<\/p>\n
Amifru<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 40\/5 mg fixed-dose tablet<\/strong> of furosemide (frusemide)<\/strong> — a loop diuretic — and amiloride<\/strong> — a potassium-sparing diuretic — from Sun Pharma. The combination is used when a loop diuretic is needed but hypokalaemia is a problem<\/strong> — amiloride blocks distal-tubule potassium loss driven by aldosterone activation, balancing the potassium depletion caused by furosemide’s upstream sodium load. Common uses: hypertension with oedema, chronic heart failure with tendency to hypokalaemia, hepatic ascites where adequate potassium-sparing is not provided by spironolactone alone. Typical dosing: one tablet once daily in the morning (some patients require twice-daily). Absolutely contraindicated in anuria, hyperkalaemia >5.5, severe CKD (eGFR <30), and Addison disease<\/strong>. Monitor potassium, sodium, and creatinine on initiation and regularly thereafter.<\/p>\n<\/div>\n \ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n \u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n Amifru is an oral fixed-dose combination tablet supplying furosemide (frusemide)<\/strong> \u03ba\u03b1\u03b9 amiloride<\/strong> in a single pill (typical ratio 40 mg furosemide + 5 mg amiloride per tablet). Made by Sun Pharma, supplied in 30-180 tablets.<\/p>\n Furosemide is the reference loop diuretic, introduced in 1964 as Lasix. Amiloride is a potassium-sparing diuretic acting at the epithelial sodium channel (ENaC) in the distal tubule — introduced by MSD in 1967 specifically to offset thiazide and loop diuretic potassium loss.<\/p>\n Loop diuretics deliver large sodium loads to the distal tubule. Aldosterone then drives distal sodium reabsorption in exchange for potassium excretion — the classical mechanism of loop-induced hypokalaemia. Two counter-strategies:<\/p>\n Amiloride is preferred over spironolactone when:<\/p>\n Amifru is particularly useful in hepatic ascites<\/strong> (where potassium losses are often severe), chronic HF patients with brittle potassium<\/strong>, \u03ba\u03b1\u03b9 patients who need a quick loop-diuretic effect without dropping potassium<\/strong>.<\/p>\n \u03a4\u03c5\u03c0\u03b9\u03ba\u03ae \u03b4\u03cc\u03c3\u03b7:<\/strong> one 40\/5 mg tablet once daily in the morning.<\/p>\n \u03a0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03b4\u03cc\u03c3\u03b7\u03c2:<\/strong> <\/p>\n \u03a0\u03c1\u03cc\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2:<\/strong><\/p>\n \u03a3\u03c5\u03c7\u03bd\u03ac (>1%):<\/strong><\/p>\n \u03a3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b1\u03bb\u03bb\u03ac \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac:<\/strong><\/p>\n \u0395\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7:<\/strong> generally avoided. Loop diuretics cross the placenta; amiloride data in pregnancy are limited. Use only for compelling indications (pulmonary oedema) under specialist care.<\/p>\n Store Amifru below 25°C in the original blister pack. Keep out of reach of children.<\/p>\n Three situations. First, if you have developed hypokalaemia on furosemide alone and want a built-in potassium-sparing component<\/strong> without adding a separate spironolactone tablet. Second, if you have developed gynaecomastia or breast pain on spironolactone and need a non-steroidal alternative. Third, if rapid potassium-sparing effect<\/strong> is needed — amiloride acts within hours, whereas spironolactone takes 24-72 hours via its active metabolites.<\/p>\n Morning, with or without food. The diuretic effect peaks 1-2 hours after dosing and has mostly worn off by evening. Evening dosing causes nocturia and disrupts sleep.<\/p>\n Yes, with monitoring. The combination of amiloride + ACE inhibitor (or + ARB) raises potassium significantly and should be avoided in advanced CKD (eGFR <45) or if baseline potassium is >5.0. If combined, check potassium at 1 week, 1 month, and every 3 months. Many patients in this situation do better on a loop diuretic alone + ACEi\/ARB (without the amiloride), accepting a potassium supplement if needed.<\/p>\n No. Loop-diuretic combinations are reserved for specific indications — hypertension with oedema or advanced CKD, chronic heart failure, or cirrhotic ascites. For standard hypertension, start with an ARB or ACE inhibitor, add a calcium-channel blocker or thiazide, and step up to spironolactone (PATHWAY-2 trial) before a loop-diuretic combination.<\/p>\n The combination is designed to be potassium-neutral<\/strong> — furosemide loses potassium, amiloride saves it, and the net effect is usually a stable potassium. A small number of patients will drift one way or the other depending on diet, kidney function, and concurrent drugs (ACEi\/ARB raise potassium; corticosteroids lower it). Check potassium at baseline and 1-2 weeks to see which direction you drift.<\/p>\n With caution. The furosemide component can raise serum uric acid and precipitate gout flares. If gout is active, address the gout with urate-lowering therapy (allopurinol) rather than stopping Amifru outright — the underlying indication (HF, oedema, advanced CKD) usually cannot be managed without a loop diuretic.<\/p>\n Chronic NSAIDs are risky on any loop-diuretic combination — they reduce the diuretic effect AND substantially raise AKI risk when combined with an ACE inhibitor or ARB. Use paracetamol preferentially for chronic pain.<\/p>\n Take it as soon as you remember unless it is nearly time for the next dose — in that case skip the missed dose. Do not double up. A single missed dose in chronic HF can let fluid accumulate; monitor weight the next day.<\/p>\n Routinely avoided. Loop diuretics cross the placenta and amiloride data in pregnancy are limited. Use only for compelling indications (pulmonary oedema, resistant heart failure) under specialist care.<\/p>\n You can buy Amifru (40\/5 mg furosemide + amiloride, 30-180 tablets) from MedsBase with discreet packaging and worldwide shipping.<\/p>\n <\/p>\n \u0386\u03bb\u03bb\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 \u03c3\u03b5 \u03a7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03a0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2<\/strong> \u03c0\u03bf\u03c5 \u03bf\u03b9 \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2:<\/p>\n Amifru is Sun Pharma’s fixed-dose furosemide 40 mg + amiloride 5 mg tablets \u2014 combines a loop diuretic with a potassium-sparing agent acting on ENaC. Designed to prevent loop-induced hypokalaemia without adding spironolactone. Preferred when gynaecomastia contraindicates spironolactone or when rapid potassium-sparing effect is needed (hours, not days). Uses: heart failure with brittle potassium, hepatic ascites, oedema with CKD.<\/p>","protected":false},"featured_media":57156,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3260,3356],"product_tag":[4244,4245,4239],"class_list":{"0":"post-57155","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-heart-blood-pressure","9":"product_cat-high-blood-pressure-medication","10":"product_tag-amifru","11":"product_tag-amiloride","12":"product_tag-frusemide","14":"first","15":"instock","16":"shipping-taxable","17":"purchasable","18":"product-type-variable","19":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/57155","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=57155"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/57156"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=57155"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=57155"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=57155"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=57155"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n
What Is Amifru?<\/h2>\n
Why Combine Furosemide With Amiloride?<\/h2>\n
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\u0394\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 & \u03a4\u03b9\u03c4\u03bb\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7<\/h2>\n
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\u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/h2>\n
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\u0391\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/h2>\n
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\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03a6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd<\/h2>\n
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\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/h2>\n
\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n
Why would I choose Amifru over plain furosemide?<\/h3>\n
When should I take Amifru?<\/h3>\n
Can I take Amifru with an ACE inhibitor or ARB?<\/h3>\n
Is Amifru a first-line blood-pressure drug?<\/h3>\n
Will I lose or gain potassium on Amifru?<\/h3>\n
I have gout — can I take Amifru?<\/h3>\n
Can I take ibuprofen with Amifru?<\/h3>\n
\u03a4\u03b9 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bd \u03c7\u03ac\u03c3\u03c9 \u03bc\u03b9\u03b1 \u03b4\u03cc\u03c3\u03b7;<\/h3>\n
Can I take Amifru in pregnancy?<\/h3>\n
Where can I buy Amifru online?<\/h3>\n
Related Antihypertensives & Diuretics on MedsBase<\/h2>\n
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\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2<\/h3>\n
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