{"id":54750,"date":"2023-09-20T10:02:54","date_gmt":"2023-09-20T10:02:54","guid":{"rendered":"https:\/\/medsname.com\/donamem\/"},"modified":"2026-04-30T16:30:23","modified_gmt":"2026-04-30T16:30:23","slug":"donamem","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/donamem\/","title":{"rendered":"Donamem"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">\u0393\u03c1\u03ae\u03b3\u03bf\u03c1\u03b7 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7<\/h3>\n<p style=\"margin-bottom:0;\"><strong>Donamem<\/strong> \u2014 donepezil + memantine fixed combination (Sun Pharma). Combined cholinesterase inhibitor + NMDA antagonist for moderate-to-severe Alzheimer&#8217;s disease. Two complementary mechanisms in one tablet \u2014 modestly better cognitive and functional outcomes than either alone.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f7f7f7;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<p style=\"margin:0 0 6px 0;\"><strong>\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong><\/p>\n<ul style=\"margin:6px 0 0 22px;padding:0;list-style:disc;\">\n<li>\u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03b7 WHO-GMP \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae<\/li>\n<li>\u03a3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u03c3\u03b5 \u03b1\u03c0\u03bb\u03cc \u03c6\u03ac\u03ba\u03b5\u03bb\u03bf \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/li>\n<li>\u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae<\/li>\n<li>\u0391\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc 1,400+ \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2 (<a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03b4\u03b9\u03b1\u03b2\u03ac\u03c3\u03c4\u03b5 \u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2<\/a>)<\/li>\n<\/ul>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"background:#eef7ee;border-left:4px solid #4caf50;padding:10px 14px;margin:14px 0;border-radius:3px;\">\ud83d\udce6 <strong>\u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2:<\/strong> \u03b1\u03bd \u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03bc\u03ad\u03c3\u03b1 \u03c3\u03b5 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03b5\u03c2 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae, \u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03bf \u03ba\u03cc\u03c3\u03c4\u03bf\u03c2. <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\">\u0394\u03b9\u03b1\u03b2\u03ac\u03c3\u03c4\u03b5 \u03c4\u03b7\u03bd \u03c0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae<\/a>.<\/p>\n<h3>\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p>Donamem ships from a WHO-GMP certified manufacturer in plain packaging, billed through a regulated payment processor (the statement descriptor reads a regulated card-payment processor \u2014 never MedsBase or any medication name). Every order carries our 20-business-day Reshipment Assurance.<\/p>\n<h2>Why combine them<\/h2>\n<p>Donepezil (cholinesterase inhibitor) and memantine (NMDA antagonist) target different neurotransmitter systems implicated in Alzheimer&#8217;s. Multiple trials (DOMINO-AD, Tariot 2004, Hartmann 2003) show that combination therapy produces small but clinically meaningful additional benefit on cognitive (SIB, MMSE) and functional (ADCS-ADL) measures in moderate-to-severe disease, compared with cholinesterase inhibitor alone. The fixed combination simplifies the regimen and improves adherence.<\/p>\n<h2>\u03a7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7<\/h2>\n<p>Available as 5 mg + 5 mg or 10 mg + 5 mg (donepezil + memantine). Patients are typically titrated up on each component separately first (memantine 5 mg\/week up to 10 mg BID; donepezil 5 mg \u2192 10 mg after 4 weeks) before being switched to the fixed combination at the appropriate strength.<\/p>\n<p>Take once daily in the evening. Renal-dose adjust the memantine component if CrCl &lt;50 mL\/min \u2014 a fixed-dose combination may not be appropriate; switch to separate components.<\/p>\n<h2>Side effects (combined profile)<\/h2>\n<ul>\n<li>GI: nausea, vomiting, diarrhoea, anorexia, weight loss (donepezil component)<\/li>\n<li>CNS: insomnia, vivid dreams, dizziness, somnolence, headache (both)<\/li>\n<li>Cardiac: bradycardia, AV block (donepezil)<\/li>\n<li>Less common: hallucinations, confusion (memantine component, especially during titration)<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:14px 0;border-radius:3px;\"><strong>Anticholinergic clash<\/strong><br \/>Avoid concurrent anticholinergic drugs (oxybutynin, tolterodine, hyoscine, TCAs, first-gen antihistamines) \u2014 they oppose donepezil&#8217;s effect AND independently worsen cognition. For overactive bladder in dementia, prefer mirabegron.<\/div>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3>Should I start on the combination directly?<\/h3>\n<p>No \u2014 both drugs require slow titration to manage GI (donepezil) and CNS (memantine) side effects. Most clinicians titrate each separately first, then switch to the fixed combination once the patient is stable on the target doses.<\/p>\n<h3>What benefit does combination give over donepezil alone?<\/h3>\n<p>Modest additional benefit on cognitive and functional measures (typically 1-2 points on SIB or 0.5-1 point on ADCS-ADL) in moderate-severe disease. Effect size is small but clinically meaningful for some families.<\/p>\n<h3>What about side effects?<\/h3>\n<p>Stacked from both components: nausea, diarrhoea, headache (donepezil); dizziness, constipation, headache (memantine). Most are dose-limiting only at high doses or with rapid titration.<\/p>\n<h3>Renal failure?<\/h3>\n<p>The memantine component is renally cleared. If CrCl &lt;50 mL\/min, switch to separate components rather than the fixed combination so memantine can be dose-reduced independently.<\/p>\n<h3>When should combination be stopped?<\/h3>\n<p>Reassess at 6-12 month intervals. Stop in advanced disease when goals shift to comfort-focused care, or if side effects (especially weight loss, syncope) outweigh perceived benefit.<\/p>\n<h3>Can it slow disease?<\/h3>\n<p>No \u2014 both drugs are symptomatic. They do not slow underlying neurodegeneration.<\/p>\n<h3>\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd;<\/h3>\n<p>Donepezil component interacts with anticholinergics (which oppose its action) and bradycardic drugs. Memantine interacts with other NMDA antagonists and urinary alkalisers. See individual product pages for the full interaction lists.<\/p>\n<h3>\u03a4\u03b9 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bd \u03be\u03b5\u03c7\u03ac\u03c3\u03b5\u03c4\u03b5 \u03bc\u03b9\u03b1 \u03b4\u03cc\u03c3\u03b7;<\/h3>\n<p>Skip the missed dose and resume the normal schedule. If several days are missed, restart on separate components at the lower titration step to avoid side effects.<\/p>\n<h3>Can my loved one drive?<\/h3>\n<p>Stable patients on the target dose can usually drive. Initial titration may cause dizziness and somnolence \u2014 do not drive until stable. Driving fitness should be reassessed regularly as dementia progresses regardless of medication.<\/p>\n<h3>Is there a difference between the 5+5 and 10+5 strengths?<\/h3>\n<p>The 10+5 strength has the fully titrated donepezil dose (10 mg) plus the half memantine dose (5 mg). The fully titrated memantine target is 10 mg twice daily \u2014 so most patients on combination need either two of the 5+5 strengths or one 10+5 strength plus a separate evening 5 mg memantine. Confirm the regimen with the prescribing clinician.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Other Alzheimer&#8217;s &#038; Dementia Medications<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/alzil\/\">Alzil<\/a> \u2014 donepezil 5\/10 mg monotherapy<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/donep\/\">Donep<\/a> \u2014 donepezil 5\/10 mg<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/donecept\/\">Donecept<\/a> \u2014 donepezil 5\/10 mg \u2014 Cipla brand<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/nemdaa\/\">Nemdaa<\/a> \u2014 memantine 5\/10 mg monotherapy<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/ashvagandha\/\">Ashvagandha<\/a> \u2014 Ayurvedic adaptogen \u2014 adjunctive only, not substitute therapy<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 16px;margin:18px 0;border-radius:3px;font-size:.95em;\"><strong>\u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u0391\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u0395\u03c5\u03b8\u03c5\u03bd\u03ce\u03bd:<\/strong> \u0391\u03c5\u03c4\u03ae \u03b7 \u03c3\u03b5\u03bb\u03af\u03b4\u03b1 \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c4\u03bf \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03ae\u03c2 \u03b1\u03c0\u03cc \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc. \u03a3\u03c5\u03b6\u03b7\u03c4\u03ae\u03c3\u03c4\u03b5 \u03ba\u03ac\u03b8\u03b5 \u03bd\u03ad\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03bc\u03b5 \u03c4\u03bf\u03bd \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc \u03ae \u03c4\u03bf\u03bd \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03c0\u03bf\u03b9\u03cc \u03c3\u03b1\u03c2.<\/div>","protected":false},"excerpt":{"rendered":"<p>Donamem (Donepezil + Memantine) \u2014 Sun Pharma fixed-combination cognitive-enhancer for moderate-severe Alzheimer&#8217;s. Dual-mechanism therapy targeting acetylcholine and glutamate systems.<\/p>","protected":false},"featured_media":54751,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3772,3141,3223],"product_tag":[3777],"class_list":{"0":"post-54750","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-alzheimers-treatment","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-donamem","11":"first","12":"outofstock","13":"shipping-taxable","14":"purchasable","15":"product-type-variable","16":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/54750","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=54750"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/54751"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=54750"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=54750"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=54750"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=54750"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}