{"id":53732,"date":"2023-09-20T09:50:02","date_gmt":"2023-09-20T09:50:02","guid":{"rendered":"https:\/\/medsname.com\/fluka-capsule\/"},"modified":"2026-04-30T10:25:09","modified_gmt":"2026-04-30T10:25:09","slug":"fluka-capsule","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/fluka-capsule\/","title":{"rendered":"Fluka Capsule"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 20px;margin:18px 0;border-radius:6px;\">\n<h3 style=\"margin-top:0;\">\ud83d\udca1 \u0393\u03c1\u03ae\u03b3\u03bf\u03c1\u03b7 \u0391\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7<\/h3>\n<p style=\"margin-bottom:0;\">Fluka Capsule is fluconazole 50 mg \/ 150 mg \/ 200 mg capsule oral tablet \u2014 a systemic triazole antifungal. Single 150 mg dose for vaginal candidiasis; 50\u2013400 mg\/day for invasive Candida, oesophageal thrush, and prophylaxis in immunocompromised patients. Inhibits fungal CYP51 (lanosterol 14-\u03b1-demethylase). Long half-life (~30 h) allows once-daily or weekly dosing. Major drug interactions via CYP3A4 \/ CYP2C9 \/ CYP2C19 inhibition \u2014 review warfarin, statins, sulfonylureas, phenytoin, oral contraceptives.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f5f5;border:1px solid #e1e1e1;padding:18px 22px;margin:24px 0;border-radius:8px;display:flex;flex-wrap:wrap;justify-content:space-around;gap:16px;align-items:center;font-size:0.95em;\">\n<div style=\"text-align:center;flex:1;min-width:140px;\">\ud83c\udfed<br \/><strong>WHO-GMP<\/strong><br \/>certified manufacturer<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\"><strong>\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n<h3>\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p>\u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n<div style=\"text-align:center;flex:1;min-width:140px;\">\ud83d\udce6<br \/><strong>\u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1<\/strong><br \/>plain envelope<\/div>\n<div style=\"text-align:center;flex:1;min-width:140px;\">\ud83c\udf0d<br \/><strong>\u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae<\/strong><br \/>to most countries<\/div>\n<div style=\"text-align:center;flex:1;min-width:140px;\">\u2b50<br \/><strong>1,400+ customers<\/strong><br \/><a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03b4\u03b9\u03b1\u03b2\u03ac\u03c3\u03c4\u03b5 \u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2<\/a><\/div>\n<\/div>\n<h2>\ud83d\udd12 Why order Fluka Capsule from MedsBase<\/h2>\n<ul>\n<li><strong>\u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03b7 WHO-GMP \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae<\/strong> \u2014 sourced from a regulated facility, finished pack with batch number and expiry.<\/li>\n<li><strong>\u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1<\/strong> \u2014 plain envelope, no medication name on the outside.<\/li>\n<li><strong>\u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae<\/strong> to most countries with <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance<\/a>.<\/li>\n<li><strong>Loyalty points<\/strong> \u2014 1 point per $1 spent (excludes peptides\/shipping); 100 points = $5 off your next order.<\/li>\n<\/ul>\n<h2 id=\"uses\">Uses &#038; indications<\/h2>\n<p>Fluka Capsule (fluconazole 50 mg \/ 150 mg \/ 200 mg capsule, Cipla) is a triazole antifungal used for both superficial and systemic Candida and Cryptococcus infections. Compared to topical-only options, oral fluconazole reaches all body compartments (including CSF, ~80% of plasma level) \u2014 making it the workhorse for any infection that is not strictly skin-deep.<\/p>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:0.95em;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">\u0395\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Typical regimen<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Vaginal candidiasis (uncomplicated)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Single 150 mg dose orally<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Recurrent vulvovaginal candidiasis<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">150 mg every 72 h \u00d7 3 doses, then 150 mg weekly \u00d7 6 months<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Oropharyngeal candidiasis<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">200 mg day 1, then 100 mg\/day \u00d7 7\u201314 days<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Oesophageal candidiasis<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">200\u2013400 mg\/day \u00d7 14\u201321 days<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Invasive candidiasis<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">800 mg day 1, then 400 mg\/day \u00d7 14 days minimum (after first negative blood culture)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Cryptococcal meningitis (consolidation)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">400 mg\/day \u00d7 8 weeks, then 200 mg\/day maintenance<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Prophylaxis in haematology \/ transplant<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">200\u2013400 mg\/day<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"how-to-take\">\u03a0\u03ce\u03c2 \u03bd\u03b1 \u03c0\u03ac\u03c1\u03b5\u03c4\u03b5<\/h2>\n<ul>\n<li>Tablets can be taken with or without food.<\/li>\n<li>For single-dose vaginal candidiasis: take one 150 mg tablet with water \u2014 symptoms usually settle within 24\u201372 h.<\/li>\n<li>For weekly maintenance: take the same day each week (e.g. every Sunday) \u2014 set a reminder to avoid missed doses.<\/li>\n<li>Do not double up after a missed dose \u2014 take the missed dose as soon as you remember unless it is close to the next dose.<\/li>\n<\/ul>\n<h2 id=\"mechanism\">\u03a0\u03ce\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af<\/h2>\n<p>Fluconazole selectively inhibits fungal cytochrome P-450 enzyme CYP51 (lanosterol 14-\u03b1-demethylase). This blocks the conversion of lanosterol to ergosterol \u2014 the principal sterol in fungal cell membranes. The resulting ergosterol-poor membrane becomes leaky and the fungal cell loses integrity. Selectivity for fungal vs. mammalian CYP enzymes is what makes fluconazole much better tolerated than the older imidazole antifungals.<\/p>\n<h2 id=\"side-effects\">Side effects &#038; monitoring<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:0.95em;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Typical effects<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Common (\u22651\/100)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Headache, nausea, abdominal pain, diarrhoea, transient ALT\/AST rise, rash<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">\u0391\u03c3\u03c5\u03bd\u03ae\u03b8\u03b9\u03c3\u03c4\u03b5\u03c2<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Vomiting, dyspepsia, taste disturbance, dizziness, mild neutropenia<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">\u03a3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b1\u03bb\u03bb\u03ac \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Hepatotoxicity (cholestatic or hepatocellular \u2014 discontinue if AST\/ALT &gt;3\u00d7 ULN), Stevens-Johnson syndrome \/ TEN, QT prolongation \/ torsades, anaphylaxis, alopecia (long courses)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 20px;margin:20px 0;border-radius:6px;\"><strong>Liver function \u2014 when to stop<\/strong><\/p>\n<div>Mild ALT\/AST rise &lt; 3\u00d7 upper limit of normal is common and usually resolves on continued therapy. Stop fluconazole and seek medical advice if you develop jaundice, pale stools, dark urine, persistent nausea, right-upper-quadrant pain, or confusion \u2014 these may indicate symptomatic hepatitis. Patients on courses &gt; 4 weeks should have LFTs checked at baseline and at intervals.<\/div>\n<\/div>\n<h2 id=\"interactions\">Drug interactions (the important ones)<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:0.95em;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Drug class \/ drug<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">\u0391\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Practical action<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">\u0392\u03b1\u03c1\u03c6\u03b1\u03c1\u03af\u03bd\u03b7<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">INR rises 2\u20134-fold (CYP2C9 inhibition)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Check INR within 3\u20135 days; reduce warfarin dose 25\u201350%<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">\u03a6\u03b1\u03b9\u03bd\u03c5\u03c4\u03bf\u0390\u03bd\u03b7<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Phenytoin levels rise 75% (CYP2C9 inhibition)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Monitor levels; reduce phenytoin<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Sulfonylureas (glipizide\/glibenclamide)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Hypoglycaemia risk<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Monitor glucose closely<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Simvastatin \/ atorvastatin \/ lovastatin<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Statin levels rise (CYP3A4) \u2192 myopathy \/ rhabdomyolysis<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Switch to pravastatin \/ rosuvastatin or hold statin during course<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Tacrolimus \/ ciclosporin \/ sirolimus<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Levels rise \u2014 nephrotoxicity, neurotoxicity<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Reduce dose; trough monitoring<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">\u0391\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ac \u03c7\u03ac\u03c0\u03b9\u03b1<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Slight rise in ethinylestradiol \/ levonorgestrel<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Continue as normal \u2014 efficacy not reduced<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Amiodarone, sotalol, citalopram, methadone, ondansetron<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Additive QT prolongation<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Avoid combinations &gt; 200 mg\/day if possible; ECG if symptomatic<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Rifampicin \/ rifabutin<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Fluconazole levels fall (induction)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Increase fluconazole dose or switch to voriconazole<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"contraindications\">Who should not take fluconazole<\/h2>\n<ul>\n<li>Documented hypersensitivity to fluconazole or other azoles.<\/li>\n<li>Co-administration with terfenadine, astemizole, cisapride, pimozide, quinidine, or erythromycin (QT prolongation).<\/li>\n<li>Concurrent simvastatin, atorvastatin, or lovastatin at full dose.<\/li>\n<li>Caution in active liver disease, congenital long-QT syndrome, and severe renal impairment (dose-adjust below).<\/li>\n<\/ul>\n<h2 id=\"renal\">Renal dose adjustment<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:0.95em;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">CrCl (mL\/min)<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">\u03a0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">&gt; 50<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">No change<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">\u2264 50 (no dialysis)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Give standard loading dose, then 50% of the maintenance dose<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">\u0391\u03b9\u03bc\u03bf\u03ba\u03ac\u03b8\u03b1\u03c1\u03c3\u03b7<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Give 100% dose after each dialysis session<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"pregnancy\">Pregnancy &#038; breastfeeding<\/h2>\n<p>Single 150 mg dose for vaginal candidiasis is generally considered low-risk in pregnancy after the first trimester, but topical clotrimazole is preferred when possible. <strong>High-dose fluconazole (\u2265 400 mg\/day) in the first trimester<\/strong> has been associated with a recognised pattern of congenital anomalies (cardiac, craniofacial, skeletal) and should be avoided. Fluconazole is excreted in breast milk at concentrations close to maternal plasma \u2014 a single 150 mg dose is compatible with breastfeeding; continuous high-dose courses are not.<\/p>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3>How long until I feel better?<\/h3>\n<p>Vaginal candidiasis: itch and discharge usually settle within 24\u201372 hours of a single 150 mg dose. Oral thrush: noticeable improvement in 3\u20135 days. Invasive candidaemia: clinical response is judged at 5\u20137 days.<\/p>\n<h3>Can I drink alcohol with fluconazole?<\/h3>\n<p>There is no specific disulfiram-like reaction, but both alcohol and fluconazole are processed by the liver. Heavy or chronic alcohol use raises the risk of hepatotoxicity \u2014 keep intake light, ideally avoid alcohol during the course, especially for treatment longer than 7 days.<\/p>\n<h3>Why is one 150 mg dose enough for thrush?<\/h3>\n<p>Fluconazole has a long elimination half-life (~30 hours) and concentrates well in vaginal fluid. After a single 150 mg dose, fungicidal levels persist for 72 hours or more \u2014 long enough to clear an uncomplicated Candida albicans infection.<\/p>\n<h3>Is fluconazole the same as Diflucan?<\/h3>\n<p>Yes \u2014 Diflucan is the original Pfizer brand of fluconazole. Fluka Capsule contains the same active ingredient, manufactured by Cipla under WHO-GMP. Bioequivalent generic.<\/p>\n<h3>Can I take fluconazole if I have liver disease?<\/h3>\n<p>Caution. Mild compensated liver disease usually permits short courses with LFT monitoring. Decompensated cirrhosis or active hepatitis \u2014 discuss with a clinician; alternative agents may be preferred.<\/p>\n<h3>I have recurrent yeast infections \u2014 what&#8217;s the maintenance plan?<\/h3>\n<p>After a 3-dose induction (150 mg every 72 h \u00d7 3), maintenance is 150 mg once weekly for 6 months. This regimen reduces recurrence by ~80% compared to placebo (Sobel 2004 NEJM).<\/p>\n<h3>What if my partner has thrush?<\/h3>\n<p>Vulvovaginal candidiasis is not a sexually-transmitted infection. Routine partner treatment is not recommended unless the male partner has symptomatic balanitis (treated with topical clotrimazole).<\/p>\n<h3>Will fluconazole interact with my contraceptive pill?<\/h3>\n<p>No \u2014 fluconazole modestly raises ethinylestradiol and levonorgestrel levels but contraceptive efficacy is preserved. Continue your normal pill regimen.<\/p>\n<h3>What if my symptoms come back after one dose?<\/h3>\n<p>If symptoms persist beyond 7 days or recur within 4 weeks, the diagnosis may be incorrect (bacterial vaginosis, trichomonas, dermatitis), or you may have azole-resistant Candida glabrata or Candida krusei \u2014 see a clinician for swab and culture.<\/p>\n<h3>Can I take fluconazole and clotrimazole pessaries together?<\/h3>\n<p>Yes \u2014 combining oral fluconazole with topical clotrimazole is safe and is sometimes used in severe or recurrent vaginal candidiasis. There is no drug-interaction concern between the two.<\/p>\n<h2 id=\"storage\">\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/h2>\n<p>Store the tablets at room temperature (below 25 \u00b0C \/ 77 \u00b0F) in the original blister pack, away from direct sunlight, heat, and moisture. Keep out of reach of children. Do not use after the expiry date printed on the pack.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Other Antifungal Medications you may be interested in<\/h2>\n<p>If Fluka Capsule is unavailable or you need a different formulation, here are alternatives \u2014 same molecule from a different manufacturer or a different drug class for indications where fluconazole is not first-line.<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/zocon\/\"><strong>Zocon (fluconazole 150 mg)<\/strong><\/a> \u2014 Single-dose oral standard for vaginal candidiasis.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/forcan\/\"><strong>Forcan (fluconazole 150 mg)<\/strong><\/a> \u2014 Same molecule, different manufacturer.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/fluka\/\"><strong>Fluka (fluconazole 150 mg)<\/strong><\/a> \u2014 Cipla brand; bioequivalent.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/clocip\/\"><strong>Clocip (clotrimazole 1% cream)<\/strong><\/a> \u2014 Topical relief for vulval \/ cutaneous Candida itch.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/sporanox-capsule\/\"><strong>Sporanox (itraconazole)<\/strong><\/a> \u2014 Alternative oral azole for fluconazole-resistant infection.<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 18px;margin:24px 0;font-size:0.95em;\"><strong>\u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03b5\u03c5\u03b8\u03c5\u03bd\u03ce\u03bd.<\/strong> This page is product information for adults ordering antifungal medicine for personal use. It is not a substitute for individual medical advice. Discuss the right antifungal, dose, and treatment duration with a qualified clinician \u2014 particularly if you have liver disease, are pregnant or breastfeeding, take warfarin, take a statin, take immunosuppressants, or have a fungal nail infection that may be a different diagnosis (psoriasis, lichen planus, trauma).<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<h5>\u2705 Broad-Spectrum Treatment<br \/>\n\u2705 Prevents Candidiasis Recurrence<br \/>\n\u2705 Quick Symptom Relief<br \/>\n\u2705 Well-Tolerated and Effective<br \/>\n\u2705 Easy Dosage Schedule<\/h5>\n<p><span style=\"color: #999999;\">Fluka contains Fluconazole<\/span><\/p>","protected":false},"featured_media":53733,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3501,3141,3504,3342],"product_tag":[3619,3632],"class_list":{"0":"post-53732","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-fungal","7":"product_cat-category-overview","8":"product_cat-fungal-infection-treatment","9":"product_cat-general-health","10":"product_tag-fluconazole","11":"product_tag-fluka","13":"first","14":"outofstock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/53732","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=53732"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/53733"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=53732"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=53732"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=53732"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=53732"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}