{"id":53283,"date":"2023-09-20T09:44:28","date_gmt":"2023-09-20T09:44:28","guid":{"rendered":"https:\/\/medsname.com\/diane-35\/"},"modified":"2026-04-30T10:09:45","modified_gmt":"2026-04-30T10:09:45","slug":"diane-35","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/diane-35\/","title":{"rendered":"Diane 35"},"content":{"rendered":"

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Quick Answer \u2014 What is Diane 35?<\/h3>\n

Diane 35 is a combined oral contraceptive containing cyproterone acetate 2 mg + ethinylestradiol 35 mcg, manufactured by Bayer. Licensed for moderate-to-severe acne and androgen-dependent hirsutism in women who have not responded to topical therapy or oral antibiotics; it provides reliable contraception while it is being taken. Taken once daily for 21 days followed by a 7-day pill-free break.<\/p>\n<\/div>\n

\n\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong> \u03a0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2 WHO-GMP \u00b7 \u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u00b7 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u00b7 1,400+ \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a>\n<\/div>\n

\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n

\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n
\n\u26a0\ufe0f Important \u2014 VTE risk is higher than with most COCs.<\/strong> Diane 35 carries a venous thromboembolism (VTE) risk approximately 1.5\u20132\u00d7 that of low-dose levonorgestrel COCs (~9\u201315 events per 10,000 woman-years vs 5\u20137 for levonorgestrel). It is licensed specifically for acne \/ hirsutism, not as first-line contraception. Stop immediately and seek urgent assessment for unexplained calf pain or swelling, sudden chest pain or breathlessness, sudden severe headache, sudden visual changes, or focal neurological symptoms. Discontinue 4 weeks before major surgery and during prolonged immobilisation.\n<\/div>\n

How Diane 35 Works<\/h2>\n

Diane 35 combines two mechanisms. Cyproterone acetate<\/strong> is a potent anti-androgen that competes with testosterone and dihydrotestosterone (DHT) at the androgen receptor in skin and hair follicles, reducing sebum production and slowing terminal hair growth on androgen-dependent areas. Ethinylestradiol<\/strong> is a synthetic estrogen that suppresses ovulation, increases sex hormone-binding globulin (SHBG) \u2014 which lowers circulating free testosterone \u2014 and provides cycle control.<\/p>\n

The combination provides contraceptive efficacy comparable to other COCs (Pearl Index ~0.7 with perfect use, ~7 with typical use), while the anti-androgen action improves moderate-to-severe acne in 70\u201380% of women within 3\u20136 months and reduces hirsutism scores in 60\u201370% over 6\u20139 months.<\/p>\n

\u0395\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/h2>\n

Diane 35 is licensed for treatment of moderate-to-severe acne related to androgen sensitivity (with or without seborrhoea) and\/or for mild hirsutism in women of reproductive age, where topical treatment or oral antibiotics have not adequately controlled the condition. Contraception is automatically provided and the product should not be used in combination with another hormonal contraceptive (this would unnecessarily multiply the VTE risk).<\/p>\n

It is sometimes prescribed off-label for polycystic ovary syndrome (PCOS) presenting with acne or hirsutism, and as anti-androgen therapy in transgender women under specialist supervision.<\/p>\n

\u03a7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7<\/h2>\n\n\n\n\n\n\n\n\n\n
\u0395\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/th>\nSchedule<\/th>\n\u0394\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2<\/th>\n<\/tr>\n<\/thead>\n
Acne \/ hirsutism<\/td>\n1 tablet daily for 21 days, then 7 day pill-free break<\/td>\nContinue for at least 3\u20134 cycles after symptom resolution; review at 6 months<\/td>\n<\/tr>\n
First-cycle start (no prior hormonal contraception)<\/td>\nStart day 1 of menstrual bleed; immediate contraceptive cover<\/td>\nContinuous as above<\/td>\n<\/tr>\n
Switching from another COC<\/td>\nStart the day after the last active tablet of the previous COC; no break<\/td>\nContinuous<\/td>\n<\/tr>\n
Missed pill (<12 hours late)<\/td>\nTake immediately; next pill on time; cover preserved<\/td>\nNo additional precautions<\/td>\n<\/tr>\n
Missed pill (>12 hours late)<\/td>\nTake immediately, take next pill on time, use barrier method 7 days<\/td>\nIf 3+ pills missed in week 1, consider emergency contraception<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Long-term continuous use beyond 24\u201336 months without symptom benefit is generally not recommended given the cumulative VTE exposure; alternative anti-androgen strategies (spironolactone, isotretinoin, finasteride for hirsutism) should be considered.<\/p>\n

\u0391\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/h2>\n