u03c1\u03b1\u03bb\u03b9\u03ba\u03cc \u03bc\u03c5\u03b5\u03bb\u03cc<\/strong>. \u0397 \u03ba\u03bb\u03bf\u03bd\u03b9\u03b4\u03af\u03bd\u03b7 \u03b5\u03b9\u03c3\u03ae\u03c7\u03b8\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7 Boehringer Ingelheim \u03c4\u03bf 1966 \u03c9\u03c2 Catapres<\/strong>. \u0391\u03c1\u03c7\u03b9\u03ba\u03ac \u03c3\u03c5\u03bd\u03b8\u03b5\u03c4\u03af\u03c3\u03c4\u03b7\u03ba\u03b5 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c3\u03c5\u03bc\u03c6\u03bf\u03c1\u03b7\u03c4\u03b9\u03ba\u03cc \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03bc\u03cd\u03c4\u03b7, \u03b1\u03bb\u03bb\u03ac \u03bc\u03b9\u03b1 \u03c4\u03c5\u03c7\u03b1\u03af\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03ad\u03bd\u03c4\u03bf\u03bd\u03b7\u03c2 \u03c5\u03c0\u03bf\u03c4\u03bf\u03bd\u03af\u03b1\u03c2 \u03c3\u03b5 \u03ad\u03bd\u03b1\u03bd \u03b5\u03b8\u03b5\u03bb\u03bf\u03bd\u03c4\u03ae \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae\u03c2 \u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b5 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03bd\u03b1\u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03ae \u03c4\u03b7\u03c2 \u03c9\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03bf\u03cd. \u0397 \u03c3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 (\u03c4\u03ad\u03c4\u03b1\u03c1\u03c4\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03ae \u03b5\u03c0\u03b5\u03af\u03b3\u03bf\u03c5\u03c3\u03b1 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7), ADHD<\/strong> (\u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd FDA \u03c3\u03c4\u03b9\u03c2 \u0397\u03a0\u0391 \u03c9\u03c2 Kapvay ER), \u03b1\u03c0\u03bf\u03c7\u03ae \u03b1\u03c0\u03cc \u03bf\u03c0\u03b9\u03bf\u03b5\u03b9\u03b4\u03ae \u03ba\u03b1\u03b9 \u03bd\u03b9\u03ba\u03bf\u03c4\u03af\u03bd\u03b7<\/strong>, \u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b5\u03bc\u03bc\u03b7\u03bd\u03cc\u03c0\u03b1\u03c5\u03c3\u03b7\u03c2, \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Tourette, \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03c0\u03cc\u03bd\u03bf (\u03b5\u03bd\u03b4\u03bf\u03c1\u03b1\u03c7\u03b9\u03b1\u03af\u03b1), \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03b1\u03bd\u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03b5\u03c4\u03bf\u03b9\u03bc\u03b1\u03c3\u03af\u03b1. \u039f \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b7\u03bc\u03b9\u03b6\u03c9\u03ae\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 12-16 \u03ce\u03c1\u03b5\u03c2 (\u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1); 20-24 \u03ce\u03c1\u03b5\u03c2 (\u03b4\u03b9\u03b1\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03cc \u03b1\u03c5\u03c4\u03bf\u03ba\u03cc\u03bb\u03bb\u03b7\u03c4\u03bf); \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 30-60 \u03bb\u03b5\u03c0\u03c4\u03ac (\u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1); \u03bc\u03ad\u03b3\u03b9\u03c3\u03c4\u03b7 \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b7 1-3 \u03ce\u03c1\u03b5\u03c2; \u03b1\u03bd\u03c4\u03b9\u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 2-4 \u03ce\u03c1\u03b5\u03c2; \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 8-12 \u03ce\u03c1\u03b5\u03c2. \u039a\u03cd\u03c1\u03b9\u03bf\u03b9 \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2: \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03ae \u03c4\u03ad\u03c4\u03b1\u03c1\u03c4\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7, \u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03ae \u03b5\u03c0\u03b5\u03af\u03b3\u03bf\u03c5\u03c3\u03b1 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 (\u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1\/\u03c5\u03c0\u03bf\u03b3\u03bb\u03ce\u03c3\u03c3\u03b9\u03b1), ADHD, \u03b1\u03c0\u03bf\u03c7\u03ae \u03b1\u03c0\u03cc \u03bf\u03c0\u03b9\u03bf\u03b5\u03b9\u03b4\u03ae\/\u03bd\u03b9\u03ba\u03bf\u03c4\u03af\u03bd\u03b7, \u03b5\u03bc\u03bc\u03b7\u03bd\u03cc\u03c0\u03b1\u03c5\u03c3\u03b7 \u03bc\u03b5 \u03b1\u03bd\u03b1\u03c6\u03bb\u03ad\u03be\u03b5\u03b9\u03c2, \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03b3\u03b9\u03b1 \u03c0\u03cc\u03bd\u03bf \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1<\/strong>. \u03a4\u03c5\u03c0\u03b9\u03ba\u03ae \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1: \u03a7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7:<\/strong> 100 mcg (0,1 mg) \u03b4\u03cd\u03bf \u03ae \u03c4\u03c1\u03b5\u03b9\u03c2 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03c4\u03b7\u03bd \u03b7\u03bc\u03ad\u03c1\u03b1, \u03bc\u03b5 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b7 \u03bc\u03ad\u03b3\u03b9\u03c3\u03c4\u03bf \u03c4\u03c9\u03bd 800 mcg\/\u03b7\u03bc\u03ad\u03c1\u03b1. \u0394\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03cc \u03c0\u03c1\u03ce\u03c4\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2<\/strong> \u2014 reserve for fourth\/fifth-line after ACEi\/ARB, CCB, thiazide, and spironolactone. \u03a5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03ae \u03b5\u03c0\u03b5\u03af\u03b3\u03bf\u03c5\u03c3\u03b1 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 (\u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1):<\/strong> 100-200 mcg loading dose, then 100 mcg every hour up to 600 mcg; lowers BP by 10-20% within 1-2 hours. Not for hypertensive emergency (end-organ damage) \u2014 use IV agents. \u03a0\u03bf\u03c4\u03ad \u03bc\u03b7\u03bd \u03b4\u03b9\u03b1\u03ba\u03cc\u03c0\u03c4\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc\u03c4\u03bf\u03bc\u03b1 \u03c4\u03bf Arkamin<\/strong> \u2014 rebound hypertension is severe and potentially life-threatening. For most hypertensive patients, modern treatment starts with an ACE inhibitor\/ARB, a calcium-channel blocker, a thiazide, and spironolactone before reaching for an alpha-blocker or centrally-acting agent.<\/p>\n<\/div>\n

\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong> \u03a0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2 WHO-GMP \u00b7 \u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u00b7 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u00b7 1,400+ \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a><\/div>\n

\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n

\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n

\u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b5\u03c1\u03b3\u03bf\u03c3\u03c4\u03ac\u03c3\u03b9\u03b1 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03b9\u03b5\u03c5\u03b8\u03cd\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03ac\u03bb\u03b9\u03c3\u03b7\u03c2.<\/p>\n

\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf Arkamin;<\/h2>\n

\u03a4\u03bf Arkamin \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b4\u03b9\u03c3\u03ba\u03af\u03bf Clonidine 100 mcg \u03b1\u03c0\u03cc \u03c4\u03b7 Torrent Pharma, \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03bf \u03c3\u03b5 \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b5\u03c2 30-90 \u03b4\u03b9\u03c3\u03ba\u03af\u03c9\u03bd. \u0397 Clonidine \u03b5\u03b9\u03c3\u03ae\u03c7\u03b8\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7 Boehringer Ingelheim \u03c4\u03bf 1966 \u03c9\u03c2 Catapres<\/strong>. \u0391\u03c1\u03c7\u03b9\u03ba\u03ac \u03c3\u03c5\u03bd\u03b8\u03b5\u03c4\u03af\u03c3\u03c4\u03b7\u03ba\u03b5 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c3\u03c5\u03bc\u03c6\u03bf\u03c1\u03b7\u03c4\u03b9\u03ba\u03cc \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03bc\u03cd\u03c4\u03b7, \u03b1\u03bb\u03bb\u03ac \u03bc\u03b9\u03b1 \u03c4\u03c5\u03c7\u03b1\u03af\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03ad\u03bd\u03c4\u03bf\u03bd\u03b7\u03c2 \u03c5\u03c0\u03bf\u03c4\u03bf\u03bd\u03af\u03b1\u03c2 \u03c3\u03b5 \u03ad\u03bd\u03b1\u03bd \u03b5\u03b8\u03b5\u03bb\u03bf\u03bd\u03c4\u03ae \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae\u03c2 \u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b5 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03bd\u03b1\u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03ae \u03c4\u03b7\u03c2 \u03c9\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03bf\u03cd. \u0397 \u03c3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 (\u03c4\u03ad\u03c4\u03b1\u03c1\u03c4\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03ae \u03b5\u03c0\u03b5\u03af\u03b3\u03bf\u03c5\u03c3\u03b1 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7), ADHD<\/strong> (\u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd FDA \u03c3\u03c4\u03b9\u03c2 \u0397\u03a0\u0391 \u03c9\u03c2 Kapvay ER), \u03b1\u03c0\u03bf\u03c7\u03ae \u03b1\u03c0\u03cc \u03bf\u03c0\u03b9\u03bf\u03b5\u03b9\u03b4\u03ae \u03ba\u03b1\u03b9 \u03bd\u03b9\u03ba\u03bf\u03c4\u03af\u03bd\u03b7<\/strong>, \u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b5\u03bc\u03bc\u03b7\u03bd\u03cc\u03c0\u03b1\u03c5\u03c3\u03b7\u03c2, \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Tourette, \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03c0\u03cc\u03bd\u03bf (\u03b5\u03bd\u03b4\u03bf\u03c1\u03b1\u03c7\u03b9\u03b1\u03af\u03b1) \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03b5\u03b3\u03c7\u03b5\u03b9\u03c1\u03b7\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1.<\/p>\n

\u03a0\u03ce\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03b7 Clonidine<\/h2>\n

\u0397 Clonidine \u03b4\u03c1\u03b1 \u03b5\u03c0\u03af \u03c0\u03c1\u03bf\u03c3\u03c5\u03bd\u03b1\u03c0\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b1-2 \u03b1\u03b4\u03c1\u03b5\u03bd\u03b5\u03c1\u03b3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 (\u03ba\u03b1\u03b9 \u03b9\u03bc\u03b9\u03b4\u03b1\u03b6\u03bf\u03bb\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd\u03c2-1 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2) \u03c3\u03c4\u03bf\u03bd \u03c1\u03bf\u03c3\u03c4\u03c1\u03b1\u03bb\u03b9\u03ba\u03cc \u03b2\u03b5\u03bd\u03c4\u03c1\u03bf\u03bb\u03b1\u03c4\u03b5\u03c1\u03b1\u03bb\u03b9\u03ba\u03cc \u03bc\u03c5\u03b5\u03bb\u03cc<\/strong>. \u039f\u03b9 \u03b5\u03c0\u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03b5\u03c2 \u03b5\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2:<\/p>\n

    \n
  • \u039c\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03c0\u03b1\u03b8\u03b7\u03c4\u03b9\u03ba\u03ae \u03c1\u03bf\u03ae<\/strong> \u2014 activation of pre-synaptic alpha-2 receptors in the rostral ventrolateral medulla suppresses descending sympathetic tone to the peripheral vasculature and heart<\/li>\n
  • \u039c\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1 \u03bd\u03bf\u03c1\u03b1\u03b4\u03c1\u03b5\u03bd\u03b1\u03bb\u03af\u03bd\u03b7<\/strong> \u2014 circulating catecholamines fall 30-50% within hours; heart rate drops 5-15 bpm; BP drops 10-30 mmHg<\/li>\n
  • \u0394\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u0399\u03bc\u03b9\u03b4\u03b1\u03b6\u03bf\u03bb\u03af\u03bd\u03b7\u03c2-1<\/strong> \u2014 an additional sympathetic-suppressing mechanism unique to imidazoline agonists (clonidine, moxonidine); may contribute to better metabolic tolerability than older centrally-acting drugs<\/li>\n
  • \u03a3\u03c0\u03bf\u03bd\u03b4\u03c5\u03bb\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03c5\u03c0\u03b5\u03c1\u03c3\u03c0\u03bf\u03bd\u03b4\u03c5\u03bb\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03bb\u03b3\u03b7\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7<\/strong> \u2014 blocks pain signal relay in the dorsal horn; basis for intrathecal clonidine in chronic pain and for anaesthetic-adjunct use<\/li>\n
  • \u039a\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03c9\u03bd \u03bd\u03bf\u03c1\u03b1\u03b4\u03c1\u03b5\u03bd\u03bf\u03b5\u03c1\u03b3\u03b9\u03ba\u03ce\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7\u03c2<\/strong> \u2014 reduces sweating, tremor, tachycardia, and hypertension during opioid, nicotine, and alcohol withdrawal<\/li>\n
  • \u0392\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03c2 \u03c4\u03cc\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03bc\u03b5\u03c4\u03c9\u03c0\u03b9\u03b1\u03af\u03bf\u03c5 \u03c6\u03bb\u03bf\u03b9\u03bf\u03cd<\/strong> \u2014 proposed mechanism for ADHD benefit (enhances top-down inhibitory control)<\/li>\n
  • \u039a\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9-\u03b8\u03b5\u03c1\u03bc\u03bf\u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7<\/strong> \u2014 basis for menopausal hot-flush benefit<\/li>\n<\/ul>\n

    \u0395\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 \u0392\u03b1\u03c3\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c3\u03b5 \u0391\u03c0\u03bf\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03a7\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n
      \n
    • \u0391\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03ae \u03c4\u03b5\u03c4\u03b1\u03c1\u03c4\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7, \u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03ae \u03b5\u03c0\u03b5\u03af\u03b3\u03bf\u03c5\u03c3\u03b1 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 (\u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2\/\u03c5\u03c0\u03bf\u03b3\u03bb\u03ce\u03c3\u03c3\u03b9\u03b1), \u0394\u0395\u03a0\u03a5, \u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7 \u03bf\u03c0\u03b9\u03bf\u03b5\u03b9\u03b4\u03ce\u03bd\/\u03bd\u03b9\u03ba\u03bf\u03c4\u03af\u03bd\u03b7\u03c2, \u03b5\u03bc\u03bc\u03b7\u03bd\u03cc\u03c0\u03b1\u03c5\u03c3\u03b7 \u03ba\u03b1\u03c5\u03c3\u03b1\u03bb\u03b3\u03af\u03b5\u03c2, \u03c0\u03cc\u03bd\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b1\u03bd\u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd<\/strong><\/li>\n
    • \u0391\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7<\/strong> (\u03c4\u03ad\u03c4\u03b1\u03c1\u03c4\u03b7\/\u03c0\u03ad\u03bc\u03c0\u03c4\u03b7 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae)<\/li>\n
    • \u03a5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03ae \u03b5\u03c0\u03b5\u03af\u03b3\u03bf\u03c5\u03c3\u03b1 \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7<\/strong> (oral 100-200 mcg loading, then 100 mcg hourly) \u2014 not for emergency with end-organ damage<\/li>\n
    • ADHD<\/strong> (\u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd FDA \u03c9\u03c2 \u03b5\u03c0\u03b5\u03ba\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b1\u03c0\u03bf\u03b4\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7\u03c2 Kapvay\u00b7 \u03bf\u03b9 \u03c4\u03c5\u03c0\u03b9\u03ba\u03ad\u03c2 IR \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b5\u03ba\u03c4\u03cc\u03c2 \u03b5\u03c4\u03b9\u03ba\u03ad\u03c4\u03b1\u03c2 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2)<\/li>\n
    • \u0391\u03c0\u03bf\u03c7\u03ae \u03b1\u03c0\u03cc \u03bf\u03c0\u03b9\u03bf\u03b5\u03b9\u03b4\u03ae \u03ba\u03b1\u03b9 \u03bd\u03b9\u03ba\u03bf\u03c4\u03af\u03bd\u03b7<\/strong> \u2014 autonomic symptom relief<\/li>\n
    • \u0395\u03bc\u03bc\u03b7\u03bd\u03bf\u03c0\u03b1\u03c5\u03c3\u03b9\u03b1\u03ba\u03ac \u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 (\u03ba\u03b1\u03c5\u03c3\u03c4\u03ad\u03c2 \u03b5\u03c6\u03b9\u03b4\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2)<\/strong> \u2014 non-hormonal option<\/li>\n
    • \u03a3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Tourette<\/strong> \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03c4\u03b9\u03ba<\/li>\n
    • \u03a7\u03c1\u03cc\u03bd\u03b9\u03bf\u03c2 \u03c0\u03cc\u03bd\u03bf\u03c2<\/strong> \u2014 intrathecal clonidine for neuropathic or cancer pain<\/li>\n
    • \u03a0\u03c1\u03bf\u03b1\u03bd\u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03b5\u03c4\u03bf\u03b9\u03bc\u03b1\u03c3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b5\u03b3\u03c7\u03b5\u03b9\u03c1\u03b7\u03c4\u03b9\u03ba\u03cc \u03c4\u03c1\u03cc\u03bc\u03bf\u03c2<\/strong><\/li>\n<\/ul>\n

      \u039a\u03c5\u03c1\u03af\u03b1\u03c1\u03c7\u03b5\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2:<\/strong> \u03a3\u03c5\u03bd\u03b5\u03c1\u03b3\u03b1\u03c4\u03b9\u03ba\u03ae \u039c\u03b5\u03bb\u03ad\u03c4\u03b7 VA \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03a5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 (1967-1970)<\/strong> \u2014 clonidine established as effective monotherapy in the era before ACEi, ARB, and CCB classes. \u0391\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03b9\u03c2 \u03c5\u03c0\u03bf\u03bf\u03bc\u03ac\u03b4\u03c9\u03bd ALLHAT<\/strong> \u2014 clonidine-based regimens generally reduced BP equivalently to first-line classes but with worse tolerability. \u0394\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 Connor et al. \u03b3\u03b9\u03b1 \u03c0\u03b1\u03b9\u03b4\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03cc ADHD<\/strong> \u2014 clonidine IR effective for hyperarousal and sleep disturbance in ADHD, though psychostimulants remain first-line. Gold et al. (1978)<\/strong> \u2014 landmark demonstration of clonidine for opiate withdrawal \u2014 abolished autonomic symptoms (sweating, piloerection, tachycardia) without cross-dependence.<\/p>\n

      \u0394\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 Arkamin<\/h2>\n

      \u039a\u03cd\u03c1\u03b9\u03b1 \u03b4\u03cc\u03c3\u03b7:<\/strong> \u03a7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7:<\/strong> 100 mcg (0,1 mg) \u03b4\u03cd\u03bf \u03ae \u03c4\u03c1\u03b5\u03b9\u03c2 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03c4\u03b7\u03bd \u03b7\u03bc\u03ad\u03c1\u03b1, \u03bc\u03b5 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b7 \u03bc\u03ad\u03b3\u03b9\u03c3\u03c4\u03bf \u03c4\u03c9\u03bd 800 mcg\/\u03b7\u03bc\u03ad\u03c1\u03b1. \u0394\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03cc \u03c0\u03c1\u03ce\u03c4\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2<\/strong> \u2014 reserve for fourth\/fifth-line after ACEi\/ARB, CCB, thiazide, and spironolactone. \u03a5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03ae \u03b5\u03c0\u03b5\u03af\u03b3\u03bf\u03c5\u03c3\u03b1 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 (\u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1):<\/strong> 100-200 mcg loading dose, then 100 mcg every hour up to 600 mcg; lowers BP by 10-20% within 1-2 hours. Not for hypertensive emergency (end-organ damage) \u2014 use IV agents.<\/p>\n

      \u0386\u03bb\u03bb\u03b5\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2:<\/strong> ADHD (\u03c0\u03b1\u03b9\u03b4\u03b9\u03ac \u03ba\u03b1\u03b9 \u03b5\u03c6\u03ae\u03b2\u03bf\u03c5\u03c2):<\/strong> 50-100 mcg \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03ce\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03cd\u03c0\u03bd\u03bf\u03c5 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac, \u03bc\u03b5 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03c3\u03b5 100-400 mcg\/\u03b7\u03bc\u03ad\u03c1\u03b1 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03b9\u03c1\u03b5\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2. \u039f\u03b9 \u03c3\u03c5\u03bd\u03b8\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b1\u03c0\u03bf\u03b4\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7\u03c2 (Kapvay) \u03c0\u03c1\u03bf\u03c4\u03b9\u03bc\u03ce\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u0397\u03a0\u0391. \u0391\u03c0\u03bf\u03c7\u03ae \u03b1\u03c0\u03cc \u03bf\u03c0\u03b9\u03bf\u03b5\u03b9\u03b4\u03ae (\u03b1\u03bd\u03b1\u03ba\u03bf\u03cd\u03c6\u03b9\u03c3\u03b7 \u03b1\u03c5\u03c4\u03cc\u03bd\u03bf\u03bc\u03c9\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd):<\/strong> 100-300 mcg \u03c4\u03c1\u03b5\u03b9\u03c2 \u03ae \u03c4\u03ad\u03c3\u03c3\u03b5\u03c1\u03b9\u03c2 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03b7\u03bc\u03b5\u03c1\u03b7\u03c3\u03af\u03c9\u03c2, \u03bc\u03b5 \u03c3\u03c4\u03b1\u03b4\u03b9\u03b1\u03ba\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03c5\u03c0\u03bf\u03c7\u03c9\u03c1\u03bf\u03cd\u03bd \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c0\u03bf\u03c7\u03ae. \u0395\u03c6\u03af\u03b4\u03c1\u03c9\u03c3\u03b7 \u03b5\u03c6\u03b7\u03b2\u03b9\u03ba\u03ae\u03c2 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2:<\/strong> 50-75 mcg \u03b4\u03cd\u03bf \u03c6\u03bf\u03c1\u03ad\u03c2 \u03b7\u03bc\u03b5\u03c1\u03b7\u03c3\u03af\u03c9\u03c2. \u03a3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Tourette:<\/strong> 25-100 mcg \u03b4\u03cd\u03bf \u03ae \u03c4\u03c1\u03b5\u03b9\u03c2 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03b7\u03bc\u03b5\u03c1\u03b7\u03c3\u03af\u03c9\u03c2. \u0394\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c0\u03bd\u03af\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2:<\/strong> 100-300 mcg\/\u03b7\u03bc\u03ad\u03c1\u03b1 (\u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ae \u03b4\u03b9\u03b1\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03ac). \u03a0\u03c1\u03bf\u03b1\u03bd\u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae:<\/strong> 200-400 mcg \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 60 \u03bb\u03b5\u03c0\u03c4\u03ac \u03c0\u03c1\u03b9\u03bd \u03c4\u03b7\u03bd \u03b5\u03c0\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7.<\/p>\n

      \u03a7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7:<\/strong> \u03bd\u03b1 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03ae \u03c7\u03c9\u03c1\u03af\u03c2 \u03c4\u03c1\u03bf\u03c6\u03ae\u00b7 \u03bf\u03b9 \u03b2\u03c1\u03b1\u03b4\u03b9\u03bd\u03ad\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03b7\u03bc\u03b5\u03c1\u03ae\u03c3\u03b9\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03c4\u03bf\u03c0\u03b9\u03c3\u03c4\u03b5\u03af \u03b7 \u03c5\u03c0\u03bd\u03b7\u03bb\u03af\u03b1 \u03c3\u03c4\u03bf\u03bd \u03cd\u03c0\u03bd\u03bf. \u039d\u03b1 \u03bc\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03bb\u03b5\u03af\u03c0\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 (\u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b1\u03bd\u03ac\u03ba\u03b1\u03bc\u03c8\u03b7\u03c2).<\/p>\n

      \u03a0\u03c1\u03cc\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2:<\/strong><\/p>\n

        \n
      • \u0392\u03b1\u03c3\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7:<\/strong> \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03af\u03b5\u03c3\u03b7 \u03c3\u03b5 \u03cd\u03c0\u03c4\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03cc\u03c1\u03b8\u03b9\u03b1 \u03c3\u03c4\u03ac\u03c3\u03b7 (\u03ba\u03b1\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae \u03bf\u03c1\u03b8\u03bf\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c4\u03ce\u03c3\u03b7\u03c2), \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1, \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03bc\u03b1 (\u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03b2\u03c1\u03b1\u03b4\u03c5\u03ba\u03b1\u03c1\u03b4\u03af\u03b1), \u03bb\u03af\u03c3\u03c4\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd (\u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ce\u03bd\u03c4\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1).<\/li>\n
      • \u0395\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1 1-2:<\/strong> \u03b5\u03c0\u03b1\u03bd\u03ac\u03bb\u03b7\u03c8\u03b7 \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7\u03c2 \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 (\u03cd\u03c0\u03c4\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03cc\u03c1\u03b8\u03b9\u03b1 \u03c3\u03c4\u03ac\u03c3\u03b7), \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae\u03c2 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2, \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd. \u03a0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03b4\u03cc\u03c3\u03b7\u03c2 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b1 \u03c0\u03ac\u03bd\u03c9 \u03ae \u03ba\u03ac\u03c4\u03c9 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b7\u03bd \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03af\u03b5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c7\u03ae.<\/li>\n
      • \u0395\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1 4-6:<\/strong> \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2\u00b7 \u03c6\u03cc\u03c1\u03c4\u03bf\u03c2 \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd\u00b7 \u03b5\u03c1\u03ce\u03c4\u03b7\u03c3\u03b7 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b3\u03b9\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bb\u03b5\u03b9\u03c0\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2.<\/li>\n
      • \u03a3\u03c5\u03bd\u03b5\u03c7\u03ae\u03c2 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7:<\/strong> \u03b5\u03c4\u03ae\u03c3\u03b9\u03b1 \u03b1\u03bd\u03b1\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2\u00b7 \u03bc\u03b7\u03bd \u03bc\u03b5\u03af\u03bd\u03b5\u03c4\u03b5 \u03c0\u03bf\u03c4\u03ad \u03c7\u03c9\u03c1\u03af\u03c2 \u03b1\u03c0\u03bf\u03b8\u03ad\u03bc\u03b1\u03c4\u03b1 (\u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b1\u03bd\u03ac\u03ba\u03b1\u03bc\u03c8\u03b7\u03c2 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7\u03c2).<\/li>\n
      • \u0394\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03b4\u03cc\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7:<\/strong> \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae\u03c2 \u03b2\u03c1\u03b1\u03b4\u03c5\u03ba\u03b1\u03c1\u03b4\u03af\u03b1\u03c2, \u03c3\u03c5\u03b3\u03ba\u03bf\u03c0\u03ae\u03c2, \u03b4\u03b5\u03c5\u03c4\u03b5\u03c1\u03bf\u03b2\u03ac\u03b8\u03bc\u03b9\u03b1\u03c2 \u03ae \u03c4\u03c1\u03b9\u03c4\u03bf\u03b2\u03ac\u03b8\u03bc\u03b9\u03b1\u03c2 AV \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03bc\u03bf\u03cd, \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae\u03c2 \u03ba\u03b1\u03c4\u03ac\u03b8\u03bb\u03b9\u03c8\u03b7\u03c2, \u03b5\u03bd\u03bf\u03c7\u03bb\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 4-8 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2.<\/li>\n<\/ul>\n

        \u0394\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae:<\/strong> CRITICAL \u2014 never stop clonidine abruptly.<\/strong> \u0391\u03bd\u03ac\u03ba\u03b1\u03bc\u03c8\u03b7 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03ad\u03be\u03b1\u03c1\u03c3\u03b7 \u03c3\u03c5\u03bc\u03c0\u03b1\u03b8\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03c3\u03c4\u03b5\u03af \u03b5\u03bd\u03c4\u03cc\u03c2 18-36 \u03c9\u03c1\u03ce\u03bd \u03c3\u03b5 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 >300 mcg\/\u03b7\u03bc\u03ad\u03c1\u03b1. \u039c\u03b5\u03b9\u03ce\u03c3\u03c4\u03b5 \u03c3\u03c4\u03b1\u03b4\u03b9\u03b1\u03ba\u03ac \u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03c3\u03b5 \u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03bc\u03b1 2-4 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03c9\u03bd<\/strong>; \u00b7 \u03b5\u03ac\u03bd \u03c3\u03c5\u03bd\u03c4\u03b1\u03b3\u03bf\u03b3\u03c1\u03b1\u03c6\u03b7\u03b8\u03b5\u03af \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b1 \u03b2-\u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1\u03c2, \u03b4\u03b9\u03b1\u03ba\u03cc\u03c8\u03c4\u03b5 \u03c0\u03c1\u03ce\u03c4\u03b1 \u03c4\u03bf\u03bd \u03b2-\u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ba\u03bb\u03bf\u03bd\u03b9\u03b4\u03af\u03bd\u03b7. \u0391\u03bd\u03b1\u03b6\u03b7\u03c4\u03ae\u03c3\u03c4\u03b5 \u03ac\u03bc\u03b5\u03c3\u03b7 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c0\u03b5\u03c1\u03af\u03b8\u03b1\u03bb\u03c8\u03b7 \u03b3\u03b9\u03b1 \u03c3\u03bf\u03b2\u03b1\u03c1\u03cc \u03c0\u03bf\u03bd\u03bf\u03ba\u03ad\u03c6\u03b1\u03bb\u03bf, \u03c0\u03cc\u03bd\u03bf \u03c3\u03c4\u03bf \u03c3\u03c4\u03ae\u03b8\u03bf\u03c2 \u03ae \u03c0\u03af\u03b5\u03c3\u03b7 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 >180\/110 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03c0\u03b1\u03c1\u03b1\u03bb\u03b5\u03b9\u03c0\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03ae \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03b5\u03af\u03c3\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2.<\/p>\n

        \u03a0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u03a3\u03ba\u03ad\u03c8\u03b5\u03b9\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd Arkamin<\/h2>\n