{"id":53624,"date":"2023-09-20T09:48:36","date_gmt":"2023-09-20T09:48:36","guid":{"rendered":"https:\/\/medsname.com\/alfusin-d\/"},"modified":"2026-04-30T10:25:11","modified_gmt":"2026-04-30T10:25:11","slug":"alfusin-d","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/alfusin-d\/","title":{"rendered":"Alfusin D"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:14px 0;border-radius:3px;\">\n<h3 style=\"margin:0 0 6px 0;\">\u0393\u03c1\u03ae\u03b3\u03bf\u03c1\u03b7 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7<\/h3>\n<p style=\"margin:0;\"><strong>Alfusin D<\/strong> \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 <strong>alfuzosin + dutasteride 10 mg + 0.5 mg<\/strong> made by Cipla Inc. It is used for moderate-to-severe benign prostatic hyperplasia (BPH) where both flow improvement <em>\u03ba\u03b1\u03b9<\/em> prostate shrinkage are needed. Take exactly as directed by your clinician \u2014 do not adjust the dose yourself.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong> \u03a0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2 WHO-GMP \u00b7 \u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u00b7 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u00b7 1,400+ \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 <a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\"><strong>\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n<div style=\"background:#f4f8fb;border:1px solid #d6e4ec;padding:12px 18px;margin:14px 0;border-radius:4px;font-size:14px;color:#3a5160;text-align:center;\"><strong>\ud83d\udd12 \u039a\u03c1\u03c5\u03c0\u03c4\u03bf\u03b3\u03c1\u03b1\u03c6\u03b7\u03bc\u03ad\u03bd\u03b7 \u039f\u03bb\u03bf\u03ba\u03bb\u03ae\u03c1\u03c9\u03c3\u03b7 \u0391\u03b3\u03bf\u03c1\u03ac\u03c2<\/strong> \u00b7 <strong>\ud83d\udcb3 \u0395\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf\u03c2 \u0395\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c2<\/strong> \u00b7 <strong>\ud83d\ude9a \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u0391\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae<\/strong> \u00b7 <strong>\u2b50 4.9\/5 \u03b1\u03c0\u03cc 1,400+ \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2<\/strong><\/div>\n<h3>\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p>\u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03c4\u03af\u03b4\u03b1 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1 <strong>\u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03b7 WHO-GMP \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae<\/strong>. \u039f\u03b9 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b5\u03c2 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03bc\u03c0\u03bf\u03c1\u03b9\u03ba\u03ae \u03c3\u03ae\u03bc\u03b1\u03bd\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03ac\u03c4\u03b5\u03c2 \u03bc\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"\/el\/medsbase-re-shipment-assurance-policy\/\">\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/a>. \u0388\u03c7\u03bf\u03c5\u03bc\u03b5 \u03b5\u03be\u03c5\u03c0\u03b7\u03c1\u03b5\u03c4\u03ae\u03c3\u03b5\u03b9 <strong>1,400+ \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2<\/strong> \u03bc\u03b5 <strong>4.9\/5 \u03bc\u03ad\u03c3\u03bf \u03cc\u03c1\u03bf \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7\u03c2<\/strong> \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c0\u03cc 600 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1.<\/p>\n<h2>What Alfusin D is and how it works<\/h2>\n<p>Alfusin D is a <strong>combination tablet<\/strong> containing two medicines that target BPH at different mechanisms:<\/p>\n<ul>\n<li><strong>Alfuzosin 10&nbsp;mg ER<\/strong> &mdash; an alpha-1 adrenoceptor antagonist that relaxes prostate, bladder-neck and urethral smooth muscle, improving flow within days.<\/li>\n<li><strong>Dutasteride 0.5&nbsp;mg<\/strong> &mdash; a dual 5-alpha-reductase inhibitor that blocks the conversion of testosterone to dihydrotestosterone (DHT). Lower DHT shrinks the prostate by ~25% over 6&ndash;12 months and lowers the long-term risk of acute urinary retention and BPH-related surgery.<\/li>\n<\/ul>\n<p>This dual approach is supported by the <strong>CombAT trial<\/strong> (Combination of Avodart and Tamsulosin, 4-year data), which showed superiority of dual therapy over either drug alone for symptom score, flow rate, retention risk and need for surgery in men with prostates &gt;30&nbsp;mL.<\/p>\n<div style=\"background:#eef7ee;border-left:4px solid #4caf50;padding:14px 18px;margin:14px 0;border-radius:3px;\">\n<p style=\"margin:0 0 6px 0;\"><strong>&#9989; Who benefits most from this combination<\/strong><\/p>\n<p style=\"margin:0;\">\u0386\u03bd\u03b4\u03c1\u03b5\u03c2 \u03bc\u03b5 <strong>moderate-to-severe LUTS (IPSS &ge; 8)<\/strong> AND a <strong>prostate volume &gt; 30&nbsp;mL<\/strong> AND\/OR <strong>PSA &gt; 1.5&nbsp;ng\/mL<\/strong>. If your gland is small (&lt; 30&nbsp;mL) the combination adds little over alfuzosin monotherapy.<\/p>\n<\/div>\n<h2>\u0394\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03cc\u03c0\u03bf\u03c2 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2<\/h2>\n<p><strong>One tablet once daily, after the same meal each day<\/strong> &mdash; usually breakfast or dinner. Swallow whole with water; do not crush, chew or open the tablet (the alfuzosin portion is an ER matrix). Improvement in flow appears within 1&ndash;2 weeks (alfuzosin component); prostate shrinkage and the full reduction in retention risk take 6&ndash;12 months (dutasteride component). Long-term treatment is usually intended.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:14px 0;border-radius:3px;\">\n<p style=\"margin:0 0 6px 0;\"><strong>&#9888; Pregnancy &mdash; do not handle if your partner is pregnant or could become pregnant<\/strong><\/p>\n<p style=\"margin:0;\">Dutasteride is absorbed through the skin and can cause <strong>genital malformations in male foetuses<\/strong>. Pregnant women and women who could become pregnant must <strong>not handle leaking or broken tablets<\/strong>. Do not donate blood while taking dutasteride and for 6 months after stopping &mdash; the half-life is ~5 weeks. Use barrier contraception if your partner could become pregnant; semen contains small amounts of dutasteride.<\/p>\n<\/div>\n<h2>\u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;\">\n<thead>\n<tr>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;text-align:left;border:1px solid #1f5d86;\">\u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;text-align:left;border:1px solid #1f5d86;\">Source<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;text-align:left;border:1px solid #1f5d86;\">\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">Dizziness, light-headedness on standing<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">Alfuzosin<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">\u03a3\u03c5\u03c7\u03bd\u03ac<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">\u039a\u03b5\u03c6\u03b1\u03bb\u03b1\u03bb\u03b3\u03af\u03b1, \u03ba\u03cc\u03c0\u03c9\u03c3\u03b7<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">Alfuzosin<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">\u03a3\u03c5\u03c7\u03bd\u03ac<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">Decreased libido<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">Dutasteride<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">Common (~3&ndash;5%)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">\u0391\u03bd\u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03c4\u03cd\u03c3\u03b7\u03c2<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">Dutasteride<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">Common (~5&ndash;7%)<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">Ejaculation disorder (reduced volume)<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">Both<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">\u03a3\u03c5\u03c7\u03bd\u03ac<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">Breast tenderness or enlargement (gynecomastia)<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">Dutasteride<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">\u0391\u03c3\u03c5\u03bd\u03ae\u03b8\u03b9\u03c3\u03c4\u03b5\u03c2<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">Intraoperative Floppy Iris Syndrome<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">Alfuzosin<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">Surgical risk &mdash; tell ophthalmologist<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">Mood changes \/ depressive symptoms<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">Dutasteride<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">Uncommon &mdash; report if severe<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;\">\n<thead>\n<tr>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;text-align:left;border:1px solid #1f5d86;\">\u03a3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;text-align:left;border:1px solid #1f5d86;\">\u0391\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;text-align:left;border:1px solid #1f5d86;\">\u0394\u03c1\u03ac\u03c3\u03b7<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">\u0399\u03c3\u03c7\u03c5\u03c1\u03bf\u03af \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 CYP3A4 (\u03ba\u03b5\u03c4\u03bf\u03ba\u03bf\u03bd\u03b1\u03b6\u03cc\u03bb\u03b7, \u03c1\u03b9\u03c4\u03bf\u03bd\u03b1\u03b2\u03af\u03c1, \u03ba\u03bb\u03b1\u03c1\u03b9\u03b8\u03c1\u03bf\u03bc\u03c5\u03ba\u03af\u03bd\u03b7)<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">Major rise in alfuzosin AND dutasteride levels<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;\"><strong>\u0391\u03c0\u03bf\u03c6\u03cd\u03b3\u03b5\u03c4\u03b5<\/strong><\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">\u0386\u03bb\u03bb\u03b1 \u03b1\u03c0\u03bb\u03cc\u03c7\u03bf\u03bb\u03b1<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">Additive hypotension<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">Do not combine<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">PDE-5 inhibitors<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">Additive hypotension<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">Stabilise on combo first; introduce cautiously<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">\u0391\u03bd\u03c4\u03b9\u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03ac<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">Additive BP lowering<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">Monitor BP, especially in first week<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">\u0392\u03b1\u03c1\u03c6\u03b1\u03c1\u03af\u03bd\u03b7<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">No clinically significant interaction<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;\">Standard INR monitoring<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Important PSA note<\/h2>\n<p>Dutasteride <strong>halves serum PSA<\/strong> within 6 months. Your urologist should <strong>double the measured PSA<\/strong> before interpreting it for prostate-cancer screening. If your PSA <em>rises<\/em> above the new (halved) baseline while on treatment, that is a flag for further investigation &mdash; do not assume the drug is failing.<\/p>\n<h2>Who should not take Alfusin D<\/h2>\n<ul>\n<li>Women, children, adolescents (dutasteride is teratogenic and there is no female indication)<\/li>\n<li>History of orthostatic hypotension or first-dose syncope<\/li>\n<li>\u03a3\u03bf\u03b2\u03b1\u03c1\u03ae \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1<\/li>\n<li>Concurrent strong CYP3A4 inhibitors<\/li>\n<li>Known hypersensitivity to alfuzosin, dutasteride, or other 5-alpha-reductase inhibitors (e.g. finasteride)<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3>How is this different from alfuzosin alone?<\/h3>\n<p>Alfuzosin alone improves <em>flow<\/em> within days, but does nothing for prostate <em>size<\/em>. Adding dutasteride shrinks the gland over 6&ndash;12 months and reduces long-term retention and surgery risk. The combination is for men whose gland is enlarged, not just symptomatic.<\/p>\n<h3>Why must my partner avoid handling the tablets?<\/h3>\n<p>Dutasteride is absorbed through skin and can disrupt male foetal development. Whole tablets are coated and safe; broken or leaking tablets must not be touched by women who could be pregnant.<\/p>\n<h3>Can I donate blood while on Alfusin D?<\/h3>\n<p>No. Dutasteride has a 5-week half-life; do not donate blood during treatment and for 6 months after stopping, to protect potentially pregnant recipients.<\/p>\n<h3>Will my PSA reading still be useful?<\/h3>\n<p>Yes &mdash; your clinician simply doubles the measured value to get an &ldquo;equivalent&rdquo; PSA. Any rise above the halved baseline is investigated normally.<\/p>\n<h3>How long before I notice an effect?<\/h3>\n<p>Flow rate improves within 1&ndash;2 weeks (alfuzosin). Symptom score (IPSS) typically drops 4&ndash;6 points by 3 months. Prostate shrinkage and the retention-risk benefit accumulate over 6&ndash;12 months (dutasteride).<\/p>\n<h3>Is sexual side-effect risk additive?<\/h3>\n<p>Partly. Each drug independently reduces ejaculate volume; dutasteride adds 3&ndash;7% rates of decreased libido and erectile dysfunction. Most are reversible on stopping, though dutasteride effects can persist for weeks after the last dose.<\/p>\n<h3>Can I crush or split the tablet?<\/h3>\n<p>No. Alfuzosin is in an extended-release matrix; crushing dumps a whole day&rsquo;s dose at once and causes severe hypotension. Swallow whole.<\/p>\n<h3>What happens if I stop taking it?<\/h3>\n<p>Alfuzosin&rsquo;s flow benefit fades within 1&ndash;2 weeks. Dutasteride&rsquo;s prostate-size reduction reverses over 6&ndash;12 months. Symptoms typically return.<\/p>\n<h3>Can I switch to dutasteride alone later?<\/h3>\n<p>Some men whose symptoms are dominated by gland size rather than tone do drop the alpha-blocker after 6&ndash;12 months. Discuss the timing with your urologist &mdash; do not self-switch.<\/p>\n<h3>Is this safe long-term?<\/h3>\n<p>Yes &mdash; both components are licensed for chronic use. Long-term safety data exists out to 4 years (CombAT) and informally beyond. Annual urology review is recommended.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>\u0386\u03bb\u03bb\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03bf\u03c5\u03c1\u03bf\u03b4\u03cc\u03c7\u03bf \u03ba\u03cd\u03c3\u03c4\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7<\/h2>\n<ul>\n<li><a href=\"\/el\/silofast\/\">Silofast (silodosin) &mdash; alpha-blocker monotherapy, more selective<\/a><\/li>\n<li><a href=\"\/el\/alfusin\/\">Alfusin (alfuzosin 10&nbsp;mg ER) &mdash; alpha-blocker alone<\/a><\/li>\n<li><a href=\"\/el\/alfusin-tab\/\">Alfusin Tab (alfuzosin 2.5&nbsp;mg) &mdash; alternative starting dose<\/a><\/li>\n<li><a href=\"\/el\/urotel-xl\/\">Urotel XL (tolterodine ER) &mdash; for storage-symptom-dominant LUTS<\/a><\/li>\n<li><a href=\"\/el\/cystone\/\">Cystone &mdash; herbal urinary support adjunct<\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:3px;font-size:13px;color:#3a5160;\">\n<p style=\"margin:0;\"><strong>\u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03b5\u03c5\u03b8\u03c5\u03bd\u03ce\u03bd.<\/strong> \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b5\u03c2 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7 \u03c3\u03b5\u03bb\u03af\u03b4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03b3\u03b5\u03bd\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b5\u03ba\u03c0\u03b1\u03b9\u03b4\u03b5\u03c5\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c3\u03ba\u03bf\u03c0\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c4\u03bf \u03c4\u03b7\u03c2 \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03ae\u03c2 \u03b5\u03bd\u03cc\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c1\u03c4\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd. \u03a3\u03c5\u03b6\u03b7\u03c4\u03ae\u03c3\u03c4\u03b5 \u03ba\u03ac\u03b8\u03b5 \u03bd\u03ad\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03ae \u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03b4\u03cc\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc \u03ae \u03c4\u03bf\u03bd \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03c0\u03bf\u03b9\u03cc \u03c3\u03b1\u03c2, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b5\u03ac\u03bd \u03b5\u03af\u03c3\u03c4\u03b5 \u03ad\u03b3\u03ba\u03c5\u03bf\u03c2, \u03b8\u03b7\u03bb\u03ac\u03b6\u03b5\u03c4\u03b5, \u03ad\u03c7\u03b5\u03c4\u03b5 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ae \u03c0\u03b1\u03af\u03c1\u03bd\u03b5\u03c4\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u2705 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03cd\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03b5\u03c5\u03c1\u03c5\u03bc\u03ad\u03bd\u03b7 \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7<br \/>\n\u2705 \u0392\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03c1\u03bf\u03ae \u03c4\u03bf\u03c5 \u03bf\u03cd\u03c1\u03bf\u03c5<br \/>\n\u2705 \u039c\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03c5\u03c7\u03bd\u03ae \u03bf\u03cd\u03c1\u03b7\u03c3\u03b7<br \/>\n\u2705 Minimizes bladder obstruction<br \/>\n\u2705 Alleviates urinary symptoms<\/p>","protected":false},"featured_media":53625,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3614,3141,3342],"product_tag":[],"class_list":{"0":"post-53624","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bladder-prostate","7":"product_cat-category-overview","8":"product_cat-general-health","10":"first","11":"outofstock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/53624","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=53624"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/53625"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=53624"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=53624"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=53624"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=53624"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}