{"id":53022,"date":"2023-09-20T09:41:37","date_gmt":"2023-09-20T09:41:37","guid":{"rendered":"https:\/\/medsname.com\/cendox\/"},"modified":"2026-05-01T06:37:00","modified_gmt":"2026-05-01T06:37:00","slug":"cendox","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/cendox\/","title":{"rendered":"Cendox"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Cendox?<\/h3>\n<p style=\"margin:0;\"><strong>Cendox<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 <strong>doxycycline hyclate 100 mg capsule<\/strong> &mdash; a tetracycline antibiotic active against a wide range of Gram-positive, Gram-negative, atypical, intracellular, and zoonotic organisms. In a gastro-health context, doxycycline is used for <strong>cholera adjunct therapy, traveller&#8217;s diarrhoea (especially when invasive E. coli or Vibrio is suspected), Helicobacter pylori second-line eradication, Whipple&#8217;s disease, and Q fever<\/strong>. Standard adult dose: <strong>100 mg twice daily for 1&ndash;14 days depending on indication<\/strong>. Manufactured by Centurion Lab under WHO-GMP standards.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f6f8;border:1px solid #e1e4e8;border-radius:6px;padding:14px 18px;margin:24px 0;font-size:14px;\"><strong>\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase:<\/strong> \u2714 <strong>\u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03b7 WHO-GMP \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae<\/strong> &#10004; Discreet packaging &#10004; Worldwide shipping &#10004; <a href=\"https:\/\/medsbase.com\/el\/reviews\/\">Verified customer reviews (1,400+ customers)<\/a><\/div>\n<h3>\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\"><strong>\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>&#9888;&#65039; Tooth staining and pregnancy contraindication.<\/strong> Doxycycline is contraindicated in pregnancy after 18 weeks gestation and in children under 8 years (deposits in developing teeth and bones, causing permanent grey-yellow tooth staining and reversible bone-growth inhibition). Take with a full glass of water and remain upright for 30 minutes to prevent oesophagitis. Photosensitivity is common &mdash; use SPF 50+ and avoid prolonged sun exposure. Avoid in severe hepatic impairment.<\/div>\n<h3 class=\"wp-block-heading\">\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p>Cendox is supplied from a <strong>\u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03b7 WHO-GMP \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae<\/strong>. Every order ships discreetly worldwide and is covered by our <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\">\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/a> &mdash; if it does not arrive within 20 business days, we reship at no cost. Doxycycline is on the WHO Essential Medicines List for several indications including cholera, brucellosis, leptospirosis, and Q fever &mdash; antibiotics with this safety and spectrum profile are increasingly precious as bacterial resistance widens.<\/p>\n<h2 class=\"wp-block-heading\">Mechanism<\/h2>\n<p>Doxycycline binds reversibly to the 30S bacterial ribosomal subunit, blocking aminoacyl-tRNA from attaching to the A-site and halting protein synthesis. It is bacteriostatic at usual doses. Unlike older tetracyclines, it has high oral bioavailability (~95 percent) that is only modestly reduced by food, a long half-life (~18 hours) allowing twice-daily dosing, and biliary plus intestinal excretion that minimises renal-dose adjustment.<\/p>\n<h2 class=\"wp-block-heading\">Gastrointestinal indications<\/h2>\n<ul>\n<li><strong>Cholera (Vibrio cholerae):<\/strong> adjunct to oral rehydration, single 300 mg dose or 100 mg twice daily for 3 days<\/li>\n<li><strong>Traveller&#8217;s diarrhoea (suspected ETEC or Vibrio):<\/strong> 100 mg twice daily for 3 days<\/li>\n<li><strong>H. pylori second-line eradication (after metronidazole\/clarithromycin failure):<\/strong> doxycycline 100 mg BD + bismuth + PPI + metronidazole for 14 days<\/li>\n<li><strong>Whipple&#8217;s disease maintenance:<\/strong> 100 mg twice daily long-term (after IV ceftriaxone induction; specialist)<\/li>\n<li><strong>Q fever (Coxiella burnetii):<\/strong> 100 mg twice daily for 14&ndash;21 days (chronic Q fever needs 18 months + hydroxychloroquine)<\/li>\n<li><strong>Brucellosis:<\/strong> 100 mg twice daily + rifampicin 600&ndash;900 mg daily for 6 weeks<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Other common uses (cross-category)<\/h2>\n<ul>\n<li>Acne vulgaris (low-dose 50&ndash;100 mg\/day for 3 months)<\/li>\n<li>Chlamydia, urethritis, PID (100 mg twice daily for 7&ndash;14 days)<\/li>\n<li>Lyme disease (100 mg twice daily for 14&ndash;21 days)<\/li>\n<li>Malaria prophylaxis (100 mg daily, started 1&ndash;2 days before travel)<\/li>\n<li>Atypical pneumonia (100 mg twice daily for 7&ndash;14 days)<\/li>\n<li>Rosacea, periorificial dermatitis, hidradenitis (sub-antimicrobial 40 mg\/day MR)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u0394\u03cc\u03c3\u03b7<\/h2>\n<p>Adults: 100 mg twice daily on day 1 (or 200 mg single first dose), then 100 mg twice daily &mdash; or 100 mg once daily for less serious infections. Maximum 200 mg\/day. Children &gt; 8 years: 4 mg\/kg\/day in 1&ndash;2 divided doses, max 200 mg\/day. Hepatic impairment: dose reduce. CrCl: no reduction needed. Take with a full glass of water and remain upright 30 minutes; can be taken with food (modest reduction in absorption).<\/p>\n<h2 class=\"wp-block-heading\">\u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/h2>\n<ul>\n<li>GI: nausea, vomiting, diarrhoea, oesophagitis (mostly preventable with upright posture and water)<\/li>\n<li>Skin: photosensitivity (very common), rash; rare Stevens-Johnson syndrome and DRESS<\/li>\n<li>Dental: permanent staining if used in children &lt; 8 or pregnancy after 18 weeks<\/li>\n<li>Hepatotoxicity (rare; LFTs in long courses)<\/li>\n<li>Benign intracranial hypertension (rare)<\/li>\n<li>Vaginal candidiasis, oral thrush<\/li>\n<li>C. difficile-associated diarrhoea (rare)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd<\/h2>\n<ul>\n<li><strong>Antacids, iron, zinc, calcium, dairy products, sucralfate, bismuth, PEG laxatives:<\/strong> chelate doxycycline and reduce absorption &mdash; separate by 2 hours before or 6 hours after.<\/li>\n<li><strong>Warfarin:<\/strong> doxycycline displaces warfarin from albumin and can raise INR &mdash; check INR a few days into the course.<\/li>\n<li><strong>Combined OC pill:<\/strong> a small theoretical effect through bowel-flora alteration; for short courses (&lt; 14 days) extra contraception is no longer routinely advised by most modern guidelines.<\/li>\n<li><strong>Carbamazepine, phenytoin, barbiturates:<\/strong> induce doxycycline metabolism &mdash; reduce levels.<\/li>\n<li><strong>Methotrexate:<\/strong> doxycycline may raise methotrexate levels.<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3 class=\"wp-block-heading\">Why is it in a gastro category?<\/h3>\n<p>Doxycycline is the standard adjunct to oral rehydration in cholera, has a role in suspected invasive traveller&#8217;s diarrhoea, and is part of bismuth quadruple therapy for second-line H. pylori eradication. The gut category lists it because of these GI uses.<\/p>\n<h3 class=\"wp-block-heading\">Can I take it with milk or yoghurt?<\/h3>\n<p>Avoid taking it with milk, yoghurt, or calcium-fortified drinks &mdash; dairy chelates doxycycline and reduces absorption by 30&ndash;50 percent. Separate by 2 hours.<\/p>\n<h3 class=\"wp-block-heading\">Why must I stay upright after the dose?<\/h3>\n<p>Doxycycline can cause severe oesophagitis (chemical burn of the oesophagus) if a tablet lodges there. Take with at least 250 mL water and remain upright (sitting or standing) for 30 minutes.<\/p>\n<h3 class=\"wp-block-heading\">How careful should I be with sun?<\/h3>\n<p>Very. Doxycycline is one of the most photosensitising oral drugs in common use. Sunburn can develop within an hour of moderate sun exposure. Use SPF 50+ daily and reapply, wear long sleeves and a hat, and avoid solariums.<\/p>\n<h3 class=\"wp-block-heading\">Will it stain my teeth?<\/h3>\n<p>Only if you are pregnant after 18 weeks or under 8 years old. After permanent teeth have erupted (around age 8) the staining risk is gone.<\/p>\n<h3 class=\"wp-block-heading\">\u0395\u03af\u03bd\u03b1\u03b9 \u03b1\u03c3\u03c6\u03b1\u03bb\u03ad\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7;<\/h3>\n<p>No after 18 weeks gestation. Avoid in early pregnancy too unless the indication is severe (e.g. life-threatening Q fever, anthrax) and no alternative exists.<\/p>\n<h3 class=\"wp-block-heading\">\u039c\u03c0\u03bf\u03c1\u03ce \u03bd\u03b1 \u03c0\u03af\u03bd\u03c9 \u03b1\u03bb\u03ba\u03bf\u03cc\u03bb;<\/h3>\n<p>Light alcohol is acceptable. Heavy alcohol increases hepatotoxicity risk and reduces immune response to infection.<\/p>\n<h3 class=\"wp-block-heading\">\u03a4\u03b9 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bd \u03c7\u03ac\u03c3\u03c9 \u03bc\u03b9\u03b1 \u03b4\u03cc\u03c3\u03b7;<\/h3>\n<p>Take it as soon as you remember unless close to the next dose. Do not double up. Maintaining the dose interval matters more than catching up.<\/p>\n<h3 class=\"wp-block-heading\">Will it interact with my contraceptive?<\/h3>\n<p>For courses under 14 days, modern guidelines no longer routinely recommend extra contraception. Use condoms if you are concerned or if breakthrough bleeding occurs.<\/p>\n<h3 class=\"wp-block-heading\">\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/h3>\n<p>Below 25&deg;C in a dry place. Avoid freezing. Keep capsules in the original blister.<\/p>\n<p class=\"medsbase-bundle-link-2026-05-01\" data-marker=\"mb-bundle-link-prep-starter-pack\">Cendox doxycycline is an effective single agent for chlamydia, Q fever, and Lyme; if you&#8217;re using it specifically as doxy-PEP within a broader HIV-prevention regimen, our <a href='\/el\/prep-starter-pack\/'>\u03a0\u03b1\u03ba\u03ad\u03c4\u03bf \u0388\u03bd\u03b1\u03c1\u03be\u03b7\u03c2 PrEP (Tenvir-EM + \u03b4\u03bf\u03be\u03c5\u03ba\u03c5\u03ba\u03bb\u03af\u03bd\u03b7 100 mg)<\/a> bundles Tenvir-EM with the doxycycline in matched supply tiers.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Other Gastro Health Medications<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/ciplox\/\">Ciplox &mdash; Ciprofloxacin (alternative for invasive enteric infection)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/synclar\/\">Synclar &mdash; Clarithromycin (H. pylori first-line)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/rcifax\/\">Rcifax &mdash; Rifaximin (gut-selective)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/rifagut\/\">Rifagut &mdash; Rifaximin<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/divaine\/\">Divaine &mdash; Minocycline (related tetracycline)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/gastro-health\/\"><strong>Browse all Gastro Health Medications<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 \u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u0391\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u0395\u03c5\u03b8\u03cd\u03bd\u03b7\u03c2.<\/strong> This page is for informational purposes only and does not replace medical advice from a qualified healthcare professional. Bloody stool, high fever, dehydration, severe abdominal pain, or no improvement in 48 hours needs urgent medical assessment.<\/div>","protected":false},"excerpt":{"rendered":"<p>Cendox (Doxycycline Hyclate 100 mg, Centurion Lab) \u2014 tetracycline antibiotic for cholera adjunct, traveller&#8217;s diarrhoea, second-line H. pylori eradication, Q fever and brucellosis. WHO Essential Medicine. Worldwide shipping from MedsBase.<\/p>","protected":false},"featured_media":53023,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3215,3141,3485,3223,3542,3342,3580,3337,3448],"product_tag":[3581,3225],"class_list":{"0":"post-53022","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-acne-treatment","7":"product_cat-category-overview","8":"product_cat-chlamydia-treatment","9":"product_cat-chronic-conditions","10":"product_cat-gastro-health","11":"product_cat-general-health","12":"product_cat-malaria-tablets","13":"product_cat-sexual-health","14":"product_cat-travel-health-category-overview","15":"product_tag-cendox","16":"product_tag-doxycycline","18":"first","19":"outofstock","20":"shipping-taxable","21":"purchasable","22":"product-type-variable","23":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/53022","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=53022"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/53023"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=53022"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=53022"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=53022"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=53022"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}