{"id":55737,"date":"2024-02-07T05:38:29","date_gmt":"2024-02-07T05:38:29","guid":{"rendered":"https:\/\/medsname.com\/azoran\/"},"modified":"2026-04-30T10:24:45","modified_gmt":"2026-04-30T10:24:45","slug":"azoran","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/azoran\/","title":{"rendered":"Azoran"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Azoran?<\/h3>\n<p style=\"margin:0;\"><strong>Azoran<\/strong> is an oral tablet from RPG Life Sciences containing <strong>azathioprine 50 mg<\/strong> &mdash; a classic <strong>purine-antagonist immunosuppressant<\/strong> metabolised in vivo to <strong>6-mercaptopurine<\/strong>. Used to prevent organ-transplant rejection and to control a wide range of autoimmune and inflammatory conditions (rheumatoid arthritis, lupus, inflammatory bowel disease, autoimmune hepatitis, myasthenia gravis, vasculitis, pemphigus). Standard adult dose: <strong>1&ndash;3 mg\/kg once daily<\/strong>, titrated up slowly. <strong>TPMT (and ideally NUDT15) genotype or enzyme-activity testing is mandatory before the first dose<\/strong> &mdash; patients with low or absent TPMT activity develop catastrophic, life-threatening myelosuppression at standard doses. Onset is slow &mdash; <strong>8&ndash;16 weeks<\/strong> for steroid-sparing effect. Long-term risks include infection, bone-marrow suppression, hepatotoxicity, and a modestly raised risk of lymphoma and non-melanoma skin cancer.<\/p>\n<\/div>\n<p><!-- medsbase-specialist-strip --><\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:0 0 24px 0;border-radius:4px;font-size:14px;\"><strong>&#9877; Specialist-supervised medicine &mdash; clinician oversight required.<\/strong> This is a serious immunomodulatory drug with specific pre-treatment screening requirements, black-box warnings, and mandatory laboratory monitoring. It should be prescribed and supervised by a rheumatologist, gastroenterologist, dermatologist, or other specialist experienced with its use. Do <strong>\u03b4\u03b5\u03bd<\/strong> self-prescribe, self-adjust the dose, or start\/stop without a prescriber&#39;s direction. Always provide your treating doctor with your current prescription before ordering from MedsBase.<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f6f8;border:1px solid #e1e4e8;border-radius:4px;padding:14px 18px;margin:18px 0;display:flex;flex-wrap:wrap;gap:14px;font-size:0.95em;\"><span>\u2705 <strong>WHO-GMP \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf<\/strong> manufacturer<\/span><span>\ud83d\udce6 <strong>\u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1<\/strong><\/span><span>\ud83c\udf0d <strong>\u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae<\/strong><\/span><span>\ud83d\udcac <a href=\"\/el\/reviews\/\">1,400+ \u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a><\/span><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\"><strong>\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n<h3>\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p>\u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n<h2 class=\"wp-block-heading\">What Is Azoran?<\/h2>\n<p>Azoran is an oral tablet manufactured by RPG Life Sciences containing <strong>azathioprine 50 mg<\/strong>. Azathioprine is a pro-drug &mdash; once absorbed, it is converted (non-enzymatically and by glutathione-S-transferase) to <strong>6-mercaptopurine (6-MP)<\/strong>, which is further metabolised to active thioguanine nucleotides that incorporate into DNA and block purine synthesis in rapidly-dividing cells, particularly lymphocytes.<\/p>\n<p>Azoran is RPG Life Sciences&#8217; branded generic azathioprine &mdash; one of the oldest immunosuppressive drugs still in routine clinical use and the classic steroid-sparing agent in IBD, SLE, autoimmune hepatitis, myasthenia gravis, and solid-organ transplant maintenance. Azathioprine has been used clinically since the 1960s and remains one of the cornerstone steroid-sparing immunosuppressants &mdash; for organ-transplant maintenance and a wide range of autoimmune conditions. Its main roles are either as a primary immunosuppressant (in mild-to-moderate disease) or as a <strong>steroid-sparing agent<\/strong> (added to corticosteroid therapy to enable steroid taper while maintaining disease control).<\/p>\n<h2 class=\"wp-block-heading\">How Does Azoran Work?<\/h2>\n<p>Azathioprine works at the DNA level of dividing immune cells:<\/p>\n<ul>\n<li><strong>Pro-drug conversion<\/strong> &mdash; azathioprine is cleaved to 6-MP within hours of ingestion.<\/li>\n<li><strong>Three-way metabolism of 6-MP<\/strong>:<\/li>\n<ul>\n<li><em>HGPRT pathway<\/em> &rarr; 6-thioguanine nucleotides (6-TGN), the main active metabolite. 6-TGN gets incorporated into DNA and disrupts purine synthesis in lymphocytes.<\/li>\n<li><em>TPMT pathway<\/em> &rarr; 6-methyl-mercaptopurine, largely inactive. Patients with low TPMT activity shunt more 6-MP to the active 6-TGN pathway &mdash; producing profound myelosuppression at normal doses.<\/li>\n<li><em>Xanthine oxidase pathway<\/em> &rarr; inactive thiouric acid. This is the pathway blocked by <strong>\u03b1\u03bb\u03bb\u03bf\u03c0\u03bf\u03c5\u03c1\u03b9\u03bd\u03cc\u03bb\u03b7<\/strong> &mdash; explaining why allopurinol + standard-dose azathioprine is a potentially lethal combination.<\/li>\n<\/ul>\n<li><strong>Lymphocyte-selective<\/strong> &mdash; T- and B-cells are particularly sensitive because they rely on the <em>de novo<\/em> purine synthesis pathway rather than salvage.<\/li>\n<\/ul>\n<p>Onset of clinical effect: <strong>8&ndash;16 weeks<\/strong> for most autoimmune conditions. Azathioprine is not a rapid-onset drug &mdash; corticosteroid cover is usually needed for the first 2&ndash;3 months until azathioprine takes over.<\/p>\n<h2 class=\"wp-block-heading\">\u03a7\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li><strong>Solid-organ transplantation<\/strong> &mdash; kidney, liver, heart transplant maintenance immunosuppression (less commonly used now &mdash; mycophenolate has largely replaced it in modern protocols)<\/li>\n<li><strong>Inflammatory bowel disease<\/strong> &mdash; steroid-sparing maintenance in Crohn&#39;s and ulcerative colitis<\/li>\n<li><strong>Rheumatoid arthritis<\/strong> &mdash; for patients who cannot tolerate methotrexate or biologics<\/li>\n<li><strong>Systemic lupus erythematosus (SLE)<\/strong> &mdash; including maintenance after lupus nephritis induction<\/li>\n<li><strong>Autoimmune hepatitis<\/strong> &mdash; standard maintenance in combination with (or replacing) low-dose prednisolone<\/li>\n<li><strong>\u039c\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1<\/strong> &mdash; steroid-sparing long-term therapy<\/li>\n<li><strong>ANCA-associated vasculitis<\/strong> &mdash; remission maintenance after induction<\/li>\n<li><strong>Pemphigus vulgaris and bullous pemphigoid<\/strong> &mdash; steroid-sparing in chronic disease<\/li>\n<li><strong>Atopic dermatitis<\/strong> &mdash; severe refractory cases<\/li>\n<li><strong>Multiple sclerosis (relapsing-remitting)<\/strong> &mdash; occasional use where disease-modifying therapies are unavailable<\/li>\n<\/ul>\n<p>Azoran is <strong>\u03b4\u03b5\u03bd<\/strong> for: undiagnosed joint pain, first-line management of most autoimmune disease when faster-acting or more effective alternatives are available, or any patient who has not had TPMT testing and baseline bloods.<\/p>\n<h2 class=\"wp-block-heading\">Before Starting Azoran &mdash; Mandatory Screening<\/h2>\n<p>Azathioprine is one of the few commonly-used drugs where pharmacogenetic testing before the first dose is standard of care. Skipping it risks fatal bone-marrow failure.<\/p>\n<ul>\n<li><strong>TPMT genotype or enzyme-activity test<\/strong> &mdash; identifies the ~1 in 300 of European-ancestry patients with absent TPMT activity (homozygous variant) and the ~10% with reduced activity (heterozygous). Absent TPMT activity means the standard dose will cause catastrophic myelosuppression within weeks.<\/li>\n<li><strong>NUDT15 genotype (where available)<\/strong> &mdash; particularly important in Asian, Hispanic, and African-ancestry patients, where NUDT15 variants cause similar myelosuppression risk independently of TPMT status.<\/li>\n<li><strong>\u03a0\u03bb\u03ae\u03c1\u03b5\u03c2 \u03b1\u03af\u03bc\u03b1<\/strong> &mdash; baseline; do not start if ANC &lt; 1.5 or platelets &lt; 100.<\/li>\n<li><strong>Liver function tests<\/strong> &mdash; baseline ALT, AST, ALP, bilirubin. Defer if significantly abnormal.<\/li>\n<li><strong>Renal function<\/strong> &mdash; azathioprine is partially cleared through inactive metabolites in urine; dose adjustment may be needed in severe renal impairment.<\/li>\n<li><strong>Hepatitis B \/ C and HIV screening<\/strong> &mdash; prevents reactivation of chronic viral hepatitis and identifies co-infection needing specialist care.<\/li>\n<li><strong>Latent TB screening<\/strong> &mdash; QuantiFERON or TST; treat latent TB before starting prolonged immunosuppression.<\/li>\n<li><strong>Varicella-zoster status<\/strong> &mdash; seronegative patients should receive varicella vaccine (live) BEFORE starting azathioprine &mdash; live vaccines are contraindicated once treatment is underway.<\/li>\n<li><strong>Pregnancy test<\/strong> in women of reproductive age; discussion of contraception needed.<\/li>\n<li><strong>Vaccination review<\/strong> &mdash; update inactivated vaccines (flu, pneumococcal, COVID-19, Shingrix, HPV). Live vaccines contraindicated during treatment.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Azoran Dosage and How to Take<\/h2>\n<p>Azoran is supplied at <strong>50 mg<\/strong>. Dose is weight-based and carefully titrated.<\/p>\n<ul>\n<li><strong>Standard adult range:<\/strong> 1&ndash;3 mg\/kg body weight once daily.<\/li>\n<li><strong>Start low:<\/strong> typically 50 mg once daily for 1&ndash;2 weeks, with CBC at week 1 and week 2; then step up to target dose if bloods are stable.<\/li>\n<li><strong>Autoimmune disease maintenance:<\/strong> 1&ndash;2.5 mg\/kg\/day typical.<\/li>\n<li><strong>Transplant maintenance:<\/strong> 1&ndash;3 mg\/kg\/day depending on regimen.<\/li>\n<li><strong>TPMT heterozygous or intermediate activity:<\/strong> reduce starting dose to 50% (0.5&ndash;1.5 mg\/kg\/day).<\/li>\n<li><strong>TPMT homozygous deficient, or NUDT15 deficient:<\/strong> azathioprine is contraindicated (or use &lt; 10% of standard dose under specialist supervision with intensive monitoring).<\/li>\n<li><strong>\u039d\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1:<\/strong> reduce dose in severe impairment; avoid in ESRD without specialist guidance.<\/li>\n<li><strong>With food:<\/strong> take with or after food to reduce nausea.<\/li>\n<\/ul>\n<h3 class=\"wp-block-heading\">How to Take Azoran Properly<\/h3>\n<ol>\n<li><strong>Never start without TPMT testing<\/strong> (and NUDT15 where available). This is the single most important safety step.<\/li>\n<li><strong>Swallow tablets whole with water, with food.<\/strong> Do not crush or chew &mdash; azathioprine is a cytotoxic drug and dust can be harmful to carers. Wash hands after handling.<\/li>\n<li><strong>Once daily at a consistent time<\/strong> &mdash; usually with the evening meal to reduce any nausea during the day.<\/li>\n<li><strong>CBC and LFTs at weeks 1, 2, 4, 8, 12, then every 3 months<\/strong> indefinitely. Any drop in WBC below 3.0 or neutrophils below 1.5 requires specialist review and usually dose reduction or interruption.<\/li>\n<li><strong>Do not miss monitoring bloods<\/strong> &mdash; delayed-onset myelosuppression can occur months or years into treatment, particularly with new co-medications (allopurinol is the classic trigger).<\/li>\n<li><strong>Daily broad-spectrum SPF 50 sunscreen<\/strong>. Azathioprine increases non-melanoma skin cancer risk substantially &mdash; annual dermatology review for fair-skinned patients or anyone on long-term treatment.<\/li>\n<li><strong>Report any sore throat, unexplained fever, bruising, bleeding, mouth ulcers or severe fatigue immediately<\/strong> &mdash; may be the first sign of bone-marrow suppression.<\/li>\n<li><strong>Inform every prescriber<\/strong> that you are on azathioprine &mdash; especially before any new medication starting with &ldquo;allopurinol&rdquo; or any urate-lowering therapy.<\/li>\n<li><strong>Avoid live vaccines<\/strong> during treatment and for at least 3 months after stopping.<\/li>\n<li><strong>Plan pregnancy in advance with the prescriber<\/strong> &mdash; azathioprine is generally considered compatible with pregnancy for maternal indications (unlike mycophenolate), but the decision is individualised.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Side Effects of Azoran<\/h2>\n<p><strong>Common (first 4&ndash;8 weeks):<\/strong><\/p>\n<ul>\n<li>Nausea, vomiting, abdominal pain (usually settles; worst in first month)<\/li>\n<li>\u0394\u03b9\u03ac\u03c1\u03c1\u03bf\u03b9\u03b1<\/li>\n<li>\u039a\u03bf\u03cd\u03c1\u03b1\u03c3\u03b7<\/li>\n<li>\u039a\u03b5\u03c6\u03b1\u03bb\u03b1\u03bb\u03b3\u03af\u03b1<\/li>\n<li>Mild hair thinning<\/li>\n<li>Mildly raised liver enzymes (ALT, AST)<\/li>\n<\/ul>\n<p><strong>\u039b\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03bb\u03bb\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac:<\/strong><\/p>\n<ul>\n<li><strong>Myelosuppression<\/strong> &mdash; leucopenia, neutropenia, thrombocytopenia, anaemia. Usually dose-dependent and reversible.<\/li>\n<li><strong>Hypersensitivity reaction<\/strong> &mdash; fever, rash, joint pain, sometimes hypotension, typically in the first 4 weeks. Resolves on stopping and usually recurs on rechallenge.<\/li>\n<li><strong>\u0397\u03c0\u03b1\u03c4\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong> &mdash; mild ALT rise common; cholestatic hepatitis and veno-occlusive disease are rare but serious.<\/li>\n<li><strong>\u03a0\u03b1\u03b3\u03ba\u03c1\u03b5\u03b1\u03c4\u03af\u03c4\u03b9\u03b4\u03b1<\/strong> &mdash; idiosyncratic, more common in IBD patients. Stop permanently if it occurs.<\/li>\n<li>Mouth ulcers<\/li>\n<li>Increased risk of infections &mdash; bacterial, viral (herpes zoster especially), fungal, parasitic<\/li>\n<\/ul>\n<p><strong>Rare but serious &mdash; seek urgent review:<\/strong><\/p>\n<ul>\n<li><strong>Severe life-threatening myelosuppression<\/strong> &mdash; TPMT-deficient patients, allopurinol co-prescription, or high-dose exposure. Sudden sore throat, fever, bruising, bleeding or severe fatigue is the warning signal.<\/li>\n<li><strong>Lymphoma<\/strong> &mdash; post-transplant lymphoproliferative disease (PTLD); hepatosplenic T-cell lymphoma (rare but often fatal; higher risk in young males with IBD on combination azathioprine + TNF inhibitor)<\/li>\n<li><strong>Non-melanoma skin cancer<\/strong> &mdash; significantly increased with long-term use, particularly in fair-skinned patients with cumulative sun exposure<\/li>\n<li><strong>Progressive multifocal leukoencephalopathy (PML)<\/strong> &mdash; rare but reported, typically in heavily-immunosuppressed patients<\/li>\n<li><strong>Reactivation of hepatitis B or zoster<\/strong>, disseminated herpes, opportunistic infection<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u03a0\u03c1\u03bf\u03b5\u03b9\u03b4\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03ac\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li><strong>Active serious infection<\/strong> &mdash; do not start; withhold during febrile illness.<\/li>\n<li><strong>History of or active malignancy (other than treated non-melanoma skin cancer)<\/strong> &mdash; relative contraindication; specialist decision.<\/li>\n<li><strong>Young males with IBD<\/strong> &mdash; specific (rare) risk of hepatosplenic T-cell lymphoma, particularly when azathioprine is combined with a TNF inhibitor. Discuss monotherapy alternatives.<\/li>\n<li><strong>Chronic hepatitis B or C<\/strong> &mdash; risk of viral reactivation; cover with antiviral therapy (entecavir or tenofovir for HBV) where appropriate.<\/li>\n<li><strong>Latent TB<\/strong> &mdash; treat before starting prolonged immunosuppression.<\/li>\n<li><strong>\u0395\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7<\/strong> &mdash; azathioprine is generally considered compatible with pregnancy for maternal autoimmune disease (unlike mycophenolate, which is absolutely contraindicated). Continuation in pregnancy should be a shared decision with specialist input; untreated active autoimmune disease often poses a higher fetal risk than the drug. Fathers on azathioprine at the time of conception: no strong evidence of teratogenicity.<\/li>\n<li><strong>\u0398\u03b7\u03bb\u03b1\u03c3\u03bc\u03cc\u03c2<\/strong> &mdash; small amounts of metabolites transfer into breast milk, but clinical use suggests low infant risk; generally considered acceptable with infant monitoring.<\/li>\n<li><strong>\u03a0\u03b1\u03b9\u03b4\u03b9\u03ac<\/strong> &mdash; used in paediatric IBD, transplant and autoimmune hepatitis. Same pharmacogenetic testing required.<\/li>\n<li><strong>Live vaccines contraindicated during treatment<\/strong>. Inactivated vaccines are fine. Plan Shingrix and travel vaccines before starting.<\/li>\n<li><strong>Sun exposure<\/strong> &mdash; daily broad-spectrum SPF 50; annual dermatology review for fair-skinned patients and those on long-term treatment.<\/li>\n<li><strong>Handling by pregnant or breastfeeding carers<\/strong> &mdash; azathioprine is classified as a cytotoxic drug. Use gloves when dispensing broken or crushed tablets; wash hands after handling.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Contraindications &mdash; Who Should NOT Take Azoran<\/h2>\n<ul>\n<li>Known hypersensitivity to azathioprine, 6-mercaptopurine, or any tablet excipient<\/li>\n<li>Complete TPMT or NUDT15 deficiency (homozygous variant) &mdash; use a different drug class<\/li>\n<li>Severe active infection (bacterial, viral, fungal, mycobacterial)<\/li>\n<li>Active untreated hepatitis B or C without antiviral cover<\/li>\n<li>Severe liver disease (decompensated cirrhosis)<\/li>\n<li>Prior azathioprine-induced pancreatitis (absolute contraindication to rechallenge)<\/li>\n<li>Severe baseline myelosuppression (ANC &lt; 1.0, platelets &lt; 75, Hb &lt; 8 g\/dL)<\/li>\n<li>Pregnancy planning where mycophenolate or methotrexate has not been considered as alternatives (specialist judgement)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03a6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u03a3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u0391\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u03a4\u03b9 \u03bd\u03b1 \u03ba\u03ac\u03bd\u03b5\u03c4\u03b5<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Allopurinol, febuxostat<\/strong> (urate-lowering)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Life-threatening myelosuppression<\/strong> &mdash; xanthine oxidase is blocked, 6-MP accumulates in the active cytotoxic pathway. Deaths reported.<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Reduce azathioprine to 25&ndash;33% of standard dose AND monitor CBC weekly for 4 weeks.<\/strong> Alternative: switch gout treatment to a non-XO agent (lesinurad, uricosurics).<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Aminosalicylates (mesalamine, sulfasalazine, olsalazine)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Inhibit TPMT &mdash; modest additional myelosuppression risk<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Common combination in IBD. Monitor CBC more frequently.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0392\u03b1\u03c1\u03c6\u03b1\u03c1\u03af\u03bd\u03b7<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Azathioprine may reduce warfarin effect (mechanism unclear)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor INR closely when starting or stopping azathioprine.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">ACE inhibitors, ARBs<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additive anaemia risk<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor Hb.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Co-trimoxazole (trimethoprim-sulfamethoxazole)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additive myelosuppression<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Often used for Pneumocystis prophylaxis in heavily-immunosuppressed patients &mdash; monitor CBC.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Ribavirin (hepatitis C treatment)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Severe myelosuppression via inosine monophosphate dehydrogenase inhibition<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Avoid combination.<\/strong> Complete HCV treatment before starting azathioprine where possible.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">TNF inhibitors (infliximab, adalimumab, certolizumab)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Standard combination in IBD; small added lymphoma risk, particularly in young males (hepatosplenic T-cell lymphoma)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Weigh benefit (IBD control) vs rare lymphoma risk. Consider monotherapy once stable.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Live vaccines (MMR, varicella, yellow fever, BCG, Zostavax, live nasal flu)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Risk of disseminated vaccine-strain infection<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Contraindicated during treatment<\/strong> and for 3 months after stopping.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u039a\u03bf\u03c1\u03c4\u03b9\u03ba\u03bf\u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ae<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additive immunosuppression (intended combination)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Standard &mdash; azathioprine is commonly used as a steroid-sparing agent.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Other immunosuppressants (MMF, cyclosporine, tacrolimus, JAK inhibitors, biologics)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additive infection and malignancy risk<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Only in carefully-monitored transplant or specialist contexts.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">\u039f\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7\u03c2<\/h2>\n<ul>\n<li>\u03a6\u03c5\u03bb\u03ac\u03be\u03c4\u03b5 \u03c3\u03b5 \u03b8\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b1 \u03b4\u03c9\u03bc\u03b1\u03c4\u03af\u03bf\u03c5, <strong>below 25&deg;C<\/strong>, in the original blister pack, protected from light and moisture.<\/li>\n<li>Keep out of reach of children &mdash; azathioprine is cytotoxic and dangerous if swallowed by a child or pet.<\/li>\n<li>Do not use after the expiry date on the pack.<\/li>\n<li>Return unused tablets to a pharmacy as cytotoxic waste &mdash; do not put in household rubbish or flush.<\/li>\n<li>Wash hands after handling. Carers should use gloves if handling broken tablets, particularly if pregnant or breastfeeding.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u039b\u03cd\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf MedsBase<\/h2>\n<p>Other medications used in anti-inflammatory and autoimmune care stocked alongside this product:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/barinat\/\"><strong>Barinat (baricitinib 2 \/ 4 mg) \u2014 JAK1\/2 inhibitor for RA<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/tofe\/\"><strong>Tofe (tofacitinib 5 mg) \u2014 JAK1\/3 inhibitor for RA, UC, PsA<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/lefuheal\/\"><strong>Lefuheal (leflunomide) \u2014 oral DMARD for rheumatoid arthritis<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/conimune-me\/\"><strong>Conimune ME (cyclosporine) \u2014 calcineurin inhibitor<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/wysolone\/\"><strong>Wysolone (prednisolone 5 \/ 10 \/ 20 mg) \u2014 oral corticosteroid<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/medrol\/\"><strong>Medrol (methylprednisolone 4 \/ 8 \/ 16 mg) \u2014 oral corticosteroid<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/predniheal\/\"><strong>Predniheal (prednisolone) \u2014 oral corticosteroid<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/hisone\/\"><strong>Hisone (hydrocortisone) \u2014 physiologic replacement steroid<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/budez-cr\/\"><strong>Budez CR (budesonide) \u2014 gut-targeted corticosteroid for Crohn&#39;s<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/kenacort\/\"><strong>Kenacort (triamcinolone) \u2014 systemic corticosteroid<\/strong><\/a><\/li>\n<\/ul>\n<p>Explore the full <a href=\"https:\/\/medsbase.com\/el\/anti-inflammatory-autoimmune-care\/\">\u0391\u03bd\u03c4\u03b9\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 &amp; \u0391\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03a6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1<\/a> \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1.<\/p>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3 class=\"wp-block-heading\">Why do I need TPMT testing before starting Azoran?<\/h3>\n<p>Thiopurine methyltransferase (TPMT) is the enzyme that detoxifies the active metabolite of azathioprine. Around 1 in 300 people of European ancestry have NO functional TPMT at all (homozygous deficiency), and about 10% have reduced activity (heterozygous). At the standard dose, a TPMT-deficient patient will develop catastrophic, life-threatening bone-marrow suppression within weeks. TPMT testing &mdash; either genotype or enzyme-activity assay &mdash; identifies these patients before they take the first tablet. NUDT15 testing is additionally important for Asian, Hispanic and African-ancestry patients, who have a different high-risk variant.<\/p>\n<h3 class=\"wp-block-heading\">When will Azoran start working?<\/h3>\n<p>Azathioprine is slow. Clinical effect takes <strong>8&ndash;16 weeks<\/strong> to be evident. During this induction window you will usually remain on corticosteroids or another rapid-onset drug for disease control. Do not expect to feel different in the first 4 weeks &mdash; and do not stop azathioprine because it &ldquo;does not seem to be working&rdquo; during the first month.<\/p>\n<h3 class=\"wp-block-heading\">Why is allopurinol so dangerous with Azoran?<\/h3>\n<p>Allopurinol blocks xanthine oxidase, one of the three enzymes that metabolise 6-MP (azathioprine&#39;s active form). With xanthine oxidase blocked, more 6-MP is shunted into the active cytotoxic pathway &mdash; levels rise sharply and severe bone-marrow failure can follow within weeks. If you are on azathioprine and need urate-lowering therapy, either (a) reduce the azathioprine dose to 25&ndash;33% of normal AND monitor CBC weekly, (b) switch to a non-XO urate-lowering drug (lesinurad, probenecid), or (c) stop the azathioprine temporarily. This is the single most dangerous drug interaction on azathioprine.<\/p>\n<h3 class=\"wp-block-heading\">What blood tests do I need on Azoran?<\/h3>\n<p>Full blood count and liver function tests at weeks 1, 2, 4, 8, 12, then every 3 months indefinitely. More frequent (weekly for 4 weeks) when starting any new medication, particularly allopurinol or co-trimoxazole. Any drop in WBC below 3.0 &times; 10&#038;sup9;\/L or ANC below 1.5, or any rise in ALT above 3&times; upper limit of normal, requires prescriber review and usually dose reduction or interruption.<\/p>\n<h3 class=\"wp-block-heading\">Can I become pregnant on Azoran?<\/h3>\n<p>Azathioprine is generally considered compatible with pregnancy for maternal autoimmune disease &mdash; the drug passes into the fetus, but the liver of the early fetus lacks the enzymes to activate it to 6-TGN, so fetal exposure to the active form is limited. This is very different from mycophenolate, which is strongly teratogenic and absolutely contraindicated in pregnancy. Many rheumatologists, IBD specialists and transplant physicians continue azathioprine through pregnancy because the risks of uncontrolled maternal disease outweigh the drug risk. Discuss with your specialist at least 3 months before planned conception. Effective contraception is not mandatory, but shared decision-making is.<\/p>\n<h3 class=\"wp-block-heading\">Why am I more prone to infections and skin cancer on Azoran?<\/h3>\n<p>Azathioprine suppresses lymphocytes generally, so your ability to respond to bacterial, viral and fungal infections is reduced &mdash; particularly herpes zoster reactivation. It also specifically impairs DNA repair in UV-damaged skin cells, substantially raising the risk of squamous and basal cell skin cancers (typically seen after 5+ years of treatment). Daily SPF 50 sun protection, sun-protective clothing, avoiding sunbeds, and annual dermatology review all meaningfully reduce this risk.<\/p>\n<h3 class=\"wp-block-heading\">What do I do if I get a severe sore throat or fever on Azoran?<\/h3>\n<p>Stop Azoran immediately and get an urgent full blood count. Unexplained fever, severe sore throat, mouth ulcers, unusual bruising, bleeding gums or extreme fatigue are warning signs of bone-marrow suppression or severe infection. Any of these in a patient on azathioprine is treated as an emergency until a normal CBC rules it out. Restart azathioprine only after review by the prescriber.<\/p>\n<h3 class=\"wp-block-heading\">Can I have live vaccines while on Azoran?<\/h3>\n<p>No. Live vaccines &mdash; MMR, varicella, yellow fever, BCG, live Zostavax shingles vaccine, live nasal flu &mdash; are contraindicated during azathioprine treatment and for 3 months after stopping. Plan all these before starting. <strong>Inactivated vaccines are fine and recommended<\/strong>: annual flu jab, pneumococcal, COVID-19, recombinant Shingrix, HPV. The recombinant Shingrix (not the older live Zostavax) is the correct shingles vaccine on immunosuppressants.<\/p>\n<h3 class=\"wp-block-heading\">How long will I stay on Azoran?<\/h3>\n<p>For most autoimmune and inflammatory conditions, azathioprine is a long-term maintenance treatment &mdash; often 2&ndash;10 years, sometimes indefinitely, depending on disease control and alternative options. For transplant indications, lifelong. Your specialist will periodically review whether continuation is still needed. Never stop azathioprine abruptly without specialist input &mdash; disease flare is common and can be severe.<\/p>\n<h3 class=\"wp-block-heading\">\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p>Azoran is supplied through a WHO-GMP certified manufacturer with full COA documentation. We ship worldwide in plain, discreet packaging, and every order is covered by our <a href=\"\/el\/medsbase-re-shipment-assurance-policy\/\">\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/a>. \u039f \u03c4\u03af\u03c4\u03bb\u03bf\u03c2 \u03c7\u03c1\u03ad\u03c9\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ba\u03ac\u03c1\u03c4\u03b1 \u03c3\u03b1\u03c2 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03b9 \u03c4\u03bf\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd (\u03ad\u03bd\u03b1\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1), \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Other Anti-Inflammatory &amp; Autoimmune Medications<\/h3>\n<p>If Azoran does not suit your situation, the following options are available in this category:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/lefuheal\/\">Lefuheal (Leflunomide 10\/20 mg) \u2014 pyrimidine synthesis inhibitor<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/conimune-me\/\">Conimune ME (Cyclosporine 25\/50\/100 mg) \u2014 calcineurin inhibitor<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/barinat\/\">Barinat (Baricitinib 2\/4 mg) \u2014 selective JAK1\/JAK2 inhibitor<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/tofe\/\">Tofe (Tofacitinib 5 mg) \u2014 pan-JAK inhibitor<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/wysolone\/\">Wysolone (Prednisolone 5\/10\/20 mg) \u2014 bridging corticosteroid<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Immune system modulation<br \/>\n\u2705 Reduces inflammation<br \/>\n\u2705 Prevents organ rejection<br \/>\n\u2705 Treats autoimmune diseases<br \/>\n\u2705 Long-term management<\/p>\n<p>Azoran contains Azathioprine.<\/p>","protected":false},"featured_media":55738,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3897,3141,3223],"product_tag":[3973,3974],"class_list":{"0":"post-55737","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-inflammatory-autoimmune-care","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-azathioprine","10":"product_tag-azoran","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/55737","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=55737"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/55738"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=55737"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=55737"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=55737"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=55737"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}