{"id":54441,"date":"2023-09-20T09:59:07","date_gmt":"2023-09-20T09:59:07","guid":{"rendered":"https:\/\/medsname.com\/duova-inhaler\/"},"modified":"2026-04-30T14:22:09","modified_gmt":"2026-04-30T14:22:09","slug":"duova-inhaler","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/duova-inhaler\/","title":{"rendered":"Duova Inhaler"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 28px 0;border-radius:4px;\">\n<h3 style=\"margin:0 0 10px 0;font-size:18px;color:#1a1a1a;\">\u26a1 Quick Answer \u2014 What is Duova Inhaler?<\/h3>\n<p><strong>Duova Inhaler<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 <strong>dual bronchodilator combination inhaler<\/strong> for COPD, containing <strong>tiotropium<\/strong> (a long-acting muscarinic antagonist, LAMA) and <strong>formoterol<\/strong> (a long-acting \u03b22 agonist, LABA). The two molecules attack airflow obstruction through complementary pathways \u2014 anticholinergic + \u03b22 \u2014 giving deeper bronchodilation than either alone. Used as <strong>twice-daily maintenance<\/strong> for moderate-to-severe COPD. Each inhaler delivers <strong>tiotropium 9 mcg + formoterol 6 mcg per actuation<\/strong>, \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7 \u03b1\u03c0\u03cc <strong>Cipla<\/strong> at WHO-GMP certified facilities. International equivalent: <strong>No exact equivalent (Spiolto Respimat is closest in concept)<\/strong>.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong> \u03a0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2 WHO-GMP \u00b7 \u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u00b7 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u00b7 1,400+ \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 <a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\"><strong>\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n<h3>\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p>\u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n<div style=\"background:#f4f8fb;border:1px solid #e0e0e0;padding:12px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;text-align:center;\">\n<strong>\ud83d\udd12 \u039a\u03c1\u03c5\u03c0\u03c4\u03bf\u03b3\u03c1\u03b1\u03c6\u03b7\u03bc\u03ad\u03bd\u03b7 \u039f\u03bb\u03bf\u03ba\u03bb\u03ae\u03c1\u03c9\u03c3\u03b7 \u0391\u03b3\u03bf\u03c1\u03ac\u03c2<\/strong> \u00b7 <strong>\ud83d\udcb3 \u0395\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf\u03c2 \u0395\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c2<\/strong> \u00b7 <strong>\ud83d\ude9a \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u0391\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae<\/strong> \u00b7 <strong>\u2b50 4.9\/5 \u03b1\u03c0\u03cc 1,400+ \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2<\/strong>\n<\/div>\n<h2>What Is Duova Inhaler?<\/h2>\n<p>Duova Inhaler combines a LAMA (tiotropium) and a LABA (formoterol) in a single inhaler. Dual bronchodilator therapy is the cornerstone of moderate-to-severe COPD management \u2014 landmark trials (FLAME, IMPACT, ETHOS) consistently show LAMA-LABA combinations reduce exacerbations and improve lung function more than LAMA alone or ICS-LABA alone in patients without elevated eosinophils.<\/p>\n<h2>How Does Duova Inhaler Work?<\/h2>\n<ul>\n<li><strong>Tiotropium<\/strong> blocks M3 muscarinic receptors on bronchial smooth muscle, relaxing parasympathetic tone for 24 hours.<\/li>\n<li><strong>Formoterol<\/strong> activates \u03b22-adrenergic receptors, raising cyclic AMP and producing rapid bronchodilation lasting 12 hours, with onset in 1\u20133 minutes.<\/li>\n<li><strong>Synergy:<\/strong> the two pathways act in parallel \u2014 together they deliver greater bronchodilation than either alone, and reduce exacerbations more than monotherapy.<\/li>\n<\/ul>\n<h2>\u03a7\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li><strong>Moderate-to-severe COPD maintenance<\/strong> \u2014 first-line dual bronchodilation at GOLD groups B and E<\/li>\n<li><strong>COPD exacerbation prevention<\/strong><\/li>\n<li><strong>Frequent rescue-inhaler use<\/strong> on LAMA or LABA monotherapy<\/li>\n<li><strong>Step-up from ICS-LABA<\/strong> in COPD without elevated eosinophils<\/li>\n<\/ul>\n<h2>Duova Inhaler Dosage<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Patient<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u0394\u03cc\u03c3\u03b7<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Adults \u2014 COPD maintenance<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>2 inhalations<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Twice daily<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>How to Use Duova Inhaler Properly<\/h3>\n<ul>\n<li>Shake the inhaler well; remove the cap.<\/li>\n<li>\u0395\u03ba\u03c0\u03bd\u03b5\u03cd\u03c3\u03c4\u03b5 \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03bc\u03b1\u03ba\u03c1\u03b9\u03ac \u03b1\u03c0\u03cc \u03c4\u03b7 \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03ae.<\/li>\n<li>Seal lips around the mouthpiece.<\/li>\n<li>Press the canister at the start of a slow deep breath (3\u20135 seconds).<\/li>\n<li>Hold breath 10 seconds, then breathe out gently.<\/li>\n<li>Wait 30 seconds before second puff if needed.<\/li>\n<li>For ICS-containing combinations: <strong>rinse mouth, gargle, and spit out<\/strong>.<\/li>\n<li>Use a spacer for children, the elderly, and during acute illness.<\/li>\n<\/ul>\n<h2>Side Effects of Duova Inhaler<\/h2>\n<p><strong>\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2:<\/strong><\/p>\n<ul>\n<li>Dry mouth (anticholinergic \u2014 usually mild)<\/li>\n<li>Mild tremor or palpitations (LABA effect)<\/li>\n<li>Throat irritation, mild cough on inhalation<\/li>\n<li>Headache, mild sinusitis<\/li>\n<\/ul>\n<p><strong>\u039b\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c5\u03c7\u03bd\u03ad\u03c2:<\/strong><\/p>\n<ul>\n<li>\u0394\u03c5\u03c3\u03ba\u03bf\u03b9\u03bb\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1<\/li>\n<li>Urinary hesitancy (men with prostatic enlargement)<\/li>\n<li>Acute angle-closure glaucoma (rare; care with mist near eyes)<\/li>\n<li>Hypokalaemia at high doses (with diuretics, theophylline, oral steroids)<\/li>\n<li>Atrial fibrillation in susceptible patients<\/li>\n<\/ul>\n<p><strong>Serious \u2014 stop and seek help:<\/strong><\/p>\n<ul>\n<li>Severe allergic reaction \/ anaphylaxis<\/li>\n<li>Paradoxical bronchospasm<\/li>\n<li>Acute eye pain, red eye, halos (suspected glaucoma \u2014 emergency)<\/li>\n<li>\u039f\u03be\u03b5\u03af\u03b1 \u03bf\u03c5\u03c1\u03bf\u03ba\u03b1\u03b8\u03b5\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03ba\u03b1\u03c4\u03b1\u03ba\u03c1\u03ac\u03c4\u03b7\u03c3\u03b7<\/li>\n<\/ul>\n<h2>\u03a0\u03c1\u03bf\u03b5\u03b9\u03b4\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03ac\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li><strong>{$brand} is a controller, not a reliever.<\/strong> Keep a SABA (Asthalin, Levolin) for acute attacks.<\/li>\n<li><strong>Use twice daily, every day.<\/strong><\/li>\n<li><strong>Avoid mist near eyes<\/strong> \u2014 risk of acute glaucoma in predisposed patients.<\/li>\n<li><strong>Cardiovascular disease:<\/strong> use cautiously in arrhythmias, severe coronary disease.<\/li>\n<li><strong>Prostatic obstruction:<\/strong> caution; risk of urinary retention.<\/li>\n<li><strong>Hypersensitivity to milk protein<\/strong> \u2014 DPI formulations contain lactose.<\/li>\n<\/ul>\n<h2>\u0391\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li>Known hypersensitivity to tiotropium, formoterol, atropine derivatives, or excipients<\/li>\n<li>Severe lactose \/ milk-protein hypersensitivity (DPI)<\/li>\n<li>Acute glaucoma \u2014 relative<\/li>\n<li>Severe symptomatic prostatic obstruction \u2014 relative<\/li>\n<\/ul>\n<h2>\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03a6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Interacting drug<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u0391\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u03a4\u03b9 \u03bd\u03b1 \u03ba\u03ac\u03bd\u03b5\u03c4\u03b5<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Other anticholinergics (oral, ophthalmic)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additive dry mouth, urinary retention, glaucoma risk<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Use with caution; monitor symptoms<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Non-selective beta-blockers (propranolol, timolol)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Block formoterol \u2014 risk of severe bronchospasm<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Avoid; switch to cardioselective if essential<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Loop or thiazide diuretics<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additive hypokalaemia from formoterol<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor potassium with high doses<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Theophylline \/ aminophylline<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additive hypokalaemia, tachycardia<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor heart rate and potassium<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">MAOIs and tricyclic antidepressants<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Potentiate \u03b2-agonist cardiovascular effects<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Caution \u2014 monitor BP\/HR<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/h2>\n<ul>\n<li>Store below <strong>25\u00b0C<\/strong>, protected from direct sunlight and heat.<\/li>\n<li>Do not refrigerate. Do not freeze.<\/li>\n<li>Do not puncture the canister; even an empty canister can explode if heated.<\/li>\n<li>Keep out of reach of children. Use within the expiry date printed on the canister.<\/li>\n<\/ul>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u039b\u03cd\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/foracort-inhaler\/\"><strong>Foracort Inhaler \u2014 \u03b2\u03bf\u03c5\u03b4\u03b5\u03c3\u03bf\u03bd\u03bf\u03af\u03b4\u03b7 + \u03c6\u03bf\u03c1\u03bc\u03bf\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7 ICS-LABA<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/seretide-accuhaler\/\"><strong>Seretide Accuhaler \u2014 fluticasone + salmeterol ICS-LABA<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/budecort-inhaler\/\"><strong>Budecort Inhaler \u2014 \u03b2\u03bf\u03c5\u03b4\u03b5\u03c3\u03bf\u03bd\u03bf\u03af\u03b4\u03b7 ICS \u03b3\u03b9\u03b1 \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/duova-inhaler\/\"><strong>Duova Inhaler \u2014 tiotropium + formoterol LAMA-LABA combo<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/triohale-inhaler\/\"><strong>Triohale Inhaler \u2014 tiotropium + formoterol + ciclesonide triple<\/strong><\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3>How is Duova different from Tiova alone?<\/h3>\n<p>Duova adds formoterol (LABA) to tiotropium (LAMA). Dual bronchodilation gives greater lung function improvement and more exacerbation reduction in moderate-to-severe COPD compared to LAMA alone.<\/p>\n<h3>Is Duova for asthma or COPD?<\/h3>\n<p>Primarily COPD \u2014 landmark trials of LAMA-LABA dual therapy (FLAME, IMPACT, ETHOS) are in COPD. Asthma usually requires ICS-LABA first; severe asthma may add LAMA on top, but a triple therapy inhaler (Triohale) is more common than Duova in asthma.<\/p>\n<h3>When does Duova add benefit over LAMA alone?<\/h3>\n<p>For COPD with persistent dyspnoea, exercise limitation, or frequent exacerbations on LAMA monotherapy \u2014 adding LABA delivers measurable lung function and symptom gains.<\/p>\n<h3>How fast does Duova start working?<\/h3>\n<p>Formoterol component begins bronchodilation in 1\u20133 minutes. Tiotropium effect peaks at 1\u20133 hours; combined effect is sustained over 12 hours.<\/p>\n<h3>Can Duova replace ICS-LABA in COPD?<\/h3>\n<p>For COPD without elevated blood eosinophils and without frequent exacerbations, LAMA-LABA (Duova) is preferred over ICS-LABA. With frequent exacerbations or eosinophilic phenotype, triple therapy (LAMA-LABA-ICS, e.g. Triohale) is preferred.<\/p>\n<h3>Why dry mouth on Duova?<\/h3>\n<p>Anticholinergic effect from tiotropium. Usually mild; manage with sips of water, gum, oral hygiene.<\/p>\n<h3>Is Duova safe in pregnancy?<\/h3>\n<p>Limited data; not first-line. Discuss with your prescriber.<\/p>\n<h3>What if mist contacts my eyes?<\/h3>\n<p>Risk of acute glaucoma in predisposed patients. Aim away from eyes.<\/p>\n<h3>Should I keep my SABA reliever with Duova?<\/h3>\n<p>Yes \u2014 Duova is a controller, not a rescue inhaler. Keep Asthalin or Levolin for acute breathlessness.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0;border-radius:4px;font-size:13px;\"><strong>\u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03b5\u03c5\u03b8\u03cd\u03bd\u03b7\u03c2:<\/strong> \u0391\u03c5\u03c4\u03ae \u03b7 \u03c3\u03b5\u03bb\u03af\u03b4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03ba\u03c0\u03b1\u03b9\u03b4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03b3\u03b3\u03b5\u03bb\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03ae. \u03a3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b5\u03af\u03c4\u03b5 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03ad\u03bd\u03b1\u03bd \u03ba\u03b1\u03c4\u03b1\u03bb\u03bb\u03ae\u03bb\u03c9\u03c2 \u03b5\u03be\u03bf\u03c0\u03bb\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b1\u03b3\u03b3\u03b5\u03bb\u03bc\u03b1\u03c4\u03af\u03b1 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2 \u03c0\u03c1\u03b9\u03bd \u03be\u03b5\u03ba\u03b9\u03bd\u03ae\u03c3\u03b5\u03c4\u03b5, \u03c3\u03c4\u03b1\u03bc\u03b1\u03c4\u03ae\u03c3\u03b5\u03c4\u03b5 \u03ae \u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c4\u03b5 \u03bf\u03c0\u03bf\u03b9\u03bf\u03bd\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03b5\u03b9\u03c3\u03c0\u03bd\u03b5\u03c5\u03c3\u03c4\u03ae\u03c1\u03b1 \u03ae \u03b1\u03bd\u03b1\u03c0\u03bd\u03b5\u03c5\u03c3\u03c4\u03b9\u03ba\u03ae \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03bd \u03ad\u03c7\u03b5\u03c4\u03b5 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2, \u03c0\u03b1\u03af\u03c1\u03bd\u03b5\u03c4\u03b5 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03c3\u03c5\u03bd\u03c4\u03b1\u03b3\u03ad\u03c2, \u03b5\u03af\u03c3\u03c4\u03b5 \u03ad\u03b3\u03ba\u03c5\u03bf\u03c2 \u03ae \u03b8\u03b7\u03bb\u03ac\u03b6\u03b5\u03c4\u03b5, \u03ae \u03b5\u03af\u03c3\u03c4\u03b5 \u03ac\u03bd\u03c9 \u03c4\u03c9\u03bd 65 \u03b5\u03c4\u03ce\u03bd.<\/div>","protected":false},"excerpt":{"rendered":"<h5>\u2705 Asthma symptom control<br \/>\n\u2705 \u0392\u03bf\u03bb\u03b9\u03ba\u03ae \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03c2 \u03b5\u03b9\u03c3\u03c0\u03bd\u03bf\u03ae\u03c2<br \/>\n\u2705 \u0393\u03c1\u03ae\u03b3\u03bf\u03c1\u03b7 \u03b1\u03bd\u03b1\u03ba\u03bf\u03cd\u03c6\u03b9\u03c3\u03b7 \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd<br \/>\n\u2705 \u0392\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b1\u03bd\u03b1\u03c0\u03bd\u03b5\u03c5\u03c3\u03c4\u03b9\u03ba\u03ae \u03ac\u03bd\u03b5\u03c3\u03b7<\/h5>\n<p><span style=\"color: #999999;\">Contains Tiotropium Bromide and Formoterol Fumarate<\/span><\/p>","protected":false},"featured_media":54442,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3681,3141,3223],"product_tag":[3737,3723,3724],"class_list":{"0":"post-54441","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-asthma-copd-treatment","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-duova-inhaler","10":"product_tag-formoterol-fumarate","11":"product_tag-tiotropium-bromide","13":"first","14":"outofstock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/54441","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=54441"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/54442"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=54441"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=54441"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=54441"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=54441"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}