{"id":55536,"date":"2024-02-07T00:02:44","date_gmt":"2024-02-07T00:02:44","guid":{"rendered":"https:\/\/medsname.com\/aprezo\/"},"modified":"2026-04-30T10:24:47","modified_gmt":"2026-04-30T10:24:47","slug":"aprezo","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/aprezo\/","title":{"rendered":"Aprezo"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Aprezo?<\/h3>\n<p style=\"margin:0;\"><strong>Aprezo<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 <strong>apremilast 30&nbsp;mg<\/strong> tablet &mdash; a <strong>PDE4 inhibitor<\/strong> \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 <strong>moderate-to-severe plaque psoriasis<\/strong>, <strong>active psoriatic arthritis<\/strong>, \u03ba\u03b1\u03b9 <strong>oral ulcers of Beh&ccedil;et&#8217;s disease<\/strong>. It is the <strong>first-line oral systemic option<\/strong> for patients who cannot or prefer not to use methotrexate, ciclosporin, or biologics. Standard maintenance dose is <strong>30&nbsp;mg twice daily<\/strong> after a 5-day titration. Clinically equivalent to Amgen&#8217;s <strong>Otezla<sup>\u00ae<\/sup><\/strong>.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong> \u03a0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2 WHO-GMP \u00b7 \u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u00b7 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u00b7 1,400+ \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 <a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\"><strong>\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n<h3>\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p>\u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n<p><strong>Aprezo<\/strong> is Glenmark&#8217;s oral <strong>apremilast 30&nbsp;mg<\/strong> tablet &mdash; an immunomodulator that represented a genuine advance in psoriasis treatment when approved by the FDA in 2014. Apremilast is a <strong>phosphodiesterase 4 (PDE4) inhibitor<\/strong> that works entirely intracellularly on immune-cell signalling, without the immunosuppression, lab-monitoring burden, or injection requirements of methotrexate or biologic agents.<\/p>\n<p>Aprezo contains the same active ingredient at the same strength as Amgen&#8217;s branded <strong>Otezla<sup>\u00ae<\/sup><\/strong> and is one of the most-prescribed oral systemic psoriasis drugs in the world. It has a favourable safety profile suitable for long-term outpatient use.<\/p>\n<h2 class=\"wp-block-heading\">What Is Aprezo?<\/h2>\n<p>Aprezo is a prescription <strong>oral immunomodulator<\/strong> that selectively inhibits PDE4 in immune and inflammatory cells. This raises intracellular cyclic AMP and shifts the cytokine balance away from pro-inflammatory signals (TNF-&alpha;, IL-23, IL-17, IFN-&gamma;) and toward anti-inflammatory ones (IL-10).<\/p>\n<p>Aprezo is indicated for:<\/p>\n<ul>\n<li><strong>Moderate-to-severe plaque psoriasis<\/strong> &mdash; in adults for whom phototherapy or other systemic therapy is appropriate<\/li>\n<li><strong>Active psoriatic arthritis<\/strong> &mdash; alone or combined with DMARDs like methotrexate<\/li>\n<li><strong>Oral ulcers associated with Beh&ccedil;et&#8217;s disease<\/strong> &mdash; FDA-approved indication since 2019<\/li>\n<li><strong>Scalp and nail psoriasis<\/strong> &mdash; often particularly responsive to apremilast<\/li>\n<li><strong>Palmoplantar and genital psoriasis<\/strong> &mdash; where topical therapy is insufficient<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">How Does Aprezo Work?<\/h2>\n<p>Apremilast&#8217;s mechanism is distinct from other psoriasis systemics:<\/p>\n<ul>\n<li><strong>Inhibits PDE4<\/strong> inside immune cells &mdash; PDE4 is the enzyme that normally breaks down intracellular cAMP<\/li>\n<li>Higher cAMP <strong>activates protein kinase A<\/strong> \u03ba\u03b1\u03b9 <strong>suppresses transcription factor NF-&kappa;B<\/strong><\/li>\n<li>Downstream effect: <strong>reduced production of TNF-&alpha;, IL-23, IL-17, IL-8, and IFN-&gamma;<\/strong>, with <strong>increased IL-10<\/strong><\/li>\n<li>No direct immunosuppression &mdash; patients are not immunocompromised and do not need routine infection screening like on biologics<\/li>\n<li>Clinical effect is gradual &mdash; most patients see meaningful psoriasis improvement by <strong>16 weeks<\/strong>; some earlier<\/li>\n<\/ul>\n<p>Because the drug does not target a single cytokine but modulates the whole signalling milieu upstream, efficacy is more moderate than TNF or IL-17 biologics but the safety margin is broader &mdash; particularly attractive for patients who cannot tolerate biologics or want to avoid injections.<\/p>\n<h2 class=\"wp-block-heading\">Aprezo Dosage and Administration<\/h2>\n<p>Apremilast uses a <strong>5-day titration<\/strong> to reduce initial GI side effects.<\/p>\n<table>\n<thead>\n<tr>\n<th>\u0397\u03bc\u03ad\u03c1\u03b1<\/th>\n<th>\u03a0\u03c1\u03c9\u03af<\/th>\n<th>Evening<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>1<\/td>\n<td>10 mg<\/td>\n<td>\u2014<\/td>\n<\/tr>\n<tr>\n<td>2<\/td>\n<td>10 mg<\/td>\n<td>10 mg<\/td>\n<\/tr>\n<tr>\n<td>3<\/td>\n<td>10 mg<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>4<\/td>\n<td>20 mg<\/td>\n<td>20 mg<\/td>\n<\/tr>\n<tr>\n<td>5<\/td>\n<td>20 mg<\/td>\n<td>30 mg<\/td>\n<\/tr>\n<tr>\n<td>6 onward<\/td>\n<td><strong>30 mg<\/strong><\/td>\n<td><strong>30 mg<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>\u03a3\u03b7\u03bc\u03b5\u03af\u03c9\u03c3\u03b7:<\/strong> the titration pack typically contains 10 mg and 20 mg tablets for days 1&ndash;5. The 30 mg tablet (Aprezo) is the maintenance strength from day 6 onward.<\/p>\n<table>\n<thead>\n<tr>\n<th>\u03a3\u03b5\u03bd\u03ac\u03c1\u03b9\u03bf<\/th>\n<th>\u0394\u03cc\u03c3\u03b7<\/th>\n<th>\u03a3\u03b7\u03bc\u03b5\u03b9\u03ce\u03c3\u03b5\u03b9\u03c2<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Plaque psoriasis \/ psoriatic arthritis (maintenance)<\/strong><\/td>\n<td>30 mg twice daily<\/td>\n<td>Continue indefinitely while effective<\/td>\n<\/tr>\n<tr>\n<td><strong>Beh&ccedil;et&#8217;s oral ulcers<\/strong><\/td>\n<td>30 mg twice daily<\/td>\n<td>Similar titration<\/td>\n<\/tr>\n<tr>\n<td><strong>Severe renal impairment (CrCl &lt;30 mL\/min)<\/strong><\/td>\n<td>30 mg once daily (morning only)<\/td>\n<td>Halve the maintenance dose; titration uses morning doses only<\/td>\n<\/tr>\n<tr>\n<td><strong>\u0397\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1<\/strong><\/td>\n<td>\u03a4\u03c5\u03c0\u03b9\u03ba\u03ae \u03b4\u03cc\u03c3\u03b7<\/td>\n<td>\u0394\u03b5\u03bd \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae<\/td>\n<\/tr>\n<tr>\n<td><strong>\u0395\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7<\/strong><\/td>\n<td>\u0391\u03c0\u03bf\u03c6\u03cd\u03b3\u03b5\u03c4\u03b5<\/td>\n<td>\u0391\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03b5\u03c4\u03b1\u03b9<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3 class=\"wp-block-heading\">How to Take Aprezo Properly<\/h3>\n<ul>\n<li>\u039a\u03b1\u03c4\u03b1\u03c0\u03b9\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf \u03b4\u03b9\u03c3\u03ba\u03af\u03bf \u03bf\u03bb\u03cc\u03ba\u03bb\u03b7\u03c1\u03bf \u03bc\u03b5 \u03bd\u03b5\u03c1\u03cc\u00b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bb\u03b7\u03c6\u03b8\u03b5\u03af \u03bc\u03b5 \u03ae \u03c7\u03c9\u03c1\u03af\u03c2 \u03c6\u03b1\u03b3\u03b7\u03c4\u03cc<\/li>\n<li>Take at roughly the same times each day (morning and evening, about 12 hours apart)<\/li>\n<li>Complete the full 5-day titration, even if you tolerate early doses well &mdash; the titration schedule reduces GI side effects meaningfully<\/li>\n<li>If nausea or diarrhoea is troublesome at maintenance dose, take with food rather than stopping<\/li>\n<li>\u0395\u03c0\u03b9\u03c4\u03c1\u03ad\u03c8\u03c4\u03b5 <strong>at least 16 weeks<\/strong> before judging efficacy &mdash; most patients who will respond do so by then<\/li>\n<li>Monitor weight monthly &mdash; unintentional weight loss occurs in a minority of patients<\/li>\n<li>Monitor mood actively &mdash; new or worsening depression has been reported<\/li>\n<li>Do not stop abruptly without medical discussion &mdash; psoriasis may flare<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Side Effects of Aprezo<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u0392\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1<\/th>\n<th>\u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 (\u22651 \u03c3\u03c4\u03bf\u03c5\u03c2 10)<\/strong><\/td>\n<td>Diarrhoea, nausea, headache (especially weeks 1&ndash;4)<\/td>\n<\/tr>\n<tr>\n<td><strong>\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 (\u22651 \u03c3\u03c4\u03bf\u03c5\u03c2 100)<\/strong><\/td>\n<td>Abdominal pain, vomiting, upper respiratory tract infection, fatigue, weight loss (&ge;5% of body weight in ~10% of users)<\/td>\n<\/tr>\n<tr>\n<td><strong>\u0391\u03c3\u03c5\u03bd\u03ae\u03b8\u03b9\u03c3\u03c4\u03b5\u03c2<\/strong><\/td>\n<td>Mood changes \/ depression, migraine, insomnia, hypersensitivity reactions<\/td>\n<\/tr>\n<tr>\n<td><strong>\u03a3\u03c0\u03ac\u03bd\u03b9\u03b5\u03c2<\/strong><\/td>\n<td>Severe diarrhoea requiring hospitalisation, severe weight loss, suicidal ideation, angioedema<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>GI side effects are usually self-limited<\/strong> &mdash; most resolve within the first 2&ndash;4 weeks as the body adapts. Persistent severe diarrhoea should prompt review.<\/p>\n<h2 class=\"wp-block-heading\">\u03a0\u03c1\u03bf\u03b5\u03b9\u03b4\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03ac\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li><strong>Depression risk.<\/strong> New or worsening depression, suicidal thoughts, or suicide have been reported in some patients. Monitor mood; report mood changes promptly<\/li>\n<li><strong>Weight loss.<\/strong> 10% of patients lose &ge;5% body weight. Monitor weight monthly &mdash; if significant unintentional loss occurs, consider dose reduction or discontinuation<\/li>\n<li><strong>Diarrhoea and nausea.<\/strong> Most common in the first 2&ndash;4 weeks &mdash; the 5-day titration schedule substantially reduces severity<\/li>\n<li><strong>\u0395\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7.<\/strong> Teratogenic in animal studies &mdash; avoid. Use reliable contraception during and for 30 days after stopping<\/li>\n<li><strong>\u0398\u03b7\u03bb\u03b1\u03c3\u03bc\u03cc\u03c2.<\/strong> \u0394\u03b5\u03bd \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac\u03c4\u03b1\u03b9<\/li>\n<li><strong>\u0391\u03bb\u03ba\u03bf\u03cc\u03bb.<\/strong> No direct interaction but worsens GI side effects in early weeks<\/li>\n<li><strong>Vaccinations.<\/strong> Live vaccines are OK on apremilast (unlike on biologics) because apremilast is not immunosuppressive<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Contraindications &mdash; Who Should NOT Take Aprezo<\/h2>\n<ul>\n<li>\u0395\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7<\/li>\n<li>Known hypersensitivity to apremilast or any excipient<\/li>\n<li>Active severe depression with suicidality (consider carefully)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03a6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u03a6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \/ \u03a4\u03ac\u03be\u03b7<\/th>\n<th>\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Strong CYP3A4 inducers (rifampicin, phenytoin, carbamazepine, phenobarbital, St John&#8217;s wort)<\/strong><\/td>\n<td><strong>\u0391\u03c0\u03bf\u03c6\u03cd\u03b3\u03b5\u03c4\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc<\/strong> &mdash; may reduce apremilast levels by 72% and lose efficacy<\/td>\n<\/tr>\n<tr>\n<td><strong>CYP3A4 inhibitors (ketoconazole, ritonavir, clarithromycin)<\/strong><\/td>\n<td>Modest rise in apremilast levels &mdash; usually clinically manageable<\/td>\n<\/tr>\n<tr>\n<td><strong>\u039c\u03b5\u03b8\u03bf\u03c4\u03c1\u03b5\u03be\u03ac\u03c4\u03b7\u03c2<\/strong><\/td>\n<td>Commonly co-prescribed in psoriatic arthritis &mdash; no adverse pharmacokinetic interaction<\/td>\n<\/tr>\n<tr>\n<td><strong>Biologic agents (TNF, IL-17, IL-23 inhibitors)<\/strong><\/td>\n<td>Usually used in sequence rather than combination &mdash; data for co-prescription limited<\/td>\n<\/tr>\n<tr>\n<td><strong>\u0391\u03bb\u03ba\u03bf\u03cc\u03bb<\/strong><\/td>\n<td>Worsens GI side effects early; moderate later<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">\u039f\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7\u03c2<\/h2>\n<ul>\n<li>\u0391\u03c0\u03bf\u03b8\u03b7\u03ba\u03b5\u03cd\u03c3\u03c4\u03b5 \u03ba\u03ac\u03c4\u03c9 \u03b1\u03c0\u03cc 25 \u00b0C \u03c3\u03b5 \u03be\u03b7\u03c1\u03cc \u03bc\u03ad\u03c1\u03bf\u03c2, \u03bc\u03b1\u03ba\u03c1\u03b9\u03ac \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ac\u03bc\u03b5\u03c3\u03b7 \u03b7\u03bb\u03b9\u03b1\u03ba\u03ae \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b2\u03bf\u03bb\u03af\u03b1<\/li>\n<li>\u0394\u03b9\u03b1\u03c4\u03b7\u03c1\u03ae\u03c3\u03c4\u03b5 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u03c6\u03c5\u03c3\u03b1\u03bb\u03af\u03b4\u03c9\u03bd<\/li>\n<li>\u039c\u03b1\u03ba\u03c1\u03b9\u03ac \u03b1\u03c0\u03cc \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac<\/li>\n<li>\u039c\u03b7\u03bd \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b5 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03b7\u03bc\u03b5\u03c1\u03bf\u03bc\u03b7\u03bd\u03af\u03b1 \u03bb\u03ae\u03be\u03b7\u03c2<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u039b\u03cd\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/dapsone\/\" rel=\"noopener\">Dapsone<\/a> &mdash; alternative oral immunomodulator for selected inflammatory skin disease<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/eczema-psoriasis-treatment\/\" rel=\"noopener\">Browse all Eczema &amp; Psoriasis Treatments &rarr;<\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3 class=\"wp-block-heading\">What is Aprezo used for?<\/h3>\n<p>Aprezo (apremilast) treats <strong>moderate-to-severe plaque psoriasis, active psoriatic arthritis, and oral ulcers of Beh&ccedil;et&#8217;s disease<\/strong>. It is often prescribed for patients who cannot or prefer not to use biologic injections or methotrexate.<\/p>\n<h3 class=\"wp-block-heading\">How fast does Aprezo work?<\/h3>\n<p>Early improvement at 4&ndash;6 weeks; meaningful response typically by <strong>16 weeks<\/strong>. Joint symptoms in psoriatic arthritis can respond faster than skin lesions.<\/p>\n<h3 class=\"wp-block-heading\">Why is there a titration pack?<\/h3>\n<p>The 5-day step-up from 10 mg to the 30 mg twice-daily maintenance dose significantly reduces initial nausea, diarrhoea, and headache. Never skip the titration &mdash; starting directly at 30 mg twice daily is much less tolerable.<\/p>\n<h3 class=\"wp-block-heading\">Is Aprezo a biologic?<\/h3>\n<p><strong>\u038c\u03c7\u03b9<\/strong> &mdash; apremilast is a small-molecule <strong>\u03c3\u03c4\u03bf\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc<\/strong> medication, not a biologic. It does not require injections, infusions, cold-chain storage, or pre-treatment tuberculosis \/ hepatitis screening. This is one of its major practical advantages.<\/p>\n<h3 class=\"wp-block-heading\">Will I lose weight on Aprezo?<\/h3>\n<p>About 10% of users lose &ge;5% of body weight. In overweight patients this can be welcome, but any significant unintentional loss should be discussed with your doctor. Monitor weight monthly.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol on Aprezo?<\/h3>\n<p>Moderate intake is acceptable. Heavy drinking can worsen GI side effects, particularly in the first weeks.<\/p>\n<h3 class=\"wp-block-heading\">Can I get pregnant on Aprezo?<\/h3>\n<p><strong>\u038c\u03c7\u03b9<\/strong> &mdash; apremilast is contraindicated in pregnancy. Use reliable contraception during treatment and for at least 30 days after stopping.<\/p>\n<h3 class=\"wp-block-heading\">Can I combine Aprezo with methotrexate?<\/h3>\n<p>Yes &mdash; this combination is common in psoriatic arthritis and is well tolerated. No adverse pharmacokinetic interaction.<\/p>\n<h3 class=\"wp-block-heading\">Does Aprezo affect the immune system?<\/h3>\n<p>Unlike biologics, apremilast does not cause immunosuppression. Routine tuberculosis or hepatitis screening is not required, and live vaccines are permitted.<\/p>\n<h3 class=\"wp-block-heading\">What if Aprezo doesn&#8217;t work after 16 weeks?<\/h3>\n<p>Efficacy is more moderate than biologics. If response is insufficient, your dermatologist or rheumatologist may switch to a biologic (adalimumab, secukinumab, ixekizumab, guselkumab) or to traditional systemics (methotrexate, ciclosporin).<\/p>\n<p><!-- medsbase-faq-h3-converted --><\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2<\/h3>\n<p>\u0386\u03bb\u03bb\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 \u03c3\u03b5 <strong>\u03a7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03a0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2<\/strong> \u03c0\u03bf\u03c5 \u03bf\u03b9 \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/inderal\/\">Inderal<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/lipaglyn\/\">Lipaglyn<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/triohale-rotacaps\/\">Triohale Rotacaps<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/seroflo-rotacaps\/\">Seroflo Rotacaps<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/amlip\/\">Amlip<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Reduces psoriasis symptoms<br \/>\n\u2705 Controls psoriatic arthritis<br \/>\n\u2705 Minimizes skin inflammation<br \/>\n\u2705 \u0391\u03bd\u03b1\u03ba\u03bf\u03c5\u03c6\u03af\u03b6\u03b5\u03b9 \u03c4\u03bf\u03bd \u03c0\u03cc\u03bd\u03bf \u03c3\u03c4\u03b9\u03c2 \u03b1\u03c1\u03b8\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2<br \/>\n\u2705 Enhances skin clarity<\/p>\n<p>Aprezo contains Apremilast.<\/p>","protected":false},"featured_media":55537,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3942],"product_tag":[3943,3944,5765,5767,5766,5761,5762,5763,5764],"class_list":{"0":"post-55536","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-eczema-psoriasis-treatment","9":"product_tag-apremilast","10":"product_tag-aprezo","11":"product_tag-behcet-disease","12":"product_tag-glenmark","13":"product_tag-immunomodulator","14":"product_tag-otezla-generic","15":"product_tag-pde4-inhibitor","16":"product_tag-plaque-psoriasis","17":"product_tag-psoriatic-arthritis","19":"first","20":"instock","21":"shipping-taxable","22":"purchasable","23":"product-type-variable","24":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/55536","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=55536"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/55537"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=55536"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=55536"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=55536"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=55536"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}