{"id":56585,"date":"2024-02-27T16:59:58","date_gmt":"2024-02-27T16:59:58","guid":{"rendered":"https:\/\/medsname.com\/dexona-tablet\/"},"modified":"2026-05-01T10:49:13","modified_gmt":"2026-05-01T10:49:13","slug":"dexona-tablet","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/dexona-tablet\/","title":{"rendered":"Dexona Tablet"},"content":{"rendered":"

<\/p>\n

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⚡ Quick Answer — What is Dexona Tablet?<\/h3>\n

Dexona Tablet<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 dexamethasone 0.5 mg oral tablet<\/strong>, a potent long-acting synthetic corticosteroid used for a wide range of inflammatory, allergic, autoimmune, and malignant conditions. It has 25 to 30 times<\/strong> the anti-inflammatory potency of hydrocortisone per milligram, no mineralocorticoid (salt-retaining) activity<\/strong>, and a long biological half-life (36–54 hours) allowing once-daily dosing. Usual doses range from 0.75 mg to 9 mg daily<\/strong> depending on indication. Always taken with food; do not stop abruptly after prolonged courses.<\/p>\n<\/div>\n

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\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n

\u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n

Dexona 0.5 mg<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b4\u03b9\u03c3\u03ba\u03ce\u03b4\u03b9\u03bf \u03b3\u03b9\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 dexamethasone<\/strong>, a synthetic long-acting glucocorticoid. Dexamethasone is on the WHO Essential Medicines List and is one of the most widely used corticosteroids in clinical practice, with applications ranging from cerebral oedema and anti-emetic cover during chemotherapy to allergic reactions, autoimmune disease, and (notably, since 2020) severe COVID-19.<\/p>\n

Compared with hydrocortisone and prednisolone, dexamethasone has three distinguishing pharmacological features:<\/p>\n

    \n
  • Very high glucocorticoid potency<\/strong> — 25–30× hydrocortisone<\/li>\n
  • No mineralocorticoid activity<\/strong> — does not cause fluid retention, does not help in adrenal crisis<\/li>\n
  • Long biological half-life (36–54 hours)<\/strong> — allows once-daily dosing<\/li>\n<\/ul>\n

    What Is Dexona Tablet Used For?<\/h2>\n
      \n
    • Cerebral oedema<\/strong> from primary or metastatic brain tumours<\/li>\n
    • Anti-emetic cover<\/strong> during chemotherapy (highly effective, often combined with 5-HT3 antagonists)<\/li>\n
    • Severe COVID-19<\/strong> requiring oxygen (RECOVERY trial 2020; 6 mg daily for up to 10 days)<\/li>\n
    • Severe acute allergic reactions<\/strong><\/li>\n
    • Autoimmune flares<\/strong> — SLE, rheumatoid arthritis, vasculitis, inflammatory bowel disease<\/li>\n
    • Acute severe asthma<\/strong> and severe COPD exacerbation (single 8–12 mg dose is effective in ED)<\/li>\n
    • Croup<\/strong> in children — a single 0.15–0.6 mg\/kg oral dose<\/li>\n
    • Antenatal use for fetal lung maturation<\/strong> (specialist obstetric use at risk of preterm delivery)<\/li>\n
    • Haematological malignancy<\/strong> — part of chemotherapy protocols (ALL, multiple myeloma)<\/li>\n
    • Bacterial meningitis<\/strong> — adjunct for reducing neurological sequelae<\/li>\n
    • Dexamethasone suppression test<\/strong> — diagnostic use for Cushing syndrome<\/li>\n<\/ul>\n

      How Does Dexamethasone Work?<\/h2>\n

      Dexamethasone binds to intracellular glucocorticoid receptors with high affinity. The activated receptor translocates to the nucleus and modulates gene transcription, producing broad anti-inflammatory, immunosuppressive, and metabolic effects. At therapeutic doses, dexamethasone suppresses cytokine production, reduces leukocyte trafficking to tissue, stabilises vascular permeability, and attenuates the inflammatory cascade.<\/p>\n

      Dexona Tablet Dosing<\/h2>\n
        \n
      • Mild inflammatory conditions:<\/strong> 0.75–3 mg\/day (1.5–6 tablets of 0.5 mg)<\/li>\n
      • Moderate conditions:<\/strong> 4–6 mg\/day<\/li>\n
      • Severe conditions, cerebral oedema, chemotherapy anti-emetic:<\/strong> 4–16 mg\/day (4 mg and 8 mg tablets — Decmax — are more practical at these doses)<\/li>\n
      • Croup (children):<\/strong> single oral dose of 0.15 mg\/kg (up to 0.6 mg\/kg)<\/li>\n
      • \u03a0\u03ac\u03c1\u03c4\u03b5 \u03bc\u03b5 \u03c6\u03b1\u03b3\u03b7\u03c4\u03cc<\/strong> to reduce gastric irritation<\/li>\n
      • \u03a0\u03c1\u03c9\u03b9\u03bd\u03ae \u03b4\u03cc\u03c3\u03b7<\/strong> (before 9 a.m.) mimics natural cortisol rhythm and reduces HPA-axis suppression<\/li>\n<\/ul>\n

        Corticosteroid Potency and Equivalence<\/h2>\n

        Different corticosteroids differ mainly in potency, duration of action, and mineralocorticoid (salt-retaining) activity. The table below gives the clinically useful equivalence — it lets you translate a dose of one steroid into the equivalent dose of another.<\/p>\n\n\n\n\n\n\n\n\n\n
        Corticosteroid<\/th>\nGlucocorticoid potency<\/th>\nEquivalent dose<\/th>\nMineralocorticoid<\/th>\n\u0394\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1<\/th>\n<\/tr>\n<\/thead>\n
        Hydrocortisone<\/td>\n1 (reference)<\/td>\n20 mg<\/td>\nSubstantial<\/td>\n8–12 h<\/td>\n<\/tr>\n
        Prednisolone<\/td>\n4<\/td>\n5 mg<\/td>\nLow<\/td>\n12–36 h<\/td>\n<\/tr>\n
        Methylprednisolone<\/td>\n5<\/td>\n4 mg<\/td>\n\u0395\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf<\/td>\n12–36 h<\/td>\n<\/tr>\n
        Dexamethasone<\/strong><\/td>\n25–30<\/td>\n0.75 mg<\/td>\nNone<\/td>\n36–54 h<\/td>\n<\/tr>\n
        Betamethasone<\/td>\n25–30<\/td>\n0.75 mg<\/td>\nNone<\/td>\n36–54 h<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

        Who Should Not Take Dexona?<\/h2>\n