{"id":53639,"date":"2023-09-20T09:49:00","date_gmt":"2023-09-20T09:49:00","guid":{"rendered":"https:\/\/medsname.com\/silofast\/"},"modified":"2026-04-30T10:25:11","modified_gmt":"2026-04-30T10:25:11","slug":"silofast","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/silofast\/","title":{"rendered":"Silofast"},"content":{"rendered":"

<\/p>\n

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\u0393\u03c1\u03ae\u03b3\u03bf\u03c1\u03b7 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7<\/h3>\n

Silofast<\/strong> \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 silodosin 4 mg \/ 8 mg<\/strong> made by Cipla Inc. It is used for the symptoms of an enlarged prostate (benign prostatic hyperplasia, BPH) in men. Take exactly as directed by your clinician \u2014 do not adjust the dose yourself.<\/p>\n<\/div>\n

\n\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong> \u03a0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2 WHO-GMP \u00b7 \u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u00b7 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u00b7 1,400+ \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a>\n<\/div>\n

\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n

\ud83d\udd12 \u039a\u03c1\u03c5\u03c0\u03c4\u03bf\u03b3\u03c1\u03b1\u03c6\u03b7\u03bc\u03ad\u03bd\u03b7 \u039f\u03bb\u03bf\u03ba\u03bb\u03ae\u03c1\u03c9\u03c3\u03b7 \u0391\u03b3\u03bf\u03c1\u03ac\u03c2<\/strong> \u00b7 \ud83d\udcb3 \u0395\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf\u03c2 \u0395\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c2<\/strong> \u00b7 \ud83d\ude9a \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u0391\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae<\/strong> \u00b7 \u2b50 4.9\/5 \u03b1\u03c0\u03cc 1,400+ \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2<\/strong><\/div>\n

\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n

\u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03c4\u03af\u03b4\u03b1 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03b7 WHO-GMP \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae<\/strong>. \u039f\u03b9 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b5\u03c2 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03bc\u03c0\u03bf\u03c1\u03b9\u03ba\u03ae \u03c3\u03ae\u03bc\u03b1\u03bd\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03ac\u03c4\u03b5\u03c2 \u03bc\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/a>. \u0388\u03c7\u03bf\u03c5\u03bc\u03b5 \u03b5\u03be\u03c5\u03c0\u03b7\u03c1\u03b5\u03c4\u03ae\u03c3\u03b5\u03b9 1,400+ \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2<\/strong> \u03bc\u03b5 4.9\/5 \u03bc\u03ad\u03c3\u03bf \u03cc\u03c1\u03bf \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7\u03c2<\/strong> \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c0\u03cc 600 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1.<\/p>\n

What Silofast is and how it works<\/h2>\n

Silofast contains silodosin<\/strong>, a uroselective alpha-1A adrenoceptor antagonist<\/strong>. The smooth muscle of the prostate, prostatic urethra and bladder neck is rich in alpha-1A receptors; blocking them relaxes that muscle and improves urine flow. Because silodosin is >100 times more selective for alpha-1A than alpha-1B receptors, blood-pressure effects are smaller than with non-selective alpha-blockers such as terazosin or doxazosin.<\/p>\n

Silofast is licensed to relieve lower urinary tract symptoms (LUTS) of benign prostatic hyperplasia<\/strong> — weak stream, hesitancy, intermittency, incomplete emptying, frequency, urgency and nocturia — in adult men. It does \u03b4\u03b5\u03bd<\/strong> shrink the prostate; if shrinkage is needed (large gland, high PSA, recurrent retention) a 5-alpha-reductase inhibitor such as dutasteride or finasteride is added.<\/p>\n

\u0394\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03cc\u03c0\u03bf\u03c2 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2<\/h2>\n\n\n\n\n\n\n\n\n\n
\u039f\u03bc\u03ac\u03b4\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd<\/th>\n\u03a3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ce\u03bc\u03b5\u03bd\u03b7 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1<\/th>\n<\/tr>\n<\/thead>\n
Adult men with BPH (normal renal function)<\/td>\n8 mg once daily<\/strong> with food<\/td>\n<\/tr>\n
Mild renal impairment (eGFR 50–80)<\/td>\n8 mg once daily — usually tolerated<\/td>\n<\/tr>\n
Moderate renal impairment (eGFR 30–50)<\/td>\nStart at 4 mg<\/strong> once daily; titrate to 8 mg if tolerated after 1 week<\/td>\n<\/tr>\n
\u03a3\u03bf\u03b2\u03b1\u03c1\u03ae \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 (eGFR <30)<\/td>\n\u0391\u03c0\u03bf\u03c6\u03cd\u03b3\u03b5\u03c4\u03b5<\/td>\n<\/tr>\n
\u03a3\u03bf\u03b2\u03b1\u03c1\u03ae \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 (Child-Pugh C)<\/td>\n\u0391\u03c0\u03bf\u03c6\u03cd\u03b3\u03b5\u03c4\u03b5<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Take with food at the same meal each day<\/strong> — food increases tolerability and gives a more predictable plasma level. Swallow whole; do not crush. Onset of symptom benefit is rapid (within days for flow rate) but the full effect takes 2–4 weeks. If you miss a dose, skip it and take the next one as scheduled — do not double up.<\/p>\n

\n

⚠ Stop and tell your eye surgeon you take silodosin<\/strong><\/p>\n

Silodosin (and other alpha-blockers) can cause \u03a3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03c7\u03b1\u03bb\u03b1\u03c1\u03ae\u03c2 \u03af\u03c1\u03b9\u03b4\u03b1\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03b5\u03b3\u03c7\u03b5\u03af\u03c1\u03b7\u03c3\u03b7 (IFIS)<\/strong> during cataract or glaucoma surgery, complicating the operation. If you have surgery planned, your ophthalmologist must be told in advance. Do not stop the medication on your own; the surgical team will plan around it.<\/p>\n<\/div>\n

\u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n
\u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1<\/th>\n\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1<\/th>\n\u0394\u03c1\u03ac\u03c3\u03b7<\/th>\n<\/tr>\n<\/thead>\n
\u0391\u03bd\u03b1\u03b4\u03c1\u03bf\u03bc\u03b9\u03ba\u03ae \u03b5\u03ba\u03c3\u03c0\u03b5\u03c1\u03bc\u03ac\u03c4\u03b9\u03c3\u03b7<\/strong> (dry orgasm)<\/td>\nVery common (~28%)<\/td>\nReversible on stopping; not harmful but discuss with partner \/ fertility plans<\/td>\n<\/tr>\n
Dizziness on standing (orthostatic hypotension)<\/td>\nCommon (~3%)<\/td>\nStand slowly; mostly first 1–2 doses<\/td>\n<\/tr>\n
\u039a\u03b5\u03c6\u03b1\u03bb\u03b1\u03bb\u03b3\u03af\u03b1<\/td>\n\u03a3\u03c5\u03c7\u03bd\u03ac<\/td>\nUsually settles within a week<\/td>\n<\/tr>\n
Nasal congestion \/ runny nose<\/td>\n\u03a3\u03c5\u03c7\u03bd\u03ac<\/td>\nSymptomatic; antihistamines fine<\/td>\n<\/tr>\n
Diarrhoea, nausea<\/td>\n\u0391\u03c3\u03c5\u03bd\u03ae\u03b8\u03b9\u03c3\u03c4\u03b5\u03c2<\/td>\nTake with food; report if persistent<\/td>\n<\/tr>\n
Decreased libido \/ erectile dysfunction<\/td>\n\u0391\u03c3\u03c5\u03bd\u03ae\u03b8\u03b9\u03c3\u03c4\u03b5\u03c2<\/td>\nDiscuss with prescriber<\/td>\n<\/tr>\n
Fainting (syncope)<\/td>\n\u03a3\u03c0\u03ac\u03bd\u03b9\u03b5\u03c2<\/td>\nStop and seek medical advice<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd<\/h2>\n\n\n\n\n\n\n\n\n\n\n
\u03a3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2<\/th>\n\u0391\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/th>\n\u0394\u03c1\u03ac\u03c3\u03b7<\/th>\n<\/tr>\n<\/thead>\n
\u0399\u03c3\u03c7\u03c5\u03c1\u03bf\u03af \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 CYP3A4 (\u03ba\u03b5\u03c4\u03bf\u03ba\u03bf\u03bd\u03b1\u03b6\u03cc\u03bb\u03b7, \u03b9\u03c4\u03c1\u03b1\u03ba\u03bf\u03bd\u03b1\u03b6\u03cc\u03bb\u03b7, \u03c1\u03b9\u03c4\u03bf\u03bd\u03b1\u03b2\u03af\u03c1, \u03ba\u03bb\u03b1\u03c1\u03b9\u03b8\u03c1\u03bf\u03bc\u03c5\u03ba\u03af\u03bd\u03b7)<\/td>\nMajor rise in silodosin levels → hypotension<\/td>\n\u0391\u03c0\u03bf\u03c6\u03cd\u03b3\u03b5\u03c4\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc<\/strong><\/td>\n<\/tr>\n
Other alpha-blockers (terazosin, doxazosin, tamsulosin, alfuzosin)<\/td>\nAdditive hypotension<\/td>\nDo not combine<\/td>\n<\/tr>\n
PDE-5 inhibitors (sildenafil, tadalafil, vardenafil)<\/td>\nAdditive hypotension; tadalafil 5 mg daily for BPH\/ED is the most studied combination<\/td>\nStable on silodosin first; introduce PDE-5 cautiously<\/td>\n<\/tr>\n
\u0391\u03bd\u03c4\u03b9\u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03ac<\/td>\nAdditive blood-pressure lowering<\/td>\nMonitor; first-dose hypotension possible<\/td>\n<\/tr>\n
P-gp inhibitors (cyclosporin)<\/td>\nModest rise in silodosin levels<\/td>\n\u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7<\/td>\n<\/tr>\n
Diuretics, alcohol<\/td>\nWorsens orthostatic symptoms<\/td>\nCaution; especially in elderly<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Who should not take Silofast<\/h2>\n