<\/p>\n
App-Up<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03bc\u03ac\u03c1\u03ba\u03b1 cyproheptadine hydrochloride<\/strong> (4 mg), a first-generation (sedating) oral antihistamine<\/strong> of the piperidine class (also a serotonin 5-HT2<\/sub> antagonist). Used for allergic rhinitis, urticaria (hives), itchy skin, insect-bite reactions, and mild allergic reactions<\/strong>. Onset: 30–60 minutes; duration: 4–6 hours — so doses are typically spread 2–3 times daily. A dual H1 + 5-HT2<\/sub> antagonist<\/strong>. Strongest anti-itch effect of the 1st-gen antihistamines, but with prominent sedation, appetite stimulation, and weight gain. Widely used in India, Latin America, and Asia — less common in Western countries, where 2nd-generation antihistamines dominate. Causes drowsiness<\/strong> in most users — do not drive or operate machinery after a dose until you know how it affects you. Avoid in narrow-angle glaucoma, bladder-outflow obstruction, severe asthma attack, and in older adults where alternatives exist. Not a treatment for anaphylaxis — severe allergic reactions need adrenaline.<\/p>\n<\/div>\n \ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n \u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n App-Up is an oral antihistamine containing cyproheptadine hydrochloride<\/strong> (4 mg), manufactured by WHO-GMP certified manufacturer. Supplied in packs of 30, 60, 90 or 180 tablets. Originator brand: Periactin (Merck, 1961).<\/p>\n cyproheptadine hydrochloride belongs to the first-generation H1 antihistamine class<\/strong> — the original antihistamines developed in the 1940s and 50s. They are effective but, unlike newer agents, cross the blood-brain barrier readily, which causes sedation and anticholinergic side effects. First-generation antihistamines are still useful for acute allergic episodes, short-term night-time itch, and specialised uses (motion sickness, certain migraine protocols, appetite stimulation).<\/p>\n Allergic rhinitis, urticaria, itchy skin, serotonin syndrome<\/strong> (antidote use), cyproheptadine is also widely used off-label as an appetite stimulant<\/strong> in poor-appetite states and failure-to-thrive. Historically used in migraine prevention, carcinoid syndrome (for diarrhoea\/flushing), and SSRI-induced sexual dysfunction.<\/p>\n cyproheptadine hydrochloride blocks histamine H1 receptors<\/strong> throughout the body. Histamine is released from mast cells and basophils during allergic reactions and causes the classic symptoms: sneezing, runny nose, itchy eyes, vasodilation, urticaria, bronchoconstriction, and mucus secretion. Blocking H1 receptors interrupts these effects.<\/p>\n Unlike newer (2nd-generation) antihistamines, first-generation agents readily cross the blood-brain barrier and bind central H1 receptors — producing sedation. They also have appreciable affinity for muscarinic acetylcholine receptors<\/strong>, causing classic anticholinergic effects (dry mouth, urinary hesitancy, blurred vision, constipation). Cyproheptadine additionally blocks serotonin 5-HT2<\/sub> receptors<\/strong>, giving it unique uses in serotonin syndrome, carcinoid syndrome, and appetite stimulation.<\/p>\n \u0394\u03cc\u03c3\u03b7:<\/strong> Adults: 4 mg 3 times daily (usual range 4–20 mg\/day; max 32 mg\/day). Children 7–14: 4 mg 2–3 times daily. Children 2–6: 2 mg 2–3 times daily.<\/p>\n Sedation:<\/strong> Cyproheptadine is markedly sedating<\/strong> and commonly causes drowsiness. Most patients experience sedation at standard doses; tolerance may develop partially over 1–2 weeks.<\/p>\n Anticholinergic:<\/strong> Moderate — dry mouth, blurred vision, urinary hesitancy, constipation. Avoid in narrow-angle glaucoma, bladder-outflow obstruction, and elderly with falls risk.<\/p>\n \u0392\u03ac\u03c1\u03bf\u03c2:<\/strong> Significant appetite stimulation and weight gain<\/strong> are characteristic effects — cyproheptadine is routinely prescribed off-label as a weight-gain aid in children with anorexia or failure to thrive. Can be a desired or undesired effect depending on context.<\/p>\n Other common side effects:<\/strong><\/p>\n \u03a3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b1\u03bb\u03bb\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac:<\/strong><\/p>\n \u0395\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7:<\/strong> first-generation antihistamines have been used for decades with a reasonable safety record, but 2nd-generation agents (loratadine, cetirizine) are preferred first-line. Discuss with your obstetrician before starting.<\/p>\n \u0398\u03b7\u03bb\u03b1\u03c3\u03bc\u03cc\u03c2:<\/strong> 1st-generation antihistamines pass into breast milk and may sedate the infant. They can also reduce milk supply. Prefer loratadine or cetirizine when treatment is needed in a breastfeeding mother.<\/p>\n \u03a0\u03b1\u03b9\u03b4\u03b9\u03ac:<\/strong> age cutoffs in the Dosage section. Paradoxical excitation can occur in young children.<\/p>\n Store App-Up below 25°C in a dry place, in the original blister. Keep out of reach of children.<\/p>\n Yes — App-Up contains the active ingredient cyproheptadine hydrochloride. Bioequivalence to the originator brand (Periactin (Merck, 1961)) is required by regulatory authorities.<\/p>\n Yes — cyproheptadine is one of the most commonly prescribed off-label appetite stimulants in children with failure-to-thrive, poor appetite, or cachexia, and sometimes in adults. Typical dose is 2–4 mg 2–3 times daily; weight gain of 1–3 kg over 4–8 weeks is typical. It is not approved as a weight-gain agent<\/strong> in most countries, and the effect is driven by H1 blockade and serotonin antagonism in the hypothalamic appetite centre. Discuss with a doctor before using for this purpose.<\/p>\n Cyproheptadine is markedly sedating<\/strong> and commonly causes drowsiness. Most patients experience sedation at standard doses; tolerance may develop partially over 1–2 weeks. Plan your first dose for a time when you do not need to drive or operate machinery for at least 6–8 hours. Effect is dose-dependent; smaller split doses often cause less sedation than a single large dose.<\/p>\n First-generation antihistamines are generally not recommended for long-term daily use when 2nd-generation agents are available — the anticholinergic burden and sedation add up. For chronic hay fever or urticaria, switch to loratadine, cetirizine, or fexofenadine. Short courses are safe for acute episodes.<\/p>\n No. Alcohol and first-generation antihistamines both depress the central nervous system; combining them significantly increases drowsiness, impaired coordination, and risk of accidents.<\/p>\n Age cutoffs differ by formulation — see the dosage section. Paradoxical excitation (irritability, hyperactivity, trouble sleeping) is a recognised reaction in young children; if it occurs, stop and consult a doctor. For routine allergies in children, cetirizine or loratadine are preferred first-line.<\/p>\n You can order App-Up (4 mg) from MedsBase in packs of 30, 60, 90 or 180 tablets. We ship worldwide with discreet packaging and genuine WHO-GMP certified manufacturer stock.<\/p>\n <\/p>\n \u0386\u03bb\u03bb\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 \u03c3\u03b5 \u03a7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03a0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2<\/strong> \u03c0\u03bf\u03c5 \u03bf\u03b9 \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2:<\/p>\n \u2705 Boosts appetite App-Up contains Cyproheptadine.<\/p>","protected":false},"featured_media":56525,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3975],"product_tag":[4109,4110],"class_list":{"0":"post-56524","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-hay-fever-allergies-treatment","9":"product_tag-app-up","10":"product_tag-cyproheptadine","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/56524","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=56524"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/56525"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=56524"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=56524"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=56524"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=56524"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n
What Is App-Up?<\/h2>\n
What Is App-Up Used For?<\/h2>\n
How Does App-Up Work?<\/h2>\n
\u0394\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03a7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7<\/h2>\n
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\u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/h2>\n
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\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03a6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd<\/h2>\n
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Who Should Not Take App-Up?<\/h2>\n
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Use in Pregnancy and Children<\/h2>\n
\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/h2>\n
\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n
Is App-Up the same as cyproheptadine hydrochloride?<\/h3>\n
Is cyproheptadine used for weight gain?<\/h3>\n
How drowsy will App-Up make me?<\/h3>\n
Can I take App-Up every day?<\/h3>\n
Can I drink alcohol with App-Up?<\/h3>\n
Can I give App-Up to my child?<\/h3>\n
Where can I buy App-Up online?<\/h3>\n
Related Allergy Medications<\/h2>\n
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\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2<\/h3>\n
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\n\u2705 Enhances weight gain
\n\u2705 Manages allergies
\n\u2705 Relieves itching
\n\u2705 Treats migraine<\/p>\n