{"id":53554,"date":"2023-09-20T09:47:39","date_gmt":"2023-09-20T09:47:39","guid":{"rendered":"https:\/\/medsname.com\/zoldria\/"},"modified":"2026-04-30T16:30:26","modified_gmt":"2026-04-30T16:30:26","slug":"zoldria","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/zoldria\/","title":{"rendered":"Zoldria"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">\u0393\u03c1\u03ae\u03b3\u03bf\u03c1\u03b7 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7<\/h3>\n<p style=\"margin-bottom:0;\"><strong>Zoldria<\/strong> \u2014 Zoledronic Acid 4 mg\/100 mL (Sun Pharma). Bisphosphonate \u2014 for cancer-related bone metastases (myeloma, breast, prostate, lung), tumour-induced hypercalcaemia, Paget&#8217;s disease, and severe osteoporosis. IV infusion under specialist supervision.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f7f7f7;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 6px 0;\"><strong>\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong><\/p>\n<ul style=\"margin:6px 0 0 22px;padding:0;list-style:disc;\">\n<li>\u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03b7 WHO-GMP \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae<\/li>\n<li>\u03a3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u03c3\u03b5 \u03b1\u03c0\u03bb\u03cc \u03c6\u03ac\u03ba\u03b5\u03bb\u03bf \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/li>\n<li>\u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae<\/li>\n<li>\u0391\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc 1,400+ \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2 (<a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03b4\u03b9\u03b1\u03b2\u03ac\u03c3\u03c4\u03b5 \u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2<\/a>)<\/li>\n<\/ul>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"background:#eef7ee;border-left:4px solid #4caf50;padding:10px 14px;margin:14px 0;border-radius:3px;\">\ud83d\udce6 <strong>\u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2:<\/strong> \u03b1\u03bd \u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03bc\u03ad\u03c3\u03b1 \u03c3\u03b5 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03b5\u03c2 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae, \u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03bf \u03ba\u03cc\u03c3\u03c4\u03bf\u03c2. <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\">\u0394\u03b9\u03b1\u03b2\u03ac\u03c3\u03c4\u03b5 \u03c4\u03b7\u03bd \u03c0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae<\/a>.<\/p>\n<h3>\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p>Zoldria ships from a WHO-GMP certified manufacturer in plain packaging, billed through a regulated payment processor (the statement descriptor reads a regulated card-payment processor \u2014 never MedsBase or any medication name). Every order carries our 20-business-day Reshipment Assurance.<\/p>\n<div class=\"medsbase-specialist-strip\" style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0;\"><strong>\u26a0\ufe0f Specialist-supervised cancer therapy<\/strong> \u2014 this medication is started, monitored, and stopped by an oncologist or haematologist. Dosing depends on tumour type, stage, body surface area, organ function, and concomitant therapy. Self-treatment is not appropriate; the information below is educational and supports informed conversations with your specialist.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>\u039f\u03c3\u03c4\u03b5\u03bf\u03bd\u03b5\u03ba\u03c1\u03ce\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b3\u03bd\u03ac\u03b8\u03bf\u03c5 (ONJ)<\/strong><br \/>All bisphosphonates carry ONJ risk \u2014 higher with IV agents (zoledronic acid, ibandronate IV) and longer cumulative therapy. Pre-treatment dental review is mandatory; complete invasive dentistry before starting. Avoid invasive dental procedures during therapy if possible. Notify dentist about bisphosphonate use lifelong (effects persist years after stopping).<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>Renal monitoring + adequate hydration<\/strong><br \/>Bisphosphonates are renally cleared. Adequate hydration before\/during IV administration. Monitor renal function and serum calcium. Hypocalcaemia is common; supplement with calcium + vitamin D throughout therapy. Avoid in CrCl &lt;30 (oral) or &lt;35 (IV).<\/div>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3>When is this used?<\/h3>\n<p>Bone metastases (myeloma, breast, prostate, lung), tumour-induced hypercalcaemia (zoledronic acid IV is fastest), Paget&#8217;s disease, and severe osteoporosis (especially adjuvant during AI therapy in breast cancer).<\/p>\n<h3>IV vs oral?<\/h3>\n<p>IV (zoledronic acid 4 mg q3-4 weekly for cancer; q12 monthly for osteoporosis; ibandronate 6 mg q3-4 weekly): more potent, fewer doses, no GI absorption issues. Oral (ibandronate 150 mg monthly): convenient, no IV access needed, but oesophagitis risk and absorption issues.<\/p>\n<h3>ONJ \u2014 how worried should I be?<\/h3>\n<p>ONJ is rare but cumulative. Risk factors: invasive dental procedures (extraction, implants), poor dental hygiene, smoking, diabetes, glucocorticoid use. Pre-treatment dental review and ongoing oral hygiene minimise risk. Discuss any planned dental work with your oncology team.<\/p>\n<h3>Calcium and vitamin D?<\/h3>\n<p>Mandatory throughout bisphosphonate therapy: calcium 1000-1500 mg\/day plus vitamin D 800-1000 IU\/day. Reduces hypocalcaemia risk and improves bone density.<\/p>\n<h3>\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd;<\/h3>\n<p>Calcium, magnesium, aluminium-containing antacids, iron, multivitamins reduce absorption (oral) \u2014 separate by \u226530 minutes. NSAIDs + bisphosphonates: increased GI risk. Aminoglycosides + bisphosphonates: increased nephrotoxicity.<\/p>\n<h3>\u0395\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7;<\/h3>\n<p>Long half-life in bone (years to decades). Generally avoided in pre-menopausal women without effective contraception. Limited human pregnancy data.<\/p>\n<h3>\u03a4\u03b9 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bd \u03c7\u03ac\u03c3\u03c9 \u03bc\u03b9\u03b1 \u03b4\u03cc\u03c3\u03b7;<\/h3>\n<p>Oral monthly: take next morning if remembered the same week; if missed entirely, return to the original schedule next month. IV: scheduled by specialist; reschedule with oncology team.<\/p>\n<h3>Atypical femoral fracture?<\/h3>\n<p>Rare class effect after long-term use (typically &gt;5 years osteoporosis use). Drug holiday at 3-5 years considered in osteoporosis. Cancer use typically continues based on disease state.<\/p>\n<h3>Acute phase reaction?<\/h3>\n<p>Common after first IV bisphosphonate dose: fever, myalgia, arthralgia, fatigue 1-3 days post-infusion. Usually mild, paracetamol-responsive, less severe with subsequent doses.<\/p>\n<h3>Stopping?<\/h3>\n<p>Specialist-determined based on disease, response, toxicity. Bisphosphonate effect on bone persists for years after stopping due to bone deposition.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Other Cancer &#038; Bone-Health Medications<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/zoldria\/\">Zoldria<\/a> \u2014 zoledronic acid IV \u2014 for bone mets and hypercalcaemia<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/bandrone\/\">Bandrone<\/a> \u2014 ibandronate \u2014 alternative bisphosphonate<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/idrofos\/\">Idrofos<\/a> \u2014 ibandronate 150 mg monthly oral<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/osteofos\/\">Osteofos<\/a> \u2014 alendronate weekly \u2014 for osteoporosis<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/calcirol\/\">Calcirol<\/a> \u2014 vitamin D3 60,000 IU sachet \u2014 for adequacy<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:18px 0;border-radius:3px;font-size:.95em;\"><strong>\u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u0391\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u0395\u03c5\u03b8\u03c5\u03bd\u03ce\u03bd:<\/strong> Cancer therapy is highly individualised. Specific drug, dose, schedule, monitoring, and supportive care must be determined by a qualified oncologist or haematologist based on tumour biology, staging, comorbidities, and goals of care. This information is educational; it does not substitute for professional medical advice.<\/div>","protected":false},"excerpt":{"rendered":"<p>Zoldria (Zoledronic Acid 4 mg\/100 mL IV) \u2014 Sun Pharma bisphosphonate for cancer-related bone metastases, hypercalcaemia of malignancy, and osteoporosis. Hospital-administered IV infusion.<\/p>","protected":false},"featured_media":53555,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[],"class_list":{"0":"post-53554","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","10":"first","11":"outofstock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/53554","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=53554"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/53555"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=53554"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=53554"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=53554"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=53554"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}