<\/p>\n
Demelan Cream<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 non-hydroquinone multi-active depigmenting cream<\/strong> from Glenmark containing thioctic acid (alpha-lipoic acid), Emblica officinalis extract, kojic acid, arbutin and glycolic acid. Used for melasma, post-inflammatory hyperpigmentation (PIH), sun-induced pigmentation, and uneven skin tone<\/strong> — particularly in patients who cannot tolerate hydroquinone, or who want a longer-term maintenance product after a Kligman-type HQ course. Apply a thin layer once daily at night<\/strong> to the cleansed, dry, affected area; rinse off in the morning. Broad-spectrum SPF 50+ sunscreen every morning is mandatory<\/strong> — any depigmenting product fails without sun protection. Expect visible improvement over 12-16 weeks<\/strong> with consistent use. NOT FDA-approved as a drug<\/strong> in the US; sold as a cosmeceutical in India and similar markets. Unlike hydroquinone, this combination can be used for longer maintenance periods without the risk of exogenous ochronosis.<\/p>\n<\/div>\n \ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n \u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n Demelan Cream is a topical depigmenting cream from Glenmark<\/strong>, supplied in a 20 g tube. The formulation contains thioctic acid (alpha-lipoic acid), Emblica officinalis extract, kojic acid, arbutin and glycolic acid. Unlike Kligman-type prescription creams (hydroquinone + tretinoin + corticosteroid), Demelan Cream is hydroquinone-free<\/strong> and relies on a multi-active approach that targets several steps of melanogenesis simultaneously. This allows longer-term use without the ochronosis, rebound hyperpigmentation, or steroid-induced skin atrophy risks that limit prescription HQ triples.<\/p>\n Demelan Cream is positioned in the cosmeceutical<\/strong> category — a product sold over the counter that contains actives with pharmacological effect on the skin, but that is not licensed as a drug. It is widely used in Indian dermatology practice as a first-line option for mild-moderate pigmentation, as a maintenance product following a short HQ course, and as an option for patients (pregnant women, breastfeeding mothers, adolescents) for whom prescription HQ is unsuitable.<\/p>\n Demelan Cream works through several complementary mechanisms:<\/p>\n The multi-active approach targets melanogenesis at three levels<\/strong>: (1) tyrosinase enzyme inhibition (kojic acid, arbutin, thioctic acid), (2) melanosome transfer and keratinocyte turnover (glycolic acid via AHA exfoliation), (3) antioxidant support against UV-induced melanogenesis (Emblica, thioctic acid). Because no single active is pushed to high doses, irritation is lower and tolerability is better than single-active HQ at matched depigmenting efficacy for mild-moderate pigmentation.<\/p>\n \u0388\u03bd\u03b1\u03c1\u03be\u03b7:<\/strong> subtle improvement in skin tone and brightness can appear within 4-6 weeks of consistent use; measurable lightening of focal pigmentation typically takes 12-16 weeks, sometimes longer for deep dermal melasma. Response on epidermal pigmentation is better than on dermal pigmentation.<\/p>\n Demelan Cream is appropriate for:<\/p>\n Demelan Cream is NOT<\/strong> \u03b3\u03b9\u03b1:<\/p>\n \u03a0\u03b1\u03b9\u03b4\u03b9\u03ac:<\/strong> not indicated under 12. \u0395\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03b8\u03b7\u03bb\u03b1\u03c3\u03bc\u03cc\u03c2:<\/strong> lower-risk than HQ products; generally considered acceptable under dermatology supervision but specialist advice is still preferred because individual components (particularly glycolic acid at higher strengths) have limited pregnancy data.<\/p>\n Store Demelan Cream below 25°C in the original tube, away from direct sunlight and humidity. Replace cap tightly. Keep out of reach of children. Use within 6 months of first opening or before the printed expiry, whichever is sooner.<\/p>\n Subtle brightening and even tone can emerge within 4-6 weeks of consistent nightly use. Measurable lightening of specific pigmented patches (PIH spots, melasma patches, sun spots) typically takes 12-16 weeks. Deep dermal pigmentation responds more slowly and may need combination therapy. If you have seen no change after 16 weeks of consistent use + daily SPF 50+, see a dermatologist — the pigmentation may have a dermal component or a specific diagnosis that needs a different approach.<\/p>\n Demelan Cream is generally considered safer in pregnancy than hydroquinone because it does not contain HQ, and systemic absorption of its components is low. It is not fully risk-free — high-strength glycolic acid has limited pregnancy data. A dermatology review before starting is preferred. Many dermatologists in India and elsewhere do prescribe this class of product for melasma of pregnancy (chloasma) when appropriate.<\/p>\n Kligman creams contain prescription hydroquinone + tretinoin + low-potency corticosteroid<\/strong>. They are more potent for focal melasma and achieve lightening faster, but they must be cycled (8 weeks on, 8 weeks off) to avoid exogenous ochronosis and steroid atrophy. Demelan Cream is HQ-free and can be used continuously without cycling. The typical clinical workflow is: Kligman course first<\/strong> (usually 8-16 weeks for active melasma) then Demelan Cream for indefinite maintenance<\/strong>.<\/p>\n Yes, absolutely. UV exposure is the single biggest driver of melasma, PIH, and solar hyperpigmentation. Any depigmenting cream applied without daily broad-spectrum SPF 50+ sunscreen is neutralised by the next UV exposure. Daily SPF 50+, re-applied every 2-3 hours of UV exposure, is more important than any cream<\/strong>. The cream is a tool; sunscreen is the foundation.<\/p>\n Yes, because Demelan Cream is applied at night and washed off in the morning. Apply moisturiser + sunscreen + makeup in that order every morning. For evening routines, makeup should be removed before applying the cream.<\/p>\n The glycolic acid component causes transient stinging in most users for the first 1-2 weeks. Mitigations: (1) apply to completely dry skin — wetness amplifies irritation; (2) start alternate nights for 2 weeks, then build to nightly; (3) apply a light moisturiser 10-15 minutes before the cream as a buffer; (4) if intolerable, rinse off after 30-60 minutes for the first 1-2 weeks. Severe, prolonged stinging (>30 minutes), frank burning or rash means stop and consult your dermatologist.<\/p>\n Yes, alternating nights is a standard combination for stubborn melasma and PIH. Use tretinoin one night, Demelan Cream the next. Do not apply both at the same time on the same night — the stinging and irritation will compound. Daily sunscreen remains mandatory. Combination with a prescription retinoid should ideally be under dermatology supervision.<\/p>\n You can order Demelan Cream from MedsBase in standard pack sizes (20 g tube). Orders ship worldwide with discreet packaging.<\/p>\n \u03a7\u03c1\u03ae\u03c3\u03b9\u03bc\u03b7 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7: \u039a\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd MedsBase<\/a>.<\/p>\n <\/p>\n \u0386\u03bb\u03bb\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 \u03c3\u03b5 \u0393\u03b5\u03bd\u03b9\u03ba\u03ae \u03a5\u03b3\u03b5\u03af\u03b1<\/strong> \u03c0\u03bf\u03c5 \u03bf\u03b9 \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2:<\/p>\n \u2705 Reduces skin pigmentation\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n
What Is Demelan Cream?<\/h2>\n
How Does Demelan Cream Work?<\/h2>\n
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When Demelan Cream Is Used<\/h2>\n
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Demelan Cream How to Apply<\/h2>\n
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\u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/h2>\n
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\u0391\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 & \u03a0\u03c1\u03bf\u03b5\u03b9\u03b4\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n
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\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03a6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd<\/h2>\n
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\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u0394\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u0396\u03c9\u03ae\u03c2<\/h2>\n
\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n
How long before I see results from Demelan Cream?<\/h3>\n
Can I use Demelan Cream in pregnancy or breastfeeding?<\/h3>\n
How is Demelan Cream different from a Kligman cream (Melacare<\/a> \u03ae A-Ret HC<\/a>)?<\/h3>\n
Is sunscreen really necessary every single morning?<\/h3>\n
Can I use makeup over Demelan Cream?<\/h3>\n
What if it stings too much?<\/h3>\n
Can I use Demelan Cream with tretinoin?<\/h3>\n
Where can I order Demelan Cream online?<\/h3>\n
Related Pigmentation Products on MedsBase<\/h2>\n
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\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2<\/h3>\n
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\n\u2705 Evens skin tone
\n\u2705 Lightens dark spots
\n\u2705 Promotes skin renewal
\n\u2705 Minimizes skin blemishes<\/p>","protected":false},"featured_media":53833,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3642,3141,3342],"product_tag":[],"class_list":{"0":"post-53832","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-beauty-skin-care","7":"product_cat-category-overview","8":"product_cat-general-health","10":"first","11":"instock","12":"shipping-taxable","13":"purchasable","14":"product-type-variable","15":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/53832","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=53832"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/53833"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=53832"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=53832"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=53832"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=53832"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}