{"id":52251,"date":"2023-09-20T09:31:01","date_gmt":"2023-09-20T09:31:01","guid":{"rendered":"https:\/\/medsname.com\/hepcinat-lp\/"},"modified":"2026-05-01T10:49:12","modified_gmt":"2026-05-01T10:49:12","slug":"hepcinat-lp","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/hepcinat-lp\/","title":{"rendered":"Hepcinat LP"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:16px 20px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin-top:0;\">Quick Answer &mdash; Hepcinat LP (Sofosbuvir 400 mg + Ledipasvir 90 mg)<\/h3>\n<ul>\n<li><strong>Active ingredients:<\/strong> sofosbuvir 400 mg + ledipasvir 90 mg, fixed-dose combination tablet, taken once daily.<\/li>\n<li><strong>Indication:<\/strong> chronic hepatitis C virus (HCV) infection, genotypes 1, 4, 5 and 6 in adults &mdash; the generic of Harvoni (Gilead).<\/li>\n<li><strong>\u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2:<\/strong> sofosbuvir is an NS5B nucleotide polymerase inhibitor; ledipasvir is an NS5A inhibitor. The combination targets two essential HCV proteins simultaneously.<\/li>\n<li><strong>Cure rate:<\/strong> 94&ndash;99% sustained virologic response (SVR12) across most regimens &mdash; functional HCV cure in 12 weeks for treatment-naive non-cirrhotic patients.<\/li>\n<li><strong>Treatment is curative<\/strong>, not chronic suppression. Once SVR12 is achieved (HCV RNA undetectable 12 weeks post-treatment), HCV is eradicated and tablets stop.<\/li>\n<li><strong>Take with care alongside:<\/strong> amiodarone (bradycardia risk &mdash; usually contraindicated), strong CYP\/P-gp inducers (rifampicin, St John&#8217;s wort, anticonvulsants &mdash; reduce DAA exposure), and acid-reducers (PPIs &mdash; lower ledipasvir absorption; separate by &gt;= 12 hours where possible).<\/li>\n<\/ul>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong> \u03a0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2 WHO-GMP \u00b7 \u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u00b7 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u00b7 1,400+ \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 <a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\"><strong>\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n<h3>\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p>\u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n<h2>What Is Hepcinat LP?<\/h2>\n<p>Hepcinat LP is a fixed-dose combination tablet containing <strong>Ledipasvir 90 mg<\/strong> \u03ba\u03b1\u03b9 <strong>Sofosbuvir 400 mg<\/strong>, manufactured by Natco Pharma \u2014 one of India&#8217;s largest specialty pharmaceutical companies. It is a direct-acting antiviral (DAA) treatment for <strong>chronic hepatitis C virus (HCV)<\/strong> infection, offering cure rates exceeding 95% in most patient populations.<\/p>\n<p>Hepcinat LP is a generic equivalent of <strong>Harvoni<\/strong> (Gilead Sciences), which revolutionized hepatitis C treatment when it launched in 2014 at a cost of $94,500 per course in the United States. Hepcinat LP delivers the same clinical outcomes at a fraction of the cost, making a hepatitis C cure accessible to patients worldwide.<\/p>\n<h2>What Does Hepcinat LP Treat?<\/h2>\n<p>Hepcinat LP is approved for the treatment of chronic hepatitis C in adults with the following genotypes:<\/p>\n<table>\n<thead>\n<tr>\n<th>HCV Genotype<\/th>\n<th>Treatment Duration<\/th>\n<th>Cure Rate (SVR12)<\/th>\n<th>\u03a3\u03b7\u03bc\u03b5\u03b9\u03ce\u03c3\u03b5\u03b9\u03c2<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Genotype 1<\/strong><\/td>\n<td>12 weeks (8 weeks in select patients)<\/td>\n<td>97\u201399%<\/td>\n<td>Most common genotype in the US and Europe<\/td>\n<\/tr>\n<tr>\n<td><strong>Genotype 4<\/strong><\/td>\n<td>12 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/td>\n<td>93\u201395%<\/td>\n<td>Common in Egypt and the Middle East<\/td>\n<\/tr>\n<tr>\n<td><strong>Genotype 5<\/strong><\/td>\n<td>12 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/td>\n<td>95%+<\/td>\n<td>Primarily found in South Africa<\/td>\n<\/tr>\n<tr>\n<td><strong>Genotype 6<\/strong><\/td>\n<td>12 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/td>\n<td>96%+<\/td>\n<td>Common in Southeast Asia<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>8-week treatment<\/strong> may be sufficient for treatment-naive genotype 1 patients without cirrhosis and with a baseline HCV RNA level below 6 million IU\/mL.<\/p>\n<p>For <strong>genotypes 2 and 3<\/strong>, a Sofosbuvir + Velpatasvir combination such as <a href=\"\/el\/velasof\/\">Velasof<\/a> \u03ae <a href=\"\/el\/velpanat\/\">Velpanat<\/a> is recommended instead, as these cover all HCV genotypes.<\/p>\n<h2>How Hepcinat LP Works<\/h2>\n<p>Hepcinat LP combines two direct-acting antivirals that target different stages of the hepatitis C replication cycle:<\/p>\n<ul>\n<li><strong>Sofosbuvir (400 mg)<\/strong> \u2014 A nucleotide analog NS5B polymerase inhibitor. It gets incorporated into the viral RNA chain during replication, causing premature chain termination. This blocks the virus from copying itself.<\/li>\n<li><strong>Ledipasvir (90 mg)<\/strong> \u2014 An NS5A inhibitor that blocks a protein essential for both viral replication and assembly of new virus particles. By targeting NS5A, Ledipasvir prevents the virus from multiplying and releasing new copies into the bloodstream.<\/li>\n<\/ul>\n<p>By attacking HCV at two different points simultaneously, Hepcinat LP achieves rapid viral suppression and prevents the development of drug-resistant strains \u2014 a problem that plagued earlier single-agent hepatitis C treatments.<\/p>\n<h2>Dosage and How to Take Hepcinat LP<\/h2>\n<ul>\n<li>\u03a0\u03ac\u03c1\u03c4\u03b5 <strong>one tablet once daily<\/strong>, with or without food.<\/li>\n<li>Swallow the tablet whole with water \u2014 do not crush, break, or chew.<\/li>\n<li>Take Hepcinat LP at the <strong>\u03af\u03b4\u03b9\u03b1 \u03ce\u03c1\u03b1 \u03ba\u03ac\u03b8\u03b5 \u03bc\u03ad\u03c1\u03b1<\/strong> for consistent drug levels.<\/li>\n<li>If you miss a dose, take it as soon as you remember on the same day. If it is already the next day, skip the missed dose and continue with your regular schedule.<\/li>\n<li><strong>Do not stop treatment early<\/strong>, even if you feel well. Completing the full course is essential to prevent viral relapse.<\/li>\n<\/ul>\n<h3>Treatment Duration<\/h3>\n<table>\n<thead>\n<tr>\n<th>Patient Type<\/th>\n<th>\u0394\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1<\/th>\n<th>Tablets Needed<\/th>\n<th>Price at MedsBase<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Treatment-naive, no cirrhosis, low viral load<\/td>\n<td>8 weeks<\/td>\n<td>56 tablets (2 packs)<\/td>\n<td>$999<\/td>\n<\/tr>\n<tr>\n<td>Treatment-naive, no cirrhosis<\/td>\n<td>12 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/td>\n<td>84 tablets (3 packs)<\/td>\n<td>$1,428<\/td>\n<\/tr>\n<tr>\n<td>Treatment-naive with compensated cirrhosis<\/td>\n<td>12 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/td>\n<td>84 tablets<\/td>\n<td>$1,428<\/td>\n<\/tr>\n<tr>\n<td>Treatment-experienced, no cirrhosis<\/td>\n<td>12 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/td>\n<td>84 tablets<\/td>\n<td>$1,428<\/td>\n<\/tr>\n<tr>\n<td>Treatment-experienced with compensated cirrhosis<\/td>\n<td>24 weeks<\/td>\n<td>168 tablets (6 packs)<\/td>\n<td>Contact us<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>What Is SVR12 (Sustained Virologic Response)?<\/h2>\n<p>SVR12 means the hepatitis C virus is <strong>undetectable in your blood 12 weeks after completing treatment<\/strong>. Achieving SVR12 is considered a functional cure \u2014 over 99% of patients who reach SVR12 remain virus-free permanently. Your doctor will order a blood test (HCV RNA PCR) at 12 weeks post-treatment to confirm cure.<\/p>\n<h2>\u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/h2>\n<p>Hepcinat LP is one of the best-tolerated hepatitis C treatments available. Most patients complete the full course with minimal or no side effects.<\/p>\n<h3>\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/h3>\n<ul>\n<li>Fatigue (reported in ~15% of patients)<\/li>\n<li>Headache (~11%)<\/li>\n<li>Nausea (~7%)<\/li>\n<li>\u0391\u03cb\u03c0\u03bd\u03af\u03b1<\/li>\n<li>\u0394\u03b9\u03ac\u03c1\u03c1\u03bf\u03b9\u03b1<\/li>\n<\/ul>\n<p>These are generally mild and do not require treatment discontinuation.<\/p>\n<h3>Serious Side Effects (Rare)<\/h3>\n<ul>\n<li><strong>Bradycardia (slow heart rate)<\/strong> \u2014 Reported when taken with amiodarone. This combination is contraindicated.<\/li>\n<li><strong>Hepatitis B reactivation<\/strong> \u2014 Patients co-infected with HBV must be monitored, as suppressing HCV can trigger HBV flare-ups.<\/li>\n<\/ul>\n<h2>Important Drug Interactions<\/h2>\n<ul>\n<li><strong>Amiodarone<\/strong> \u2014 Do NOT take with Hepcinat LP. Can cause life-threatening bradycardia.<\/li>\n<li><strong>Rifampin, carbamazepine, phenytoin, St. John&#8217;s wort<\/strong> \u2014 Strong P-gp inducers that significantly reduce Sofosbuvir and Ledipasvir levels, potentially causing treatment failure.<\/li>\n<li><strong>Proton pump inhibitors (omeprazole, esomeprazole)<\/strong> \u2014 Reduce Ledipasvir absorption. If necessary, take a PPI at a dose not exceeding 20 mg, at least 2 hours before Hepcinat LP.<\/li>\n<li><strong>Antacids (Tums, Maalox)<\/strong> \u2014 Separate by at least 4 hours from Hepcinat LP.<\/li>\n<li><strong>Rosuvastatin<\/strong> \u2014 Levels may increase; limit to 10 mg\/day.<\/li>\n<li><strong>HIV antiretrovirals<\/strong> \u2014 Tenofovir levels may increase when combined with certain HIV regimens. Renal monitoring is recommended. Products like <a href=\"\/el\/tenvir-af\/\">Tenvir AF<\/a> (TAF-based) are preferred over TDF-based regimens.<\/li>\n<\/ul>\n<h2>\u03a0\u03c1\u03bf\u03b5\u03b9\u03b4\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03ac\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li><strong>Hepatitis B co-infection:<\/strong> All patients should be tested for HBV before starting treatment. HBV reactivation can cause serious liver injury or death.<\/li>\n<li><strong>Decompensated cirrhosis:<\/strong> Hepcinat LP is not recommended for patients with decompensated liver disease (Child-Pugh B or C). A regimen containing Sofosbuvir + Velpatasvir + Voxilaprevir may be considered instead.<\/li>\n<li><strong>Kidney impairment:<\/strong> No dose adjustment needed for mild to moderate kidney impairment. Not recommended for severe renal impairment (eGFR &lt; 30 mL\/min).<\/li>\n<li><strong>Pregnancy:<\/strong> Not enough data to confirm safety. Avoid unless clearly necessary.<\/li>\n<\/ul>\n<h2>Hepcinat LP vs Other Hepatitis C Treatments<\/h2>\n<p>MedsBase offers several hepatitis C medications. Here&#8217;s how they compare:<\/p>\n<table>\n<thead>\n<tr>\n<th>\u03a0\u03c1\u03bf\u03ca\u03cc\u03bd<\/th>\n<th>Active Ingredients<\/th>\n<th>Genotypes Covered<\/th>\n<th>Price (12-week course)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Hepcinat LP<\/strong><\/td>\n<td>Ledipasvir 90 mg + Sofosbuvir 400 mg<\/td>\n<td>1, 4, 5, 6<\/td>\n<td>$1,428<\/td>\n<\/tr>\n<tr>\n<td><a href=\"\/el\/ledifos\/\">Ledifos<\/a><\/td>\n<td>Ledipasvir 90 mg + Sofosbuvir 400 mg<\/td>\n<td>1, 4, 5, 6<\/td>\n<td>Check price<\/td>\n<\/tr>\n<tr>\n<td><a href=\"\/el\/hepcvir-l\/\">Hepcvir L<\/a><\/td>\n<td>Ledipasvir 90 mg + Sofosbuvir 400 mg<\/td>\n<td>1, 4, 5, 6<\/td>\n<td>Check price<\/td>\n<\/tr>\n<tr>\n<td><a href=\"\/el\/myhep-lvir\/\">MyHep LVIR<\/a><\/td>\n<td>Ledipasvir 90 mg + Sofosbuvir 400 mg<\/td>\n<td>1, 4, 5, 6<\/td>\n<td>Check price<\/td>\n<\/tr>\n<tr>\n<td><a href=\"\/el\/velasof\/\">Velasof<\/a><\/td>\n<td>Velpatasvir 100 mg + Sofosbuvir 400 mg<\/td>\n<td><strong>All (1\u20136)<\/strong><\/td>\n<td>Check price<\/td>\n<\/tr>\n<tr>\n<td><a href=\"\/el\/velpanat\/\">Velpanat<\/a><\/td>\n<td>Velpatasvir 100 mg + Sofosbuvir 400 mg<\/td>\n<td><strong>All (1\u20136)<\/strong><\/td>\n<td>Check price<\/td>\n<\/tr>\n<tr>\n<td><a href=\"\/el\/myhep-all\/\">MyHep All<\/a><\/td>\n<td>Velpatasvir 100 mg + Sofosbuvir 400 mg<\/td>\n<td><strong>All (1\u20136)<\/strong><\/td>\n<td>Check price<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Which should you choose?<\/strong> If you know your HCV genotype is 1, 4, 5, or 6, Hepcinat LP is a proven and cost-effective choice. If you are unsure of your genotype, a pan-genotypic option like <a href=\"\/el\/velasof\/\">Velasof<\/a> \u03ae <a href=\"\/el\/velpanat\/\">Velpanat<\/a> covers all genotypes and eliminates the need for genotyping tests.<\/p>\n<h2>\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/h2>\n<p>Store at room temperature (20\u201325\u00b0C \/ 68\u201377\u00b0F). Protect from moisture and direct sunlight. Keep out of reach of children. Do not use after the expiration date on the packaging.<\/p>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3>What is the cure rate of Hepcinat LP?<\/h3>\n<p>Clinical trials and real-world studies show cure rates (SVR12) of <strong>95\u201399%<\/strong> for hepatitis C genotype 1 patients. Cure rates for genotypes 4, 5, and 6 are similarly high, typically exceeding 93%.<\/p>\n<h3>Is Hepcinat LP the same as Harvoni?<\/h3>\n<p>Yes. Hepcinat LP is a generic version of Harvoni, containing the same active ingredients (Ledipasvir 90 mg + Sofosbuvir 400 mg) in the same doses. It is manufactured by Natco Pharma under a voluntary license from Gilead Sciences and is bioequivalent to the branded product.<\/p>\n<h3>How long do I need to take Hepcinat LP?<\/h3>\n<p>Most patients take Hepcinat LP for <strong>12 weeks (84 days)<\/strong>. Some treatment-naive patients without cirrhosis and with low viral loads may qualify for an 8-week course. Treatment-experienced patients with cirrhosis may need 24 weeks. Your doctor will determine the appropriate duration.<\/p>\n<h3>Can Hepcinat LP cure all types of hepatitis C?<\/h3>\n<p>Hepcinat LP is most effective for HCV genotypes 1, 4, 5, and 6. For genotypes 2 and 3, a Sofosbuvir + Velpatasvir combination (such as <a href=\"\/el\/velasof\/\">Velasof<\/a>) is recommended instead.<\/p>\n<h3>What tests do I need before starting Hepcinat LP?<\/h3>\n<p>Before starting treatment, your doctor should order: HCV genotype test, HCV viral load (RNA PCR), hepatitis B surface antigen test, liver function tests, and a kidney function test (eGFR). If cirrhosis is suspected, a FibroScan or liver biopsy may be recommended.<\/p>\n<h3>Can I take Hepcinat LP if I have cirrhosis?<\/h3>\n<p>Yes \u2014 Hepcinat LP is effective for patients with <strong>compensated cirrhosis<\/strong> (Child-Pugh A). A 12-week course is recommended. However, it is <strong>not recommended for decompensated cirrhosis<\/strong> (Child-Pugh B or C), which requires specialist management.<\/p>\n<h3>Can I take Hepcinat LP with HIV medications?<\/h3>\n<p>Hepcinat LP can be used with most HIV antiretroviral regimens. However, Tenofovir disoproxil fumarate (TDF) levels may increase when combined with Ledipasvir, so renal function should be monitored. TAF-based regimens such as <a href=\"\/el\/tenvir-af\/\">Tenvir AF<\/a> are generally preferred.<\/p>\n<h3>Do I need a prescription to buy Hepcinat LP?<\/h3>\n<p>At MedsBase, you can order Hepcinat LP online without a prescription. We offer discreet packaging and worldwide shipping. We strongly recommend consulting a hepatologist or gastroenterologist before starting treatment to determine the correct duration and monitor your response.<\/p>\n<h2>\u0391\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u0395\u03c5\u03b8\u03c5\u03bd\u03ce\u03bd<\/h2>\n<p>\u0397 \u03bc\u03cc\u03bd\u03b7 \u03bc\u03b1\u03c2 \u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03bf\u03c5\u03bc\u03b5 \u03cc\u03c4\u03b9 \u03bf\u03b9 \u03ba\u03b1\u03c4\u03b1\u03bd\u03b1\u03bb\u03c9\u03c4\u03ad\u03c2 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b1\u03c0\u03cc \u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd\u03c2, \u03b1\u03ba\u03c1\u03b9\u03b2\u03b5\u03af\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03be\u03b9\u03cc\u03c0\u03b9\u03c3\u03c4\u03b5\u03c2. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03bf\u03b9 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03b4\u03ce \u0394\u0395\u039d \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd \u03c9\u03c2 \u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c4\u03bf \u03c4\u03b7\u03c2 \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03ae\u03c2 \u03b5\u03bd\u03cc\u03c2 \u03c0\u03c1\u03bf\u03c3\u03ce\u03c0\u03bf\u03c5 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b7 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03ba\u03b1\u03c4\u03ac\u03c1\u03c4\u03b9\u03c3\u03b7. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03b4\u03ce \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03b5\u03bd\u03b7\u03bc\u03b5\u03c1\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c3\u03ba\u03bf\u03c0\u03bf\u03cd\u03c2. \u0391\u03c5\u03c4\u03cc \u03b5\u03bd\u03b4\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03bc\u03b7\u03bd \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03b9 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2, \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd \u03ae \u03c0\u03c1\u03bf\u03b5\u03b9\u03b4\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9\u03c2. \u03a0\u03b1\u03c1\u03b1\u03ba\u03b1\u03bb\u03bf\u03cd\u03bc\u03b5 \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf\u03bd \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc \u03c3\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03b6\u03b7\u03c4\u03ae\u03c3\u03c4\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03b5\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c3\u03b1\u03c2 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03bf\u03c0\u03bf\u03b9\u03b1\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1 \u03ae \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf. \u03a3\u03ba\u03bf\u03c0\u03cc\u03c2 \u03bc\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03be\u03bf\u03c5\u03bc\u03b5, \u03cc\u03c7\u03b9 \u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ae\u03c3\u03bf\u03c5\u03bc\u03b5, \u03c4\u03b7 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03b3\u03b9\u03b1\u03c4\u03c1\u03bf\u03cd-\u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2<\/h3>\n<p>\u0386\u03bb\u03bb\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 \u03c3\u03b5 <strong>\u03a7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03a0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2<\/strong> \u03c0\u03bf\u03c5 \u03bf\u03b9 \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/neurobion-forte-rf-injection\/\">Neurobion Forte RF Injection (Methylcobalamin + B6 + B3) \u2014 Nerve Repair<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/bonair-inhaler\/\">Bonair Inhaler<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/budecort-respules\/\">Budecort Respules<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/zosert\/\">Zosert<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/lidogab-gel\/\">Lidogab Gel<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Treats Hepatitis C<br \/>\n\u2705 High success rate<br \/>\n\u2705 Shortens treatment duration<br \/>\n\u2705 Lowers risk of liver damage<br \/>\n\u2705 Improves liver function<\/p>\n<p>Hepcinat LP contains Ledipasvir + Sofosbuvir.<\/p>","protected":false},"featured_media":52252,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3334],"product_tag":[3478,3479,3480],"class_list":{"0":"post-52251","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-hepatitis-medication","9":"product_tag-hepcinat-lp","10":"product_tag-ledipasvir","11":"product_tag-sofosbuvir","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/52251","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=52251"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/52252"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=52251"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=52251"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=52251"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=52251"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}