{"id":55940,"date":"2024-02-07T05:46:49","date_gmt":"2024-02-07T05:46:49","guid":{"rendered":"https:\/\/medsname.com\/bupron-xl\/"},"modified":"2026-04-30T10:24:42","modified_gmt":"2026-04-30T10:24:42","slug":"bupron-xl","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/bupron-xl\/","title":{"rendered":"Bupron XL"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Bupron XL?<\/h3>\n<p style=\"margin:0;\"><strong>Bupron XL<\/strong> is an extended-release <strong>bupropion hydrochloride<\/strong> \u03b4\u03b9\u03c3\u03ba\u03af\u03bf \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 <strong>major depressive disorder (MDD)<\/strong>, <strong>seasonal affective disorder (SAD)<\/strong>, and as an aid to <strong>smoking cessation<\/strong>. Available in <strong>150&nbsp;mg and 300&nbsp;mg<\/strong> strengths for once-daily dosing. Unlike SSRIs, bupropion does <strong>not cause sexual dysfunction or weight gain<\/strong>, and often <strong>reduces appetite<\/strong>. Manufactured as a generic equivalent of GSK&#8217;s Wellbutrin XL<sup>\u00ae<\/sup> and Zyban<sup>\u00ae<\/sup>.<\/p>\n<\/div>\n<p><strong>Bupron XL<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 <strong>extended-release bupropion hydrochloride<\/strong> \u03b4\u03b9\u03c3\u03ba\u03af\u03bf \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 <strong>depression<\/strong> and to help people <strong>quit smoking<\/strong>. Each tablet contains 150 mg or 300 mg of bupropion in an extended-release matrix designed to deliver once-daily dosing over 24 hours. Manufactured by Sun Pharma, Bupron XL is the generic equivalent of GSK&#8217;s <strong>Wellbutrin XL<sup>\u00ae<\/sup><\/strong> (for depression) and <strong>Zyban<sup>\u00ae<\/sup><\/strong> (for smoking cessation) &mdash; at a fraction of the price.<\/p>\n<p>Bupropion is an <strong>atypical antidepressant<\/strong> classified as a <strong>norepinephrine-dopamine reuptake inhibitor (NDRI)<\/strong>. It stands apart from SSRIs because it has a distinctive side-effect profile: no sexual dysfunction, no weight gain (and often mild weight loss), minimal sedation, and a modest stimulant-like effect in many patients.<\/p>\n<h2 class=\"wp-block-heading\">What Is Bupron XL?<\/h2>\n<p>Bupron XL is a prescription <strong>NDRI<\/strong> that selectively inhibits reuptake of <strong>norepinephrine (noradrenaline)<\/strong> \u03ba\u03b1\u03b9 <strong>dopamine<\/strong> in central nervous system neurons. Unlike SSRIs, bupropion has little effect on serotonin &mdash; which is what explains its clean profile on sexual function, weight, and sleep.<\/p>\n<p>Bupron XL is most commonly used for:<\/p>\n<ul>\n<li><strong>Major depressive disorder (MDD)<\/strong> &mdash; including depression not responding to or not tolerated with SSRIs<\/li>\n<li><strong>Seasonal affective disorder (SAD)<\/strong> &mdash; preventing depressive episodes in autumn\/winter in people with a history of SAD<\/li>\n<li><strong>Smoking cessation<\/strong> &mdash; reduces cravings and withdrawal; doubles quit rates vs placebo<\/li>\n<li><strong>Adjunct in sexual dysfunction caused by SSRIs<\/strong> &mdash; off-label, but widely used to counteract SSRI-induced anorgasmia and low libido<\/li>\n<li><strong>Adult ADHD<\/strong> &mdash; off-label, an evidence-supported alternative for adults who cannot take stimulants<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">How Does Bupron XL Work?<\/h2>\n<p>Bupropion acts as a <strong>selective norepinephrine and dopamine reuptake inhibitor<\/strong> at central synapses:<\/p>\n<ul>\n<li>It blocks the <strong>norepinephrine transporter (NET)<\/strong> \u03ba\u03b1\u03b9 <strong>dopamine transporter (DAT)<\/strong>, raising synaptic concentrations of both monoamines<\/li>\n<li>This increases activity in brain regions associated with <strong>drive, motivation, reward, and attention<\/strong> &mdash; particularly the prefrontal cortex and mesolimbic system<\/li>\n<li>Bupropion and its active metabolite <strong>hydroxybupropion<\/strong> also non-competitively block nicotinic acetylcholine receptors, which explains its usefulness for smoking cessation<\/li>\n<li>It has <strong>almost no effect on serotonin<\/strong>, which is why sexual function, weight, and sleep are typically preserved<\/li>\n<\/ul>\n<p>Onset of antidepressant effect is usually noticeable within <strong>2 weeks<\/strong> and full effect within <strong>4\u20136 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/strong>. For smoking cessation, Bupron XL is started <strong>1&ndash;2 weeks before the planned quit day<\/strong>, because steady-state drug levels take that long to build up.<\/p>\n<h2 class=\"wp-block-heading\">\u03a7\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li><strong>Major depressive disorder (MDD)<\/strong> &mdash; first-line in many guidelines, particularly for patients who cannot tolerate SSRI sexual or weight side effects<\/li>\n<li><strong>Seasonal affective disorder (SAD)<\/strong> &mdash; preventive use starting in late summer \/ early autumn before seasonal dip<\/li>\n<li><strong>Smoking cessation<\/strong> &mdash; 7&ndash;12 week courses; can be combined with nicotine replacement therapy (NRT)<\/li>\n<li><strong>\u03a3\u03b5\u03be\u03bf\u03c5\u03b1\u03bb\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc SSRI<\/strong> &mdash; added at 150&ndash;300 mg daily to an existing SSRI<\/li>\n<li><strong>Adult ADHD<\/strong> &mdash; off-label for patients where stimulants are contraindicated or poorly tolerated<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Bupron XL Dosage and Administration<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u0395\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/th>\n<th>Starter Dose<\/th>\n<th>Target \/ Max Dose<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Major depressive disorder<\/strong><\/td>\n<td>150 mg once daily (morning) &times; 4 days<\/td>\n<td>300 mg once daily; max 450 mg\/day in divided doses<\/td>\n<\/tr>\n<tr>\n<td><strong>Seasonal affective disorder<\/strong><\/td>\n<td>150 mg once daily for 7 days starting in autumn<\/td>\n<td>300 mg once daily through winter; taper in spring<\/td>\n<\/tr>\n<tr>\n<td><strong>Smoking cessation<\/strong><\/td>\n<td>150 mg once daily for 3 days<\/td>\n<td>150 mg twice daily (or 300 mg XL once daily) for 7&ndash;12 weeks<\/td>\n<\/tr>\n<tr>\n<td><strong>Elderly or low body weight<\/strong><\/td>\n<td>150 mg alternate days initially<\/td>\n<td>Titrate to response; lower ceiling<\/td>\n<\/tr>\n<tr>\n<td><strong>Mild&ndash;moderate hepatic impairment<\/strong><\/td>\n<td>Reduce dose and \/ or frequency<\/td>\n<td>Close monitoring<\/td>\n<\/tr>\n<tr>\n<td><strong>\u03a3\u03bf\u03b2\u03b1\u03c1\u03ae \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 (Child-Pugh C)<\/strong><\/td>\n<td>150 mg every other day<\/td>\n<td>Max 150 mg every other day<\/td>\n<\/tr>\n<tr>\n<td><strong>\u039d\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1<\/strong><\/td>\n<td>Consider lower starter dose<\/td>\n<td>Active metabolites accumulate<\/td>\n<\/tr>\n<tr>\n<td><strong>\u039c\u03ad\u03b3\u03b9\u03c3\u03c4\u03b7 \u03b7\u03bc\u03b5\u03c1\u03ae\u03c3\u03b9\u03b1 \u03b4\u03cc\u03c3\u03b7<\/strong><\/td>\n<td>450 mg (in divided IR doses only)<\/td>\n<td>XL formulations: max 300 mg once daily<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3 class=\"wp-block-heading\">How to Take Bupron XL Properly<\/h3>\n<ul>\n<li>Swallow the tablet <strong>whole<\/strong> &mdash; do NOT crush, chew, or split the XL tablet. Breaking the matrix releases the full dose at once and raises seizure risk<\/li>\n<li>\u03a0\u03ac\u03c1\u03c4\u03b5 <strong>in the morning<\/strong> &mdash; evening dosing can cause insomnia<\/li>\n<li>\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bb\u03b7\u03c6\u03b8\u03b5\u03af \u03bc\u03b5 \u03ae \u03c7\u03c9\u03c1\u03af\u03c2 \u03c4\u03c1\u03bf\u03c6\u03ae<\/li>\n<li>\u0395\u03c0\u03b9\u03c4\u03c1\u03ad\u03c8\u03c4\u03b5 <strong>2 weeks<\/strong> for early antidepressant response and <strong>4\u20136 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/strong> for full effect<\/li>\n<li>\u0393\u03b9\u03b1 <strong>smoking cessation<\/strong>, set a quit date and start Bupron XL <strong>1&ndash;2 weeks before<\/strong> that date<\/li>\n<li>\u039a\u03ac\u03bd\u03c4\u03b5 <strong>not stop abruptly<\/strong> after long-term use &mdash; taper over 2&ndash;4 weeks under medical supervision<\/li>\n<li>\u0395\u03c0\u03b9\u03c4\u03c1\u03ad\u03c8\u03c4\u03b5 <strong>14 days<\/strong> between stopping an MAOI and starting bupropion, and vice versa<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Side Effects of Bupron XL<\/h2>\n<p>Bupropion has a distinctive side-effect profile &mdash; fewer sexual and weight side effects than SSRIs, but more activation, insomnia, and seizure risk if not dosed correctly.<\/p>\n<table>\n<thead>\n<tr>\n<th>\u0392\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1<\/th>\n<th>\u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 (\u22651 \u03c3\u03c4\u03bf\u03c5\u03c2 10)<\/strong><\/td>\n<td>Dry mouth, insomnia, headache, nausea<\/td>\n<\/tr>\n<tr>\n<td><strong>\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 (\u22651 \u03c3\u03c4\u03bf\u03c5\u03c2 100)<\/strong><\/td>\n<td>Agitation, anxiety, tremor, dizziness, constipation, sweating, tinnitus, blurred vision, taste changes, reduced appetite \/ mild weight loss<\/td>\n<\/tr>\n<tr>\n<td><strong>\u0391\u03c3\u03c5\u03bd\u03ae\u03b8\u03b9\u03c3\u03c4\u03b5\u03c2<\/strong><\/td>\n<td>Tachycardia, raised blood pressure, rash, urticaria, palpitations<\/td>\n<\/tr>\n<tr>\n<td><strong>\u03a3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b1\u03bb\u03bb\u03ac \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae<\/strong><\/td>\n<td>Seizures (dose-dependent), serum-sickness-like syndrome, Stevens-Johnson syndrome, severe hypertension, suicidal ideation (especially in young adults), psychosis or mania in susceptible patients<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Seizure risk is the most important dose-related side effect.<\/strong> At doses up to 300 mg XL daily, incidence is about 0.1% &mdash; comparable to other antidepressants. Above 450 mg\/day or with crushed\/split tablets, risk rises sharply. Never exceed recommended dose and never split or crush the XL form.<\/p>\n<h2 class=\"wp-block-heading\">\u03a0\u03c1\u03bf\u03b5\u03b9\u03b4\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03ac\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li><strong>Seizure risk<\/strong> is dose-related. Do not exceed 300 mg XL once daily (or 450 mg total daily if using IR). Avoid in patients with any history of seizures, brain injury, or factors that lower seizure threshold<\/li>\n<li><strong>Suicidal thoughts.<\/strong> Like all antidepressants, bupropion carries a black-box warning for suicidal ideation in patients under 25. Monitor closely in the first 2&ndash;4 weeks of treatment and after any dose change<\/li>\n<li><strong>Neuropsychiatric symptoms in smoking cessation.<\/strong> Cases of agitation, depressed mood, and rarely psychosis have been reported. Patients should be warned to report such symptoms promptly<\/li>\n<li><strong>Hypertension.<\/strong> Check blood pressure before starting and at follow-up; can cause modest BP rise, especially when combined with nicotine replacement therapy<\/li>\n<li><strong>Activation \/ anxiety \/ insomnia.<\/strong> Start at 150 mg; if insomnia is prominent, take earlier in the day or consider short-term hypnotic support<\/li>\n<li><strong>\u0391\u03bb\u03ba\u03bf\u03cc\u03bb.<\/strong> Avoid heavy drinking &mdash; alcohol lowers seizure threshold and can trigger neuropsychiatric effects<\/li>\n<li><strong>Pregnancy \/ breastfeeding.<\/strong> Use only if benefits clearly outweigh risks. Bupropion passes into breast milk in small amounts<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Contraindications &mdash; Who Should NOT Take Bupron XL<\/h2>\n<ul>\n<li><strong>Any history of seizure disorder<\/strong><\/li>\n<li><strong>Current or past bulimia or anorexia nervosa<\/strong> &mdash; higher seizure risk in electrolyte-disturbed patients<\/li>\n<li><strong>Acute alcohol or benzodiazepine withdrawal<\/strong><\/li>\n<li><strong>\u03a7\u03c1\u03ae\u03c3\u03b7 MAOI \u03c4\u03b9\u03c2 \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b5\u03c2 14 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2<\/strong> (including linezolid, methylene blue)<\/li>\n<li><strong>Use of another bupropion-containing product<\/strong> (additive seizure risk)<\/li>\n<li><strong>\u03a3\u03bf\u03b2\u03b1\u03c1\u03ae \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1<\/strong> (unless dose-reduced per specialist)<\/li>\n<li>Known hypersensitivity to bupropion or any excipient<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03a6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u03a6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \/ \u03a4\u03ac\u03be\u03b7<\/th>\n<th>\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>MAOIs (phenelzine, tranylcypromine, moclobemide, linezolid)<\/strong><\/td>\n<td><strong>\u0391\u03c0\u03cc\u03bb\u03c5\u03c4\u03b7 \u03b1\u03bd\u03c4\u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7<\/strong> &mdash; serotonergic\/noradrenergic crisis risk. 14-day washout either direction<\/td>\n<\/tr>\n<tr>\n<td><strong>Other seizure-threshold-lowering drugs<\/strong> (tramadol, theophylline, systemic steroids, antipsychotics)<\/td>\n<td>Additive seizure risk &mdash; use cautiously<\/td>\n<\/tr>\n<tr>\n<td><strong>CYP2B6 inhibitors (ticlopidine, clopidogrel)<\/strong><\/td>\n<td>Increase bupropion levels &mdash; may need dose reduction<\/td>\n<\/tr>\n<tr>\n<td><strong>CYP2B6 inducers (carbamazepine, phenytoin, rifampicin, ritonavir)<\/strong><\/td>\n<td>Lower bupropion levels &mdash; may reduce efficacy<\/td>\n<\/tr>\n<tr>\n<td><strong>CYP2D6 substrates (tamoxifen, codeine, beta-blockers, many antidepressants, atomoxetine)<\/strong><\/td>\n<td>Bupropion is a <strong>strong CYP2D6 inhibitor<\/strong> &mdash; substrates accumulate. Clinically important with tamoxifen (reduces efficacy) and codeine (reduces analgesia)<\/td>\n<\/tr>\n<tr>\n<td><strong>Nicotine patches \/ gum \/ varenicline<\/strong><\/td>\n<td>Can be combined for smoking cessation &mdash; monitor blood pressure<\/td>\n<\/tr>\n<tr>\n<td><strong>\u0391\u03bb\u03ba\u03bf\u03cc\u03bb<\/strong><\/td>\n<td>Lowers seizure threshold &mdash; limit strictly<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Always share a full list of prescription and non-prescription medications, including recreational drugs, herbal supplements, and nicotine products, with your prescriber before starting Bupron XL.<\/p>\n<h2 class=\"wp-block-heading\">\u03a4\u03b9 \u03bd\u03b1 \u039a\u03ac\u03bd\u03b5\u03c4\u03b5 \u03c3\u03b5 \u03a0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03a5\u03c0\u03b5\u03c1\u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2<\/h2>\n<p>Bupropion overdose can cause seizures, cardiac conduction abnormalities, severe hypertension, and altered consciousness. There is no specific antidote &mdash; management is supportive with airway protection, benzodiazepines for seizures, and cardiac monitoring. Contact your local poisons service or emergency department immediately if overdose is suspected.<\/p>\n<h2 class=\"wp-block-heading\">\u039f\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7\u03c2<\/h2>\n<ul>\n<li>Store below 25&nbsp;&deg;C in a dry place, away from direct sunlight<\/li>\n<li>\u0394\u03b9\u03b1\u03c4\u03b7\u03c1\u03ae\u03c3\u03c4\u03b5 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u03c6\u03c5\u03c3\u03b1\u03bb\u03af\u03b4\u03c9\u03bd<\/li>\n<li>\u039c\u03b1\u03ba\u03c1\u03b9\u03ac \u03b1\u03c0\u03cc \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac<\/li>\n<li>\u039c\u03b7\u03bd \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b5 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03b7\u03bc\u03b5\u03c1\u03bf\u03bc\u03b7\u03bd\u03af\u03b1 \u03bb\u03ae\u03be\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03b3\u03c1\u03ac\u03c6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1<\/li>\n<li>\u0391\u03c0\u03bf\u03c1\u03c1\u03af\u03c8\u03c4\u03b5 \u03c4\u03b1 \u03b1\u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03af\u03b7\u03c4\u03b1 \u03b4\u03b9\u03c3\u03ba\u03af\u03b1 \u03bc\u03ad\u03c3\u03c9 \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae\u03c2 \u03c3\u03b5 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03af\u03bf, \u03cc\u03c0\u03bf\u03c5 \u03b1\u03c5\u03c4\u03cc \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u039b\u03cd\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf MedsBase<\/h2>\n<p>Looking for related antidepressant or smoking-cessation options?<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/champix\/\" rel=\"noopener\">Champix<\/a> &mdash; varenicline, another smoking-cessation option that works on nicotinic receptors<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/mirtaz\/\" rel=\"noopener\">Mirtaz<\/a> &mdash; mirtazapine, an atypical antidepressant with strong sleep and appetite effects (counter-profile to bupropion)<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/sertima\/\" rel=\"noopener\">Sertima<\/a> &mdash; sertraline, a common SSRI; often considered alongside bupropion or combined with it<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/mental-health-and-psychiatric-medications\/\" rel=\"noopener\">Browse all Mental Health medications &rarr;<\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3 class=\"wp-block-heading\">How long does Bupron XL take to work?<\/h3>\n<p>For depression, most people notice an early response within <strong>2 weeks<\/strong> (energy, concentration, appetite) with full antidepressant effect by <strong>4\u20136 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/strong>. For smoking cessation, the craving-reduction effect is usually present by the quit day, which is why treatment starts <strong>1&ndash;2 weeks before<\/strong> quitting.<\/p>\n<h3 class=\"wp-block-heading\">Does Bupron XL cause sexual side effects?<\/h3>\n<p><strong>\u038c\u03c7\u03b9<\/strong> &mdash; this is one of bupropion&#8217;s defining advantages over SSRIs. Bupropion has minimal effect on serotonin and preserves libido, arousal, and orgasm. It is often prescribed specifically to counter SSRI-induced sexual dysfunction.<\/p>\n<h3 class=\"wp-block-heading\">Does Bupron XL cause weight gain?<\/h3>\n<p><strong>\u038c\u03c7\u03b9<\/strong> &mdash; and in many patients it produces mild weight loss (typically 2&ndash;5 lb \/ 1&ndash;2 kg). It reduces appetite in the early weeks and does not cause the metabolic weight gain seen with SSRIs, tricyclics, or mirtazapine.<\/p>\n<h3 class=\"wp-block-heading\">Is Bupron XL the same as Wellbutrin and Zyban?<\/h3>\n<p>Yes in active ingredients &mdash; Bupron XL is bupropion hydrochloride extended-release, identical to Wellbutrin XL<sup>\u00ae<\/sup> (for depression) and to Zyban<sup>\u00ae<\/sup> (for smoking cessation; usually the shorter-acting SR formulation). Clinically equivalent, much lower price.<\/p>\n<h3 class=\"wp-block-heading\">Can I split or crush Bupron XL tablets?<\/h3>\n<p><strong>No, never.<\/strong> The extended-release matrix is essential. Breaking, crushing, or chewing the tablet releases the full dose at once and sharply raises seizure risk.<\/p>\n<h3 class=\"wp-block-heading\">Can I combine Bupron XL with an SSRI?<\/h3>\n<p>Yes &mdash; this combination is common in clinical practice for patients who respond partially to SSRIs but have residual low energy, motivation, or sexual dysfunction. Serotonin syndrome risk is very low because bupropion has little serotonergic activity.<\/p>\n<h3 class=\"wp-block-heading\">How do I use Bupron XL for smoking cessation?<\/h3>\n<p>Set a quit date 1&ndash;2 weeks ahead. Start Bupron XL at 150 mg once daily for 3 days, then 150 mg twice daily (or 300 mg XL once daily). Continue for <strong>7&ndash;12 weeks<\/strong> total. Can be combined with nicotine replacement therapy (patches, gum, lozenges) for higher quit rates. If you have not stopped smoking by 7 weeks, the course can be extended.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol on Bupron XL?<\/h3>\n<p>Heavy drinking should be avoided &mdash; it lowers seizure threshold and can trigger neuropsychiatric side effects. <strong>Acute alcohol withdrawal while on bupropion is dangerous<\/strong> because seizure risk compounds. Moderate social drinking is usually tolerated, but discuss with your prescriber.<\/p>\n<h3 class=\"wp-block-heading\">What is the difference between Bupron SR and Bupron XL?<\/h3>\n<p>Both contain bupropion HCl, but differ in release profile. <strong>SR (sustained-release)<\/strong> is given twice daily. <strong>XL (extended-release)<\/strong> is once daily. XL is the preferred form for convenience and smoother plasma levels.<\/p>\n<h3 class=\"wp-block-heading\">Is Bupron XL addictive?<\/h3>\n<p><strong>\u038c\u03c7\u03b9<\/strong> &mdash; bupropion is not addictive and has no abuse potential despite its dopaminergic effect, because the increase in extracellular dopamine is modest and slow. It is not a controlled substance in most jurisdictions.<\/p>\n<h3 class=\"wp-block-heading\">Can I stop Bupron XL suddenly?<\/h3>\n<p>Short courses (e.g. the 7&ndash;12 week smoking-cessation course) can usually be stopped without tapering. For depression treatment lasting several months, <strong>taper over 2&ndash;4 weeks<\/strong> to minimise return of low mood or withdrawal-like symptoms. Discuss the taper with your prescriber.<\/p>\n<p><!-- medsbase-faq-h3-converted --><\/p>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong> \u03a0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2 WHO-GMP \u00b7 \u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u00b7 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u00b7 1,400+ \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 <a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\"><strong>\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n<h3>\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p>Bupron XL at MedsBase is supplied directly from a WHO-GMP certified manufacturer in plain, discreet packaging. Every order is covered by our <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\">\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/a> \u2014 \u03c0\u03b1\u03c1\u03ac\u03b8\u03c5\u03c1\u03bf \u03ac\u03c6\u03b9\u03be\u03b7\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd \u03ae \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u03c7\u03c9\u03c1\u03af\u03c2 \u03c7\u03c1\u03ad\u03c9\u03c3\u03b7 \u2014 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03ba\u03b1\u03b9\u03bf\u03cd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03c3\u03c4\u03bf <a href=\"https:\/\/medsbase.com\/el\/loyalty-points\/\">\u03c0\u03c1\u03cc\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 \u03b1\u03c6\u03bf\u03c3\u03af\u03c9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a>. \u0394\u03b9\u03b1\u03c4\u03af\u03b8\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u03c3\u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c0\u03c1\u03bf\u03bf\u03c1\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2<\/h3>\n<p>\u0386\u03bb\u03bb\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 \u03c3\u03b5 <strong>\u0393\u03b5\u03bd\u03b9\u03ba\u03ae \u03a5\u03b3\u03b5\u03af\u03b1<\/strong> \u03c0\u03bf\u03c5 \u03bf\u03b9 \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/erythromycin\/\">\u0395\u03c1\u03c5\u03b8\u03c1\u03bf\u03bc\u03c5\u03ba\u03af\u03bd\u03b7<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/orzine\/\">Orzine<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/reglan\/\">Reglan<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/dulcoflex\/\">Dulcoflex<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/lurakem\/\">Lurakem<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Bupron XL (Bupropion 150\/300 mg XL) \u2014 NDRI antidepressant for major depression and smoking cessation. once-daily XL \u2014 no sexual dysfunction, weight-neutral.<\/p>","protected":false},"featured_media":55941,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3906],"product_tag":[5684,4015,4014,5677,5681,5682,5683,5680,5678,5679],"class_list":{"0":"post-55940","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-mental-health-and-psychiatric-medications","9":"product_tag-atypical-antidepressant","10":"product_tag-bupron-xl","11":"product_tag-bupropion","12":"product_tag-bupropion-hcl","13":"product_tag-major-depression","14":"product_tag-mdd","15":"product_tag-ndri","16":"product_tag-smoking-cessation","17":"product_tag-wellbutrin-generic","18":"product_tag-zyban","20":"first","21":"instock","22":"shipping-taxable","23":"purchasable","24":"product-type-variable","25":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/55940","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=55940"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/55941"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=55940"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=55940"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=55940"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=55940"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}