{"id":53217,"date":"2023-09-20T09:43:58","date_gmt":"2023-09-20T09:43:58","guid":{"rendered":"https:\/\/medsname.com\/cyclophil-me\/"},"modified":"2026-04-30T16:30:27","modified_gmt":"2026-04-30T16:30:27","slug":"cyclophil-me","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/cyclophil-me\/","title":{"rendered":"Cyclophil Me"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">\u0393\u03c1\u03ae\u03b3\u03bf\u03c1\u03b7 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7<\/h3>\n<p style=\"margin-bottom:0;\"><strong>Cyclophil ME<\/strong> \u2014 Cyclosporine ME (Microemulsion) 25\/50\/100 mg (Sun Pharma). Calcineurin inhibitor (microemulsion formulation) for solid-organ transplant maintenance immunosuppression, severe atopic dermatitis, refractory psoriasis, severe rheumatoid arthritis, dry-eye syndrome (topical), nephrotic syndrome. Therapeutic drug monitoring required.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f7f7f7;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 6px 0;\"><strong>\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong><\/p>\n<ul style=\"margin:6px 0 0 22px;padding:0;list-style:disc;\">\n<li>\u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03b7 WHO-GMP \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae<\/li>\n<li>\u03a3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u03c3\u03b5 \u03b1\u03c0\u03bb\u03cc \u03c6\u03ac\u03ba\u03b5\u03bb\u03bf \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/li>\n<li>\u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae<\/li>\n<li>\u0391\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc 1,400+ \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2 (<a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03b4\u03b9\u03b1\u03b2\u03ac\u03c3\u03c4\u03b5 \u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2<\/a>)<\/li>\n<\/ul>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"background:#eef7ee;border-left:4px solid #4caf50;padding:10px 14px;margin:14px 0;border-radius:3px;\">\ud83d\udce6 <strong>\u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2:<\/strong> \u03b1\u03bd \u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03bc\u03ad\u03c3\u03b1 \u03c3\u03b5 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03b5\u03c2 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae, \u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03bf \u03ba\u03cc\u03c3\u03c4\u03bf\u03c2. <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\">\u0394\u03b9\u03b1\u03b2\u03ac\u03c3\u03c4\u03b5 \u03c4\u03b7\u03bd \u03c0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae<\/a>.<\/p>\n<h3>\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p>Cyclophil ME ships from a WHO-GMP certified manufacturer in plain packaging, billed through a regulated payment processor (the statement descriptor reads a regulated card-payment processor \u2014 never MedsBase or any medication name). Every order carries our 20-business-day Reshipment Assurance.<\/p>\n<div class=\"medsbase-specialist-strip\" style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0;\"><strong>\u26a0\ufe0f Specialist-supervised cancer therapy<\/strong> \u2014 this medication is started, monitored, and stopped by an oncologist or haematologist. Dosing depends on tumour type, stage, body surface area, organ function, and concomitant therapy. Self-treatment is not appropriate; the information below is educational and supports informed conversations with your specialist.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>Specialist monitoring required<\/strong><br \/>Immunosuppressants need ongoing specialist supervision (transplant, rheumatology, or haematology). Drug levels (cyclosporine, sirolimus, tacrolimus), FBC, LFTs, renal function, lipids, glucose, BP \u2014 all need regular monitoring. Infection surveillance is mandatory. Vaccination status must be optimised before starting; live vaccines contraindicated during therapy.<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>Infection risk + cancer surveillance<\/strong><br \/>Long-term immunosuppression increases risks: opportunistic infections (PCP, CMV, EBV-driven PTLD), bacterial\/fungal infection, reactivation of latent TB or HBV\/HCV. Increased risk of skin cancer (especially squamous cell), lymphoproliferative disease, and other malignancies. Annual skin checks, regular cancer surveillance per guidelines.<\/div>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3>When is this used?<\/h3>\n<p>Calcineurin inhibitor (microemulsion formulation) for solid-organ transplant maintenance immunosuppression, severe atopic dermatitis, refractory psoriasis, severe rheumatoid arthritis, dry-eye syndrome (topical), nephrotic syndrome. Therapeutic drug monitoring required. Always specialist-supervised \u2014 transplant, rheumatology, haematology, or oncology context.<\/p>\n<h3>Why is monitoring needed?<\/h3>\n<p>Therapeutic drug monitoring (cyclosporine, sirolimus, tacrolimus): trough levels target organ-protection without toxicity. Renal function: most are nephrotoxic. Lipids\/glucose: metabolic effects. FBC: marrow suppression.<\/p>\n<h3>\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd;<\/h3>\n<p>Critical class \u2014 strong CYP3A4 substrates (calcineurin inhibitors, mTOR inhibitors). Many interactions: antifungals raise levels (often dramatically \u2014 even 5-10\u00d7), rifampicin drops levels (rejection risk), grapefruit raises levels. Any new medication should be checked first.<\/p>\n<h3>Vaccines?<\/h3>\n<p>Inactivated vaccines fine; live vaccines contraindicated during therapy. Optimise vaccinations BEFORE starting \u2014 pneumococcal, annual influenza, hepatitis B, varicella, MMR, HPV as appropriate.<\/p>\n<h3>\u0395\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7;<\/h3>\n<p>Mycophenolate is teratogenic \u2014 strict contraception. Cyclosporine, tacrolimus, azathioprine are used in pregnancy with specialist supervision. mTOR inhibitors generally avoided. Always discuss family planning with specialist.<\/p>\n<h3>Cancer screening?<\/h3>\n<p>Skin checks every 6-12 months (lifelong skin cancer risk). Cervical cytology more frequent. Lymph nodes \u2014 monitor for lymphoproliferative disease.<\/p>\n<h3>Infections?<\/h3>\n<p>Cotrimoxazole prophylaxis for PCP first 6-12 months post-transplant. CMV monitoring. TB screening before starting. Ongoing infection vigilance \u2014 fever needs prompt assessment.<\/p>\n<h3>Sun protection?<\/h3>\n<p>Daily broad-spectrum SPF 50+ from the day of transplant onwards. Annual dermatology review. Skin cancer is the most common post-transplant malignancy.<\/p>\n<h3>\u03a4\u03b9 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bd \u03c7\u03ac\u03c3\u03c9 \u03bc\u03b9\u03b1 \u03b4\u03cc\u03c3\u03b7;<\/h3>\n<p>Take when you remember if same day; if &gt;12 hours late, skip and resume next dose. Do not double up. Consistent levels matter \u2014 discuss adherence with your transplant team.<\/p>\n<h3>Stopping?<\/h3>\n<p>Never stop without specialist guidance \u2014 risks acute rejection (transplant) or disease flare (autoimmune). Tapers happen over months, not days, and only when clinically appropriate.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Other Immunosuppressant &#038; Cancer Medications<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/mycept\/\">Mycept<\/a> \u2014 mycophenolate mofetil 250 mg \u2014 alternative MMF brand<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/mycofit\/\">Mycofit<\/a> \u2014 mycophenolate mofetil 500 mg<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/cyclophil-me\/\">Cyclophil ME<\/a> \u2014 cyclosporine ME 25\/50\/100 mg<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/renodapt-s\/\">Renodapt S<\/a> \u2014 mycophenolate sodium 360 mg \u2014 enteric-coated<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/rapact\/\">Rapact<\/a> \u2014 sirolimus 5\/10 mg \u2014 mTOR inhibitor<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:18px 0;border-radius:3px;font-size:.95em;\"><strong>\u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u0391\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u0395\u03c5\u03b8\u03c5\u03bd\u03ce\u03bd:<\/strong> Cancer therapy is highly individualised. Specific drug, dose, schedule, monitoring, and supportive care must be determined by a qualified oncologist or haematologist based on tumour biology, staging, comorbidities, and goals of care. This information is educational; it does not substitute for professional medical advice.<\/div>","protected":false},"excerpt":{"rendered":"<p>Cyclophil ME (Cyclosporine 25\/50\/100 mg) \u2014 Sun Pharma calcineurin inhibitor microemulsion for transplant maintenance, severe atopic dermatitis, refractory psoriasis, RA. TDM essential.<\/p>","protected":false},"featured_media":53218,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[],"class_list":{"0":"post-53217","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","10":"first","11":"outofstock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/53217","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=53217"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/53218"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=53217"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=53217"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=53217"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=53217"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}