<\/p>\n
Loceryl Nail LIQ is amorolfine 5% w\/v medicated nail lacquer \u2014 a morpholine antifungal applied weekly to fungus-affected fingernails or toenails. Best evidence is for mild distal-edge onychomycosis<\/strong> involving < 50% of nail surface and not extending to the matrix. Cure rates from topical-only therapy are modest (~38\u201345%); for moderate to severe nail infection, oral terbinafine or itraconazole is more effective. Treatment courses are very long: 6 months for fingernails, 9\u201312 months for toenails.<\/p>\n<\/div>\n \ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n \u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n Loceryl Nail LIQ (amorolfine 5% w\/v nail lacquer, Galderma) is a topical antifungal formulated as a film-forming nail lacquer. It is used for onychomycosis (fungal nail infection) caused by dermatophytes, yeasts, or non-dermatophyte moulds.<\/p>\n Best evidence is in mild distal-edge disease<\/strong> \u2014 i.e. fungal change limited to the outer 50% of the nail and not involving the lunula (matrix). For deeper or more extensive infection, oral therapy (terbinafine 250 mg\/day \u00d7 6 weeks for fingernails, 12 weeks for toenails; or itraconazole pulse) is more effective. Combination therapy (oral + topical) is sometimes used for refractory cases.<\/p>\n Amorolfine is structurally a morpholine derivative \u2014 distinct from azoles or allylamines. It inhibits fungal \u039414-reductase and \u03947-\u03948-isomerase \u2014 two enzymes downstream of squalene epoxidase in the ergosterol biosynthesis pathway. The result is depletion of ergosterol and accumulation of sterol intermediates, killing the fungus. The lacquer film delivers the drug into the nail plate over a week, allowing once-weekly dosing.<\/p>\n Limited data. Minimal systemic absorption. Onychomycosis is not life-threatening \u2014 many clinicians defer treatment until after pregnancy and breastfeeding. If using during pregnancy, weigh against the option of doing nothing.<\/p>\n The drug clears the fungus in the nail it can reach but the dead, fungus-affected portion of the nail keeps growing out from the cuticle. Toenails grow 1\u20131.5 mm per month, so a fully grown-out toenail takes ~9\u201312 months. Photo at month 0, 3, 6, 12 to track objectively.<\/p>\n Topical drug penetration into nail is limited. Oral terbinafine reaches the nail bed via the bloodstream and accumulates from below. Topical lacquer reaches the nail from above and penetrates < 1 mm. For thick or matrix-involved infection, topical alone fails.<\/p>\n Mild distal-edge infection involving < 50% of nail and not the lunula; patients who can’t take oral antifungals (active liver disease, drug interactions, pregnancy \/ breastfeeding, refusal of oral therapy); maintenance after a successful oral course to prevent relapse.<\/p>\n Yes \u2014 combination (oral terbinafine 12 weeks PLUS weekly amorolfine lacquer for 12 months) gives the highest cure rates for severe onychomycosis, especially toe-nail. Cost and complexity are higher.<\/p>\n Some amorolfine products allow cosmetic polish to be applied 24 hours after the medicated lacquer \u2014 check the leaflet for your specific brand. Remove cosmetic polish before the next weekly application.<\/p>\n Yes \u2014 Loceryl is the original Galderma brand of amorolfine. Loceryl Nail LIQ contains the same active ingredient (amorolfine 5%), manufactured by Galderma under WHO-GMP. Bioequivalent.<\/p>\n Yes. Nail debridement (mechanical thinning by a podiatrist or dermatologist with a burr) before starting topical therapy improves penetration and outcomes. For thick toenails, debridement + oral terbinafine + topical lacquer is the most effective combination.<\/p>\n It’s a single-use disposable file specifically to avoid spreading fungus to other nails. Don’t reuse files between nails \u2014 that’s how the index finger gets infected from the great toe.<\/p>\n Yes \u2014 use a different file for fingers vs. toes; avoid cross-contamination. Treat both for the appropriate duration.<\/p>\n Apply as soon as you remember and resume the weekly schedule. A missed week occasionally is acceptable; multiple missed weeks reduce the cure probability further.<\/p>\n Store the bottle tightly capped at 15\u201325 \u00b0C, away from heat and direct sunlight (the solvent is volatile). Keep out of reach of children. Do not use after expiry. Discard 6 months after opening if specified on the leaflet.<\/p>\n <\/p>\n If Loceryl Nail LIQ is unavailable, here are alternatives.<\/p>\n \u2705 Treats fungal infections Loceryl Nail Liq contains Amorolfine.<\/p>","protected":false},"featured_media":55485,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3501,3141,3504,3342],"product_tag":[3934,3935],"class_list":{"0":"post-55484","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-fungal","7":"product_cat-category-overview","8":"product_cat-fungal-infection-treatment","9":"product_cat-general-health","10":"product_tag-amorolfine","11":"product_tag-loceryl-nail-liq","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/55484","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=55484"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/55485"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=55484"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=55484"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=55484"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=55484"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
WHO-GMP<\/strong>
certified manufacturer<\/div>\n\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n
\u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1<\/strong>
plain envelope<\/div>\n
\u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae<\/strong>
to most countries<\/div>\n
1,400+ customers<\/strong>
\u03b4\u03b9\u03b1\u03b2\u03ac\u03c3\u03c4\u03b5 \u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2<\/a><\/div>\n<\/div>\n\ud83d\udd12 Why order Loceryl Nail LIQ from MedsBase<\/h2>\n
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\u03a7\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n
\u03a0\u03ce\u03c2 \u03bd\u03b1 \u03ba\u03ac\u03bd\u03b5\u03c4\u03b5 \u03b1\u03af\u03c4\u03b7\u03c3\u03b7<\/h2>\n
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\u03a0\u03ce\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af<\/h2>\n
\u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/h2>\n
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Pregnancy & breastfeeding<\/h2>\n
\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n
How long until my toenail looks normal?<\/h3>\n
Why are cure rates lower than oral therapy?<\/h3>\n
When should I use lacquer instead of oral therapy?<\/h3>\n
Should I combine lacquer with oral terbinafine?<\/h3>\n
Can I use cosmetic nail polish over the lacquer?<\/h3>\n
Is Loceryl Nail LIQ the same as Loceryl?<\/h3>\n
What if my nail is thick \u2014 should I see a podiatrist?<\/h3>\n
Why does the file in the kit look so cheap?<\/h3>\n
Can I get this on my fingers and feet at the same time?<\/h3>\n
What if I miss a weekly application?<\/h3>\n
\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/h2>\n
Other Antifungal Medications you may be interested in<\/h2>\n
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\n\u2705 Strengthens nails
\n\u2705 Restores nail health
\n\u2705 Prevents further infection
\n\u2705 Easy to apply<\/p>\n