{"id":54337,"date":"2023-09-20T09:57:38","date_gmt":"2023-09-20T09:57:38","guid":{"rendered":"https:\/\/medsname.com\/depo-medrol-injection\/"},"modified":"2026-04-30T14:22:10","modified_gmt":"2026-04-30T14:22:10","slug":"depo-medrol-injection","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/depo-medrol-injection\/","title":{"rendered":"Depo-Medrol Injection"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 28px 0;border-radius:4px;\">\n<h3 style=\"margin:0 0 10px 0;font-size:18px;color:#1a1a1a;\">\u26a1 Quick Answer \u2014 What is Depo-Medrol Injection?<\/h3>\n<p><strong>Depo-Medrol Injection<\/strong> \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 <strong>methylprednisolone acetate<\/strong>, a long-acting depot corticosteroid administered as an <strong>intramuscular (IM)<\/strong> \u03ae <strong>intra-articular (joint)<\/strong> injection. The depot formulation provides sustained anti-inflammatory effect over <strong>1\u20133 weeks<\/strong> from a single dose. Used for severe asthma exacerbations, severe allergic reactions, autoimmune flares, and inflammatory joint disease. <strong>\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc:<\/strong> Depo-Medrol is a systemic corticosteroid with significant side effects \u2014 short courses are preferred over long-term repeated dosing. Manufactured by <strong>Pfizer India<\/strong>.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong> \u03a0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2 WHO-GMP \u00b7 \u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u00b7 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u00b7 1,400+ \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 <a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\"><strong>\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n<h3>\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p>\u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n<div style=\"background:#f4f8fb;border:1px solid #e0e0e0;padding:12px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;text-align:center;\">\n<strong>\ud83d\udd12 \u039a\u03c1\u03c5\u03c0\u03c4\u03bf\u03b3\u03c1\u03b1\u03c6\u03b7\u03bc\u03ad\u03bd\u03b7 \u039f\u03bb\u03bf\u03ba\u03bb\u03ae\u03c1\u03c9\u03c3\u03b7 \u0391\u03b3\u03bf\u03c1\u03ac\u03c2<\/strong> \u00b7 <strong>\ud83d\udcb3 \u0395\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf\u03c2 \u0395\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c2<\/strong> \u00b7 <strong>\ud83d\ude9a \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u0391\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae<\/strong> \u00b7 <strong>\u2b50 4.9\/5 \u03b1\u03c0\u03cc 1,400+ \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2<\/strong>\n<\/div>\n<h2>What Is Depo-Medrol Injection?<\/h2>\n<p>Depo-Medrol contains methylprednisolone acetate \u2014 an ester formulation that releases active methylprednisolone slowly from the injection site over days to weeks. Used in respiratory medicine for severe asthma exacerbations, severe allergic reactions, and autoimmune respiratory disease. Same drug oral formulation: Medrol tablets.<\/p>\n<h2>How Does Methylprednisolone Work?<\/h2>\n<p>Methylprednisolone is a synthetic glucocorticoid with high anti-inflammatory potency and minimal mineralocorticoid activity. It binds intracellular glucocorticoid receptors, modulating transcription of hundreds of genes:<\/p>\n<ul>\n<li>Reduces eosinophil, lymphocyte, and neutrophil recruitment<\/li>\n<li>Suppresses pro-inflammatory cytokines (TNF-\u03b1, IL-1, IL-6, leukotrienes, prostaglandins)<\/li>\n<li>Stabilises mast-cell and lysosomal membranes<\/li>\n<li>Reduces vascular permeability and oedema<\/li>\n<li>Suppresses immune response (T-cell proliferation, antibody production at high doses)<\/li>\n<\/ul>\n<h2>\u03a7\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li><strong>Severe asthma exacerbations<\/strong> \u2014 depot dose for sustained release<\/li>\n<li><strong>Severe allergic reactions<\/strong> \u2014 anaphylaxis adjunct, severe allergic rhinitis with depot effect<\/li>\n<li><strong>Autoimmune respiratory disease<\/strong> \u2014 sarcoidosis, eosinophilic pneumonia<\/li>\n<li><strong>Inflammatory joint disease<\/strong> \u2014 rheumatoid arthritis, ankylosing spondylitis (intra-articular)<\/li>\n<li><strong>Post-extubation laryngeal oedema prophylaxis<\/strong><\/li>\n<li><strong>Acute hypersensitivity reactions<\/strong> requiring sustained corticosteroid effect<\/li>\n<\/ul>\n<h2>Depo-Medrol Dosage<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u0395\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u0394\u03cc\u03c3\u03b7<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u0394\u03b9\u03b1\u03b4\u03c1\u03bf\u03bc\u03ae<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Severe asthma exacerbation (adult)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>40\u2013120 mg<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">IM, single dose<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Allergic reactions (adult)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>40\u2013120 mg<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0395\u03bd\u03b4\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Joint inflammation (large joint)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>20\u201380 mg<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Intra-articular<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Joint inflammation (small joint)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>4\u201320 mg<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Intra-articular<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Children \u2014 case by case<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0395\u03c0\u03af\u03b2\u03bb\u03b5\u03c8\u03b7 \u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0395\u03bd\u03b4\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>Administration Notes<\/h3>\n<ul>\n<li>Always administered by a healthcare professional.<\/li>\n<li>IM site: deltoid (small dose) or upper outer quadrant of buttock (gluteus maximus).<\/li>\n<li>Shake the vial before drawing up \u2014 methylprednisolone acetate is a suspension.<\/li>\n<li>Do not give intravenously \u2014 this is a depot suspension, not for IV use.<\/li>\n<li>Rotate injection sites if multiple doses required.<\/li>\n<\/ul>\n<h2>\u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/h2>\n<p><strong>Common (with repeated or high doses):<\/strong><\/p>\n<ul>\n<li>Mood elevation, insomnia, irritability \u2014 typically the first 1\u20132 weeks<\/li>\n<li>Increased appetite, weight gain<\/li>\n<li>Mild fluid retention, ankle swelling<\/li>\n<li>Mild blood glucose elevation<\/li>\n<li>Acneiform rash<\/li>\n<li>Easy bruising at higher cumulative doses<\/li>\n<\/ul>\n<p><strong>\u039b\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03bb\u03bb\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac:<\/strong><\/p>\n<ul>\n<li>Adrenal suppression (with repeated depot doses or doses lasting >3 weeks)<\/li>\n<li>Osteoporosis with repeated use<\/li>\n<li>Cataracts and glaucoma with repeated use<\/li>\n<li>Avascular necrosis of femoral or humeral head<\/li>\n<li>Increased infection risk (latent TB reactivation, fungal infections)<\/li>\n<li>Peptic ulcer (less than older steroids; still possible)<\/li>\n<\/ul>\n<p><strong>\u03a3\u03bf\u03b2\u03b1\u03c1\u03ad\u03c2:<\/strong><\/p>\n<ul>\n<li>\u03a3\u03bf\u03b2\u03b1\u03c1\u03ae \u03b1\u03bb\u03bb\u03b5\u03c1\u03b3\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03af\u03b4\u03c1\u03b1\u03c3\u03b7<\/li>\n<li>Acute psychosis (rare; reversible)<\/li>\n<li>Cushingoid syndrome with chronic exposure<\/li>\n<li>Adrenal crisis on abrupt withdrawal after repeated use<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>Steroid taper warning.<\/strong> After repeated Depo-Medrol depot doses, the hypothalamic-pituitary-adrenal (HPA) axis can be suppressed. Abrupt withdrawal during illness or surgery can cause adrenal crisis. If multiple courses have been given, taper future systemic steroid doses, carry a steroid card, and ensure stress-dose hydrocortisone cover during illness or surgery.<\/div>\n<h2>\u03a0\u03c1\u03bf\u03b5\u03b9\u03b4\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03ac\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li><strong>Single short courses<\/strong> are preferred over repeated long-term depot dosing \u2014 cumulative side effects build with chronic exposure.<\/li>\n<li><strong>Active infection:<\/strong> screen for and treat any active infection before steroid; latent TB is a particular concern.<\/li>\n<li><strong>Diabetes:<\/strong> blood glucose monitoring during and after dosing.<\/li>\n<li><strong>Hypertension and cardiovascular disease:<\/strong> monitor BP; sodium retention risk.<\/li>\n<li><strong>Peptic ulcer history:<\/strong> consider concurrent PPI cover.<\/li>\n<li><strong>Live vaccines:<\/strong> contraindicated within 4 weeks of high-dose steroid.<\/li>\n<li><strong>\u0395\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03b8\u03b7\u03bb\u03b1\u03c3\u03bc\u03cc\u03c2:<\/strong> use only when benefits clearly outweigh risks.<\/li>\n<li><strong>\u03a0\u03b1\u03b9\u03b4\u03b9\u03ac:<\/strong> growth monitoring with repeated use.<\/li>\n<\/ul>\n<h2>\u0391\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li>Hypersensitivity to methylprednisolone<\/li>\n<li>Systemic fungal infection (untreated)<\/li>\n<li>IV administration (suspension is for IM\/intra-articular only)<\/li>\n<li>Live vaccine within 4 weeks<\/li>\n<li>Untreated active TB<\/li>\n<\/ul>\n<h2>\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03a6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u03a6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u0391\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u03a4\u03b9 \u03bd\u03b1 \u03ba\u03ac\u03bd\u03b5\u03c4\u03b5<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Strong CYP3A4 inhibitors (ritonavir, ketoconazole, clarithromycin)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Increased methylprednisolone exposure \u2192 Cushingoid risk<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Avoid prolonged use; monitor<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">CYP3A4 inducers (rifampicin, phenytoin, carbamazepine)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduced methylprednisolone effect<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">May need higher dose<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0396\u03c9\u03bd\u03c4\u03b1\u03bd\u03ac \u03b5\u03bc\u03b2\u03cc\u03bb\u03b9\u03b1<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Reduced response; risk of disseminated infection<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Contraindicated within 4 weeks<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">\u039c\u03b7 \u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ae \u03b1\u03bd\u03c4\u03b9\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 (NSAIDs)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Increased GI bleed risk<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Use PPI cover; minimise NSAID<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Diuretics, \u03b2-agonists<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u03a0\u03c1\u03bf\u03c3\u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03ba\u03b1\u03bb\u03b9\u03b1\u03b9\u03bc\u03af\u03b1<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor potassium<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0392\u03b1\u03c1\u03c6\u03b1\u03c1\u03af\u03bd\u03b7<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u039c\u03b5\u03c4\u03b1\u03b2\u03bb\u03b7\u03c4\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03c4\u03bf INR<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor INR more frequently<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/h2>\n<ul>\n<li>Store at 2\u201325 \u00b0C; do not freeze.<\/li>\n<li>Shake well before use to resuspend the depot suspension.<\/li>\n<li>Discard after use; do not save partially-used vials for later.<\/li>\n<\/ul>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u039b\u03cd\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/asthalin-inhaler\/\"><strong>Asthalin Inhaler \u2014 \u03c3\u03b1\u03bb\u03b2\u03bf\u03c5\u03c4\u03b1\u03bc\u03cc\u03bb\u03b7 \u03b3\u03b9\u03b1 \u03ac\u03bc\u03b5\u03c3\u03b7 \u03b1\u03bd\u03b1\u03ba\u03bf\u03cd\u03c6\u03b9\u03c3\u03b7<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/budecort-inhaler\/\"><strong>Budecort Inhaler \u2014 \u03b2\u03bf\u03c5\u03b4\u03b5\u03c3\u03bf\u03bd\u03bf\u03af\u03b4\u03b7 ICS \u03b3\u03b9\u03b1 \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/foracort-inhaler\/\"><strong>Foracort Inhaler \u2014 \u03b2\u03bf\u03c5\u03b4\u03b5\u03c3\u03bf\u03bd\u03bf\u03af\u03b4\u03b7 + \u03c6\u03bf\u03c1\u03bc\u03bf\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7 ICS-LABA<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/montair\/\"><strong>Montair \u2014 \u03c4\u03b1\u03bc\u03c0\u03bb\u03ad\u03c4\u03b1 montelukast LTRA<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/tiova-inhaler\/\"><strong>Tiova Inhaler \u2014 \u03c4\u03b9\u03bf\u03c4\u03c1\u03bf\u03c0\u03af\u03bf\u03c5 LAMA \u03b3\u03b9\u03b1 \u03a7\u0391\u03a0<\/strong><\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3>Why depot rather than oral?<\/h3>\n<p>Depot formulations provide sustained anti-inflammatory effect over 1\u20133 weeks from a single injection \u2014 useful when oral compliance is unreliable, when sustained sustained effect is needed (severe allergy, autoimmune flare), or for intra-articular use.<\/p>\n<h3>How fast does Depo-Medrol work?<\/h3>\n<p>Onset is gradual \u2014 1\u20132 days for noticeable effect; peak within 1\u20132 weeks. For acute severe asthma, IV hydrocortisone or oral prednisolone is usually used initially, with depot reserved for sustained cover.<\/p>\n<h3>Will Depo-Medrol cure my asthma?<\/h3>\n<p>No \u2014 it controls acute inflammation but does not address the underlying disease. Long-term asthma management is built on inhaled corticosteroids (Budecort, Beclate, Foracort) plus reliever therapy.<\/p>\n<h3>Are repeated doses safe?<\/h3>\n<p>Repeated depot doses cumulate \u2014 the side-effect profile (osteoporosis, cataract, adrenal suppression, infection risk) becomes significant. Short courses are preferred; long-term inflammation should be controlled with steroid-sparing agents.<\/p>\n<h3>How long does one dose last?<\/h3>\n<p>1\u20133 weeks of meaningful anti-inflammatory effect from a depot dose, depending on the dose given.<\/p>\n<h3>Is Depo-Medrol safe in pregnancy?<\/h3>\n<p>Use only when benefits clearly outweigh risks; the safest steroid in pregnancy is generally hydrocortisone or prednisolone, not depot methylprednisolone.<\/p>\n<h3>Why must the vial be shaken?<\/h3>\n<p>Methylprednisolone acetate is a suspension \u2014 the active drug is in particulate form. Shaking ensures even distribution before drawing up the dose.<\/p>\n<h3>Can I give myself Depo-Medrol at home?<\/h3>\n<p>No \u2014 IM injection requires healthcare professional administration. The sustained effect and side-effect profile make supervised dosing essential.<\/p>\n<h3>Is there a non-depot alternative?<\/h3>\n<p>Oral prednisolone (5\u201360 mg daily for 5\u201314 days) is the standard non-depot systemic steroid course for severe asthma exacerbations. IV hydrocortisone is used in hospital for life-threatening attacks.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0;border-radius:4px;font-size:13px;\"><strong>\u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03b5\u03c5\u03b8\u03cd\u03bd\u03b7\u03c2:<\/strong> \u0391\u03c5\u03c4\u03ae \u03b7 \u03c3\u03b5\u03bb\u03af\u03b4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03ba\u03c0\u03b1\u03b9\u03b4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03b3\u03b3\u03b5\u03bb\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03ae. \u03a3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b5\u03af\u03c4\u03b5 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03ad\u03bd\u03b1\u03bd \u03ba\u03b1\u03c4\u03b1\u03bb\u03bb\u03ae\u03bb\u03c9\u03c2 \u03b5\u03be\u03bf\u03c0\u03bb\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b1\u03b3\u03b3\u03b5\u03bb\u03bc\u03b1\u03c4\u03af\u03b1 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2 \u03c0\u03c1\u03b9\u03bd \u03be\u03b5\u03ba\u03b9\u03bd\u03ae\u03c3\u03b5\u03c4\u03b5, \u03c3\u03c4\u03b1\u03bc\u03b1\u03c4\u03ae\u03c3\u03b5\u03c4\u03b5 \u03ae \u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c4\u03b5 \u03bf\u03c0\u03bf\u03b9\u03bf\u03bd\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03b5\u03b9\u03c3\u03c0\u03bd\u03b5\u03c5\u03c3\u03c4\u03ae\u03c1\u03b1 \u03ae \u03b1\u03bd\u03b1\u03c0\u03bd\u03b5\u03c5\u03c3\u03c4\u03b9\u03ba\u03ae \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03bd \u03ad\u03c7\u03b5\u03c4\u03b5 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2, \u03c0\u03b1\u03af\u03c1\u03bd\u03b5\u03c4\u03b5 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03c3\u03c5\u03bd\u03c4\u03b1\u03b3\u03ad\u03c2, \u03b5\u03af\u03c3\u03c4\u03b5 \u03ad\u03b3\u03ba\u03c5\u03bf\u03c2 \u03ae \u03b8\u03b7\u03bb\u03ac\u03b6\u03b5\u03c4\u03b5, \u03ae \u03b5\u03af\u03c3\u03c4\u03b5 \u03ac\u03bd\u03c9 \u03c4\u03c9\u03bd 65 \u03b5\u03c4\u03ce\u03bd.<\/div>","protected":false},"excerpt":{"rendered":"<h5>\u2705 Rapid anti-inflammatory action<br \/>\n\u2705 Long-lasting relief<br \/>\n\u2705 Convenient injectable form<br \/>\n\u2705 Improved comfort<\/h5>\n<p><span style=\"color: #999999;\">Contains Methylprednisolone Acetate<\/span><\/p>","protected":false},"featured_media":54338,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3681,3141,3223],"product_tag":[3714,3715],"class_list":{"0":"post-54337","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-asthma-copd-treatment","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-depo-medrol-40-mg","10":"product_tag-methylprednisolone-acetate","12":"first","13":"outofstock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/54337","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=54337"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/54338"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=54337"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=54337"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=54337"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=54337"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}