{"id":57260,"date":"2024-02-27T17:32:43","date_gmt":"2024-02-27T17:32:43","guid":{"rendered":"https:\/\/medsname.com\/griseofulvin\/"},"modified":"2026-04-30T10:24:29","modified_gmt":"2026-04-30T10:24:29","slug":"griseofulvin","status":"publish","type":"product","link":"https:\/\/medsbase.com\/el\/griseofulvin\/","title":{"rendered":"Griseofulvin"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 20px;margin:18px 0;border-radius:6px;\">\n<h3 style=\"margin-top:0;\">\ud83d\udca1 \u0393\u03c1\u03ae\u03b3\u03bf\u03c1\u03b7 \u0391\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7<\/h3>\n<p style=\"margin-bottom:0;\">Griseofulvin is griseofulvin 250 mg \/ 500 mg \u2014 an older oral antifungal used mainly for <strong>tinea capitis (scalp ringworm) in children<\/strong>, especially when the cause is Microsporum canis (terbinafine works less well on this organism). Active only against dermatophytes (Trichophyton, Epidermophyton, Microsporum); inactive against Candida, Malassezia, moulds. Long course required (6\u20138 weeks for tinea capitis, 6\u201312 months for onychomycosis). Mostly displaced by terbinafine and itraconazole for adult dermatophyte infections, but still relevant in paediatrics.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f5f5;border:1px solid #e1e1e1;padding:18px 22px;margin:24px 0;border-radius:8px;display:flex;flex-wrap:wrap;justify-content:space-around;gap:16px;align-items:center;font-size:0.95em;\">\n<div style=\"text-align:center;flex:1;min-width:140px;\">\ud83c\udfed<br \/><strong>WHO-GMP<\/strong><br \/>\u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\"><strong>\u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03b3\u03b3\u03cd\u03b7\u03c3\u03b7\u03c2 \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<\/strong><\/a> \u2014 \u03b5\u03ac\u03bd \u03c4\u03bf \u03b4\u03ad\u03bc\u03b1 \u03c3\u03b1\u03c2 \u03b4\u03b5\u03bd \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 20 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03c9\u03bd \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd, \u03c4\u03bf \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bc\u03b5.<\/p>\n<h3>\u0393\u03b9\u03b1\u03c4\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03af\u03bb\u03b5\u03c4\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7 MedsBase<\/h3>\n<p>\u03a4\u03b1 \u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03ac \u03bc\u03b1\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd WHO-GMP \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bb\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u2014 \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b4\u03ad\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u03b4\u03c1\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae (\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03b5\u03ba\u03ba\u03b1\u03b8\u03ac\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03ba\u03ac\u03c1\u03c4\u03b1 \u2014 \u03c0\u03bf\u03c4\u03ad \u201cMedsBase\u201d \u03ae \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5). \u0393\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03c2 \u03bc\u03b5 \u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03bd\u03bf\u03bc\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03c0\u03b5\u03b6\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac SEPA. \u039a\u03ac\u03b8\u03b5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03a0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03ae \u0395\u03c0\u03b1\u03bd\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u0395\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03ce\u03c2 \u03bc\u03b1\u03c2.<\/p>\n<div style=\"text-align:center;flex:1;min-width:140px;\">\ud83d\udce6<br \/><strong>\u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1<\/strong><br \/>\u03b1\u03c0\u03bb\u03cc \u03c6\u03ac\u03ba\u03b5\u03bb\u03bf<\/div>\n<div style=\"text-align:center;flex:1;min-width:140px;\">\ud83c\udf0d<br \/><strong>\u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae<\/strong><br \/>\u03c3\u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c7\u03ce\u03c1\u03b5\u03c2<\/div>\n<div style=\"text-align:center;flex:1;min-width:140px;\">\u2b50<br \/><strong>1,400+ \u03c0\u03b5\u03bb\u03ac\u03c4\u03b5\u03c2<\/strong><br \/><a href=\"https:\/\/medsbase.com\/el\/reviews\/\">\u03b4\u03b9\u03b1\u03b2\u03ac\u03c3\u03c4\u03b5 \u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2<\/a><\/div>\n<\/div>\n<h2>\ud83d\udd12 Why order Griseofulvin from MedsBase<\/h2>\n<ul>\n<li><strong>\u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03b7 WHO-GMP \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae<\/strong> \u2014 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c1\u03c5\u03b8\u03bc\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b5\u03b3\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7, \u03bf\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1 \u03bc\u03b5 \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03c0\u03b1\u03c1\u03c4\u03af\u03b4\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03b7\u03bc\u03b5\u03c1\u03bf\u03bc\u03b7\u03bd\u03af\u03b1 \u03bb\u03ae\u03be\u03b7\u03c2.<\/li>\n<li><strong>\u0394\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1<\/strong> \u2014 \u03b1\u03c0\u03bb\u03cc \u03c6\u03ac\u03ba\u03b5\u03bb\u03bf, \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bd\u03bf\u03bc\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc.<\/li>\n<li><strong>\u03a0\u03b1\u03b3\u03ba\u03cc\u03c3\u03bc\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae<\/strong> \u03c3\u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c7\u03ce\u03c1\u03b5\u03c2 \u03bc\u03b5 <a href=\"https:\/\/medsbase.com\/el\/medsbase-re-shipment-assurance-policy\/\">Reshipment Assurance<\/a>.<\/li>\n<li><strong>\u03a0\u03cc\u03bd\u03c4\u03bf\u03b9 \u03b1\u03c6\u03bf\u03c3\u03af\u03c9\u03c3\u03b7\u03c2<\/strong> \u2014 1 \u03c0\u03cc\u03bd\u03c4\u03bf\u03c2 \u03b1\u03bd\u03ac $1 \u03c0\u03bf\u03c5 \u03be\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b5 (\u03b5\u03be\u03b1\u03b9\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1\/\u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae)\u00b7 100 \u03c0\u03cc\u03bd\u03c4\u03bf\u03c5\u03c2 = $5 \u03ad\u03ba\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1 \u03c3\u03b1\u03c2.<\/li>\n<\/ul>\n<h2 id=\"uses\">\u03a7\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2 &amp; \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/h2>\n<p>Griseofulvin (griseofulvin 250 mg \/ 500 mg, generic) is one of the oldest oral antifungal agents. It binds to fungal microtubules, disrupting mitosis and inhibiting hyphal growth. Modern practice has largely replaced it with terbinafine and itraconazole for adults \u2014 but it remains relevant when:<\/p>\n<ul>\n<li>Treating tinea capitis caused by <strong>Microsporum<\/strong> (terbinafine has lower cure rates against Microsporum than against Trichophyton).<\/li>\n<li>Treating tinea capitis in children \u2014 long-established paediatric experience and safety data.<\/li>\n<li>Newer oral antifungals are unavailable, contraindicated, or unaffordable.<\/li>\n<\/ul>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:0.95em;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">\u0395\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">\u03a4\u03c5\u03c0\u03b9\u03ba\u03cc \u03c3\u03c7\u03ae\u03bc\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Tinea capitis \u2014 children<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">10\u201320 mg\/kg\/day microsize (or 5\u201310 mg\/kg ultramicrosize) \u00d7 6\u20138 weeks<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Tinea capitis \u2014 adults<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">500 mg\/day microsize \u00d7 4\u20136 weeks<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Tinea corporis \/ cruris \/ pedis (refractory)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">500 mg\/day microsize \u00d7 2\u20136 weeks<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Onychomycosis \u2014 fingernail (largely abandoned)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">500\u20131000 mg\/day microsize \u00d7 4\u20136 months<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Onychomycosis \u2014 toenail (largely abandoned)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">500\u20131000 mg\/day microsize \u00d7 9\u201312 months<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"how-to-take\">\u03a0\u03ce\u03c2 \u03bd\u03b1 \u03c0\u03ac\u03c1\u03b5\u03c4\u03b5<\/h2>\n<ul>\n<li>Take with a fatty meal \u2014 fat increases griseofulvin absorption ~2-fold.<\/li>\n<li>For children, the tablet can be crushed into food or yogurt if a paediatric oral suspension is unavailable.<\/li>\n<li>Complete the full course \u2014 symptomatic improvement comes within 1\u20132 weeks but stopping early causes relapse.<\/li>\n<\/ul>\n<h2 id=\"mechanism\">\u03a0\u03ce\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af<\/h2>\n<p>Griseofulvin binds to fungal microtubules (specifically, \u03b2-tubulin) and disrupts mitotic spindle formation. The result is impaired hyphal growth. The drug is incorporated into newly-synthesised keratin in the hair, skin, and nail \u2014 meaning protected new growth replaces fungus-infected old keratin as it sheds. This is why long courses are required, especially for nail (which grows slowly).<\/p>\n<h2 id=\"side-effects\">\u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:0.95em;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">Effects<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">\u03a3\u03c5\u03c7\u03bd\u03ac<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Headache (often early in therapy, often resolves), nausea, abdominal pain, photosensitivity, urticaria, dizziness<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">\u0391\u03c3\u03c5\u03bd\u03ae\u03b8\u03b9\u03c3\u03c4\u03b5\u03c2<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Mild LFT rise, leukopenia, peripheral neuritis, taste disturbance, insomnia<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">\u03a3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b1\u03bb\u03bb\u03ac \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Severe hepatitis (rare), Stevens-Johnson syndrome, lupus exacerbation, agranulocytosis, photosensitive rash that can resemble erythema multiforme<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"interactions\">\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:0.95em;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">\u03a6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">\u0391\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ccc;\">\u0394\u03c1\u03ac\u03c3\u03b7<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">\u0392\u03b1\u03c1\u03c6\u03b1\u03c1\u03af\u03bd\u03b7<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\"><strong>INR falls<\/strong> (griseofulvin induces metabolism)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Monitor INR; increase warfarin dose<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Combined oral contraceptive pill<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\"><strong>Reduced contraceptive efficacy<\/strong> (CYP induction; ethinylestradiol metabolism)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Use additional barrier contraception during therapy and for 1 month after<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">Phenobarbital<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Reduces griseofulvin levels<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Increase griseofulvin dose 50%<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">\u039a\u03b9\u03ba\u03bb\u03bf\u03c3\u03c0\u03bf\u03c1\u03af\u03bd\u03b7<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Levels fall<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Monitor; increase ciclosporin<\/td>\n<\/tr>\n<tr style=\"background:#fff;\">\n<td style=\"padding:8px;border:1px solid #ccc;\">\u0391\u03bb\u03ba\u03bf\u03cc\u03bb<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Disulfiram-like flushing reaction (rare)<\/td>\n<td style=\"padding:8px;border:1px solid #ccc;\">Limit alcohol<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"contraindications\">\u0391\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/h2>\n<ul>\n<li>Severe liver disease, porphyria.<\/li>\n<li>Pregnancy (teratogenic in animals).<\/li>\n<li>Hypersensitivity to griseofulvin.<\/li>\n<li>Systemic lupus erythematosus (can precipitate flares).<\/li>\n<\/ul>\n<h2 id=\"pregnancy\">\u0395\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7 &amp; \u03b8\u03b7\u03bb\u03b1\u03c3\u03bc\u03cc\u03c2<\/h2>\n<p>Griseofulvin is contraindicated in pregnancy. Effective contraception is required during therapy <strong>and for 1 month after the last dose<\/strong> (washout period). Men: limited data suggest sperm quality may be temporarily reduced \u2014 many guidelines recommend avoiding conception for 6 months after a course in men too, though the evidence base is weaker. Excretion in breast milk is unclear \u2014 alternatives are preferred.<\/p>\n<h2 id=\"faqs\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/h2>\n<h3>When is griseofulvin still preferred over terbinafine?<\/h3>\n<p>For tinea capitis caused by Microsporum canis (typically picked up from cats \/ dogs). Terbinafine has 60\u201370% cure rates for Microsporum versus &gt; 90% for Trichophyton; griseofulvin has 80\u201390% cure rates for Microsporum. The cause is determined by fungal culture or PCR. Pre-school children with kitten exposure \u2014 Microsporum is a common cause.<\/p>\n<h3>My child has scalp ringworm \u2014 what should I expect?<\/h3>\n<p>6\u20138 weeks of daily oral griseofulvin (or 4 weeks oral terbinafine if Trichophyton). Plus medicated shampoo (selenium sulphide or ketoconazole) twice weekly to reduce shedding to others. Don&#8217;t share hairbrushes \/ hats. School policy: most schools allow attendance once treatment is started.<\/p>\n<h3>Why does griseofulvin reduce the contraceptive pill?<\/h3>\n<p>Griseofulvin induces hepatic CYP enzymes that metabolise oestrogen and progestogen. Ethinylestradiol levels can fall enough to allow ovulation. Use additional barrier contraception during the course and for 1 month after the last dose. This warning applies to combined pills, mini-pills, contraceptive patch, and vaginal ring; the levonorgestrel IUS and copper IUD are unaffected.<\/p>\n<h3>Why a fatty meal?<\/h3>\n<p>Griseofulvin is poorly water-soluble. Taken with a high-fat meal (e.g. eggs, full-fat yogurt, peanut butter on toast), bioavailability roughly doubles compared to fasting. For paediatric dosing, mixing the crushed tablet into yogurt or peanut butter is both an absorption strategy and a palatability strategy.<\/p>\n<h3>Is Griseofulvin the same as Fulcin \/ Grisactin?<\/h3>\n<p>Yes \u2014 Fulcin and Grisactin are older brand names of griseofulvin. Griseofulvin contains the same active ingredient, manufactured by generic under WHO-GMP. Bioequivalent.<\/p>\n<h3>Why am I getting a rash on my arms in the sun?<\/h3>\n<p>Griseofulvin is photosensitising. UV exposure during therapy can produce an itchy rash on sun-exposed skin. Use SPF 30+ broad-spectrum sunscreen, long sleeves outdoors, and avoid sunbeds during the course.<\/p>\n<h3>Can my child play sport with tinea capitis?<\/h3>\n<p>Yes \u2014 once treatment is started. Avoid sharing helmets \/ caps \/ hairbrushes; wash bedding hot. Most school and sports authorities allow return to activity 24\u201348 hours after starting oral antifungal.<\/p>\n<h3>What if my tinea pedis or onychomycosis hasn&#8217;t cleared after 12 weeks of griseofulvin?<\/h3>\n<p>Switch to terbinafine or itraconazole \u2014 both have higher cure rates for adult-onset dermatophyte nail and skin infections. Recheck the fungal diagnosis with a clipping for microscopy \/ culture before changing \u2014 the original diagnosis may have been wrong.<\/p>\n<h3>Is it safe to drink alcohol on griseofulvin?<\/h3>\n<p>A rare disulfiram-like reaction (flushing, tachycardia, nausea) has been reported. Most patients tolerate moderate alcohol without issue. Avoid heavy drinking during the course.<\/p>\n<h3>Why is the course so long for nails?<\/h3>\n<p>Griseofulvin only protects newly-formed keratin \u2014 it does not eradicate fungus from existing infected nail. The nail has to grow out from the cuticle. Toenails grow ~1.5 mm per month, so a fully grown-out toenail takes ~9 months. Modern practice prefers terbinafine or itraconazole for nail because they concentrate in the existing nail and shorten the active treatment phase.<\/p>\n<h2 id=\"storage\">\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7<\/h2>\n<p>Store tablets at 15\u201325 \u00b0C, away from light and moisture. Keep out of reach of children. Do not use after expiry.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>\u0386\u03bb\u03bb\u03b1 \u0391\u03bd\u03c4\u03b9\u03bc\u03c5\u03ba\u03b7\u03c4\u03b9\u03b1\u03c3\u03b9\u03ba\u03ac \u03a6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03b1\u03c2 \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd<\/h2>\n<p>If Griseofulvin is unavailable, here are alternatives \u2014 same molecule from a different manufacturer, plus first-line modern alternatives where griseofulvin is no longer preferred.<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/el\/zimig\/\"><strong>Zimig (terbinafine 250 mg)<\/strong><\/a> \u2014 First-line for adult dermatophyte tinea \/ onychomycosis.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/sporanox-capsule\/\"><strong>Sporanox (itraconazole 100 mg)<\/strong><\/a> \u2014 Onychomycosis pulse therapy alternative.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/clocip\/\"><strong>Clocip (clotrimazole 1% \u03ba\u03c1\u03ad\u03bc\u03b1)<\/strong><\/a> \u2014 Topical for skin tinea + Candida; pregnancy-safe.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/keto-cream\/\"><strong>Keto Cream (ketoconazole 2%)<\/strong><\/a> \u2014 Topical for tinea + seborrhoeic dermatitis.<\/li>\n<li><a href=\"https:\/\/medsbase.com\/el\/loceryl-nail-liq\/\"><strong>Loceryl (amorolfine 5%)<\/strong><\/a> \u2014 Topical lacquer for mild distal nail infection.<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:12px 18px;margin:24px 0;font-size:0.95em;\"><strong>\u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03b5\u03c5\u03b8\u03c5\u03bd\u03ce\u03bd.<\/strong> \u0391\u03c5\u03c4\u03ae \u03b7 \u03c3\u03b5\u03bb\u03af\u03b4\u03b1 \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03b9 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b5\u03c2 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03c9\u03bd \u03b3\u03b9\u03b1 \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03ad\u03bb\u03bd\u03bf\u03c5\u03bd \u03b1\u03bd\u03c4\u03b9\u03bc\u03c5\u03ba\u03b7\u03c4\u03b9\u03b1\u03c3\u03b9\u03ba\u03ac \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b9\u03ba\u03ae \u03c7\u03c1\u03ae\u03c3\u03b7. \u0394\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c4\u03bf \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03ae\u03c2. \u03a3\u03c5\u03b6\u03b7\u03c4\u03ae\u03c3\u03c4\u03b5 \u03c4\u03bf \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03bf \u03b1\u03bd\u03c4\u03b9\u03bc\u03c5\u03ba\u03b7\u03c4\u03b9\u03b1\u03c3\u03b9\u03ba\u03cc, \u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03bc\u03b5 \u03ad\u03bd\u03b1\u03bd \u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u2014 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b5\u03ac\u03bd \u03ad\u03c7\u03b5\u03c4\u03b5 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf, \u03b5\u03af\u03c3\u03c4\u03b5 \u03ad\u03b3\u03ba\u03c5\u03bf\u03c2 \u03ae \u03b8\u03b7\u03bb\u03ac\u03b6\u03b5\u03c4\u03b5, \u03c0\u03b1\u03af\u03c1\u03bd\u03b5\u03c4\u03b5 warfarin, \u03c0\u03b1\u03af\u03c1\u03bd\u03b5\u03c4\u03b5 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7, \u03c0\u03b1\u03af\u03c1\u03bd\u03b5\u03c4\u03b5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ac \u03ae \u03ad\u03c7\u03b5\u03c4\u03b5 \u03bc\u03c5\u03ba\u03b7\u03c4\u03b9\u03b1\u03c3\u03b9\u03ba\u03ae \u03bc\u03cc\u03bb\u03c5\u03bd\u03c3\u03b7 \u03bd\u03c5\u03c7\u03b9\u03ce\u03bd \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 (\u03c8\u03c9\u03c1\u03af\u03b1\u03c3\u03b7, \u03b5\u03c1\u03c5\u03b8\u03b7\u03bc\u03b1\u03c4\u03ce\u03b4\u03b7\u03c2 \u03bb\u03b5\u03b9\u03c7\u03ae\u03bd\u03b1\u03c2, \u03c4\u03c1\u03b1\u03c5\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03cc\u03c2).<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u2705 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03cd\u03b5\u03b9 \u039c\u03c5\u03ba\u03b7\u03c4\u03b9\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u039b\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03b9\u03c2<br \/>\n\u2705 Clears Ringworm<br \/>\n\u2705 Effective Antifungal Agent<br \/>\n\u2705 Targets Dermatophytes<br \/>\n\u2705 Inhibits Fungal Growth<\/p>\n<p>Contains Griseofulvin.<\/p>","protected":false},"featured_media":57261,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3501,3141,3504,3342],"product_tag":[4272],"class_list":{"0":"post-57260","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-fungal","7":"product_cat-category-overview","8":"product_cat-fungal-infection-treatment","9":"product_cat-general-health","10":"product_tag-griseofulvin","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product\/57260","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/comments?post=57260"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media\/57261"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/media?parent=57260"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_brand?post=57260"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_cat?post=57260"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/el\/wp-json\/wp\/v2\/product_tag?post=57260"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}