{"id":54331,"date":"2023-09-20T09:57:38","date_gmt":"2023-09-20T09:57:38","guid":{"rendered":"https:\/\/medsname.com\/doxolin\/"},"modified":"2026-04-30T10:24:59","modified_gmt":"2026-04-30T10:24:59","slug":"doxolin","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/doxolin\/","title":{"rendered":"Doxolin"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 28px 0;border-radius:4px;\">\n<h3 style=\"margin:0 0 10px 0;font-size:18px;color:#1a1a1a;\">\u26a1 Quick Answer \u2014 What is Doxolin?<\/h3>\n<p><strong>Doxolin<\/strong> \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 <strong>doxofylline<\/strong>, \u03ad\u03bd\u03b1 <strong>methylxanthine bronchodilator<\/strong> with anti-inflammatory effects, used as add-on therapy for chronic asthma and COPD. Doxofylline is a newer methylxanthine with similar efficacy to theophylline but a wider safety margin \u2014 fewer cardiac, GI, and CNS side effects. No routine drug-level monitoring required. Dose is 400 mg once or twice daily. Each tablet contains <strong>400 mg<\/strong>, \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7 \u03b1\u03c0\u03cc <strong>Zydus Cadila<\/strong> \u03c3\u03b5 \u03b5\u03b3\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b1\u03c0\u03cc WHO-GMP.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong> \u03a0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2 WHO-GMP \u00b7 \u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u00b7 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u00b7 1,400+ \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 <a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\"><strong>\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n<h3>\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p>\u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n<div style=\"background:#f4f8fb;border:1px solid #e0e0e0;padding:12px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;text-align:center;\">\n<strong>\ud83d\udd12 \u039a\u03c1\u03c5\u03c0\u03c4\u03bf\u03b3\u03c1\u03b1\u03c6\u03b7\u03bc\u03ad\u03bd\u03b7 \u039f\u03bb\u03bf\u03ba\u03bb\u03ae\u03c1\u03c9\u03c3\u03b7 \u0391\u03b3\u03bf\u03c1\u03ac\u03c2<\/strong> \u00b7 <strong>\ud83d\udcb3 \u0395\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf\u03c2 \u0395\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c2<\/strong> \u00b7 <strong>\ud83d\ude9a \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u0391\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae<\/strong> \u00b7 <strong>\u2b50 4.9\/5 \u03b1\u03c0\u03cc 1,400+ \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2<\/strong>\n<\/div>\n<h2>What Is Doxolin?<\/h2>\n<p>Doxolin is an oral methylxanthine bronchodilator. Methylxanthines are derived from natural alkaloids (theophylline is the dimethylxanthine present in tea). Their use has declined since the 1990s as inhaled \u03b22-agonists and corticosteroids became first-line \u2014 but they retain a role as third-line add-on therapy in difficult asthma and COPD.<\/p>\n<h2>How Does Doxolin Work?<\/h2>\n<ul>\n<li><strong>Phosphodiesterase inhibition (PDE3, PDE4)<\/strong> \u2014 raises cyclic AMP in airway smooth muscle and inflammatory cells; net result is bronchodilation and reduced mediator release.<\/li>\n<li><strong>Adenosine receptor antagonism<\/strong> \u2014 blocks adenosine-mediated bronchoconstriction and mast-cell mediator release.<\/li>\n<li><strong>HDAC2 activation<\/strong> (theophylline at low serum levels 5\u201310 mg\/L) \u2014 restores corticosteroid responsiveness in COPD and severe asthma where steroid resistance is partly mediated by reduced HDAC2.<\/li>\n<li><strong>Diaphragm contractility<\/strong> \u2014 methylxanthines reduce diaphragm fatigue, useful in COPD with severe airflow limitation.<\/li>\n<\/ul>\n<h2>\u03a7\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li><strong>Severe chronic asthma<\/strong> \u2014 add-on to high-dose ICS-LABA where additional bronchodilation is needed<\/li>\n<li><strong>COPD maintenance<\/strong> \u2014 add-on to LAMA-LABA or triple therapy<\/li>\n<li><strong>Nocturnal asthma<\/strong> \u2014 sustained-release formulation provides overnight bronchodilation<\/li>\n<li><strong>Apnoea of prematurity<\/strong> (theophylline) \u2014 neonatal use<\/li>\n<li><strong>Theophylline-intolerant patients<\/strong> \u2014 better-tolerated alternative<\/li>\n<\/ul>\n<h2>Doxolin Dosage<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u0391\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u0394\u03cc\u03c3\u03b7<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Adults \u2014 initial<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>200 mg<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Three times daily \u2014 first 7 days<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Adults \u2014 maintenance<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>400 mg<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Once or twice daily<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Elderly \/ liver disease<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Halve dose<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Once or twice daily<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Side Effects of Doxolin<\/h2>\n<ul>\n<li>Nausea, vomiting, dyspepsia<\/li>\n<li>\u039a\u03b5\u03c6\u03b1\u03bb\u03b1\u03bb\u03b3\u03af\u03b1<\/li>\n<li>\u03a4\u03c1\u03cc\u03bc\u03bf\u03c2<\/li>\n<li>Insomnia, restlessness<\/li>\n<li>Mild palpitations (less than theophylline)<\/li>\n<li>Mild hypokalaemia at high doses<\/li>\n<\/ul>\n<p><strong>Serious \u2014 stop and seek help:<\/strong><\/p>\n<ul>\n<li>Severe palpitations or arrhythmia<\/li>\n<li>Persistent vomiting<\/li>\n<li>\u03a3\u03bf\u03b2\u03b1\u03c1\u03ae \u03b1\u03bb\u03bb\u03b5\u03c1\u03b3\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03af\u03b4\u03c1\u03b1\u03c3\u03b7<\/li>\n<\/ul>\n<h2>\u03a0\u03c1\u03bf\u03b5\u03b9\u03b4\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03ac\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li><strong>No routine blood-level monitoring<\/strong> \u2014 wider safety margin than theophylline.<\/li>\n<li><strong>Many drug interactions<\/strong> \u2014 see interactions table. Most metabolised by CYP1A2; many inhibitors and inducers shift levels significantly.<\/li>\n<li><strong>Smoking<\/strong> induces CYP1A2 and lowers theophylline levels by ~50% \u2014 re-titrate at smoking cessation.<\/li>\n<li><strong>Cardiac disease:<\/strong> use cautiously in arrhythmias, heart failure, severe hypertension.<\/li>\n<li><strong>Hyperthyroidism:<\/strong> increased clearance plus exaggerated adrenergic effects.<\/li>\n<li><strong>\u0395\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03b8\u03b7\u03bb\u03b1\u03c3\u03bc\u03cc\u03c2:<\/strong> generally avoided; use only if benefit clear.<\/li>\n<li><strong>Liver disease:<\/strong> reduce dose \u2014 methylxanthines are hepatically metabolised.<\/li>\n<\/ul>\n<h2>\u0391\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li>Hypersensitivity to doxofylline or other xanthines (caffeine, theobromine)<\/li>\n<li>\u0395\u03bd\u03b5\u03c1\u03b3\u03cc \u03c0\u03b5\u03c0\u03c4\u03b9\u03ba\u03cc \u03ad\u03bb\u03ba\u03bf\u03c2<\/li>\n<li>Uncontrolled tachyarrhythmias<\/li>\n<li>Severe heart failure (NYHA IV)<\/li>\n<\/ul>\n<h2>\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03a6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Interacting drug<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u0391\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u03a4\u03b9 \u03bd\u03b1 \u03ba\u03ac\u03bd\u03b5\u03c4\u03b5<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Ciprofloxacin, erythromycin, clarithromycin, fluvoxamine<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Inhibit CYP1A2 \u2192 raise theophylline levels \u2192 toxicity (nausea, arrhythmia, seizures)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Avoid or reduce theophylline dose 50%; check serum levels<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Cimetidine, allopurinol<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Raise theophylline levels<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduce dose; monitor levels<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Phenytoin, carbamazepine, rifampicin<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Induce CYP \u2014 lower levels<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Higher dose may be needed<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Smoking<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Induces CYP1A2 \u2014 lower levels<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Re-titrate dose at smoking cessation<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u03b2-agonists, diuretics<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additive hypokalaemia<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor potassium<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/h2>\n<ul>\n<li>\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7 \u03ba\u03ac\u03c4\u03c9 \u03b1\u03c0\u03cc <strong>25\u00b0C<\/strong> in a cool, dry place away from direct sunlight.<\/li>\n<li>Keep in original packaging until use to protect from moisture and light.<\/li>\n<li>Do not use after the expiry date printed on the strip.<\/li>\n<li>\u039c\u03b7\u03bd \u03b1\u03c6\u03ae\u03bd\u03b5\u03c4\u03b5 \u03c3\u03b5 \u03bc\u03ad\u03c1\u03b7 \u03c0\u03c1\u03bf\u03c3\u03b2\u03ac\u03c3\u03b9\u03bc\u03b1 \u03b1\u03c0\u03cc \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac.<\/li>\n<\/ul>\n<h2>\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u039b\u03cd\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/asthalin-inhaler\/\"><strong>Asthalin Inhaler \u2014 \u03c3\u03b1\u03bb\u03b2\u03bf\u03c5\u03c4\u03b1\u03bc\u03cc\u03bb\u03b7 \u03b3\u03b9\u03b1 \u03ac\u03bc\u03b5\u03c3\u03b7 \u03b1\u03bd\u03b1\u03ba\u03bf\u03cd\u03c6\u03b9\u03c3\u03b7<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/budecort-inhaler\/\"><strong>Budecort Inhaler \u2014 \u03b2\u03bf\u03c5\u03b4\u03b5\u03c3\u03bf\u03bd\u03bf\u03af\u03b4\u03b7 ICS \u03b3\u03b9\u03b1 \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/foracort-inhaler\/\"><strong>Foracort Inhaler \u2014 \u03b2\u03bf\u03c5\u03b4\u03b5\u03c3\u03bf\u03bd\u03bf\u03af\u03b4\u03b7 + \u03c6\u03bf\u03c1\u03bc\u03bf\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7 ICS-LABA<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/tiova-inhaler\/\"><strong>Tiova Inhaler \u2014 \u03c4\u03b9\u03bf\u03c4\u03c1\u03bf\u03c0\u03af\u03bf\u03c5 LAMA \u03b3\u03b9\u03b1 \u03a7\u0391\u03a0<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/montair\/\"><strong>Montair \u2014 \u03c4\u03b1\u03bc\u03c0\u03bb\u03ad\u03c4\u03b1 montelukast LTRA<\/strong><\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3>How is doxofylline different from theophylline?<\/h3>\n<p>Doxofylline is a newer methylxanthine (introduced in the 1990s) with similar bronchodilator efficacy and a wider safety margin. Cardiac, GI, and CNS side effects are less common; routine blood-level monitoring is not required; and it has fewer drug interactions.<\/p>\n<h3>Why prefer doxofylline over theophylline?<\/h3>\n<p>Better tolerability, simpler dosing (no level monitoring), fewer interactions. Particularly useful in elderly patients and those who could not tolerate theophylline.<\/p>\n<h3>How fast does Doxolin work?<\/h3>\n<p>Bronchodilation begins within 1 hour; full effect over days.<\/p>\n<h3>Is Doxolin a reliever?<\/h3>\n<p>No \u2014 it is a controller. Keep a SABA (Asthalin, Levolin) for acute attacks.<\/p>\n<h3>Can I take Doxolin with my ICS?<\/h3>\n<p>Yes \u2014 doxofylline is typically added on top of ICS or ICS-LABA when additional bronchodilation is needed.<\/p>\n<h3>What are the common side effects?<\/h3>\n<p>Nausea, mild headache, tremor, insomnia. Generally milder than theophylline at equivalent bronchodilation.<\/p>\n<h3>Is Doxolin safe in pregnancy?<\/h3>\n<p>Limited data; inhaled therapy is preferred.<\/p>\n<h3>Can children take Doxolin?<\/h3>\n<p>Use with caution; specialist supervision recommended in paediatric use.<\/p>\n<h3>How does Doxolin compare to roflumilast (Rofaday)?<\/h3>\n<p>Both are oral non-bronchodilator-class agents with anti-inflammatory effects. Roflumilast is specifically for severe COPD with chronic bronchitis. Doxofylline has broader use across asthma and COPD as an add-on bronchodilator.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0;border-radius:4px;font-size:13px;\"><strong>\u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03b5\u03c5\u03b8\u03cd\u03bd\u03b7\u03c2:<\/strong> \u0391\u03c5\u03c4\u03ae \u03b7 \u03c3\u03b5\u03bb\u03af\u03b4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03ba\u03c0\u03b1\u03b9\u03b4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03b3\u03b3\u03b5\u03bb\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03ae. \u03a3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b5\u03af\u03c4\u03b5 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03ad\u03bd\u03b1\u03bd \u03ba\u03b1\u03c4\u03b1\u03bb\u03bb\u03ae\u03bb\u03c9\u03c2 \u03b5\u03be\u03bf\u03c0\u03bb\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b1\u03b3\u03b3\u03b5\u03bb\u03bc\u03b1\u03c4\u03af\u03b1 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2 \u03c0\u03c1\u03b9\u03bd \u03be\u03b5\u03ba\u03b9\u03bd\u03ae\u03c3\u03b5\u03c4\u03b5, \u03c3\u03c4\u03b1\u03bc\u03b1\u03c4\u03ae\u03c3\u03b5\u03c4\u03b5 \u03ae \u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c4\u03b5 \u03bf\u03c0\u03bf\u03b9\u03bf\u03bd\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03b5\u03b9\u03c3\u03c0\u03bd\u03b5\u03c5\u03c3\u03c4\u03ae\u03c1\u03b1 \u03ae \u03b1\u03bd\u03b1\u03c0\u03bd\u03b5\u03c5\u03c3\u03c4\u03b9\u03ba\u03ae \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03bd \u03ad\u03c7\u03b5\u03c4\u03b5 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2, \u03c0\u03b1\u03af\u03c1\u03bd\u03b5\u03c4\u03b5 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03c3\u03c5\u03bd\u03c4\u03b1\u03b3\u03ad\u03c2, \u03b5\u03af\u03c3\u03c4\u03b5 \u03ad\u03b3\u03ba\u03c5\u03bf\u03c2 \u03ae \u03b8\u03b7\u03bb\u03ac\u03b6\u03b5\u03c4\u03b5, \u03ae \u03b5\u03af\u03c3\u03c4\u03b5 \u03ac\u03bd\u03c9 \u03c4\u03c9\u03bd 65 \u03b5\u03c4\u03ce\u03bd.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2<\/h3>\n<p>\u0386\u03bb\u03bb\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 \u03c3\u03b5 <strong>\u03a7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03a0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2<\/strong> \u03c0\u03bf\u03c5 \u03bf\u03b9 \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/asthalin-syrup\/\">Asthalin Syrup<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/topme-xl\/\">Topme XL<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/bencid\/\">Bencid<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/dynapar\/\">Dynapar<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/decdan\/\">Decdan<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<h5>\u2705 \u0394\u03b9\u03b1\u03c7\u03b5\u03af\u03c1\u03b9\u03c3\u03b7 \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03ac\u03c3\u03b8\u03bc\u03b1\u03c4\u03bf\u03c2<br \/>\n\u2705 Convenient tablet format<br \/>\n\u2705 Easy administration<br \/>\n\u2705 \u0392\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b1\u03bd\u03b1\u03c0\u03bd\u03b5\u03c5\u03c3\u03c4\u03b9\u03ba\u03ae \u03ac\u03bd\u03b5\u03c3\u03b7<\/h5>\n<p><span style=\"color: #999999;\">Contains Doxofylline<\/span><\/p>","protected":false},"featured_media":54332,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3681,3141,3223],"product_tag":[3713],"class_list":{"0":"post-54331","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-asthma-copd-treatment","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-doxofylline","11":"first","12":"instock","13":"shipping-taxable","14":"purchasable","15":"product-type-variable","16":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/54331","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=54331"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/54332"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=54331"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=54331"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=54331"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=54331"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}