{"id":57135,"date":"2024-02-27T17:25:45","date_gmt":"2024-02-27T17:25:45","guid":{"rendered":"https:\/\/medsname.com\/frusenex\/"},"modified":"2026-05-01T10:49:13","modified_gmt":"2026-05-01T10:49:13","slug":"frusenex","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/frusenex\/","title":{"rendered":"Frusenex"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Frusenex?<\/h3>\n<p style=\"margin:0;\"><strong>Frusenex<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 <strong>100 mg furosemide tablet<\/strong> from Sanofi-Aventis &mdash; a <strong>loop diuretic (sulfonamide derivative)<\/strong> \u03c0\u03bf\u03c5 \u03b4\u03c1\u03b1 \u03c3\u03c4\u03bf\u03bd <strong>NKCC2 (Na-K-2Cl cotransporter) in the thick ascending limb of the loop of Henle<\/strong>. Furosemide (frusemide in UK\/India nomenclature) was introduced by Hoechst in 1964 as <strong>Lasix<\/strong> &mdash; &#8220;Lasts Six hours,&#8221; the eponymous duration of its diuretic effect. The first loop diuretic and still the most prescribed, with extensive acute-hospital and outpatient use. Half-life 1-2 hours (short; diuretic effect fades within 6 hours); onset 30-60 minutes (PO) or 5 minutes (IV); peak effect 1-2 hours; duration 6-8 hours. Primary indication: <strong>heart-failure oedema, pulmonary oedema, ascites, oliguric acute kidney injury, hypercalcaemia, refractory hypertension (NOT first-line HTN)<\/strong>. \u03a4\u03c5\u03c0\u03b9\u03ba\u03ae \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1: <strong>Furosemide is NOT a first-line antihypertensive.<\/strong> It is too short-acting (6-hour effect) for once-daily BP control and the strong natriuresis causes blood pressure swings. Reserve for HTN with concurrent oedema, advanced CKD (eGFR &lt;30 where thiazides fail), or resistant hypertension. Key contraindications: see full list below. Monitor electrolytes, creatinine, and glucose. <strong>\u039c\u03b7\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03bb\u03af\u03b8\u03b9\u03bf<\/strong> (\u03c4\u03b1 \u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b9\u03b1\/\u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03b2\u03c1\u03cc\u03c7\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03bf\u03c5\u03bd \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bb\u03b9\u03b8\u03af\u03bf\u03c5). <strong>\u0397 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bd\u03ac \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7<\/strong> (\u03b2\u03bb. \u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7\u03c2). \u0393\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5\u03c2 \u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2, \u03c4\u03b1 \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03c9\u03c2 <strong>\u03c4\u03bf \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03bf \u03ae \u03c4\u03c1\u03af\u03c4\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf<\/strong> \u2014 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 ARB, \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 ACE \u03ae \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 \u03b4\u03b9\u03b1\u03cd\u03bb\u03c9\u03bd \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03b1.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03b7\u03bd MedsBase:<\/strong> \u03a0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2 WHO-GMP \u00b7 \u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u00b7 \u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u00b7 1,400+ \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 <a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03bb\u03b1\u03c4\u03ce\u03bd<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\"><strong>\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n<h3>\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p>\u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n<h2 class=\"wp-block-heading\">What Is Frusenex?<\/h2>\n<p>Frusenex is an oral 100 mg furosemide tablet from Sanofi-Aventis, supplied in 30-180 tablets. Furosemide (frusemide in UK\/India nomenclature) was introduced by Hoechst in 1964 as <strong>Lasix<\/strong> &mdash; &#8220;Lasts Six hours,&#8221; the eponymous duration of its diuretic effect. The first loop diuretic and still the most prescribed, with extensive acute-hospital and outpatient use.<\/p>\n<h2 class=\"wp-block-heading\">How Furosemide Works<\/h2>\n<p>Furosemide inhibits the <strong>NKCC2 (Na-K-2Cl cotransporter) in the thick ascending limb of the loop of Henle<\/strong>. \u039f\u03b9 \u03b5\u03c0\u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03b5\u03c2 \u03b5\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2:<\/p>\n<ul>\n<li><strong>Dramatic reduction in sodium reabsorption<\/strong> &mdash; loop diuretics block the largest sodium-reabsorbing segment of the nephron; up to 25% of filtered sodium can be excreted<\/li>\n<li><strong>Large diuresis<\/strong> within 1-2 hours of oral dosing (5 minutes IV) &mdash; useful for acute decompensated heart failure and pulmonary oedema<\/li>\n<li><strong>Loss of magnesium and calcium<\/strong> in addition to sodium and potassium &mdash; contrasts with thiazides which retain calcium<\/li>\n<li><strong>Direct venodilation<\/strong> within minutes of IV dosing &mdash; contributes to symptom relief in acute pulmonary oedema before the diuresis arrives<\/li>\n<li><strong>Activates prostaglandin synthesis<\/strong> in the kidney &mdash; the basis of the NSAID interaction (NSAIDs blunt loop diuretic effect)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u0395\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 \u0392\u03b1\u03c3\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c3\u03b5 \u0391\u03c0\u03bf\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03a7\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li><strong>Heart-failure oedema, pulmonary oedema, ascites, oliguric acute kidney injury, hypercalcaemia, refractory hypertension (NOT first-line HTN)<\/strong> \u2014 \u03ba\u03cd\u03c1\u03b9\u03b1 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9<\/li>\n<li><strong>Acute decompensated heart failure \/ pulmonary oedema<\/strong> &mdash; IV bolus with or without nitrate<\/li>\n<li><strong>Chronic heart failure with oedema or congestion<\/strong><\/li>\n<li><strong>Cirrhotic ascites<\/strong> (combined with spironolactone)<\/li>\n<li><strong>Oliguric acute kidney injury<\/strong> &mdash; to convert oliguric to polyuric AKI (does NOT improve survival; facilitates fluid management)<\/li>\n<li><strong>Hypercalcaemia of malignancy<\/strong> &mdash; after adequate saline rehydration<\/li>\n<li><strong>\u0391\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7<\/strong> with concurrent oedema or advanced CKD (eGFR &lt;30)<\/li>\n<\/ul>\n<p><strong>\u039a\u03c5\u03c1\u03af\u03b1\u03c1\u03c7\u03b5\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2:<\/strong> <strong>DOSE trial (2011)<\/strong> &mdash; high-dose vs low-dose, bolus vs continuous-infusion furosemide in acute HF; no mortality difference, high-dose gave faster symptom relief at cost of more creatinine rise. <strong>TRANSFORM-HF (2023)<\/strong> &mdash; torasemide vs furosemide in HF showed no significant mortality difference, supporting furosemide as equivalent in practice. Historical evidence base is largely observational given that loop diuretics predate modern trial standards.<\/p>\n<h2 class=\"wp-block-heading\">Frusenex Dosage<\/h2>\n<p><strong>Heart-failure dose:<\/strong> <strong>Furosemide is NOT a first-line antihypertensive.<\/strong> It is too short-acting (6-hour effect) for once-daily BP control and the strong natriuresis causes blood pressure swings. Reserve for HTN with concurrent oedema, advanced CKD (eGFR &lt;30 where thiazides fail), or resistant hypertension.<\/p>\n<p><strong>\u0386\u03bb\u03bb\u03b5\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2:<\/strong> <strong>Chronic heart failure:<\/strong> 20-40 mg PO daily initially; titrate to 40-500 mg\/day or twice-daily split, guided by daily weights and symptoms. <strong>Acute decompensated HF \/ pulmonary oedema:<\/strong> 40-80 mg IV bolus (or home-dose equivalent); repeat after 30-60 minutes if no diuresis; add IV nitrate for afterload reduction. <strong>Cirrhotic ascites:<\/strong> furosemide 40 mg + spironolactone 100 mg (1:2.5 ratio); titrate both. <strong>Hypercalcaemia of malignancy:<\/strong> after adequate IV saline rehydration, furosemide 20-40 mg IV q6h to promote calciuric diuresis.<\/p>\n<p><strong>\u03a7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7:<\/strong> \u03bc\u03af\u03b1 \u03c6\u03bf\u03c1\u03ac \u03c4\u03b7\u03bd \u03b7\u03bc\u03ad\u03c1\u03b1 (\u03ae \u03b4\u03cd\u03bf \u03c6\u03bf\u03c1\u03ad\u03c2 \u03c4\u03b7\u03bd \u03b7\u03bc\u03ad\u03c1\u03b1 \u03b3\u03b9\u03b1 \u03c5\u03c8\u03b7\u03bb\u03ad\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03b8\u03b7\u03bb\u03b1\u03ba\u03b9\u03ba\u03ce\u03bd \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03c3\u03b5 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1), \u03c4\u03bf \u03c0\u03c1\u03c9\u03af. \u0397 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03bf \u03b2\u03c1\u03ac\u03b4\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03bd\u03c5\u03ba\u03c4\u03bf\u03c5\u03c1\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c6\u03b5\u03cd\u03b3\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03bd. \u039b\u03ae\u03c8\u03b7 \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03ce\u03c1\u03b1 \u03ba\u03ac\u03b8\u03b5 \u03bc\u03ad\u03c1\u03b1. \u0397 \u03c4\u03c1\u03bf\u03c6\u03ae \u03b4\u03b5\u03bd \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03ba\u03b1\u03bd\u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03ac \u03c4\u03b1 \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac.<\/p>\n<p><strong>\u03a0\u03c1\u03cc\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2:<\/strong><\/p>\n<ul>\n<li><strong>\u0392\u03b1\u03c3\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7:<\/strong> \u03bf\u03c5\u03c1\u03af\u03b1, \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03bb\u03cd\u03c4\u03b5\u03c2 (\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03ba\u03ac\u03bb\u03b9\u03bf \u03ba\u03b1\u03b9 \u03bd\u03ac\u03c4\u03c1\u03b9\u03bf), \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7, eGFR, \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7, \u03bf\u03c5\u03c1\u03b9\u03ba\u03cc \u03bf\u03be\u03cd \u03bf\u03c1\u03bf\u03cd. \u039f\u03b9\u03ba\u03b9\u03b1\u03ba\u03ae \u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03af\u03b5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03cc \u03b2\u03ac\u03c1\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1.<\/li>\n<li><strong>1-2 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03ae \u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03b4\u03cc\u03c3\u03b7\u03c2:<\/strong> \u03b5\u03c0\u03b1\u03bd\u03b1\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03cc\u03bc\u03b5\u03bd\u03b7 U&amp;E \u03ba\u03b1\u03b9 \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7. \u0391\u03bd\u03b1\u03bc\u03ad\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ae\u03c0\u03b9\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03c4\u03c9\u03bd \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03bb\u03c5\u03c4\u03ce\u03bd\u00b7 \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bb\u03bb\u03b1\u03b3\u03ce\u03bd.<\/li>\n<li><strong>4-6 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2:<\/strong> \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03ae\u03c1\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb.<\/li>\n<li><strong>\u03a3\u03c5\u03bd\u03b5\u03c7\u03ae\u03c2 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7:<\/strong> \u03b5\u03c4\u03ae\u03c3\u03b9\u03b1 U&amp;E, \u03bf\u03c5\u03c1\u03b9\u03ba\u03cc \u03bf\u03be\u03cd, \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7 \u03ba\u03b1\u03b9 \u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03af\u03bf \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03bc\u03cc\u03bb\u03b9\u03c2 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af. \u03a0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03ac \u03c3\u03b5 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf, \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03ae \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1.<\/li>\n<li><strong>\u0394\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03b4\u03cc\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7:<\/strong> \u03bd\u03ac\u03c4\u03c1\u03b9\u03bf &lt;130 \u03bc\u03b5 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1, \u03ba\u03ac\u03bb\u03b9\u03bf 5.5, \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7\u03c2 &gt;30%, \u03bd\u03b5\u03b1\u03c1\u03ae \u03bf\u03c5\u03c1\u03b9\u03ba\u03ae \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1, \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae\u03c2 \u03b1\u03c6\u03c5\u03b4\u03ac\u03c4\u03c9\u03c3\u03b7\u03c2.<\/li>\n<\/ul>\n<p><strong>\u0394\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae:<\/strong> \u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7\u03c2 \u03b1\u03bb\u03bb\u03ac \u03b7 \u03b1\u03c0\u03cc\u03c4\u03bf\u03bc\u03b7 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03b5\u03b9 \u03b1\u03bd\u03ac\u03ba\u03b1\u03bc\u03c8\u03b7 \u03cc\u03b3\u03ba\u03bf\u03c5 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c3\u03b5 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c5\u03c8\u03b7\u03bb\u03ae \u03b4\u03cc\u03c3\u03b7 \u03b8\u03b7\u03bb\u03b1\u03ba\u03b9\u03ba\u03ce\u03bd \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u2014 \u03c3\u03c4\u03b1\u03b4\u03b9\u03b1\u03ba\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03cc\u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03bd \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2.<\/p>\n<ul>\n<li><strong>Highly variable oral bioavailability (10-90%).<\/strong> Torasemide has 80-100% bioavailability and is preferred in patients with gut oedema or inconsistent response to oral furosemide.<\/li>\n<li><strong>Ototoxicity<\/strong> at high IV doses and rapid infusion &mdash; rare with PO or moderate IV use. Avoid rapid-bolus doses &gt;80 mg IV.<\/li>\n<li><strong>&#8220;Braking phenomenon&#8221;<\/strong> &mdash; chronic loop diuretic use produces distal tubule hypertrophy that compensates. Add a thiazide (metolazone 2.5-5 mg) or HCTZ for &#8220;sequential nephron blockade&#8221; in refractory oedema.<\/li>\n<li><strong>Bioavailability falls with gut wall oedema<\/strong> (congested HF patients) &mdash; a common cause of apparent &#8220;furosemide resistance&#8221; that responds to IV dosing.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/h2>\n<p><strong>\u03a3\u03c5\u03c7\u03bd\u03ac (&gt;1%):<\/strong><\/p>\n<ul>\n<li><strong>\u03a5\u03c0\u03bf\u03ba\u03b1\u03bb\u03b9\u03b1\u03b9\u03bc\u03af\u03b1<\/strong> &mdash; more severe than with thiazides; monitor closely<\/li>\n<li><strong>Hypomagnesaemia<\/strong> &mdash; loop-specific; contributes to arrhythmia risk<\/li>\n<li><strong>\u03a5\u03c0\u03bf\u03bd\u03b1\u03c4\u03c1\u03b9\u03b1\u03b9\u03bc\u03af\u03b1<\/strong><\/li>\n<li><strong>\u03a5\u03c0\u03bf\u03ba\u03b1\u03bbcemia<\/strong> (opposite direction from thiazides; exploited therapeutically in hypercalcaemia)<\/li>\n<li><strong>Pre-renal acute kidney injury<\/strong> in over-diuresis, dehydration, or concurrent NSAID\/ACEi+ARB<\/li>\n<li><strong>Ototoxicity<\/strong> at high IV doses (&gt;160 mg bolus) or rapid infusion<\/li>\n<li><strong>\u03a5\u03c0\u03b5\u03c1\u03bf\u03c5\u03c1\u03b9\u03c7\u03b1\u03b9\u03bc\u03af\u03b1<\/strong> and gout<\/li>\n<li><strong>Modest hyperglycaemia<\/strong> (less than with thiazides)<\/li>\n<li><strong>Postural hypotension<\/strong><\/li>\n<li><strong>\u0395\u03be\u03ac\u03bd\u03b8\u03b7\u03bc\u03b1 \u03c6\u03c9\u03c4\u03bf\u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1\u03c2<\/strong><\/li>\n<\/ul>\n<p><strong>\u03a3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b1\u03bb\u03bb\u03ac \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac:<\/strong><\/p>\n<ul>\n<li><strong>\u03a3\u03bf\u03b2\u03b1\u03c1\u03ae \u03c5\u03c0\u03bf\u03bd\u03b1\u03c4\u03c1\u03b9\u03b1\u03b9\u03bc\u03af\u03b1<\/strong> \u2014 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03bc\u03b5 \u03b4\u03af\u03b1\u03b9\u03c4\u03b1 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae\u03c2 \u03b1\u03bb\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2, \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b5 \u03c4\u03ac\u03c3\u03b7 \u03b3\u03b9\u03b1 SIADH \u03ae \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 SSRIs. \u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03ba\u03b4\u03b7\u03bb\u03c9\u03b8\u03b5\u03af \u03c9\u03c2 \u03c3\u03cd\u03b3\u03c7\u03c5\u03c3\u03b7, \u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03ae \u03c3\u03c0\u03b1\u03c3\u03bc\u03bf\u03af.<\/li>\n<li><strong>\u03a0\u03b1\u03b3\u03ba\u03c1\u03b5\u03b1\u03c4\u03af\u03c4\u03b9\u03b4\u03b1<\/strong> \u2014 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03ba\u03bb\u03ac\u03c3\u03b7\u03c2 \u03b8\u03b5\u03b9\u03b1\u03b6\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd\/\u03b2\u03c1\u03cc\u03b3\u03c7\u03c9\u03bd\u00b7 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03ac\u03bc\u03b5\u03c3\u03b1 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03ac\u03bd\u03c9 \u03ba\u03bf\u03b9\u03bb\u03b9\u03b1\u03ba\u03bf\u03cd \u03c0\u03cc\u03bd\u03bf\u03c5 \u03bc\u03b5 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03bb\u03b9\u03c0\u03ac\u03c3\u03b7\u03c2<\/li>\n<li><strong>\u0398\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c0\u03b5\u03bd\u03af\u03b1, \u03bb\u03b5\u03c5\u03ba\u03bf\u03c0\u03b5\u03bd\u03af\u03b1, \u03b1\u03b3\u03ba\u03c1\u03b1\u03bd\u03bf\u03c5\u03bb\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03c3\u03b7<\/strong> \u2014 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b5\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 (\u03c0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03bc\u03b5 \u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b9\u03b1 \u03c0\u03b1\u03c1\u03ac \u03bc\u03b5 \u03b2\u03c1\u03cc\u03b3\u03c7\u03bf\u03c5\u03c2)<\/li>\n<li><strong>\u039f\u03be\u03b5\u03af\u03b1 \u03bc\u03c5\u03c9\u03c0\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b3\u03bb\u03b1\u03cd\u03ba\u03c9\u03bc\u03b1 \u03ba\u03bb\u03b5\u03b9\u03c3\u03c4\u03ae\u03c2 \u03b3\u03c9\u03bd\u03af\u03b1\u03c2<\/strong> \u2014 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b1\u03bd\u03c4\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03ba\u03bb\u03ac\u03c3\u03b7\u03c2 \u03c3\u03bf\u03c5\u03bb\u03c6\u03bf\u03bd\u03b1\u03bc\u03b9\u03b4\u03ce\u03bd \u03b5\u03bd\u03c4\u03cc\u03c2 \u03c9\u03c1\u03ce\u03bd \u03ae \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7\u00b7 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03ac\u03bc\u03b5\u03c3\u03b1 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03be\u03b1\u03c6\u03bd\u03b9\u03ba\u03bf\u03cd \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03bf\u03cd \u03c0\u03cc\u03bd\u03bf\u03c5 \u03ae \u03b1\u03bb\u03bb\u03b1\u03b3\u03ae\u03c2 \u03cc\u03c1\u03b1\u03c3\u03b7\u03c2<\/li>\n<li><strong>\u03a3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Stevens-Johnson \/ \u03c4\u03bf\u03be\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae \u03bd\u03b5\u03ba\u03c1\u03cc\u03bb\u03c5\u03c3\u03b7<\/strong> \u2014 \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03c3\u03c0\u03ac\u03bd\u03b9\u03bf \u03b1\u03bb\u03bb\u03ac \u03ad\u03c7\u03b5\u03b9 \u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03b8\u03b5\u03af<\/li>\n<li><strong>Ototoxicity<\/strong> at high IV doses or rapid infusion &mdash; usually reversible; permanent hearing loss rare<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u0391\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li>Anuria (not responsive to loop diuretics in absence of renal perfusion)<\/li>\n<li>\u03a5\u03c0\u03b5\u03c1\u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03b5 \u03c3\u03bf\u03c5\u03bb\u03c6\u03bf\u03bd\u03b1\u03bc\u03af\u03b4\u03b5\u03c2<\/li>\n<li>Severe hypokalaemia or hyponatraemia at baseline (&lt;3.0 or &lt;125)<\/li>\n<li>Severe dehydration and pre-renal azotaemia<\/li>\n<li>Hepatic coma (can precipitate via electrolyte shift)<\/li>\n<\/ul>\n<p><strong>\u0395\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7:<\/strong> avoided for routine hypertension; use only for clear indications (pulmonary oedema, resistant HF) under specialist care. Loop diuretics cross the placenta and can reduce fetal urine output.<\/p>\n<p><strong>\u0398\u03b7\u03bb\u03b1\u03c3\u03bc\u03cc\u03c2:<\/strong> \u03b3\u03b5\u03bd\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03c3\u03b5 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ad\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2\u00b7 \u03bf\u03b9 \u03c5\u03c8\u03b7\u03bb\u03ad\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b5\u03af\u03bb\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b3\u03b1\u03bb\u03bf\u03c5\u03c7\u03af\u03b1 (\u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03bf\u03b9 \u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b5\u03c2). \u03a0\u03c1\u03bf\u03c4\u03b9\u03bc\u03ce\u03bd\u03c4\u03b1\u03b9 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03ac (\u03c0\u03c1\u03bf\u03c0\u03c1\u03b1\u03bd\u03cc\u03bb\u03bf\u03bb, \u03bd\u03b9\u03c6\u03b5\u03b4\u03b9\u03c0\u03af\u03bd\u03b7) \u03cc\u03c4\u03b1\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03bd.<\/p>\n<h2 class=\"wp-block-heading\">\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03a6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd<\/h2>\n<ul>\n<li><strong>\u039b\u03af\u03b8\u03b9\u03bf \u2014 \u039a\u03a1\u0399\u03a3\u0399\u039c\u0397 \u0391\u039b\u039b\u0397\u039b\u0395\u03a0\u0399\u0394\u03a1\u0391\u03a3\u0397.<\/strong> \u039f\u03b9 \u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03bf\u03af \u03b2\u03c1\u03cc\u03b3\u03c7\u03bf\u03c5 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03ba\u03ac\u03b8\u03b1\u03c1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bb\u03b9\u03b8\u03af\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03bf\u03c5\u03bd \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bb\u03b9\u03b8\u03af\u03bf\u03c5. \u0391\u03c0\u03bf\u03c6\u03cd\u03b3\u03b5\u03c4\u03b5 \u03c4\u03bf\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03b5\u03ac\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03bd\u00b7 \u03b5\u03ac\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c0\u03cc\u03c6\u03b5\u03c5\u03ba\u03c4\u03bf\u03c2, \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03ae\u03c3\u03c4\u03b5 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03bb\u03b9\u03b8\u03af\u03bf\u03c5 \u03b5\u03b2\u03b4\u03bf\u03bc\u03b1\u03b4\u03b9\u03b1\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03c0\u03c1\u03ce\u03c4\u03bf \u03bc\u03ae\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b9\u03ce\u03c3\u03c4\u03b5 \u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03bb\u03b9\u03b8\u03af\u03bf\u03c5 \u03ba\u03b1\u03c4\u03ac 25-50%.<\/li>\n<li><strong>\u039c\u03b7 \u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ae \u03b1\u03bd\u03c4\u03b9\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 (NSAIDs)<\/strong> \u2014 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 (\u03bc\u03ad\u03c3\u03c9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03b3\u03bb\u03b1\u03bd\u03b4\u03b9\u03bd\u03ce\u03bd) \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03bf\u03be\u03b5\u03af\u03b1\u03c2 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b2\u03bb\u03ac\u03b2\u03b7\u03c2 \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 ACEi\/ARB (\u03c4\u03bf \u201c\u03c4\u03c1\u03b9\u03c0\u03bb\u03cc \u03c7\u03c4\u03cd\u03c0\u03b7\u03bc\u03b1\u201d). \u03a7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b5 \u03c0\u03c1\u03bf\u03c4\u03b9\u03bc\u03b7\u03c3\u03b9\u03b1\u03ba\u03ac \u03c0\u03b1\u03c1\u03b1\u03ba\u03b5\u03c4\u03b1\u03bc\u03cc\u03bb\u03b7 \u03b3\u03b9\u03b1 \u03c7\u03c1\u03cc\u03bd\u03b9\u03bf \u03c0\u03cc\u03bd\u03bf.<\/li>\n<li><strong>\u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 ACE \u03ba\u03b1\u03b9 ARBs<\/strong> \u2014 \u03bf \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c4\u03ac\u03bd\u03c4\u03b1\u03c1\u03c4 \u03ba\u03b1\u03b9 \u03c9\u03c6\u03ad\u03bb\u03b9\u03bc\u03bf\u03c2 \u03c3\u03c4\u03b7\u03bd \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7\u00b7 \u03b7 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 ACEi\/ARB \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03b1\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 RAAS \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7. \u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03ae\u03c3\u03c4\u03b5 \u03ba\u03ac\u03bb\u03b9\u03bf \u03ba\u03b1\u03b9 \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7.<\/li>\n<li><strong>\u03a0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b5\u03c2 \u03ba\u03b1\u03bb\u03af\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03c0\u03bf\u03c5 \u03b5\u03be\u03bf\u03b9\u03ba\u03bf\u03bd\u03bf\u03bc\u03bf\u03cd\u03bd \u03ba\u03ac\u03bb\u03b9\u03bf<\/strong> \u2014 \u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03b1\u03b8\u03bc\u03b9\u03c3\u03c4\u03b5\u03af \u03b7 \u03c5\u03c0\u03bf\u03ba\u03b1\u03bb\u03b9\u03b1\u03b9\u03bc\u03af\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03b2\u03c1\u03cc\u03b3\u03c7\u03bf\u03c5\/\u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b5\u03c2. \u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03ae\u03c3\u03c4\u03b5 \u03c4\u03bf \u03ba\u03ac\u03bb\u03b9\u03bf\u00b7 \u03b1\u03c0\u03bf\u03c6\u03cd\u03b3\u03b5\u03c4\u03b5 \u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7.<\/li>\n<li><strong>\u039d\u03c4\u03b9\u03b3\u03ba\u03bf\u03be\u03af\u03bd\u03b7<\/strong> \u2014 \u03b7 \u03c5\u03c0\u03bf\u03ba\u03b1\u03bb\u03b9\u03b1\u03b9\u03bc\u03af\u03b1 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b4\u03b9\u03b3\u03bf\u03be\u03af\u03bd\u03b7\u03c2 (\u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03b2\u03c1\u03cc\u03b3\u03c7\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b5\u03c2)\u00b7 \u03b7 \u03c3\u03c0\u03b9\u03c1\u03bf\u03bd\u03bf\u03bb\u03b1\u03ba\u03c4\u03cc\u03bd\u03b7 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03ac\u03bc\u03b5\u03c3\u03b1 \u03c4\u03b7\u03bd \u03ba\u03ac\u03b8\u03b1\u03c1\u03c3\u03b7 \u03b4\u03b9\u03b3\u03bf\u03be\u03af\u03bd\u03b7\u03c2. \u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03ae\u03c3\u03c4\u03b5 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b4\u03b9\u03b3\u03bf\u03be\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03bb\u03af\u03bf\u03c5 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03ae \u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd.<\/li>\n<li><strong>\u03a3\u03c4\u03bf\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03af \u03ba\u03bf\u03c1\u03c4\u03b9\u03ba\u03bf\u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03b5\u03af\u03c2, \u03b1\u03bc\u03c6\u03bf\u03c4\u03b5\u03c1\u03b9\u03ba\u03af\u03bd\u03b7 \u0392, \u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b8\u03b1\u03c1\u03c4\u03b9\u03ba\u03ac<\/strong> \u2014 \u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b7 \u03c5\u03c0\u03bf\u03ba\u03b1\u03bb\u03b9\u03b1\u03b9\u03bc\u03af\u03b1 (\u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03b2\u03c1\u03cc\u03b3\u03c7\u03bf\u03c5\/\u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b5\u03c2) \u03ae \u03ba\u03c1\u03c5\u03bc\u03bc\u03ad\u03bd\u03b7 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03b3\u03b9\u03b1 \u03ba\u03ac\u03bb\u03b9\u03bf (\u03c3\u03c0\u03b9\u03c1\u03bf\u03bd\u03bf\u03bb\u03b1\u03ba\u03c4\u03cc\u03bd\u03b7).<\/li>\n<li><strong>\u03a3\u03c4\u03bf\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03b4\u03b9\u03b1\u03b2\u03b7\u03c4\u03b9\u03ba\u03ac \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1, \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7<\/strong> \u2014 \u03bf\u03b9 \u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b5\u03c2 \u03ba\u03b1\u03b9 (\u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf) \u03c4\u03b1 \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03b2\u03c1\u03cc\u03b3\u03c7\u03bf\u03c5 \u03b5\u03c0\u03b9\u03b4\u03b5\u03b9\u03bd\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c7\u03ae \u03c3\u03c4\u03b7 \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7\u00b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ad\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2.<\/li>\n<li><strong>\u03a7\u03bf\u03bb\u03b7\u03c3\u03c4\u03c5\u03c1\u03b1\u03bc\u03af\u03bd\u03b7 \/ \u03ba\u03bf\u03bb\u03b5\u03c3\u03c4\u03b9\u03c0\u03cc\u03bb\u03b7<\/strong> \u2014 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b8\u03b5\u03b9\u03b1\u03b6\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03b8\u03b7\u03bb\u03c5\u03ba\u03c9\u03b4\u03ce\u03bd \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03c4\u03ac 40-85%. \u03a7\u03c9\u03c1\u03af\u03c3\u03c4\u03b5 \u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03ba\u03ac\u03b8\u03b5 4 \u03ce\u03c1\u03b5\u03c2.<\/li>\n<li><strong>Aminoglycoside antibiotics (gentamicin, amikacin)<\/strong> &mdash; additive ototoxicity. Avoid concurrent use at high IV doses.<\/li>\n<li><strong>\u0391\u03bb\u03ba\u03bf\u03cc\u03bb<\/strong> \u2014 \u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b7 \u03bf\u03c1\u03b8\u03bf\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ae \u03c5\u03c0\u03cc\u03c4\u03b1\u03c3\u03b7.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Where Frusenex Fits in the Diuretic Class<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u039a\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u0395\u03ba\u03c0\u03c1\u03cc\u03c3\u03c9\u03c0\u03bf\u03b9<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u03a4\u03c5\u03c0\u03b9\u03ba\u03ae \u03c7\u03c1\u03ae\u03c3\u03b7<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0398\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b9\u03bf<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><a href=\"https:\/\/medsbase.com\/el\/aquazide\/\">HCTZ<\/a>, \u03c7\u03bb\u03bf\u03c1\u03b8\u03b1\u03bb\u03b9\u03b4\u03cc\u03bd\u03b7<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u03a0\u03c1\u03ce\u03c4\u03b7 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae \u03b3\u03b9\u03b1 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7, \u03c0\u03ad\u03c4\u03c1\u03b5\u03c2 \u03bd\u03b5\u03c6\u03c1\u03ce\u03bd, \u03bd\u03b5\u03c6\u03c1\u03bf\u03b3\u03b5\u03bd\u03ae \u0394\u0399<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0398\u03b5\u03b9\u03b1\u03b6\u03b9\u03b4\u03b9\u03ba\u03cc<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><a href=\"https:\/\/medsbase.com\/el\/natrilix-sr\/\">\u0399\u03bd\u03b4\u03b1\u03c0\u03b1\u03bc\u03af\u03b4\u03b7<\/a>, \u03bc\u03b5\u03c4\u03bf\u03bb\u03b1\u03b6\u03cc\u03bd\u03b7<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u03a5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 (\u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03b9, \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 HYVET), \u03b4\u03b9\u03b1\u03b4\u03bf\u03c7\u03b9\u03ba\u03ae \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03bc\u03cc\u03c2<\/td>\n<\/tr>\n<tr style=\"background:#fff3cd;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0392\u03c1\u03cc\u03b3\u03c7\u03bf\u03c2 (\u03b2\u03c1\u03b1\u03c7\u03cd\u03b2\u03b9\u03bf\u03c2)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><a href=\"https:\/\/medsbase.com\/el\/lasix\/\">\u03a6\u03bf\u03c5\u03c1\u03bf\u03c3\u03b5\u03bc\u03af\u03b4\u03b7<\/a>, \u03b2\u03bf\u03c5\u03bc\u03b5\u03c4\u03b1\u03bd\u03af\u03b4\u03b7<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u039f\u03be\u03cd \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03cc \u03bf\u03af\u03b4\u03b7\u03bc\u03b1, \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1, \u03b1\u03c3\u03ba\u03af\u03c4\u03b7\u03c2, \u03c5\u03c0\u03b5\u03c1\u03ba\u03b1\u03bb\u03b9\u03b1\u03b9\u03bc\u03af\u03b1<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0392\u03c1\u03cc\u03b3\u03c7\u03bf\u03c2 (\u03bc\u03b1\u03ba\u03c1\u03cc\u03b2\u03b9\u03bf\u03c2)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><a href=\"https:\/\/medsbase.com\/el\/dytor\/\">\u03a4\u03bf\u03c1\u03b1\u03c3\u03b5\u03bc\u03af\u03b4\u03b7<\/a><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u03a7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1, \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 (\u03bc\u03cc\u03bd\u03bf \u03b2\u03c1\u03cc\u03b3\u03c7\u03bf\u03c2 \u03bc\u03b5 \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7\u03c2), \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03bc\u03b5 \u03bf\u03af\u03b4\u03b7\u03bc\u03b1<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0391\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ae\u03c2 \u03b1\u03bb\u03b4\u03bf\u03c3\u03c4\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><a href=\"https:\/\/medsbase.com\/el\/aldactone\/\">\u03a3\u03c0\u03b9\u03c1\u03bf\u03bd\u03bf\u03bb\u03b1\u03ba\u03c4\u03cc\u03bd\u03b7<\/a>, \u03b5\u03c0\u03bb\u03b5\u03c1\u03b5\u03bd\u03cc\u03bd\u03b7<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u039a\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03bc\u03b5 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf \u03ba\u03bb\u03ac\u03c3\u03bc\u03b1 \u03b5\u03be\u03ce\u03c3\u03b5\u03c9\u03c2 (RALES), \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 (PATHWAY-2), \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Conn, \u03ba\u03b9\u03c1\u03c1\u03c9\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b1\u03c3\u03ba\u03af\u03c4\u03b7\u03c2<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0386\u03bb\u03bb\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1 \u03ba\u03ac\u03bb\u03b9\u03bf<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0391\u03bc\u03b9\u03bb\u03bf\u03c1\u03af\u03b4\u03b7, \u03c4\u03c1\u03b9\u03b1\u03bc\u03c4\u03b5\u03c1\u03ad\u03bd\u03b7 (\u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03cd\u03c2)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u03a0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03c5\u03c0\u03bf\u03ba\u03b1\u03bb\u03b9\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 \u03cc\u03c4\u03b1\u03bd \u03c0\u03c1\u03bf\u03c3\u03c4\u03af\u03b8\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b2\u03c1\u03cc\u03b3\u03c7\u03bf\/\u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b9\u03bf<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0391\u03bd\u03b8\u03c1\u03b1\u03ba\u03b9\u03ba\u03ae \u03b1\u03bd\u03c5\u03b4\u03c1\u03ac\u03c3\u03b7<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u0391\u03ba\u03b5\u03c4\u03b1\u03b6\u03bf\u03bb\u03b1\u03bc\u03af\u03b4\u03b7<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u03a5\u03c8\u03bf\u03c6\u03bf\u03b2\u03af\u03b1, \u03b3\u03bb\u03b1\u03cd\u03ba\u03c9\u03bc\u03b1, \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03b1\u03bb\u03ba\u03ac\u03bb\u03c9\u03c3\u03b7<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/h2>\n<p>Store Frusenex below 25&deg;C in the original blister pack. Keep out of reach of children.<\/p>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3 class=\"wp-block-heading\">When should I take Frusenex &mdash; morning or evening?<\/h3>\n<p><strong>\u03a0\u03c1\u03c9\u03af<\/strong> in almost all cases. The diuretic effect produces increased urine output for 2-4 hours after dosing. Evening dosing causes nocturia and disrupts sleep. Patients on twice-daily loop diuretics typically dose at breakfast and early afternoon (not bedtime).<\/p>\n<h3 class=\"wp-block-heading\">Is Frusenex a first-line blood-pressure drug?<\/h3>\n<p><strong>\u038c\u03c7\u03b9.<\/strong> Loop diuretics are <strong>not first-line antihypertensives<\/strong> &mdash; they are too short-acting and produce BP swings. Loop diuretics are used for hypertension only in specific situations: concurrent heart-failure oedema, advanced CKD (eGFR &lt;30) where thiazides fail, or resistant hypertension as an add-on. For standard hypertension, choose a thiazide, ARB, ACE inhibitor, or calcium-channel blocker instead.<\/p>\n<h3 class=\"wp-block-heading\">Will Frusenex affect my potassium?<\/h3>\n<p>Yes &mdash; Frusenex <strong>\u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9<\/strong> \u03c4\u03bf \u03ba\u03ac\u03bb\u03b9\u03bf \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03ba\u03b1\u03bb\u03af\u03bf\u03c5 \u03c3\u03c4\u03bf\u03bd \u03bc\u03b1\u03ba\u03c1\u03b9\u03bd\u03cc \u03c3\u03c9\u03bb\u03ae\u03bd\u03b1. \u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03ae\u03c3\u03c4\u03b5 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c1\u03c7\u03ae, \u03c3\u03b5 1-2 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bf\u03b4\u03b9\u03ba\u03ac. \u039f \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03c5\u03c0\u03bf\u03ba\u03b1\u03bb\u03b9\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 <strong>\u03b5\u03bb\u03b1\u03c7\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc<\/strong> Frusenex with an ARB or ACE inhibitor &mdash; which is the standard combination in hypertension anyway. If potassium drops below 3.5 in isolated diuretic use, add potassium supplementation, a potassium-rich diet, or a small dose of a potassium-sparing agent (spironolactone, eplerenone, or an <a href=\"https:\/\/medsbase.com\/el\/amifru\/\">\u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 \u03b1\u03bc\u03b9\u03bb\u03bf\u03c1\u03af\u03b4\u03b7<\/a>).<\/p>\n<h3 class=\"wp-block-heading\">I have gout &mdash; can I take Frusenex?<\/h3>\n<p>\u039c\u03b5 \u03c0\u03c1\u03bf\u03c3\u03bf\u03c7\u03ae. \u03a4\u03b1 \u03b8\u03b5\u03b9\u03b1\u03b6\u03b9\u03b4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 (\u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf) \u03c4\u03b1 \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03b2\u03c1\u03cc\u03c7\u03bf\u03c5 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf \u03bf\u03c5\u03c1\u03b9\u03ba\u03cc \u03bf\u03be\u03cd \u03c3\u03c4\u03bf \u03b1\u03af\u03bc\u03b1 \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b1 \u03c4\u03b7\u03bd \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03c4\u03bf \u03b5\u03b3\u03b3\u03cd\u03c2 \u03c3\u03c9\u03bb\u03b7\u03bd\u03b1\u03c1\u03af\u03bf. \u03a3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c4\u03ac\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03bf\u03c5\u03c1\u03b9\u03ba\u03ae \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1: \u03c0\u03c1\u03bf\u03c4\u03b9\u03bc\u03ae\u03c3\u03c4\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03cd\u03c2 \u03bc\u03b5 \u03bb\u03bf\u03b6\u03b1\u03c1\u03c4\u03ac\u03bd\u03b7 (<a href=\"https:\/\/medsbase.com\/el\/cosart-h\/\">Cosart H<\/a>, <a href=\"https:\/\/medsbase.com\/el\/cozartan-h\/\">Cozartan H<\/a>) whose losartan component is uniquely uricosuric and offsets the thiazide urate rise. If Frusenex is already in use and gout flares, add or continue urate-lowering therapy (allopurinol) rather than stopping Frusenex outright.<\/p>\n<h3 class=\"wp-block-heading\">I&rsquo;m diabetic &mdash; is Frusenex safe?<\/h3>\n<p>Mostly yes, but be aware that thiazides and (to a lesser extent) loop diuretics <strong>modestly worsen glucose tolerance<\/strong> (average fasting glucose rise 5-8 mg\/dL, HbA1c 0.1-0.3%). The BP benefit outweighs this in most diabetics. If you want a more metabolically neutral combination, ARB+CCB is an alternative (<a href=\"https:\/\/medsbase.com\/el\/olmezest-am\/\">Olmezest AM<\/a>).<\/p>\n<h3 class=\"wp-block-heading\">Can I take ibuprofen with Frusenex?<\/h3>\n<p>\u0397 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c4\u03b1\u03c3\u03b9\u03b1\u03ba\u03ae \u03b2\u03c1\u03b1\u03c7\u03c5\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b5\u03bd\u03c4\u03ac\u03be\u03b5\u03b9. \u0397 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b7\u03bc\u03b5\u03c1\u03ae\u03c3\u03b9\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b7 NSAIDs (\u03b9\u03b2\u03bf\u03c5\u03c0\u03c1\u03bf\u03c6\u03b1\u03af\u03bd\u03b7, \u03b4\u03b9\u03c7\u03bb\u03bf\u03c6\u03b1\u03b9\u03bd\u03ac\u03ba\u03b7, \u03bd\u03b1\u03c0\u03c1\u03bf\u03be\u03ad\u03bd\u03b7) <strong>\u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03bf \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/strong> of Frusenex (prostaglandin blockade) and substantially raise the AKI risk when combined with an ACE inhibitor or ARB &mdash; the &#8220;triple whammy.&#8221; Use paracetamol preferentially for chronic pain.<\/p>\n<h3 class=\"wp-block-heading\">\u0398\u03b1 \u03bf\u03c5\u03c1\u03ce \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c4\u03b7 \u03bd\u03cd\u03c7\u03c4\u03b1;<\/h3>\n<p>Usually no, if you take Frusenex in the morning. The diuretic effect peaks 2-4 hours after dosing and has mostly worn off by evening. Nocturia is a common complaint when patients switch to evening dosing; switch back to morning dosing and nocturia resolves within 1-3 days.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Frusenex in pregnancy?<\/h3>\n<p>Routinely avoided. Loop diuretics cross the placenta and can affect the fetus. For hypertension in pregnancy, switch to <a href=\"https:\/\/medsbase.com\/el\/labebet\/\">\u03bb\u03b1\u03b2\u03b5\u03c4\u03b1\u03bb\u03cc\u03bb\u03b7<\/a>, \u03bc\u03b5\u03b8\u03c5ldopa \u03ae \u03bd\u03b9\u03c6\u03b5\u03b4\u03af\u03c0\u03b7. \u03a4\u03b1 \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7 \u03bc\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 (\u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03cc \u03bf\u03af\u03b4\u03b7\u03bc\u03b1, \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1) \u03c5\u03c0\u03cc \u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b2\u03bb\u03b5\u03c8\u03b7.<\/p>\n<h3 class=\"wp-block-heading\">\u03a4\u03b9 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bd \u03c7\u03ac\u03c3\u03c9 \u03bc\u03b9\u03b1 \u03b4\u03cc\u03c3\u03b7;<\/h3>\n<p>\u03a0\u03ac\u03c1\u03c4\u03b5 \u03c4\u03bf \u03bc\u03cc\u03bb\u03b9\u03c2 \u03c4\u03bf \u03b8\u03c5\u03bc\u03b7\u03b8\u03b5\u03af\u03c4\u03b5, \u03b5\u03ba\u03c4\u03cc\u03c2 \u03b1\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c7\u03b5\u03b4\u03cc\u03bd \u03ce\u03c1\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03c3\u03b1\u03c2 \u2014 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c0\u03b1\u03c1\u03b1\u03bb\u03b5\u03af\u03c8\u03c4\u03b5 \u03c4\u03b7 \u03c7\u03b1\u03bc\u03ad\u03bd\u03b7 \u03b4\u03cc\u03c3\u03b7. \u039c\u03b7\u03bd \u03c0\u03ac\u03c1\u03b5\u03c4\u03b5 \u03b4\u03b9\u03c0\u03bb\u03ae \u03b4\u03cc\u03c3\u03b7. \u039c\u03af\u03b1 \u03bc\u03cc\u03bd\u03bf \u03c7\u03b1\u03bc\u03ad\u03bd\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03b4\u03b5\u03bd \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03bd \u03bc\u03b1\u03ba\u03c1\u03bf\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c4\u03b7\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 \u03ae \u03c4\u03c9\u03bd \u03c5\u03b3\u03c1\u03ce\u03bd.<\/p>\n<h3 class=\"wp-block-heading\">Where can I buy Frusenex online?<\/h3>\n<p>You can buy Frusenex (100 mg furosemide, 30-180 tablets) from MedsBase with discreet packaging and worldwide shipping.<\/p>\n<h2 class=\"wp-block-heading\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u0391\u03bd\u03c4\u03b9\u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03ac &amp; \u0394\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/aquazide\/\">Aquazide &mdash; Hydrochlorothiazide (HCTZ) thiazide<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/cosart-h\/\">Cosart H &mdash; Losartan + HCTZ fixed combination<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/hydrocl\/\">Hydrocl \u2014 Hydrochlorothiazide (HCTZ)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/lasix\/\">Lasix \u2014 Furosemide 40 mg (loop)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/natrilix-sr\/\">Natrilix SR \u2014 \u0399\u03bd\u03b4\u03b1\u03c0\u03b1\u03bc\u03af\u03b4\u03b7 1.5 mg SR (\u03b8\u03b5\u03b9\u03b1\u03b6\u03b9\u03b4\u03b9\u03ba\u03cc)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/ramcor\/\">Ramcor &mdash; Ramipril (ACEi partner for diuretic)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/high-blood-pressure-medication\/\"><strong>\u03a0\u03b5\u03c1\u03b9\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c3\u03b5 \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03a6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b3\u03b9\u03b1 \u03a5\u03c8\u03b7\u03bb\u03ae \u03a0\u03af\u03b5\u03c3\u03b7 \u0391\u03af\u03bc\u03b1\u03c4\u03bf\u03c2<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 \u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u0391\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u0395\u03c5\u03b8\u03cd\u03bd\u03b7\u03c2.<\/strong> \u0391\u03c5\u03c4\u03ae \u03b7 \u03c3\u03b5\u03bb\u03af\u03b4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03b5\u03bd\u03b7\u03bc\u03b5\u03c1\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c3\u03ba\u03bf\u03c0\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03c4\u03b7\u03bd \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03ae \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1\u03bd \u03ba\u03b1\u03c4\u03b1\u03be\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b1\u03b3\u03b3\u03b5\u03bb\u03bc\u03b1\u03c4\u03af\u03b1 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2. \u0397 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7, \u03b7 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03b1\u03c1\u03c1\u03c5\u03b8\u03bc\u03af\u03b5\u03c2 \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7, \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03b4\u03cc\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc \u2014 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b5 \u03b2-\u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c5\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b2\u03bb\u03b5\u03c8\u03b7.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2<\/h3>\n<p>\u0386\u03bb\u03bb\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 \u03c3\u03b5 <strong>\u03a7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03a0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2<\/strong> \u03c0\u03bf\u03c5 \u03bf\u03b9 \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/gravitor\/\">Gravitor<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/lidogab-gel\/\">Lidogab Gel<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/venish-sr\/\">Venish SR<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/flomist-nasal-spray\/\">Flomist Nasal Spray<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/amlode\/\">Amlode<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Frusenex is furosemide 100 mg \u2014 high-strength loop diuretic used when standard furosemide 40 mg no longer produces adequate natriuresis: advanced chronic kidney disease (eGFR below 30), refractory heart-failure oedema, cirrhotic ascites, and nephrotic syndrome. Equivalent to 250 mg torasemide or 4 mg bumetanide. Target-organ delivery of high-dose loop diuretic requires monitoring for ototoxicity, severe hypokalaemia, hyponatraemia, and pre-renal AKI. Not a first-line antihypertensive \u2014 reserved for HTN with concurrent oedema or advanced CKD.<\/p>","protected":false},"featured_media":57136,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3260,3356],"product_tag":[4239,4240],"class_list":{"0":"post-57135","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-heart-blood-pressure","9":"product_cat-high-blood-pressure-medication","10":"product_tag-frusemide","11":"product_tag-frusenex","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/57135","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=57135"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/57136"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=57135"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=57135"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=57135"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=57135"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}